Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: A phase I trial

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2001-03-13

• Fields of study

  Medicine

• Identifiers
  DOI 10.1073/pnas.051626298PMID 11248068PMCID PMC30643
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus QS-21.

  2000cited by this paper
• Development of a new vaccine formulation that enhances the immunogenicity of tumor-associated antigen CaMBr1

  2000cited by this paper
• Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens.

  2000cited by this paper
• Immunogenicity of a fucosyl-GM1-keyhole limpet hemocyanin conjugate vaccine in patients with small cell lung cancer.

  1999cited by this paper
• A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle.

  1999cited by this paper
• Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease.

  1999cited by this paper
• Carbohydrate vaccines in cancer: immunogenicity of a fully synthetic globo H hexasaccharide conjugate in man.

  1999cited by this paper
• A novel and efficient method for synthetic carbohydrate conjugate vaccine preparation: synthesis of sialyl Tn-KLH conjugate using a 4-(4-N-maleimidomethyl) cyclohexane-1-carboxyl hydrazide (MMCCH) linker arm

  1998cited by this paper
• Carbohydrate vaccines that induce antibodies against cancer. 1. Rationale

  1997cited by this paper
• Immunization of Mice with a Fully Synthetic Globo H Antigen Results in Antibodies against Human Cancer Cells: A Combined Chemical—Immunological Approach to the Fashioning of an Anticancer Vaccine

  1997cited by this paper
• Selection of tumor antigens as targets for immune attack using immunohistochemistry: I. Focus on gangliosides

  1997cited by this paper
• Carbohydrate vaccines that induce antibodies against cancer. 2. Previous experience and future plans

  1997cited by this paper
• Tumor cell reactivity mediated by IgM antibodies in sera from melanoma patients vaccinated with GM2 ganglioside covalently linked to KLH is increased by IgG antibodies

  1997cited by this paper
• Pre-immunotherapy serum CA27.29 (MUC-1) mucin level and CD69+ lymphocytes correlate with effects of Theratope® sialyl-Tn-KLH cancer vaccine in active specific immunotherapy

  1996cited by this paper
• Optimal sample size for a series of pilot trials of new agents.

  1996cited by this paper
• Augmenting the immunogenicity of synthetic MUC1 peptide vaccines in mice.

  1996cited by this paper
• Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.

  1996cited by this paper
• Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer.

  1996cited by this paper
• TOTAL SYNTHESIS OF A HUMAN BREAST TUMOR ASSOCIATED ANTIGEN

  1995cited by this paper
• GD3 vaccines for melanoma: superior immunogenicity of keyhole limpet hemocyanin conjugate vaccines.

  1994cited by this paper
• Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside.

  1994cited by this paper
• Phase 1 trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma.

  1994cited by this paper
• Antibodies against autologous tumor cell proteins in patients with small-cell lung cancer: association with improved survival.

  1993cited by this paper
• Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex.

  1991cited by this paper
• Characterization of a glycosphingolipid antigen defined by the monoclonal antibody MBr1 expressed in normal and neoplastic epithelial cells of human mammary gland.

  1984cited by this paper
• Generation of monoclonal antibodies reacting with normal and cancer cells of human breast.

  1983cited by this paper
• Prolonged survival for melanoma patients with elevated IgM antibody to oncofetal antigen.

  1981cited by this paper

• Development of Globo-H conjugated bacteriophage Qβ mutant virus-like particles as an anticancer vaccine

  2025cites this paper
• Expediting Glycospace Exploration: Therapeutic Glycans via Automated Synthesis

  2025cites this paper
• QS-21: Structural insights, immunological mechanisms, and prospects for rational design of safer vaccine adjuvants.

  2025cites this paper
• Immunotherapy and its racial specificity for breast cancer treatment in Asia: a narrative review

  2024cites this paper
• Enhanced Antitumor Immunity of a Globo H-Based Vaccine Enabled by the Combination Adjuvants of 3D-MPL and QS-21.

  2024cites this paper
• Computer-aided automated flow chemical synthesis of polymers

  2024cites this paper
• Design, Synthesis, and Bioactivity Evaluation of a TF-Based Cancer Vaccine Candidate Using Lipid A Mimetics As a Built-In Adjuvant.

  2024cites this paper
• Long Prime–Boost Interval and Heightened Anti-GD2 Antibody Response to Carbohydrate Cancer Vaccine

  2024cites this paper
• Immunotherapy: Review of the Existing Evidence and Challenges in Breast Cancer

  2023cites this paper
• Carrier diversity and chemical ligations in the toolbox for designing tumor-associated carbohydrate antigens (TACAs) as synthetic vaccine candidates.

  2023cites this paper
• Precision Glycan Supplementation Improves Gut Microbiota Diversity, Performance, and Disease Outbreak Resistance in Broiler Chickens

  2023cites this paper
• Lung cancer immunotherapy: progress, pitfalls, and promises

  2023cites this paper
• Immunobiology of Cholangiocarcinoma.

