The p122 Subunit of Tobacco Mosaic Virus Replicase Is a Potent Silencing Suppressor and Compromises both Small Interfering RNA- and MicroRNA-Mediated Pathways

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Virology

• Publication date

  2007-08-22

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1128/JVI.01230-07PMID 17715232PMCID PMC2168790
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transitivity in Arabidopsis can be primed, requires the redundant action of the antiviral Dicer-like 4 and Dicer-like 2, and is compromised by viral-encoded suppressor proteins.

  2016influential reference
• Molecular Bases of Viral RNA Targeting by Viral Small Interfering RNA-Programmed RISC

  2007cited by this paper
• Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants.

  2007cited by this paper
• Erratum: Functions of microRNAs and related small RNAs in plants

  2006cited by this paper
• Transgenically expressed viral RNA silencing suppressors interfere with microRNA methylation in Arabidopsis

  2006cited by this paper
• Molecular characterization of geminivirus-derived small RNAs in different plant species

  2006cited by this paper
• Functions of microRNAs and related small RNAs in plants

  2006cited by this paper
• F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function.

  2006cited by this paper
• Double-Stranded RNA Binding May Be a General Plant RNA Viral Strategy To Suppress RNA Silencing

  2006cited by this paper
• Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense.

  2006cited by this paper
• The diversity of RNA silencing pathways in plants.

  2006cited by this paper
• Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing

  2006cited by this paper
• Small RNA binding is a common strategy to suppress RNA silencing by several viral suppressors

  2006cited by this paper
• AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1.

  2006cited by this paper
• Nuclear processing and export of microRNAs in Arabidopsis.

  2005cited by this paper
• Linkage mapping of a complex trait in the New York population of the GAW14 simulated dataset: a multivariate phenotype approach

  2005cited by this paper
• Plant nuclear RNA polymerase IV mediates siRNA and DNA methylation-dependent heterochromatin formation.

  2005cited by this paper
• Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes.

  2005cited by this paper
• Expression of Arabidopsis MIRNA Genes1[w]

  2005cited by this paper
• Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs.

  2005cited by this paper
• DICER-LIKE 4 functions in trans-acting small interfering RNA biogenesis and vegetative phase change in Arabidopsis thaliana.

  2005cited by this paper
• microRNA-directed phasing during trans-acting siRNA biogenesis in plants.

  2005cited by this paper
• Plant Virus-Derived Small Interfering RNAs Originate Predominantly from Highly Structured Single-Stranded Viral RNAs

  2005cited by this paper
• Atypical RNA polymerase subunits required for RNA-directed DNA methylation

  2005cited by this paper
• Induction and suppression of RNA silencing: insights from viral infections

  2005cited by this paper
• Perspective: machines for RNAi.

  2005cited by this paper
• A pathway for the biogenesis of trans-acting siRNAs in Arabidopsis.

  2005cited by this paper
• Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis.

  2005cited by this paper
• microRNA biogenesis and function in plants

  2005cited by this paper
• Dual modes of RNA-silencing suppression by Flock House virus protein B2

  2005cited by this paper
• Biochemical specialization within Arabidopsis RNA silencing pathways.

  2005cited by this paper
• RNA Polymerase IV Directs Silencing of Endogenous DNA

  2005cited by this paper
• Methylation as a Crucial Step in Plant microRNA Biogenesis

  2005cited by this paper
• Prediction and identification of Arabidopsis thaliana microRNAs and their mRNA targets

  2004cited by this paper
• RISC assembly defects in the Drosophila RNAi mutant armitage.

  2004cited by this paper
• RETRACTED: Probing the MicroRNA and Small Interfering RNA Pathways with Virus-Encoded Suppressors of RNA Silencing[W]

  2004cited by this paper
• Molecular mechanism of RNA silencing suppression mediated by p19 protein of tombusviruses

  2004cited by this paper
• Genetic and Functional Diversification of Small RNA Pathways in Plants

  2004cited by this paper
• RNA silencing in plants

  2004cited by this paper
• The role of RNA interference in heterochromatic silencing

  2004cited by this paper
• Effects and side-effects of viral RNA silencing suppressors on short RNAs.

