Exhaled nitric oxide thresholds associated with a sputum eosinophil count ≥3% in a cohort of unselected patients with asthma

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Thorax

• Publication date

  2010-07-29

• Fields of study

  Medicine

• Identifiers
  DOI 10.1136/thx.2009.124925PMID 20671307
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sputum and serum calprotectin are useful biomarkers during CF exacerbation.

  2010cited by this paper
• Thorax

  2009cited by this paper
• Asthma control, airway responsiveness and airway inflammation

  2009cited by this paper
• Association between asthma control and bronchial hyperresponsiveness and airways inflammation: a cross‐sectional study in daily practice

  2009cited by this paper
• Exhaled nitric oxide as a marker of asthma control in smoking patients

  2009influential reference
• Using fractional exhaled nitric oxide to guide asthma therapy: design and methodological issues for ASthma TReatment ALgorithm studies

  2009cited by this paper
• Both allergic and nonallergic asthma are associated with increased FENO levels, but only in never‐smokers

  2009cited by this paper
• Exhaled nitric oxide: independent effects of atopy, smoking, respiratory tract infection, gender and height.

  2008cited by this paper
• Reference ranges for exhaled nitric oxide derived from a random community survey of adults.

  2007influential reference
• Noneosinophilic asthma: a distinct clinical and pathologic phenotype.

  2007cited by this paper
• Smoking and Asthma: Clinical and Radiologic Features, Lung Function, and Airway Inflammation

  2007cited by this paper
• Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies.

  2007cited by this paper
• The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial.

  2007cited by this paper
• Effects of smoking cessation on lung function and airway inflammation in smokers with asthma.

  2006cited by this paper
• Inflammatory subtypes in asthma: Assessment and identification using induced sputum

  2006cited by this paper
• Smoking and asthma: clinical and radiologic features, lung function, and airway inflammation.

  2006cited by this paper
• Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations

  2006cited by this paper
• Exhaled nitric oxide measurements: clinical application and interpretation

  2006cited by this paper
• The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma

  2005cited by this paper
• Exhaled nitric oxide: a predictor of steroid response.

  2005cited by this paper
• Nebulised salbutamol administered during sputum induction improves bronchoprotection in patients with asthma

  2004cited by this paper
• Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.

  2002cited by this paper
• Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids

  2002cited by this paper
• Sputum eosinophil count in a large population of patients with mild to moderate steroid‐naive asthma: distribution and relationship with methacholine bronchial hyperresponsiveness

  2002cited by this paper
• Non-eosinophilic asthma: importance and possible mechanisms

  2002cited by this paper
• Smoking and airway inflammation in patients with mild asthma.

  2001cited by this paper
• A comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation.

  2000cited by this paper
• Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma

  1999influential reference
• Development and validation of a questionnaire to measure asthma control.

  1999cited by this paper
• Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils, and exhaled nitric oxide levels in patients with asthma

  1999cited by this paper
• Non-eosinophilic corticosteroid unresponsive asthma.

  1999cited by this paper
• The effect of cigarette smoking on exhaled nitric oxide in mild steroid-naive asthmatics.

  1999cited by this paper
• Superoxide released from neutrophils causes a reduction in nitric oxide gas.

  1998cited by this paper
• Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells.

  1998cited by this paper
• Superoxide released from neutrophils causes a reduction in nitric oxide gas.

  1998cited by this paper
• The effect of treatment with oral corticosteroids on asthma symptoms and airway inflammation.

  1997cited by this paper
• Smoking cessation is associated with an increase in exhaled nitric oxide.

  1997cited by this paper
• Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients.

  1996cited by this paper
• Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials.

  1992influential reference

• Identifying optimal flow rates for airway eosinophilia detection in asthma.