  2023cites this paper
• Cancer Vaccines for Triple-Negative Breast Cancer: A Systematic Review

  2023cites this paper
• The clinical relevance of humoral immune responses to Globo H-KLH vaccine adagloxad simolenin (OBI-822)/OBI-821 and expression of Globo H in metastatic breast cancer

  2022cites this paper
• GLORIA: phase III, open-label study of adagloxad simolenin/OBI-821 in patients with high-risk triple-negative breast cancer.

  2022cites this paper
• Glycobiology of cellular expiry: Decrypting the role of glycan-lectin regulatory complex and therapeutic strategies focusing on cancer.

  2022cites this paper
• Triple-Negative Breast Cancer: A Brief Review About Epidemiology, Risk Factors, Signaling Pathways, Treatment and Role of Artificial Intelligence

  2022cites this paper
• Immunotherapy in triple negative breast cancer: beyond checkpoint inhibitors

  2022cites this paper
• Effect of Oral β-Glucan on Antibody Response to Ganglioside Vaccine in Patients With High-Risk Neuroblastoma: A Phase 2 Randomized Clinical Trial.

  2022cites this paper
• Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development

  2022cites this paper
• Targeting Tumor Glycans for Cancer Therapy: Successes, Limitations, and Perspectives

  2022cites this paper
• Recent advances and future perspectives on carbohydrate-based cancer vaccines and therapeutics.

  2022cites this paper
• Fully synthetic Mincle-dependent self-adjuvanting cancer vaccines elicit robust humoral and T cell-dependent immune responses and protect mice from tumor development

  2021cites this paper
• Emerging immunotherapeutic strategies for the treatment of breast cancer

  2021cites this paper
• Preclinical Studies of OBI-999: A Novel Globo H–Targeting Antibody–Drug Conjugate

  2021cites this paper
• Synthesis and immunological evaluation of N-acyl modified Globo H derivatives as anticancer vaccine candidates.

  2021cites this paper
• Glikoznanost-nova smjernica u suvremenom

  2021cites this paper
• Application of the Antibody-Inducing Activity of Glycosphingolipids to Human Diseases

  2021cites this paper
• The role of Globo H and SSEA-4 in the development and progression of cancer, and their potential as therapeutic targets.

  2021cites this paper
• The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans

  2021cites this paper
• Globo H Is a Promising Theranostic Marker for Intrahepatic Cholangiocarcinoma

  2021cites this paper
• Screening of Clinical Factors Related to Prognosis of Breast Cancer Based on the Cox Proportional Risk Model.

  2020cites this paper
• in with randomized,

  2020cites this paper
• Altered glycosylation in cancer: A promising target for biomarkers and therapeutics.

  2020cites this paper
• Programmable One-pot Synthesis of Oligosaccharides.

  2020cites this paper
• Triple-negative breast cancer therapy: Current and future perspectives (Review)

  2020cites this paper
• Efficacy of cancer vaccines in selected gynaecological breast and ovarian cancers: A 20-year systematic review and meta-analysis.

  2020cites this paper
• Targeting glycosphingolipids for cancer immunotherapy

  2020cites this paper
• A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer

  2020cites this paper
• Globo H-KLH vaccine adagloxad simolenin (OBI-822)/OBI-821 in patients with metastatic breast cancer: phase II randomized, placebo-controlled study

  2020cites this paper
• Antigens: CarbohydratesII

  2020cites this paper
• Total Synthesis of the Congested, Bis-Phosphorylated Morganella Morganii Zwitterionic Trisaccharide Repeating Unit.

  2019cites this paper
• The Use of Immunotherapy to Treat Metastatic Breast Cancer.

  2019cites this paper
• Glycosylation in health and disease

  2019cites this paper
• Breast cancer vaccines: Heeding the lessons of the past to guide a path forward.

  2019cites this paper
• Saponins from Quillaja saponaria and Quillaja brasiliensis: Particular Chemical Characteristics and Biological Activities

  2019cites this paper
• Production of a mouse monoclonal IgM antibody that targets the carbohydrate Thomsen-nouveau cancer antigen resulting in in vivo and in vitro tumor killing

  2018cites this paper
• "One-Pot" Protection, Glycosylation, and Protection-Glycosylation Strategies of Carbohydrates.

  2018cites this paper
• Carbohydrate‐based vaccines for oncotherapy

  2018cites this paper
• Hierarchical and programmable one-pot synthesis of oligosaccharides

  2018cites this paper
• La réponse immunitaire anti-tumorale dans le cancer du sein : état des lieux et perspectives thérapeutiques

  2017cites this paper
• Design and synthesis of multivalent glycoconjugates for anti-cancer immunotherapy

  2017cites this paper
• Antibody repertoire profiling with mimotope arrays

  2017cites this paper
• N-Heterocyclic Carbene Catalyzed Stereoselective Glycosylation of 2-Nitrogalactals.