  2004cited by this paper
• Novel and Stress-Regulated MicroRNAs and Other Small RNAs from Arabidopsis

  2004cited by this paper
• In vivo investigation of the transcription, processing, endonucleolytic activity, and functional relevance of the spatial distribution of a plant miRNA.

  2004cited by this paper
• Viral RNA silencing suppressors inhibit the microRNA pathway at an intermediate step.

  2004cited by this paper
• A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila.

  2004cited by this paper
• Probing the MicroRNA and Small Interfering RNA Pathways with Virus-Encoded Suppressors of RNA Silencing

  2004cited by this paper
• Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs.

  2004cited by this paper
• Negative feedback regulation of Dicer-Like1 in Arabidopsis by microRNA-guided mRNA degradation.

  2003cited by this paper
• Control of leaf morphogenesis by microRNAs

  2003cited by this paper
• Size selective recognition of siRNA by an RNA silencing suppressor.

  2003cited by this paper
• Asymmetry in the Assembly of the RNAi Enzyme Complex

  2003cited by this paper
• ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation

  2003cited by this paper
• P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA unction.

  2003cited by this paper
• Recognition of small interfering RNA by a viral suppressor of RNA silencing

  2003cited by this paper
• Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance.

  2003cited by this paper
• Double-stranded RNA-binding proteins could suppress RNA interference-mediated antiviral defences.

  2003cited by this paper
• Asymmetry in the assembly of the RNAi enzyme complex.

  2003cited by this paper
• Tomato Mosaic Virus Replication Protein Suppresses Virus-Targeted Posttranscriptional Gene Silencing

  2003cited by this paper
• In vitro analysis of RNA interference in Drosophila melanogaster.

  2003cited by this paper
• Matthews' plant virology

  2002cited by this paper
• Short Defective Interfering RNAs of Tombusviruses Are Not Targeted but Trigger Post-Transcriptional Gene Silencing against Their Helper Virus Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.010366.

  2002cited by this paper
• P0 of Beet Western Yellows Virus Is a Suppressor of Posttranscriptional Gene Silencing

  2002cited by this paper
• A viral protein suppresses RNA silencing and binds silencing‐generated, 21‐ to 25‐nucleotide double‐stranded RNAs

  2002cited by this paper
• Identification and functional analysis of an interaction between domains of the 126/183-kDa replicase-associated proteins of tobacco mosaic virus.

  2001cited by this paper
• Construct design for efficient, effective and high-throughput gene silencing in plants.

  2001cited by this paper
• Potato Virus X Amplicons in Arabidopsis Mediate Genetic and Epigenetic Gene Silencing

  2000cited by this paper
• Isolation from Tobacco Mosaic Virus-Infected Tobacco of a Solubilized Template-Specific RNA-Dependent RNA Polymerase Containing a 126K/183K Protein Heterodimer

  1999influential reference
• Incorporation of terminal phosphorothioates into oligonucleotides.

  1998cited by this paper
• Complete nucleotide sequence and genome organization of a tobamovirus infecting cruciferae plants

  1994cited by this paper
• Functional analysis of cymbidium ringspot virus genome.

  1993cited by this paper
• In vitro mutagenesis of the putative replicase genes of tobacco mosaic virus.

  1986cited by this paper

• Transposable element-derived siRNAs control viral disease in Arabidopsis

  2026cites this paper
• Tobacco Mosaic Virus Movement: From Capsid Disassembly to Transport Through Plasmodesmata

  2025cites this paper
• The roles of movement and coat proteins in the transport of tobamoviruses between plant cells

  2025cites this paper
• Small RNA mobility and plant virus diseases

  2025cites this paper
• Tracking of Tobacco Mosaic Virus in Taxonomically Different Plant Fungi

  2025cites this paper
• Control of tomato brown rugose fruit virus (ToBRFV) in tomato plants using in vivo synthesized dsRNA

  2025cites this paper
• Shallot virus X p42 Protein Expressed in Concert with Virus Movement Proteins Is a Suppressor of Two Plant Antiviral Defense Mechanisms