  2026cites this paper
• Bioaccumulation of Heavy Metals and Arsenic in the Tissues of Striped Field Mouse (Apodemus agrarius) (Muridae, Rodentia) Inhabits Moscow Parks

  2025cites this paper
• Biomarker profile and disease burden associated with intermittent and long-term oral corticosteroid use in patients with severe asthma prior to biologic initiation in real-life (STAR)

  2025cites this paper
• What drives rescue bronchodilators overuse in asthma patients? Demographic features, low forced expiratory volume in 1 s and high sputum eosinophil counts

  2025cites this paper
• Breath-based stratification of asthma severity using the MISTRAL platform with integrated H2S sensor and clinical validation

  2025cites this paper
• When patient-reported respiratory symptoms shed light on pathophysiology in adult asthma: a cross-sectional study

  2024cites this paper
• Biologics for eosinophilic otitis media: a retrospective case study in a multidisciplinary center

  2024cites this paper
• Exhaled nitric oxide levels in COPD patients who use electronic cigarettes.

  2024cites this paper
• Evidence for two clusters among non-eosinophilic asthmatics.

  2024cites this paper
• Comparing the utility of lung function parameters and fractional exhaled nitric oxide in predicting lung cancer

  2024cites this paper
• Biologics alter the relationship between exhaled nitric oxide fraction and sputum eosinophils in severe T2-high asthma patients

  2024cites this paper
• Exhaled Nitric Oxide and Sputum Eosinophils Are Complementary Tools for Diagnosing Occupational Asthma

  2024cites this paper
• When sequential use of mepolizumab and dupilumab in a severe atopic eosinophilic asthmatic questions the role of eosinophils in mediating the clinical expression of the disease: a case report

  2024cites this paper
• Biologics in Asthma: Role of Biomarkers.

  2024cites this paper
• Presence of sputum IgG against eosinophilic inflammatory proteins in asthma

  2024cites this paper
• Association between pre-biologic T2-biomarker combinations and response to biologics in patients with severe asthma

  2024cites this paper
• Phenotyping of Severe Asthma in the Era of Broad-acting Anti-asthma Biologics.

  2024cites this paper
• Évaluation de l’inflammation dans l’asthme : les multiples facettes de « l’inflammométrie »

  2023cites this paper
• Predictors of change in asthma-related quality of life: a longitudinal real-life study in adult asthmatics

  2023cites this paper
• TƯƠNG QUAN GIỮA MỨC NITRIC OXIDE TRONG KHÍ THỞ RA VỚI MỘT VÀI ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ CÁC MỨC ĐỘ KIỂM SOÁT HEN Ở BỆNH NHÂN HEN PHẾ QUẢN NGƯỜI LỚN

  2023cites this paper
• Airway Hyperresponsiveness Reflects Corticosteroid-Sensitive Mast Cell Involvement Across Asthma Phenotypes.

  2023cites this paper
• Involvement of Transforming Growth Factor-β-Associated Kinase 1 in Fixed Airway Obstruction in Asthmatic Patients with Longer Disease Duration Independent on Airway Eosinophilia

  2023cites this paper
• Benralizumab in severe eosinophilic asthma in real life: confirmed effectiveness and contrasted effect on sputum eosinophilia versus exhaled nitric oxide fraction – PROMISE

  2023cites this paper
• Diagnostic accuracy of blood eosinophils in comparison to other common biomarkers for identifying sputum eosinophilia in patients with chronic cough

  2023cites this paper
• Effect of High-Intensity Interval Training on Inhaled Corticosteroid Dose in Asthma Patients: A Randomized Controlled Trial.

  2023cites this paper
• Association of fractional exhaled nitric oxide with asthma morbidity in urban minority children

  2022cites this paper
• Effect of combined glucocorticoid therapy on bronchial asthma dynamics.

  2022cites this paper
• Advances in Evaluation and Treatment of Severe Asthma (Part One).

  2022cites this paper
• Revisiting differences between atopic and non-atopic asthmatics: When age is shaping airway inflammatory profile

  2022cites this paper
• Paucigranulocytic Asthma: Potential Pathogenetic Mechanisms, Clinical Features and Therapeutic Management

  2022cites this paper
• Associations and dose-response relationships between different kinds of urine polycyclic aromatic hydrocarbons metabolites and adult lung functions

  2021cites this paper
• [Update of the 2021 recommendations for the management and follow-up of adult asthmatic patients under the guidance of the French Society of Pulmonology and the Paediatric Society of Pulmonology and Allergology. Long version].

  2021cites this paper
• Recommandations pour la prescription et l’interprétation des examens biologiques utilisables dans le cadre du diagnostic ou du suivi des allergies, disponibles en France. Partie 1 : préambule

  2021cites this paper
• Consensus document on asthma and smoking of the Regional Asthma Forum of SEPAR.