  2017cites this paper
• Lawrence Berkeley National Laboratory Recent Work Title Cross-linked self-assembling peptide scaffolds Permalink

  2017cites this paper
• Evaluation of Virus-Like Particle-Based Tumor-Associated Carbohydrate Immunogen in a Mouse Tumor Model.

  2017cites this paper
• Globo H expression is associated with driver mutations and PD-L1 expressions in stage I non-small cell lung cancer

  2017cites this paper
• Cross-linked self-assembling peptide scaffolds

  2017cites this paper
• [The anti-tumor immune response in breast cancer: Update and therapeutic perspectives].

  2017cites this paper
• Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens.

  2016cites this paper
• Aberrant expression of tumor‐associated carbohydrate antigen Globo H in thyroid carcinoma

  2016cites this paper
• Dysregulated Expression of Glycolipids in Tumor Cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents

  2016cites this paper
• Efficient and regioselective synthesis of globotriose by a novel α-galactosidase from Bacteroides fragilis

  2016cites this paper
• Recent Advance in Tumor-associated Carbohydrate Antigens (TACAs)-based Antitumor Vaccines.

  2016cites this paper
• Automated assembly of oligosaccharides containing multiple cis-glycosidic linkages

  2016cites this paper
• Sequential One-Pot Multienzyme Chemoenzymatic Synthesis of Glycosphingolipid Glycans.

  2016cites this paper
• Targeting Glycans for Immunotherapy of Human Cancers

  2016cites this paper
• Alterations of Glycosphingolipids in Embryonic Stem Cell Differentiation and Development of Glycan-Targeting Cancer Immunotherapy

  2016cites this paper
• A Phase I Study of Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization of Patients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer in First Remission

  2016cites this paper
• Development of Globo-H cancer vaccine.

  2015cites this paper
• One-step synthesis of α-Gal epitope and globotriose derivatives by an engineered α-galactosidase

  2015cites this paper
• First synthesis of diethyl N-acetyl-glycosamine-1-difluoromethylphosphonate from 2-nitroglycals as phosphate analog

  2015cites this paper
• Infusion of Sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate-Conjugated MOG35–55-Coupled Spleen Cells Effectively Prevents and Reverses Experimental Autoimmune Encephalomyelitis in Mice

  2015cites this paper
• Synthesis and vaccine evaluation of the tumor-associated carbohydrate antigen RM2 from prostate cancer.

  2015cites this paper
• A fully synthetic self-adjuvanting globo H-Based vaccine elicited strong T cell-mediated antitumor immunity

  2015cites this paper
• Carbohydrate-based vaccine adjuvants – discovery and development

  2015cites this paper
• Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer

  2015cites this paper
• Carbohydrate drugs: current status and development prospect.

  2015cites this paper
• Chemical Synthesis of the Tumor-Associated Globo H Antigen.

  2015cites this paper
• Conjugation Strategies Used for the Preparation of Carbohydrate‐Conjugate Vaccines

  2014cites this paper
• Immunogenicity study of Globo H analogues with modification at the reducing or nonreducing end of the tumor antigen.

  2014cites this paper
• Stereoselective Access to β‐C‐Glycosamines by Nitro‐Michael Addition of Organolithium Reagents

  2014cites this paper
• Glycotherapy: new advances inspire a reemergence of glycans in medicine.

  2014cites this paper
• Chemical biology approaches to designing defined carbohydrate vaccines.

  2014cites this paper
• 2‐Nitroglycals: Versatile Building Blocks for the Synthesis of 2‐Aminoglycosides

  2014cites this paper
• The glycosphingolipid P1 is an ovarian cancer-associated carbohydrate antigen involved in migration

  2014cites this paper
• Synthetic oligosaccharides as active pharmaceutical ingredients: lessons learned from the full synthesis of one heparin derivative on a large scale.

  2014cites this paper
• Therapeutic potential of carbohydrate-based polymeric and nanoparticle systems

  2014cites this paper
• Downregulation of microRNA‐15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2‐induced Globo H expression

  2014cites this paper
• The role of anti-LeY antibody in the downregulation of MAPKs/COX-2 pathway in gastric cancer.

  2014cites this paper
• Clustered carbohydrates in synthetic vaccines.

  2013cites this paper
• Effective sugar nucleotide regeneration for the large-scale enzymatic synthesis of Globo H and SSEA4.

  2013cites this paper
• Reentrant structural phase transition in amphiphilic self-assembly

  2013cites this paper
• Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer

  2013cites this paper
• ‘Multicopy Multivalent’ Glycopolymer-Stabilized Gold Nanoparticles as Potential Synthetic Cancer Vaccines

  2013cites this paper
• Synthetically defined glycoprotein vaccines: current status and future directions

  2013cites this paper
• Preactivation: An Alternative Strategy in Stereoselective Glycosylation and Oligosaccharide Synthesis

  2013cites this paper
• A vision for vaccines built from fully synthetic tumor-associated antigens: from the laboratory to the clinic.

  2013cites this paper
• Preclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imaging.

  2013cites this paper