A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Chemico-Biological Interactions

• Publication date

  1999-05-14

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0009-2797(99)00012-5PMID 10421437
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificity.

  1999cited by this paper
• Structure and Function of Cholinesterases and Related Proteins

  1998cited by this paper
• Crystal Structures of “Aged” Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase

  1998cited by this paper
• Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase.

  1998cited by this paper
• STRATEGY: a program to optimize the starting spindle angle and scan range for X-ray data collection

  1997cited by this paper
• Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase.

  1997cited by this paper
• The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase.

  1996cited by this paper
• Raman spectroscopic study of conjugates of butyrylcholinesterase with organophosphates.

  1995cited by this paper
• Origins and diversity of the aging reaction in phosphonate adducts of serine hydrolase enzymes: what characteristics of the active site do they probe?

  1995cited by this paper
• The cholinesterases: from genes to proteins.

  1994cited by this paper
• Molecular recognition in acetylcholinesterase catalysis: free-energy correlations for substrate turnover and inhibition by trifluoro ketone transition-state analogs.

  1994cited by this paper
• Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.

  1993cited by this paper
• Parallel mechanisms in acetylcholinesterase-catalyzed hydrolysis of choline esters

  1993cited by this paper
• PROCHECK: a program to check the stereochemical quality of protein structures

  1993cited by this paper
• Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors.

  1993cited by this paper
• The alpha/beta hydrolase fold.

  1992cited by this paper
• The α/β hydrolase fold

  1992cited by this paper
• Catalysis at the interface: the anatomy of a conformational change in a triglyceride lipase.

  1992cited by this paper
• Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin.

  1991cited by this paper
• Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein

  1991cited by this paper
• A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex

  1991cited by this paper
• WHAT IF: a molecular modeling and drug design program.

  1990cited by this paper
• Conformational differences between aged and non-aged organophosphoryl conjugates of chymotrypsin.

  1989cited by this paper
• Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy.

  1989cited by this paper
• Cryocrystallography of biological macromolecules: a generally applicable method.

  1988cited by this paper
• Catalytic recruitment in the inactivation of acetylcholinesterase by soman: temperature dependence of the solvent isotope effect

  1988cited by this paper
• Nerve agent stereoisomers: analysis, isolation and toxicology

  1988cited by this paper
• Measures of cooperativity in the binding of ligands to proteins and their relation to non-additivity in protein-protein interactions

  1986cited by this paper
• Effects of site-specific amino acid modification on protein interactions and biological function.

  1985cited by this paper
• Direct determination of acetyl-enzyme intermediate in the acetylcholinesterase-catalyzed hydrolysis of acetylcholine and acetylthiocholine.

  1984cited by this paper
• Chemical approaches to understanding enzyme catalysis

  1983cited by this paper
• A hydrophobic dimer of acetylcholinesterase from Torpedo californica electric organ is solubilized by phosphatidylinositol-specific phospholipase C.

  1983cited by this paper
• Novel pyrene-containing organophosphates as fluorescent probes for studying aging-induced conformational changes in organophosphate-inhibited acetylcholinesterase.

  1982cited by this paper
• Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin.

  1981influential reference
• Fluorinated aldehydes and ketones acting as quasi-substrate inhibitors of acetylcholinesterase.

  1979cited by this paper
• Serine proteases: structure and mechanism of catalysis.

  1977cited by this paper
• The structure of bovine trypsin: electron density maps of the inhibited enzyme at 5 Angstrom and at 2-7 Angstron resolution.

  1974cited by this paper
• The structure of bovine trypsin : Electron density maps of the inhibited enzyme at 5 Å and at 2·7 Å resolution☆

  1974cited by this paper
• Enzyme inhibitors as substrates : interactions of esterases with esters of organophosphorus and carbamic acids

  1972cited by this paper
• The Chemical bassis of the "ageing process" of DFP-inhibited pseudocholinesterase.

  1959cited by this paper

• Exploring the potential of a novel phenoxyethyl piperidine derivative with cholinesterase inhibitory properties as a treatment for dementia: insights from STZ animal model of dementia.

