RecQ helicases: guardian angels of the DNA replication fork

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Chromosoma

• Publication date

  2008-01-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00412-007-0142-4PMID 18188578
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
• Role of the BLM helicase in replication fork management.

  2007cited by this paper
• Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks

  2007cited by this paper
• Maintenance of fork integrity at damaged DNA and natural pause sites.

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  2006influential reference
• A conserved G4 DNA binding domain in RecQ family helicases.

  2006cited by this paper
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• Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability.

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• DNA helicases required for homologous recombination and repair of damaged replication forks.

  2006influential reference
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• A Positive Involvement of RecQL4 in UV-Induced S-Phase Arrest

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• Accumulation of FFA-1, the Xenopus homolog of Werner helicase, and DNA polymerase delta on chromatin in response to replication fork arrest.

  2006influential reference
• The RecQ gene family in plants.

  2006cited by this paper
• The Bloom's Syndrome Helicase Can Promote the Regression of a Model Replication Fork*

  2006cited by this paper
• Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome.

  2006influential reference
• The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.

  2006cited by this paper
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  2006influential reference
• Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance

  2005influential reference
• Human Bloom Protein Stimulates Flap Endonuclease 1 Activity by Resolving DNA Secondary Structure*

  2005cited by this paper
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  2005cited by this paper
• Deficient DNA repair in the human progeroid disorder, Werner syndrome.

  2005cited by this paper
• Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutations.

  2005influential reference
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  2005cited by this paper
• Physical and Functional Mapping of the Replication Protein A Interaction Domain of the Werner and Bloom Syndrome Helicases*

  2005cited by this paper
• Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.

  2005influential reference
• The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA

  2005cited by this paper
• Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase.

  2005cited by this paper
• Stimulation of Flap Endonuclease-1 by the Bloom's Syndrome Protein*

  2004influential reference
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  2004cited by this paper
• RPA alleviates the inhibitory effect of vinylphosphonate internucleotide linkages on DNA unwinding by BLM and WRN helicases.

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• Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases

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  2004influential reference
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• Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A.

  2004cited by this paper
• Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle

  2003cited by this paper
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  2003influential reference
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  2003cited by this paper
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  2003cited by this paper
• RecQ helicases: suppressors of tumorigenesis and premature aging.

  2003cited by this paper
• WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork.

  2003influential reference
• DNA Damage-Induced Replication Fork Regression and Processing in Escherichia coli

  2003cited by this paper
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  2003influential reference
• The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication

  2003influential reference
• Okazaki Fragment Maturation in Yeast

  2003cited by this paper
• Constitutive DNA damage is linked to DNA replication abnormalities in Bloom's syndrome cells

  2003influential reference
• Okazaki Fragment Maturation in Yeast

  2003influential reference
• Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA.

  2003cited by this paper
• DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1

  2003influential reference
• Coupling of DNA Helicase and Endonuclease Activities of Yeast Dna2 Facilitates Okazaki Fragment Processing*

  2002influential reference
• RecQ helicases: at the heart of genetic stability

  2002cited by this paper
• Asymmetry of DNA replication fork progression in Werner's syndrome

  2002influential reference
• A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway

  2002cited by this paper
• A unified view of the DNA-damage checkpoint.

  2002cited by this paper
• WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex

  2002cited by this paper
• Biochemical characterization of the WRN-FEN-1 functional interaction.

  2002cited by this paper
• Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition

  2002cited by this paper
• Interactions between the Werner Syndrome Helicase and DNA Polymerase δ Specifically Facilitate Copying of Tetraplex and Hairpin Structures of the d(CGG) n Trinucleotide Repeat Sequence*

  2001cited by this paper
• Werner helicase relocates into nuclear foci in response to DNA damaging agents and co‐localizes with RPA and Rad51

  2001cited by this paper
• Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled

  2001cited by this paper
• Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

  2001cited by this paper
• Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.

  2001cited by this paper
• Topoisomerase III Acts Upstream of Rad53p in the S-Phase DNA Damage Checkpoint

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  2001influential reference
• Evidence for a Replication Function of Ffa-1, the Xenopus Orthologue of Werner Syndrome Protein

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• Rescue of stalled replication forks by RecG: Simultaneous translocation on the leading and lagging strand templates supports an active DNA unwinding model of fork reversal and Holliday junction formation

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  2000cited by this paper
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  2000cited by this paper
• Werner protein recruits DNA polymerase δ to the nucleolus

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  2000influential reference
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  2000influential reference
• Functional interaction between the Werner Syndrome protein and DNA polymerase delta.

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  1999influential reference
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
• Positional Cloning of the Werner's Syndrome Gene

  1996cited by this paper
• A yeast gene required for DNA replication encodes a protein with homology to DNA helicases.

  1995cited by this paper
• The Bloom's syndrome gene product is homologous to RecQ helicases.

  1995cited by this paper
• FFA-1, a protein that promotes the formation of replication centers within nuclei.

  1995cited by this paper
• CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro.

  1995cited by this paper
• Pausing of DNA Synthesis in Vitro at Specific Loci in CTG and CGG Triplet Repeats from Human Hereditary Disease Genes (*)

  1995cited by this paper
• Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines.

  1992cited by this paper
• An abnormal profile of DNA replication intermediates in Bloom's syndrome.

  1990cited by this paper

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• Bloom syndrome and the underlying causes of genetic instability.

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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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