Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Science

• Publication date

  2013-06-14

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1126/science.1236862PMID 23766324PMCID PMC4409680
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phenotypic plasticity in blood–oxygen transport in highland and lowland deer mice

  2013cited by this paper
• Deer mouse hemoglobin exhibits a lowered oxygen affinity owing to mobility of the E helix.

  2013cited by this paper
• Oxygen transport by hemoglobin.

  2012cited by this paper
• Altitudinal Variation at Duplicated β-Globin Genes in Deer Mice: Effects of Selection, Recombination, and Gene Conversion

  2012cited by this paper
• Initial Mutations Direct Alternative Pathways of Protein Evolution

  2011cited by this paper
• Molecular mechanisms of epistasis within and between genes.

  2011cited by this paper
• Expression and Purification of Recombinant Hemoglobin in Escherichia coli

  2011cited by this paper
• Epistasis between Beneficial Mutations and the Phenotype-to-Fitness Map for a ssDNA Virus

  2011cited by this paper
• Reciprocal Sign Epistasis between Frequently Experimentally Evolved Adaptive Mutations Causes a Rugged Fitness Landscape

  2011cited by this paper
• Pervasive Cryptic Epistasis in Molecular Evolution

  2010cited by this paper
• Fitness Epistasis and Constraints on Adaptation in a Human Immunodeficiency Virus Type 1 Protein Region

  2010cited by this paper
• Genetic differences in hemoglobin function between highland and lowland deer mice

  2010influential reference
• An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

  2009cited by this paper
• Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin

  2009cited by this paper
• Stepwise acquisition of pyrimethamine resistance in the malaria parasite

  2009cited by this paper
• Effects of Spatially Varying Selection on Nucleotide Diversity and Linkage Disequilibrium: Insights From Deer Mouse Globin Genes

  2008cited by this paper
• Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

  2008cited by this paper
• HEMOGLOBIN FUNCTION AND PHYSIOLOGICAL ADAPTATION TO HYPOXIA IN HIGH-ALTITUDE MAMMALS

  2007cited by this paper
• The Molecular Basis of High-Altitude Adaptation in Deer Mice

  2007cited by this paper
• Empirical fitness landscapes reveal accessible evolutionary paths

  2007cited by this paper
• Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis

  2007cited by this paper
• Inference of macromolecular assemblies from crystalline state.

  2007cited by this paper
• 1.25 A resolution crystal structures of human haemoglobin in the oxy, deoxy and carbonmonoxy forms.

  2006cited by this paper
• The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

  2006cited by this paper
• Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins

  2006cited by this paper
• PERSPECTIVE: SIGN EPISTASIS AND GENETIC COSTRAINT ON EVOLUTIONARY TRAJECTORIES

  2005cited by this paper
• The Biochemical Architecture of an Ancient Adaptive Landscape

  2005cited by this paper
• Missense meanderings in sequence space: a biophysical view of protein evolution

  2005cited by this paper
• PERSPECTIVE:SIGN EPISTASIS AND GENETIC CONSTRAINT ON EVOLUTIONARY TRAJECTORIES

  2005cited by this paper
• Effects of 2,3-diphosphoglycerate and other organic phosphate compounds on oxygen affinity and intracellular pH of human erythrocytes

  2004cited by this paper
• Biochemical and physiological correlates of deer mouse a-chain hemoglobin polymorphisms

  1999cited by this paper
• Transient flow of a Maxwell fluid on a rotating disk

  1993cited by this paper
• Interactions between Hb, Mg, DPG, ATP, and Cl determine the change in Hb-O2 affinity at high altitude.

  1993cited by this paper
• Comparative protein modelling by satisfaction of spatial restraints.

  1993cited by this paper
• Use of ionic and zwitterionic (Tris/BisTris and HEPES) buffers in studies on hemoglobin function.

  1992cited by this paper
• Mechanisms of Cooperativity and Allosteric Regulation in Proteins

  1990cited by this paper
• Mechanisms of cooperativity and allosteric regulation in proteins

  1989cited by this paper
• HEMOGLOBIN POLYMORPHISMS IN DEER MICE (PEROMYSCUS MANICULATUS): PHYSIOLOGY OF BETA‐GLOBIN VARIANTS AND ALPHA‐GLOBIN RECOMBINANTS

  1988cited by this paper
• Biochemical and physiological correlates of deer mouse alpha-chain hemoglobin polymorphisms.

  1984cited by this paper
• 2,3-diphosphoglycerate in high- and low-altitude populations of the deer mouse.

  1982cited by this paper
• Allosteric Effects in Haemoglobin

  1982cited by this paper
• Differences in the Interaction of 2,3-Diphosphoglycerate with Certain Mammalian Hemoglobins

  1971cited by this paper
• On the mechanisms of the hypoxia-induced increase of 2,3-diphosphoglycerate in erythrocytes

  1971cited by this paper
• Influence of chronic and acute hypoxia on oxygen affinity and red cell 2,3 diphosphoglycerate of rats and guinea pigs.

  1971cited by this paper
• Allosteric Effects in Hemoglobin

  1963cited by this paper

• Physiological Differences Underlying Divergent Hypoxia Responses and Altitude Adaptations in Humans, Rats and Mice

  2025cites this paper
• Effects of Hemoglobin-O2 Affinity on Breathing and Gas Exchange in Deer Mice.