  2025cites this paper
• Cellular Partners of Tobamoviral Movement Proteins

  2025cites this paper
• Identification of an RNA silencing suppressor encoded by an Indian citrus ringspot virus

  2024cites this paper
• Exogenous application of dsRNAs targeting multiple genes of cucumber mosaic virus in Cucumis sativus significantly reduces the viral titre

  2024cites this paper
• Plant Immunity against Tobamoviruses

  2024cites this paper
• A novel ilarvirus protein CP-RT is expressed via stop codon readthrough and suppresses RDR6-dependent RNA silencing

  2024cites this paper
• Breaking Boundaries: The Perpetual Interplay Between Tobamoviruses and Plant Immunity.

  2023cites this paper
• Tobamoviruses: old and new threats to tomato cultivation

  2023cites this paper
• Dicer-like2b suppresses the wiry leaf phenotype in tomato induced by tobacco mosaic virus.

  2023cites this paper
• Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense

  2023influential citation
• Designing Climate-Resilient Crops for Sustainable Agriculture: A Silent Approach

  2022cites this paper
• The Impact of Tobamovirus Infection on Tomato Root Development Involves Induction of AUXIN RESPONSE FACTOR 10a in Tomato.

  2022cites this paper
• Small RNAs Participate in Plant–Virus Interaction and Their Application in Plant Viral Defense

  2022cites this paper
• Ecotype-specific blockage of tasiARF production by two different RNA viruses in Arabidopsis

  2022cites this paper
• RNAi-Based Antiviral Innate Immunity in Plants

  2022cites this paper
• Plant Immunity Is Regulated by Biological, Genetic, and Epigenetic Factors

  2022cites this paper
• RNA and Protein Determinants Mediate Differential Binding of miRNAs by a Viral Suppressor of RNA Silencing Thus Modulating Antiviral Immune Responses in Plants

  2022cites this paper
• Characterization of small interfering RNAs derived from pepper mild mottle virus in infected pepper plants by high-throughput sequencing.

  2021cites this paper
• RNA Interference: A Novel Technology for Virus Disease Management in Crop Plants

  2021cites this paper
• Viral suppressors from members of the family Closteroviridae combating antiviral RNA silencing: a tale of a sophisticated arms race in host-pathogen interactions

  2021cites this paper
• Interlaboratory Comparison Study on Ribodepleted Total RNA High-Throughput Sequencing for Plant Virus Diagnostics and Bioinformatic Competence

  2021cites this paper
• Exploring the Multifunctional Roles of Odontoglossum Ringspot Virus P126 in Facilitating Cymbidium Mosaic Virus Cell-to-Cell Movement during Mixed Infection

  2021cites this paper
• Molecular biology of antiviral arms race between plants and viruses

  2021cites this paper
• Genetically Modified Crops: Current Status, Prospects and Challenges Volume 2

  2021cites this paper
• Role of small RNA in regulating plant viral pathogenesis

  2020cites this paper
• A single amino acid in coat protein of Pepper mild mottle virus determines its subcellular localization and the chlorosis symptom on leaves of pepper

  2020cites this paper
• Analysis of Small RNAs of Barley Genotypes Associated with Resistance to Barley Yellow Dwarf Virus

  2020cites this paper
• GM Crops for Plant Virus Resistance: A Review

  2020cites this paper
• The C-terminal region of the 2a protein and 2b protein of cucumber mosaic virus are involved in the induction of shoestring-like leaf blade in tomato.

  2020cites this paper
• Potential Role of Accessory Domains in Polyproteins Encoded by Retrotransposons in Anti-viral Defense of Host Cells

  2019cites this paper
• Full-Length Infectious Clones of Two New Isolates of Tomato Mosaic Virus Induce Distinct Symptoms Associated with Two Differential Amino Acid Residues in 128-kDa Protein

  2019cites this paper
• Geminiviruses Versus Host’s Gene Silencing Mechanism

  2019cites this paper
• A Single Amino Acid Substitution in the Intervening Region of 129K protein of Cucumber Green Mottle Mosaic Virus Resulted in Attenuated Symptoms.