  2021cites this paper
• Predictors of asthma‐related quality of life in a large cohort of asthmatics: A cross‐sectional study in a secondary care center

  2021cites this paper
• Consensus document on asthma and smoking of the Regional Asthma Forum of SEPAR Documento de consenso sobre asma y tabaquismo del Foro Autonómico de Asma de la SEPAR

  2021cites this paper
• Metabolomics reveals a correlation between hydroxyeicosatetraenoic acids and allergic asthma: Evidence from three years' immunotherapy

  2021cites this paper
• Recommandations pour la prescription et l’interprétation des examens biologiques utilisables dans le cadre du diagnostic ou du suivi des allergies, disponibles en France. Partie 4 : allergie aux médicaments

  2021cites this paper
• Lower Airways: Assessment and Treatment for Cough

  2021cites this paper
• Exhaled volatile organic compounds for better asthma control: could it be a future noninvasive adherence test?

  2020cites this paper
• Driving progress in exhaled breath biomarkers: Breath Biopsy Conference 2019

  2020cites this paper
• An emerging role for exhaled nitric oxide in guiding biological treatment in severe asthma.

  2020cites this paper
• Chronic obstructive pulmonary disease - diagnosis and management of stable disease; a personalized approach to care, using the treatable traits concept based on clinical phenotypes. Position paper of the Czech Pneumological and Phthisiological Society.

  2020cites this paper
• Identification and treatment of T2-low asthma in the era of biologics

  2020cites this paper
• Multimodal combination of GC × GC-HRTOFMS and SIFT-MS for asthma phenotyping using exhaled breath

  2020cites this paper
• Exhaled nitric oxide measurements are not influenced by anti-eosinophil therapy in asthmatics: a retrospective analysis.

  2020cites this paper
• Advances with glucocorticoids in the treatment of asthma: state of the art

  2020cites this paper
• An official JRS statement: The principles of fractional exhaled nitric oxide (FeNO) measurement and interpretation of the results in clinical practice.

  2020cites this paper
• cAssessment of diagnostic accuracy of lung function indices and FeNO for a positive methacholine challenge.

  2020cites this paper
• Predictors of Asthma-related Quality of Life in a Large Cohort of Asthmatics: Towards a New Vison on Feno – A Cross-sectional Study in a Secondary Care Center 

  2020cites this paper
• Predictors of a good response to Inhaled Corticosteroids in obesity-associated asthma.

  2020cites this paper
• Intérêt de la mesure de l’inflammation en clinique dans l’asthme

  2020cites this paper
• Basic characteristics and clinical value of FeNO in smoking asthmatics—a systematic review

  2019cites this paper
• Relationship between upper airway diseases, exhaled nitric oxide, and bronchial hyperresponsiveness to methacholine

  2019cites this paper
• Approaches to the assessment of severe asthma: barriers and strategies

  2019cites this paper
• New Aspects of Mast Cell Progenitors in Health and Disease

  2019cites this paper
• Exhaled Volatile Organic Compounds are Able to Discriminate between Neutrophilic and Eosinophilic Asthma.

  2019cites this paper
• The functional status of neutrophils in patients with bronchial asthma, chronic obstructive pulmonary disease, bronchial asthma with chronic obstructive pulmonary disease, and community-acquired pneumonia

  2018cites this paper
• Towards precision medicine in severe asthma: Treatment algorithms based on treatable traits.

  2018cites this paper
• Noninvasive Biomarkers of Asthma

  2018cites this paper
• Validation of ATS clinical practice guideline cut-points for FeNO in asthma.

  2018cites this paper
• Implication of fraction of exhaled nitric oxide and blood eosinophil count in severe asthma.

