Chemical carcinogens produce mutations to ouabain resistance in transformable C3H/10T1/2 Cl 8 mouse fibroblasts.

No abstract is available for this paper.

• Publication year

  1979

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1979-02-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1073/pnas.76.2.930PMID 284417PMCID PMC383096
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Relationship between somatic mutation and neoplastic transformation.

  1978cited by this paper
• Induction of ouabain-resistant mutations in C3H 10T1/2 mouse cells by ultraviolet light.

  1978cited by this paper
• Evidence for the progressive nature of neoplastic transformation in vitro.

  1978cited by this paper
• Liver cell-mediated mutagenesis of mammalian cells by liver carcinogens.

  1978cited by this paper
• Human bronchus-mediated mutagenesis of mammalian cells by carcinogenic polynuclear aromatic hydrocarbons.

  1978cited by this paper
• Neoplastic transformation induced by a direct perturbation of DNA

  1978cited by this paper
• Temporal acquistion of enhanced fibrinolytic activity by syrian hamster embryo cells following treatment with benzo(a)pyrene.

  1977cited by this paper
• Mutagenesis at the ouabain-resistance locus in human diploid fibroblasts.

  1977cited by this paper
• Cell density dependence of focus formation in the C3H/10T1/2 transformation assay.

  1977cited by this paper
• Liver homogenate-mediated mutagenesis in chinese hamster V79 cells by polycyclic aromatic hydrocarbons and aflatoxins.

  1977cited by this paper
• Relationships between mutation and transformation frequencies in mammalian cells treated "in vitro" with chemical carcinogens.

  1977cited by this paper
• Exceptional mutagenicity of a benzo[a]pyrene diol epoxide in cultured mammalian cells

  1976cited by this paper
• Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.

  1976cited by this paper
• Ouabain‐resistant human lymphoblastoid lines altered in the (Na+ + K+)‐dependent ATPase membrane transport system

  1976cited by this paper
• Mutagenesis and transformation of normal cells by chemical carcinogens

  1976cited by this paper
• Chemical carcinogenesis.

  1975cited by this paper
• Mutagenic and cytotoxic activity of benzol[a]pyrene 4,5-, 7,8-, and 9,10-oxides and the six corresponding phenols.

  1975cited by this paper
• Mutations to azaguanine resistance induced in cultured diploid human fibroblasts by the carcinogen, N-acetoxy-2-acetylaminofluorene.

  1975cited by this paper
• A comparison of the 8-azaguanine and ouabain-resistance systems for the selection of induced mutant Chinese hamster cells.

  1975cited by this paper
• The induction of ouabain-resistant mutants by N-methyl-N'-nitro-N-nitrosoguanidine in Chinese hamster cells.

  1974cited by this paper
• Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division.

  1973cited by this paper
• Chemical oncogenesis in culture.

  1973cited by this paper
• Somatic cell mutation. Detection and quantification of x-ray-induced mutation in cultured, diploid human fibroblasts.

  1973cited by this paper
• Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.

  1973cited by this paper
• A quantitative system for assay of malignant transformation by chemical carcinogens using a clone derived from BALB/3T3

  1973cited by this paper
• Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.

  1973cited by this paper
• In vitro Transformation of Syrian Hamster Embryo Cells by Diverse Chemical Carcinogens

  1972cited by this paper
• Quantitation of chemically induced neoplastic transformation of BALB-3T3 cloned cell lines.

  1972cited by this paper
• Mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbons.

  1971cited by this paper
• Quantitative studies of in vitro transformation by chemical carcinogens.

  1969cited by this paper
• Quantitative studies on the malignant transformation of mouse prostate cells by carcinogenic hydrocarbons in vitro

  1969cited by this paper
• In Vitro Cell Transformation with Chemical Carcinogens

  1963cited by this paper
• CLONAL GROWTH OF MAMMALIAN CELLS IN VITRO

  1956cited by this paper

• Mammalian cell-transforming potential of traffic-linked ultrafine particulate matter PM0.056 in urban roadside atmosphere.

  2014cites this paper
• Dysregulation of pathways involved in the processing of cancer and microenvironment information in MCA + TPA transformed C3H/10T1/2 cells

  2013cites this paper
• Development of a New Zirconia-Toughened Alumina: Promising Mechanical Properties and Absence of In Vitro Carcinogenicity

  2009cites this paper
• Chemically Induced Morphological and Neoplastic Transformation in C3H/10T1/2 Cl 8 Mouse Embryo Cells

  2005cites this paper
• Amplification of the Ect2 proto-oncogene and over-expression of Ect2 mRNA and protein in nickel compound and methylcholanthrene-transformed 10T1/2 mouse fibroblast cell lines.

