Point mutations in the S protein connect the sialic acid binding activity with the enteropathogenicity of transmissible gastroenteritis coronavirus

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Journal of Virology

• Publication date

  1997-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/jvi.71.4.3285-3287.1997PMID 9060696PMCID PMC191465
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Physicochemical properties of transmissible gastroenteritis virus hemagglutinin

  2005cited by this paper
• Hemagglutination with transmissible gastroenteritis virus

  2005cited by this paper
• Transmissible gastroenteritis coronavirus, but not the related porcine respiratory coronavirus, has a sialic acid (N-glycolylneuraminic acid) binding activity

  1996influential reference
• Site-specific alteration of transmissible gastroenteritis virus spike protein results in markedly reduced pathogenicity.

  1995influential reference
• Sialic Acid as Receptor Determinant of Ortho- and Paramyxoviruses

  1995cited by this paper
• Enteric coronaviruses of animals

  1994cited by this paper
• Further characterization of aminopeptidase-N as a receptor for coronaviruses.

  1993cited by this paper
• Genetic evolution and tropism of transmissible gastroenteritis coronaviruses

  1992cited by this paper
• Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV

  1992cited by this paper
• Genetic analysis of porcine respiratory coronavirus, an attenuated variant of transmissible gastroenteritis virus

  1991cited by this paper
• Viral infections of the gastrointestinal tract

  1991cited by this paper
• Antigenic homology among coronaviruses related to transmissible gastroenteritis virus

  1990cited by this paper
• Intestinal replication of a porcine respiratory coronavirus closely related antigenically to the enteric transmissible gastroenteritis virus

  1990cited by this paper
• Four major antigenic sites of the coronavirus transmissible gastroenteritis virus are located on the amino-terminal half of spike glycoprotein S.

  1990cited by this paper
• Hemagglutinating encephalomyelitis virus attaches to N-acetyl-9-O-acetylneuraminic acid-containing receptors on erythrocytes: comparison with bovine coronavirus and influenza C virus

  1990cited by this paper
• Porcine respiratory coronavirus differs from transmissible gastroenteritis virus by a few genomic deletions.

  1990cited by this paper
• Antigenic structure of the E2 glycoprotein from transmissible gastroenteritis coronavirus

  1988cited by this paper
• Antigenic structure of transmissible gastroenteritis virus. I. Properties of monoclonal antibodies directed against virion proteins.

  1986cited by this paper
• Antigenic structure of transmissible gastroenteritis virus. II. Domains in the peplomer glycoprotein.

  1986influential reference

• Cell entry mechanisms of porcine enteric coronaviruses.

  2026cites this paper
• A SARS-CoV-2 variant-induced NTD-targeting antibody enhances viral infection via a distinctive binding mode

  2026cites this paper
• Transmissible Gastroenteritis Virus (TGEV) and Porcine Respiratory Coronavirus (PRCV): Epidemiology and Molecular Characteristics—An Updated Overview

  2025cites this paper
• Rethinking the drivers of coronavirus virulence and pathogenesis; toward an understanding of the dynamic world of mutations, indels, and recombination within the alphacoronaviruses

  2025cites this paper
• Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics

  2025cites this paper
• Up, up, down, down: the structural biology of the SARS-CoV-2 spike protein and how it cheats the immune system

  2024cites this paper
• Porcine respiratory coronavirus genome sequences; comparisons and relationships to transmissible gastroenteritis viruses.

  2024cites this paper
• Structural characterization of human monoclonal antibodies targeting uncommon antigenic sites on spike glycoprotein of SARS-CoV

  2024cites this paper
• The role of receptors in the cross-species spread of coronaviruses infecting humans and pigs

  2024cites this paper
• N-terminal Domain (NTD) of Spike Protein from SARS-CoV-2 May Cause COVID-19 Multiple Tropisms and Serve as a Potential Drug Target

  2024influential citation
• Dipeptidyl peptidase 4 interacts with porcine coronavirus PHEV spikes and mediates host range expansion

  2024cites this paper
• Transmissible Gastroenteritis Virus: An Update Review and Perspective

  2023influential citation
• Deletion of pentad residues in the N-terminal domain of spike protein attenuates porcine epidemic diarrhea virus in piglets.