  2018cites this paper
• FeNO-based asthma management results in faster improvement of airway hyperresponsiveness

  2018cites this paper
• Association between fractional exhaled nitric oxide, sputum induction and peripheral blood eosinophil in uncontrolled asthma

  2018cites this paper
• Priorities for future research into asthma diagnostic tools: A PAN‐EU consensus exercise from the European asthma research innovation partnership (EARIP)

  2018influential citation
• A novel nutritional intervention improves lung function in overweight/obese adolescents with poorly controlled asthma: the Supplemental Nutrition in Asthma Control (SNAC) pilot study

  2018cites this paper
• IgE sensitization to food allergens and airborne allergens in relation to biomarkers of type 2 inflammation in asthma

  2018cites this paper
• Targeted anti-IL-13 therapies in asthma: current data and future perspectives

  2018cites this paper
• Association of Mycoplasma pneumoniae infection with increased risk of asthma in children

  2017cites this paper
• Correlation between fractional exhaled nitric oxide and sputum eosinophilia in exacerbations of COPD

  2017cites this paper
• Clinical, functional and inflammatory characteristics in patients with paucigranulocytic stable asthma: Comparison with different sputum phenotypes

  2017cites this paper
• Is it possible to claim or refute sputum eosinophils ≥ 3% in asthmatics with sufficient accuracy using biomarkers?

  2017cites this paper
• Adult-onset eosinophilic asthma

  2017cites this paper
• Correlation between fractional exhaled nitric oxide and sputum eosinophilia in exacerbations of COPD

  2017cites this paper
• Volatile organic compounds discriminate between eosinophilic and neutrophilic inflammation in vitro

  2016cites this paper
• Defining asthma–COPD overlap syndrome: a population-based study

  2016cites this paper
• Blood eosinophil count to predict bronchial eosinophilic inflammation in COPD

  2016cites this paper
• Biomarkers Guided Treatment Strategies in Adult Patients with Asthma: Ready for the Clinical Field?

  2016cites this paper
• Clinical and inflammatory features of asthma with dissociation between fractional exhaled nitric oxide and eosinophils in induced sputum

  2016cites this paper
• The clinical profile of benralizumab in the management of severe eosinophilic asthma

  2016cites this paper
• Clinical usefulness of mepolizumab in severe eosinophilic asthma

  2016influential citation
• Biomarkers in the Management of Difficult Asthma

  2016cites this paper
• IgE mediated sensitisation to aeroallergens in an asthmatic cohort: relationship with inflammatory phenotypes and disease severity

  2016cites this paper
• Fractional exhaled nitric oxide for the management of asthma in adults: a systematic review

  2016cites this paper
• Phenotyping and Endotyping Asthma Based on Biomarkers.

  2016cites this paper
• Fractional exhaled nitric oxide levels as a predictor of long-term prognoses in patients with mild asthma.

  2016cites this paper
• Responsiveness to methacholine, but not leukotriene D4, correlates with fractional exhaled nitric oxide in asthma

  2016cites this paper
• Mepolizumab for severe refractory eosinophilic asthma: evidence to date and clinical potential

  2016cites this paper
• Exacerbation risk in severe asthma is stratified by inflammatory phenotype using longitudinal measures of sputum eosinophils

  2016cites this paper
• Towards a practical clinical use of fractioned exhaled nitric oxide levels in chronic cough.

  2016cites this paper
• Eosinophilia and Chronic Airway Diseases

  2016cites this paper
• Identificación del fenotipo inflamatorio del asma mediante métodos no invasivos

  2016influential citation
• Fractional Exhaled Nitric Oxide: Comparison Between Portable Devices and Correlation With Sputum Eosinophils

  2015cites this paper
• Biomarkers to identify sputum eosinophilia in different adult asthma phenotypes

  2015cites this paper
• The Calcitriol Study A Randomised Placebo Controlled Clinical Trial to Test the Effects of Calcitriol in Steroid Resistant Asthma.

  2015cites this paper
• The past, present, and future of monoclonal antibodies to IL-5 and eosinophilic asthma: a review

  2015cites this paper
• Measurement of exhaled nitric oxide concentration in asthma: a systematic review and economic evaluation of NIOX MINO, NIOX VERO and NObreath.

  2015cites this paper
• Heterogeneity of phenotypes in severe asthmatics. The Belgian Severe Asthma Registry (BSAR).

  2014cites this paper
• Importance of concomitant local and systemic eosinophilia in uncontrolled asthma

  2014cites this paper
• Body mass index, asthma and exhaled nitric oxide in U.S. Adults, 2007–2010

  2014cites this paper