  2005cites this paper
• Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes

  2004cites this paper
• Molecular biology of nickel carcinogenesis: Identification of differentially expressed genes in morphologically transformed C3H10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by pecific insoluble nickel compounds

  2004cites this paper
• Chemical Carcinogens Transform BHK Cells by Inducing a Recessive Mutation

  2003cites this paper
• Genotoxicity of samples of nickel refinery dust.

  2003cites this paper
• Molecular biology of deregulated gene expression in transformed C3H/10T1/2 mouse embryo cell lines induced by specific insoluble carcinogenic nickel compounds.

  2002influential citation
• Thiourea toxicity in mouse C3H/10T1/2 cells expressing human flavin-dependent monooxygenase 3.

  2002cites this paper
• Hydrocarbon carcinogens evade cellular defense mechanism of G1 arrest in nontransformed and malignant lung cell lines.

  2001cites this paper
• 8,9-dihydroxy-8,9-dihydrodibenzo[a,l]pyrene is a potent morphological cell-transforming agent in C3H10T(1)/(2)Cl8 mouse embryo fibroblasts in the absence of detectable stable covalent DNA adducts.

  2000cites this paper
• Role of free radicals in metal-induced carcinogenesis.

  1999cites this paper
• Chromium-induced genotoxicity and apoptosis: relationship to chromium carcinogenesis (review).

  1998cites this paper
• Benzo[a]pyrene diol epoxide-DNA cis adduct formation through a trans chlorohydrin intermediate.

  1997cites this paper
• Is a mutagenic event involved in radiation induced malignant transformation?

  1996cites this paper
• Comments on the evidence in support of the epigenetic nature of radiogenic initiation.

  1996cites this paper
• LITHIUM INHIBITS GROWTH IN A MURINE NEURAL PRECURSOR CELL LINE

  1996cites this paper
• Evidence that carcinogenesis involves an imbalance between epigenetic high-frequency initiation and suppression of promotion.

  1995cites this paper
• Direct transforming activity of TGF‐β on rat fibroblasts

  1995cites this paper
• Direct transforming activity of TGF-beta on rat fibroblasts.

  1995cites this paper
• Induction of chromosomal aberrations, cytotoxicity, and morphological transformation in mammalian cells by the antiparasitic drug flubendazole and the antineoplastic drug harringtonine.

  1994cites this paper
• Molecular mechanisms of transformation of C3H/10T1/2 C1 8 mouse embryo cells and diploid human fibroblasts by carcinogenic metal compounds.

  1994cites this paper
• Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites.

  1994cites this paper
• Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

  1993cites this paper
• The Discovery of ras and Its Biological Importance

  1993cites this paper
• The origin of point mutations in human tumor cells.

  1992influential citation
• Transformation of rodent fibroblasts by herpes simplex virus: Presence of morphological transforming region 1 (MTR 1) is not required for the maintenance of the transformed state

  1992cites this paper
• Acquisition of responsiveness to chemical carcinogens by rodent embryo fibroblasts expressing high levels of the c‐myc proto‐oncogene

  1992cites this paper
• The cytotoxic properties of malachite green are associated with the increased demethylase, aryl hydrocarbon hydroxylase and lipid peroxidation in primary cultures of Syrian hamster embryo cells.

  1992cites this paper
• Can a non-tumorigenic dose of carcinogen cause two or more errors in a cell?

  1992cites this paper
• Relation between carcinogenesis, chromatin structure and poly(ADP-ribosylation) (review).

  1991cites this paper
• Expression dynamics of transforming phenotypes in X-irradiated Syrian golden hamster embryo cells.

  1991cites this paper
• Induction of ouabain-resistance mutation and cycle-dependent transformation of C3H/10T1/2 cells by N-nitroso-2-acetylaminofluorene.

  1990cites this paper
• Role of valence state and solubility of chromium compounds on induction of cytotoxicity, mutagenesis, and anchorage independence in diploid human fibroblasts.

  1990cites this paper
• Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells.