  2019cites this paper
• The Three Essential Motifs in P0 for Suppression of RNA Silencing Activity of Potato leafroll virus Are Required for Virus Systemic Infection

  2019cites this paper
• Transcriptome reprogramming in the shoot apical meristem of CymRSV‐infected Nicotiana benthamiana plants associates with viral exclusion and the lack of recovery

  2019influential citation
• Tobacco mosaic virus infection triggers an RNAi-based response in Phytophthora infestans

  2019cites this paper
• Molecular characterization and In Vitro synthesis of infectious RNA of a Turnip vein-clearing virus isolated from Alliaria petiolata in Hungary

  2019cites this paper
• A Viral Suppressor Modulates the Plant Immune Response Early in Infection by Regulating MicroRNA Activity

  2018cites this paper
• Crosstalk between PTGS and TGS pathways in natural antiviral immunity and disease recovery

  2018cites this paper
• Tomato geminivirus encoded RNAi suppressor protein, AC4 interacts with host AGO4 and precludes viral DNA methylation.

  2018cites this paper
• Chapter 2 Plasmodesmata : Channels for Viruses on the Move

  2018cites this paper
• The nonstop decay and the RNA silencing systems operate cooperatively in plants

  2018cites this paper
• Viruses and Phytoparasitic Nematodes of Cicer arietinum L.: Biotechnological Approaches in Interaction Studies and for Sustainable Control

  2018cites this paper
• Plant Defense and Counter Defense by Viruses

  2018cites this paper
• Striga hermonthica (Delile) Benth. Resistance Mechanisms in KSTP’94 Maize Variety and Host Induced Gene Silencing of CYSTEINE PROTEASE

  2018cites this paper
• Revisiting the Roles of Tobamovirus Replicase Complex Proteins in Viral Replication and Silencing Suppression.

  2018cites this paper
• The No-go decay system degrades plant mRNAs that contain a long A-stretch in the coding region.

  2018cites this paper
• Functional analysis of a weak viral RNA silencing suppressor using two GFP variants as silencing inducers.

  2017cites this paper
• Malus hupehensis miR168 Targets to ARGONAUTE1 and Contributes to the Resistance against Botryosphaeria dothidea Infection by Altering Defense Responses

  2017cites this paper
• New Korean isolates of Pepper mild mottle virus (PMMoV) differ in symptom severity and subcellular localization of the 126 kDa protein

  2017cites this paper
• Biochemical analysis of NSs from different tospoviruses.

  2017cites this paper
• Host induced gene silencing, an emerging science to engineer crop resistance against harmful plant pathogens

  2017cites this paper
• Untangling the piRNA pathway in the arbovirus vector mosquito Aedes aegypti

  2017cites this paper
• Altered accumulation of osa-miR171b contributes to rice stripe virus infection by regulating disease symptoms

  2017cites this paper
• Tobacco rattle virus (TRV)-Mediated Silencing of Nicotiana benthamiana ARGONAUTES (NbAGOs) Reveals New Antiviral Candidates and Dominant Effects of TRV-NbAGO1.

  2017cites this paper
• Investigation of genes participating in antiviral RNA silencing against Cymbidium ringspot virus and, the RNA silencing suppressor, protein p19

  2017cites this paper
• RNAi, It’s Mechanism and Potential use in Crop Improvement : A review

  2017cites this paper
• RNA helicase domains of viral origin in proteins of insect retrotransposons: possible source for evolutionary advantages

  2017cites this paper
• Plant-Virus Interactions

  2016cites this paper
• Distinct Effects of p19 RNA Silencing Suppressor on Small RNA Mediated Pathways in Plants

  2016cites this paper
• Infection, Replication, and Expression of Plant Viruses in Filamentous Fungi

  2016cites this paper
• Tospovirus : induction and suppression of RNA silencing

  2016cites this paper
• Antiviral Silencing and Suppression of Gene Silencing in Plants

  2016cites this paper
• Replication of Tobamovirus RNA.