  2023cites this paper
• Metavirome Analysis Reveals a High Prevalence of Porcine Hemagglutination Encephalomyelitis Virus in Clinically Healthy Pigs in China

  2023cites this paper
• Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives

  2023cites this paper
• Porcine Respiratory Coronavirus (PRCV): Isolation and Characterization of a Variant PRCV from USA Pigs

  2023cites this paper
• Natural selection differences detected in key protein domains between non-pathogenic and pathogenic feline coronavirus phenotypes

  2023cites this paper
• Experimental Infection of Pigs with a Traditional or a Variant Porcine Respiratory Coronavirus (PRCV) Strain and Impact on Subsequent Influenza A Infection

  2023cites this paper
• Natural selection differences detected in key protein domains between non-pathogenic and pathogenic Feline Coronavirus phenotypes

  2023cites this paper
• PEDV: Insights and Advances into Types, Function, Structure, and Receptor Recognition

  2022influential citation
• Comparison of SARS-CoV-2 spike RNA sequences in feces and nasopharynx indicates intestinal replication

  2022cites this paper
• Quantum Deep Learning for Mutant COVID-19 Strain Prediction

  2022cites this paper
• Known Cellular and Receptor Interactions of Animal and Human Coronaviruses: A Review

  2022cites this paper
• Recent Zoonotic Spillover and Tropism Shift of a Canine Coronavirus Is Associated with Relaxed Selection and Putative Loss of Function in NTD Subdomain of Spike Protein.

  2022cites this paper
• Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions

  2022cites this paper
• Porcine Respiratory Coronavirus as a Model for Acute Respiratory Coronavirus Disease

  2022cites this paper
• Host microRNAs exhibit differential propensity to interact with SARS-CoV-2 and variants of concern

  2022cites this paper
• Network analysis uncovers the communication structure of SARS-CoV-2 spike protein identifying sites for immunogen design

  2022cites this paper
• Multifaceted membrane binding head of the SARS-CoV-2 spike protein

  2022cites this paper
• Characterization of Deltacoronavirus in Black-Headed Gulls (Chroicocephalus ridibundus) in South China Indicating Frequent Interspecies Transmission of the Virus in Birds

  2022cites this paper
• Antibody–nanobody combination increases their neutralizing activity against SARS-CoV-2 and nanobody H11-H4 is effective against Alpha, Kappa and Delta variants

  2022cites this paper
• Progressive membrane-binding mechanism of SARS-CoV-2 variant spike proteins

  2022cites this paper
• Porcine enteric coronaviruses: an updated overview of the pathogenesis, prevalence, and diagnosis

  2021cites this paper
• Sialic Acid Receptors: The Key to Solving the Enigma of Zoonotic Virus Spillover

  2021cites this paper
• Porcine Coronaviruses: Overview of the State of the Art

  2021cites this paper
• Research progress on coronavirus S proteins and their receptors

  2021cites this paper
• Recent Zoonotic Spillover and Tropism Shift of a Canine Coronavirus Is Associated with Relaxed Selection and Putative Loss of Function in NTD Subdomain of Spike Protein

  2021influential citation
• SARS-CoV-2’nin Temel Virolojik Özellikleri ve Koronavirüs Reseptör Tan ı ma Mekanizmas ı Basic Virological of SARS-CoV-2 and Receptor Recognition Mechanism of Coronavirus

  2021cites this paper
• Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein

  2021cites this paper
• Cell Entry of Animal Coronaviruses

  2021cites this paper
• Mechanisms of SARS-CoV-2 entry into cells

  2021cites this paper
• A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants

  2021cites this paper
• SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation

  2021cites this paper
• The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation

  2021cites this paper
• Therapeutically effective covalent spike protein inhibitors in treatment of SARS-CoV-2

  2021cites this paper
• Network analysis outlines strengths and weaknesses of emerging SARS-CoV-2 Spike variants

  2021cites this paper
• Which ones, when and why should renin-angiotensin system inhibitors work against COVID-19?

  2021cites this paper
• SARS-CoV-2 Spike Protein Extrapolation for COVID Diagnosis and Vaccine Development

  2021cites this paper
• Electrostatic Interactions Explain the Higher Binding Affinity of the CR3022 Antibody for SARS-CoV-2 than the 4A8 Antibody

  2021cites this paper
• Molecular scaffolds from mother nature as possible lead compounds in drug design and discovery against coronaviruses: A landscape analysis of published literature and molecular docking studies

  2021cites this paper
• Sialylated Carbohydrates as Inhinitors of Coronavirus Infection

  2021cites this paper
• The role of cell surface sialic acids for SARS-CoV-2 infection