  1989influential citation
• Molecular and cellular mechanisms of transformation of C3H/10T1/2 Cl 8 and diploid human fibroblasts by unique carcinogenic, nonmutagenic metal compounds. A review.

  1989cites this paper
• Molecular and cellular mechanisms of transformation of C3H/10T1/2 Cl 8 and diploid human fibroblasts by unique carcinogenic, nonmutagenic metal compounds

  1989cites this paper
• Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds

  1989cites this paper
• The relationship between DNA damage and mutation frequency in mammalian cell lines treated with N-nitroso-N-2-fluorenylacetamide.

  1989cites this paper
• Isozymes of the Na+/K+-ATPase.

  1989cites this paper
• Spontaneous formation of foci of morphologically transformed cells in populations of C3H 10T1/2 (clone 8) cells.

  1988cites this paper
• Transformation of C3H/10T1/2 mouse embryo cells to focus formation and anchorage independence by insoluble lead chromate but not soluble calcium chromate: relationship to mutagenesis and internalization of lead chromate particles.

  1988cites this paper
• Mutagenic potency at the Na+/K+ ATPase locus correlates with cycle-dependent killing of 10T1/2 cells.

  1988cites this paper
• A continuum of transformed phenotypes in C3H/10T1/2 derivatives.

  1988cites this paper
• DT-diaphorase activity and the cytotoxicity of quinones in C3H/10T1/2 mouse embryo cells.

  1988cites this paper
• Interlaboratory evaluation of the C3H/10T1/2 cell transformation assay.

  1988cites this paper
• Clonal growth of normal human uroepithelial cells

  1988cites this paper
• Increased expression of the glucose-regulated gene encoding the Mr 78,000 glucose-regulated protein in chemically and radiation-transformed C3H 10T1/2 mouse embryo cells.

  1987cites this paper
• Effects of a poly(ADP-ribose) polymerase inhibitor on mutation frequencies in dividing and quiescent C3H10T1/2 cells.

  1987cites this paper
• Enhanced expression and state of the c-myc oncogene in chemically and X-ray-transformed C3H/10T1/2 Cl 8 mouse embryo fibroblasts.

  1987cites this paper
• A comparison of the radiation-induced mutation at the HGPRT locus in V79 and BHK cells.

  1987cites this paper
• A method for the amplification of chemically induced transformation in C3H/10T1/2 clone 8 cells: its use as a potential screening assay.

  1987cites this paper
• Induction of anchorage independence in human diploid foreskin fibroblasts by carcinogenic metal salts.

  1987cites this paper
• Effect of aliphatic amides on oncogenic transformation, sister chromatid exchanges, and mutations induced by cyclopenta[cd]-pyrene and benzo[a]pyrene.

  1986cites this paper
• In vitro genotoxicity studies using complex hydrophobic mixtures: efficient delivery of a petroleum sample to cultured C3H/10T1/2 cells via lipid vesicle incorporation.

  1986cites this paper
• Enhanced expression of c-myc and decreased expression of c-fos protooncogenes in chemically and radiation-transformed C3H/10T1/2 Cl 8 mouse embryo cell lines.

  1986cites this paper
• Transformation of C3H10T1/2 cells by N-ethyl-N-nitrosourea occurs as a single, low frequency, mutation-like event.

  1986cites this paper
• The induction and control of radiogenic transformation in vitro: cellular and molecular mechanisms.

  1985cites this paper
• S-9 metabolic activation enhances aflatoxin-mediated transformation of C3H/10T1/2 cells.

  1985cites this paper
• [Spontaneous rate of occurrence of 2 characters of the transformation phenotype in a mouse fibroblast culture].

  1985cites this paper
• Resistance to mutagenesis of cells biochemically transformed by herpesvirus DNA fragments.

  1985cites this paper
• Cytotoxicity and negligible genotoxicity of borax and borax ores to cultured mammalian cells.

  1985cites this paper
• Effect of nicotinamide analogues on recovery from DNA damage in C3H10T1/2 cells.

  1984cites this paper
• pBR322 plasmid DNA modified with 2‐acetylaminofluorene derivatives: transforming activity and in vitro strand cleavage by the Escherichia coli uvrABC endonuclease.

  1984cites this paper
• Studies on the induction of histocompatibility gene mutations in germ cells of mice by chemical mutagens and/or virus-inducing compounds.