  2016cites this paper
• Exogenous application of double-stranded RNA molecules from TMV p126 and CP genes confers resistance against TMV in tobacco

  2016cites this paper
• Plant Defence and Viral Interference

  2016cites this paper
• Complete nucleotide sequences and construction of full-length infectious cDNA clones of cucumber green mottle mosaic virus (CGMMV) in a versatile newly developed binary vector including both 35S and T7 promoters

  2016cites this paper
• Virus P19 RNA Silencing Suppressor Effects 8. MicroRNAs: A New Paradigm For Gene Regulation

  2016cites this paper
• Viral Transport and Interaction with the Host Cytoskeleton

  2016cites this paper
• Role of Small RNAs in Virus-Host Interaction

  2016cites this paper
• Alfalfa dwarf cytorhabdovirus P protein is a local and systemic RNA silencing supressor which inhibits programmed RISC activity and prevents transitive amplification of RNA silencing.

  2016cites this paper
• Viral RNA Silencing Suppression: The Enigma of Bunyavirus NSs Proteins

  2016cites this paper
• Transgenic down-regulation of ARGONAUTE2 expression in Nicotiana benthamiana interferes with several layers of antiviral defenses.

  2015cites this paper
• Phylogenetic relationship of some “accessory” helicases of plant positive-stranded RNA viruses: toward understanding the evolution of triple gene block

  2015cites this paper
• Differential mRNA Accumulation upon Early Arabidopsis thaliana Infection with ORMV and TMV-Cg Is Associated with Distinct Endogenous Small RNAs Level

  2015cites this paper
• Plasmodesmata: channels for viruses on the move.

  2015cites this paper
• Expressing p20 hairpin RNA of Citrus tristeza virus confers Citrus aurantium with tolerance/resistance against stem pitting and seedling yellow CTV strains

  2015cites this paper
• viral silencing suppressors: Tools forged to fine-tune host-pathogen coexistence.

  2015cites this paper
• Development of molecular tools to enhance understanding of antiviral RNAi in mosquitoes

  2015cites this paper
• Homeologs of the Nicotiana benthamiana Antiviral ARGONAUTE1 Show Different Susceptibilities to microRNA168-Mediated Control1[OPEN]

  2015cites this paper
• Acquisition of Full-Length Viral Helicase Domains by Insect Retrotransposon-Encoded Polypeptides

  2015cites this paper
• Molecular analysis of an attenuated strain of Cucumber green mottle mosaic virus using in vitro infectious cDNA clone: pathogenicity and suppression of RNA silencing

  2015cites this paper
• Functions of the 5'- and 3'-untranslated regions of tobamovirus RNA.

  2015cites this paper
• Factors involved in the systemic transport of plant RNA viruses: the emerging role of the nucleus.

  2014cites this paper
• Key Importance of Small RNA Binding for the Activity of a Glycine-Tryptophan (GW) Motif-containing Viral Suppressor of RNA Silencing*

  2014cites this paper
• Structural insights into the arms race between host and virus along RNA silencing pathways in Arabidopsis thaliana

  2014cites this paper
• Alteration of host-encoded miRNAs in virus infected plants—experimentally verified

  2014cites this paper
• The Silent Assassins: Informatics of Plant Viral Silencing Suppressors

  2014cites this paper
• Symptom recovery in Tomato ringspot virus infected Nicotiana benthamiana plants : investigation into the role of plant RNA silencing mechanisms

  2014influential citation
• Do virus-encoded suppressors of RNA silencing reduce plant eIF2a kinase activity and thereby increase susceptibility to infection?

  2014cites this paper
• An Overview of Antiviral RNA Silencing in Plant: Biogenesis, Host-Virus Interaction and Potential Applications

  2014cites this paper
• Plant miRNAome and antiviral resistance: a retrospective view and prospective challenges

  2014cites this paper
• Amino acid sequence motifs essential for P0-mediated suppression of RNA silencing in an isolate of potato leafroll virus from Inner Mongolia.

  2014cites this paper
• Plant Defense and the Counter Defense by Viruses

  2014cites this paper