RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cell Cycle

• Publication date

  2015-01-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/15384101.2015.1007001PMID 25602958PMCID PMC4612657
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• RecQ helicases in DNA double strand break repair and telomere maintenance.

  2012cited by this paper
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• The effect of the intra-S-phase checkpoint on origins of replication in human cells.

  2011cited by this paper
• Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.

  2011cited by this paper
• The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells. Role of the N-terminal region of RECQL4 in cells.

  2011cited by this paper
• RECQL4, the Protein Mutated in Rothmund-Thomson Syndrome, Functions in Telomere Maintenance*

  2011cited by this paper
• Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases.

  2011cited by this paper
• Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication

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• How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

  2010cited by this paper
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  2010cited by this paper
• Damage-Induced Phosphorylation of Sld3 is Important to Block Late Origin Firing

  2010cited by this paper
• Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.

  2010cited by this paper
• Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology.

  2010cited by this paper
• Regulation of the initiation step of DNA replication by cyclin-dependent kinases

  2010cited by this paper
• Eukaryotic chromosome DNA replication: where, when, and how?

  2010cited by this paper
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  2010cited by this paper
• Dual DNA unwinding activities of the Rothmund–Thomson syndrome protein, RECQ4

  2009cited by this paper
• Assembly of the Cdc45-Mcm2–7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

  2009cited by this paper
• MCM10 mediates RECQ4 association with MCM2‐7 helicase complex during DNA replication

  2009cited by this paper
• The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

  2009cited by this paper
• Human TopBP1 Participates in Cyclin E/CDK2 Activation and Preinitiation Complex Assembly during G1/S Transition*

  2007cited by this paper
• Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.

  2007influential reference
• Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast

  2007cited by this paper
• Mcm10 and And-1/CTF4 recruit DNA polymerase α to chromatin for initiation of DNA replication

  2007cited by this paper
• Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication.

  2007cited by this paper
• CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

  2007cited by this paper
• The molecular role of the Rothmund-Thomson-, RAPADILINO- and Baller-Gerold-gene product, RECQL4: recent progress

  2007cited by this paper
• Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins

  2006cited by this paper
• GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

  2006cited by this paper
• Rothmund-Thomson syndrome and RECQL4 defect: splitting and lumping.

  2006cited by this paper
• Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

  2006cited by this paper
• Identification of new fluorescent protein fragments for bimolecular fluorescence complementation analysis under physiological conditions.

  2006cited by this paper
• Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.

  2005cited by this paper
• Saccharomyces cerevisiae CTF18 and CTF4 Are Required for Sister Chromatid Cohesion

  2001cited by this paper
• Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae

  2001cited by this paper
• Uninterrupted MCM2-7 function required for DNA replication fork progression.

  2000cited by this paper
• Evidence for Sequential Action of cdc7 and cdk2 Protein Kinases during Initiation of DNA Replication in Xenopus Egg Extracts*

  2000cited by this paper
• Rb interacts with histone deacetylase to repress transcription.

  1998cited by this paper

• Mimosine: A multifaceted non-protein amino acid with potent anticancer potential across diverse malignancies

  2025cites this paper
• How DNA secondary structures drive replication fork instability

  2025cites this paper
• Mcm10 and RecQL4 Synergize to Activate the Eukaryotic Replicative DNA Helicase

  2025cites this paper
• Selective interactions at pre-replication complexes categorize baseline and dormant origins

  2025cites this paper
• Single-Molecule Imaging Reveals the Mechanism of Bidirectional Replication Initiation in Metazoa

  2024cites this paper
• Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases

  2024cites this paper
• H4S47 O-GlcNAcylation regulates the activation of mammalian replication origins

  2023cites this paper
• The Response of the Replication Apparatus to Leading Template Strand Blocks

  2023cites this paper
• DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation

  2023cites this paper
• The Involvement of WDHD1 in the Occurrence of Esophageal Cancer as a Downstream Target of PI3K/AKT Pathway

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• Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation.

  2022cites this paper
• Human RecQL4 as a Novel Molecular Target for Cancer Therapy

  2021cites this paper
• The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation

  2021influential citation
• Regulation of Rothmund–Thomson syndrome protein RecQL4 functions in DNA replication by SIRT1-mediated deacetylation

  2021cites this paper
• Comprehensive analysis of DNA replication timing in genetic diseases and gene knockouts identifies MCM10 as a novel regulator of the replication program

  2021influential citation
• Molecular Mechanisms of the RECQ4 Pathogenic Mutations

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• RECQ DNA Helicases and Osteosarcoma.

  2020cites this paper
• Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

  2020cites this paper
• Pathogenic mutations reveal a role of RECQ4 in mitochondrial RNA:DNA hybrid formation and resolution

  2020cites this paper
• RecQL4 tethering on the pre-replicative complex induces unscheduled origin activation and replication stress in human cells

  2019cites this paper
• ATM activation is impaired in human cells defective in RecQL4 helicase activity.

  2019cites this paper
• Helicase Dysfunctions in Human Diseases

  2019cites this paper
• Overexpression of MCM10 promotes cell proliferation and predicts poor prognosis in prostate cancer

  2018cites this paper
• Regulation of the initiation of DNA replication in human cells.

  2018cites this paper
• Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.

  2018cites this paper
• Targeted inhibition of WRN helicase, replication stress and cancer.

  2017cites this paper
• Studies on the role of RecQL4 in cellular response to DNA damages in human cells

  2017cites this paper
• Distinct functions of human RecQ helicases during DNA replication.

  2017cites this paper
• Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders.

  2017cites this paper
• Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks

  2017cites this paper
• Mechanistic insights into how CMG helicase facilitates replication past DNA roadblocks.

  2017cites this paper
• The Role of Mcm10 in Replication Initiation

  2016cites this paper
• Xenopus Mcm10 is a CDK-substrate required for replication fork stability

  2016cites this paper
• Order from clutter: selective interactions at mammalian replication origins

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• Roles of Sld2, Sld3, and Dpb11 in Replication Initiation

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• Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging

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• Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA

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  2014cites this paper