  1984cites this paper
• The Control of Cell Transformation, Mutagenesis, and Differentiation by Chemicals that Initiate or Promote Tumor Formation

  1984cites this paper
• Promoting effect of bile acids on the chemical transformation of C3H/10T1/2 fibroblasts in vitro.

  1984cites this paper
• Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture.

  1984cites this paper
• Temporal dissociation in the exposure times required for maximal induction of cytotoxicity, mutation, and transformation by N-methyl-N'-nitro-N-nitrosoguanidine in the BALB/3T3 ClA31-1-1 cell line.

  1984cites this paper
• In Vitro Cell Transformation

  1984cites this paper
• Chemical Carcinogenesis In Vitro: Limitations and Possibilities in the Use of Rat Liver Epithelial Cells for Screening Carcinogens

  1983cites this paper
• Mutation of Chinese Hamster V79 cells and transformation and mutation of mouse fibroblast C3H/10T1/2 clone 8 cells by aflatoxin B1 and four other furocoumarins isolated from two Nigerian medicinal plants.

  1983cites this paper
• Teratogenicity in vitro of 2-acetylaminofluorene: role of biotransformation in the rat.

  1983cites this paper
• Microcell-mediated transfer of carcinogen-induced ouabain resistance from C3H/10T1/2 Cl 8 mouse fibroblasts to human cells.

  1983cites this paper
• Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program.

  1983cites this paper
• The binding of a carcinogen to the nucleosomal and non-nucleosomal regions of the simian virus 40 chromosome in vivo.

  1983cites this paper
• Induction of ouabain-resistant mutants by chemical carcinogens in rat prostate epithelial cells.

  1983cites this paper
• O6-methylguanine, but not N7-methylguanine or N3-methyladenine, induces gene mutations, sister-chromatid exchanges and chromosomal aberrations in Chinese hamster cells.

  1983cites this paper
• [Genetic nature of one of the traits of malignant cell transformation in vitro].

  1983cites this paper
• Mutagenesis and morphological transformation by N-methyl-N'-nitro-N-nitrosoguanidine in the BALB/3T3 clone A31-1-1 cell line.

  1983cites this paper
• Genetic and probability aspects of cell transformation by chemical carcinogens.

  1983cites this paper
• The mutational origin of serum independence in Chinese hamster cells in vitro

  1983cites this paper
• In vitro transformation assays for chemical carcinogens.

  1983cites this paper
• Influence of benzoflavone on aflatoxin B1-induced cytotoxicity, mutation, and transformation of C3H/10T1/2 cells.

  1983cites this paper
• An information-theory model of cellular survival, mutation and transformation and the relevance of this model to chemical carcinogenesis.

  1983cites this paper
• Analysis at the sequence level of mutations induced by the ultimate carcinogen N-acetoxy-N-2-acetylaminofluorene

  1983cites this paper
• Mammalian Cell Mutagenesis: Relevance For Detection of Environmental Mutagens/Carcinogens

  1983cites this paper
• Influenceof Benzoflavone onAflatoxinBHnducedCytotoxicity, Mutation,andTransformation of C3H/10T1/2Cells1'2

  1983cites this paper
• In Vitro Carcinogenesis with Cell Lines

  1983cites this paper
• The mutational origin of serum independence in Chinese hamster cells in vitro.

  1983cites this paper
• Metabolic Activation Systems in Vitro for Carcinogen/Mutagen Screening Tests

  1982cites this paper
• Chemical carcinogens transform BHK cells by inducing a recessive mutation

  1982cites this paper
• Interaction of benzo(a)pyrene and its dihydrodiol-epoxide derivative with nuclear and mitochondrial DNA in C3H10T 1/2 cell cultures.

  1982cites this paper
• Initiation of C3H/10T1/2 cell transformation by N-methyl-N'-nitro-N-nitrosoguanidine and aflatoxin B1.

  1982cites this paper
• Improved transformation of C3H10T1/2CL8 cells by direct- and indirect-acting carcinogens.

  1982cites this paper
• Induction of cytotoxicity, mutation, cytogenetic changes, and neoplastic transformation by benzo(a)pyrene and derivatives in C3H/10T1/2 clone 8 mouse fibroblasts.

  1982cites this paper
• Dissociated occurrence of single‐gene mutation and oncogenic transformation in C3H 10T½ cells exposed to ultraviolet light and caffeine

  1982cites this paper
• When do carcinogen-treated 10T1/2 cells acquire the commitment to form transformed foci?

  1982cites this paper