  2023cites this paper
• The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer’s Disease

  2021cites this paper
• Inhibition of acetylcholinesterases by stereoisomeric organophosphorus compounds containing both thioester and p-nitrophenyl leaving groups.

  2020cites this paper
• Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREB/BDNF Pathway in Alloxan-Induced Diabetic Mice

  2020cites this paper
• A novel on-flow mass spectrometry-based dual enzyme assay.

  2019cites this paper
• Characterization of the interactions between coumarin-derivatives and acetylcholinesterase: Examination by NMR and docking simulations

  2018cites this paper
• The implementation of NMR techniques for measuring interactions between small organic molecules/inhibitors and enzyme Acetylcholinesterase: a step towards Alzheimer´s control

  2015cites this paper
• Large-Scale First-Principles Molecular Dynamics Simulations with Electrostatic Embedding: Application to Acetylcholinesterase Catalysis.

  2015cites this paper
• Point Mutations Associated with Organophosphate and Carbamate Resistance in Chinese Strains of Culex pipiens quinquefasciatus (Diptera: Culicidae)

  2014cites this paper
• Acetylcholinesterase immobilized capillary reactors coupled to protein coated magnetic beads: a new tool for plant extract ligand screening.

  2013cites this paper
• The use of mixed self-assembled monolayers as a strategy to improve the efficiency of carbamate detection in environmental monitoring

  2013cites this paper
• Acetylcholinesterase immobilized capillary reactors-tandem mass spectrometry: an on-flow tool for ligand screening.

  2013cites this paper
• Enhancement of the Enzymatic Activity of Escherichia coli Acetyl Esterase by a Double Mutation Obtained by Random Mutagenesis

  2012cites this paper
• In silico methods to assist drug developers in acetylcholinesterase inhibitor design.

  2011cites this paper
• Kinetics of inhibition of acetylcholinesterase in the presence of acetonitrile

  2009cites this paper
• An Amino Acid Substitution on the Acetylcholinesterase in the Field Strains of House Mosquito, Culex Pipiens Pallens (Diptera: Culicidae) in China

  2009cites this paper
• Customizing scoring functions for docking

  2008cites this paper
• Dissociation Between the Potent β-Amyloid Protein Pathway Inhibition and Cholinergic Actions of the Alzheimer Drug Candidates Phenserine and Cymserine

  2008cites this paper
• Molecular modelling and enzymatic studies of acetylcholinesterase and butyrylcholinesterase recognition with paraquat and related compounds

  2007cites this paper
• Structural Characterization of Acetylcholinesterase 1 from the Sand Fly Lutzomyia longipalpis (Diptera: Psychodidae)

  2007cites this paper
• Acetylcholinesterase

  2007cites this paper
• Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.

  2006cites this paper
• Kinetic analysis of the inhibition of human butyrylcholinesterase with cymserine.

  2006cites this paper
• Análise estrutural e funcional do cDNA para a enzima acetilcolinesterase de Lutzomyia longipalpis

  2006influential citation
• The unique mutation in ace‐1 giving high insecticide resistance is easily detectable in mosquito vectors

  2004cites this paper
• Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.

  2003cites this paper
• Prediction of organophosphorus acetylcholinesterase inhibition using three-dimensional quantitative structure-activity relationship (3D-QSAR) methods.

  2001cites this paper
• Bioresponse-Linked Analysis Based on Acetylcholinesterase Inhibition

  2001cites this paper
• Structural studies on vertebrate and invertebrate acetylcholinesterases and their complexes with functional ligands

  2000cites this paper
• 1H NMR relaxation investigation of inhibitors interacting with Torpedo californica acetylcholinesterase.

  2000cites this paper
• Alpha/Beta-hydrolase fold enzymes: structures, functions and mechanisms.

  2000cites this paper
• Distinctive structural and kinetic properties of an unusual juvenile hormone-hydrolyzing esterase.

  2000cites this paper
• Chapter 1 General Introduc�on

  year unknowncites this paper