  2021cites this paper
• SARS-CoV-2 Evolutionary Adaptation toward Host Entry and Recognition of Receptor O-Acetyl Sialylation in Virus–Host Interaction

  2020cites this paper
• Lessons Learned from SARS-CoV and MERS-CoV: Preparation for SARS-CoV-2 induced COVID-19

  2020cites this paper
• Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources

  2020cites this paper
• Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective

  2020cites this paper
• Naturally Occurring Animal Coronaviruses as Models for Studying Highly Pathogenic Human Coronaviral Disease

  2020cites this paper
• The V617I Substitution in Avian Coronavirus IBV Spike Protein Plays a Crucial Role in Adaptation to Primary Chicken Kidney Cells

  2020cites this paper
• Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development

  2020cites this paper
• Molecular diversity of coronavirus host cell entry receptors

  2020cites this paper
• Characterization and evaluation of the pathogenicity of a natural recombinant transmissible gastroenteritis virus in China

  2020cites this paper
• Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies

  2020cites this paper
• Progress and Prospects on Vaccine Development against SARS-CoV-2

  2020influential citation
• Role of Porcine Aminopeptidase N and Sialic Acids in Porcine Coronavirus Infections in Primary Porcine Enterocytes

  2020influential citation
• A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability

  2020cites this paper
• A glance on anti-viral strategy target Coronavirus life cycle

  2020cites this paper
• A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

  2020cites this paper
• Post-Glycosylation Modification of Sialic Acid and Its Role in Virus Pathogenesis

  2019cites this paper
• Membrane Protein of Human Coronavirus NL63 Is Responsible for Interaction with the Adhesion Receptor

  2019cites this paper
• Emerging and re-emerging coronaviruses in pigs

  2019cites this paper
• Construction and characterization of porcine single-chain fragment variable antibodies that neutralize transmissible gastroenteritis virus in vitro

  2019cites this paper
• Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD

  2019cites this paper
• Structural insights into coronavirus entry

  2019cites this paper
• Decline of transmissible gastroenteritis virus and its complex evolutionary relationship with porcine respiratory coronavirus in the United States

  2019cites this paper
• Minimum Determinants of Transmissible Gastroenteritis Virus Enteric Tropism Are Located in the N-Terminus of Spike Protein

  2019cites this paper
• Virus–Receptor Interactions: The Key to Cellular Invasion

  2018cites this paper
• Priming Time: How Cellular Proteases Arm Coronavirus Spike Proteins

  2018influential citation
• The enhanced replication of an S-intact PEDV during coinfection with an S1 NTD-del PEDV in piglets

  2018cites this paper
• Cellular Determinants of Coronavirus Entry Routes

  2017cites this paper
• Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein

  2017cites this paper
• Determination of the cell tropism of serotype 1 feline infectious peritonitis virus using the spike affinity histochemistry in paraffin‐embedded tissues

  2017cites this paper
• Structure and function of coronaviral S proteins and their receptors

  2017influential citation
• Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1

  2017cites this paper
• Construction of an oral vaccine for transmissible gastroenteritis virus based on the TGEV N gene expressed in an attenuated Salmonella typhimurium vector.

  2016cites this paper
• Coronavirus Spike Protein and Tropism Changes

  2016influential citation
• Deciphering the biology of porcine epidemic diarrhea virus in the era of reverse genetics

  2016cites this paper
• Cellular entry of the porcine epidemic diarrhea virus

  2016influential citation
• ellular entry of the porcine epidemic diarrhea virus

  2016cites this paper
• Structural and Molecular Evidence Suggesting Coronavirus-driven Evolution of Mouse Receptor

  2016cites this paper
• Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy

  2016cites this paper
• Experimental feline enteric coronavirus infection reveals an aberrant infection pattern and shedding of mutants with impaired infectivity in enterocyte cultures

  2016cites this paper
• Structure, Function, and Evolution of Coronavirus Spike Proteins.

  2016cites this paper
• Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses

  2016cites this paper
• Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains

  2016cites this paper
• Development and evaluation of bivalent dna vaccine against avian infectious bronchitis

  2015cites this paper
• Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond

  2015cites this paper
• Receptor Usage and Cell Entry of Porcine Epidemic Diarrhea Coronavirus

  2015cites this paper
• Molecular characterization and phylogenetic analysis of transmissible gastroenteritis virus HX strain isolated from China

  2015cites this paper
• The avian coronavirus spike protein

  2014cites this paper
• Role of sialic acids in feline enteric coronavirus infections.

  2014cites this paper