nparcomp: An R Software Package for Nonparametric Multiple Comparisons and Simultaneous Confidence Intervals

One-way layouts, i.e., a single factor with several levels and multiple observations at each level, frequently arise in various fields. Usually not only a global hypothesis is of interest but also multiple comparisons between the different treatment levels. In most practical situations, the distribution of observed data is unknown and there may exist a number of atypical measurements and outliers. Hence, use of parametric and semiparametric procedures that impose restrictive distributional assumptions on observed samples becomes questionable. This, in turn, emphasizes the demand on statistical procedures that enable us to accurately and reliably analyze one-way layouts with minimal conditions on available data. Nonparametric methods offer such a possibility and thus become of particular practical importance. In this article, we introduce a new R package nparcomp which provides an easy and user-friendly access to rank-based methods for the analysis of unbalanced one-way layouts. It provides procedures performing multiple comparisons and computing simultaneous confidence intervals for the estimated effects which can be easily visualized. The special case of two samples, the nonparametric Behrens-Fisher problem, is included. We illustrate the implemented procedures by examples from biology and medicine.

• Publication year

  2015

• Venue

  Journal of Statistical Software

• Publication date

  2015-03-20

• Fields of study

  Mathematics, Computer Science

• Identifiers
  DOI 10.18637/JSS.V064.I09
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006influential reference
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