  2025cites this paper
• Canalization of globins in the adaptive evolution of birds

  2025cites this paper
• Geographic Variation in Epigenetic Responses to Hypoxia in Deer Mice ( Peromyscus maniculatus ) Distributed Along an Elevational Gradient

  2025cites this paper
• Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network

  2025cites this paper
• A novel, fig-associated microbe promotes reproductive success via variable life history mechanisms in C. elegans and C. inopinata

  2025cites this paper
• The Mutational Road not Taken: Using Ancestral Sequence Resurrection to Evaluate the Evolution of Plant Enzyme Substrate Preferences

  2024cites this paper
• Higher-order epistasis within Pol II trigger loop haplotypes

  2024cites this paper
• Epistasis facilitates functional evolution in an ancient transcription factor

  2024cites this paper
• Higher-order epistasis within Pol II trigger loop haplotypes

  2024cites this paper
• Applications of ancestral sequence reconstruction for understanding the evolution of plant specialized metabolism

  2024cites this paper
• Addressing epistasis in the design of protein function

  2024cites this paper
• Convergent High O2 Affinity but Distinct ATP-Mediated Allosteric Regulation of Hemoglobins in Oviparous and Viviparous Eremias Lizards from the Qinghai-Tibet Plateau

  2024cites this paper
• Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network

  2024cites this paper
• Hypoxia Inducible Factor pathway proteins in high-altitude mammals.

  2023cites this paper
• Not Quite Lost in Translation: Mistranslation Alters Adaptive Landscape Topography and the Dynamics of Evolution

  2023cites this paper
• Widespread epistasis shapes RNA polymerase II active site function and evolution

  2023cites this paper
• Intragenic compensation through the lens of deep mutational scanning

  2022cites this paper
• Contingency and Entrenchment of Drug-Resistance Mutations in HIV Viral Proteins.

  2022cites this paper
• Evolution in reproductive tempo and investment across the Peromyscus radiation

  2022cites this paper
• A homotetrameric hemoglobin expressed in alveolar epithelial cells increases blood oxygenation in high-altitude plateau pika (Ochotona curzoniae).

  2022cites this paper
• Evolution and molecular basis of a novel allosteric property of crocodilian hemoglobin

  2022cites this paper
• A hybrid model combining evolutionary probability and machine learning leverages data-driven protein engineering

  2022cites this paper
• Epistatic drift causes gradual decay of predictability in protein evolution

  2022cites this paper
• Exploring the expanse between theoretical questions and experimental approaches in the modern study of evolvability

  2022cites this paper
• A New Homotetramer Hemoglobin in the Pulmonary Surfactant of Plateau Zokors (Myospalax Baileyi)

  2022cites this paper
• The landscape of transcriptional and translational changes over 22 years of bacterial adaptation

  2022cites this paper
• Physiological insight into the evolution of complex phenotypes: aerobic performance and the O2 transport pathway of vertebrates.

  2021cites this paper
• The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach

  2021cites this paper
• The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice

  2021cites this paper
• Commentary: Hierarchical reductionism approach to understanding adaptive variation in animal performance.

  2021cites this paper
• The landscape of transcriptional and translational changes over 22 years of bacterial adaptation

  2021cites this paper
• The adaptive benefit of evolved increases in hemoglobin-O 2 affinity is 2 contingent on tissue O 2 diffusing capacity in high-altitude deer mice 3

  2021cites this paper
• Epistasis and intramolecular networks in protein evolution.

  2021cites this paper
• Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice.

  2021cites this paper
• Comparison of hematological traits and oxygenation properties of hemoglobins from highland and lowland Asiatic toad (Bufo gargarizans)

  2021cites this paper
• High-Altitude Adaptation: Mechanistic Insights from Integrated Genomics and Physiology

  2021cites this paper
• High-altitude deer mouse hypoxia-inducible factor-2α shows defective interaction with CREB-binding protein

  2021cites this paper
• Altitude acclimatization, hemoglobin-oxygen affinity, and circulatory oxygen transport in hypoxia.

  2021cites this paper
• Genomic variation in captive deer mouse (Peromyscus maniculatus) populations

  2021cites this paper
• Synthesis of Recombinant Human Hemoglobin With NH2‐Terminal Acetylation in Escherichia coli

  2020cites this paper
• Predicting evolutionary change at the DNA level in a natural Mimulus population

  2020cites this paper
• Emergence and propagation of epistasis in metabolic networks

  2020cites this paper
• Biochemical pedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope

  2020cites this paper
• Tibetan PHD2, an allele with loss-of-function properties

  2020cites this paper
• Ontogenesis of evolved changes in respiratory physiology in deer mice native to high altitude

  2020cites this paper
• Biochemical paedomorphosis and genetic assimilation in the hypoxia adaptation of Tibetan antelope

  2020cites this paper
• Adaptive evolution of β-globin gene in subterranean in South America octodontid rodents.

  2020cites this paper
• Evolved increases in hemoglobin-oxygen affinity and the Bohr effect coincided with the aquatic specialization of penguins

  2020cites this paper
• Physiological Genomics of Adaptation to High-Altitude Hypoxia.

  2020cites this paper
• The adaptive benefit of increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice

  2020cites this paper
• Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library

  2020cites this paper
• Epistasis on the stability landscape of de novo TIM barrels explored by a modular design approach

  2020cites this paper
• Searching for a mechanistic description of pairwise epistasis in protein systems

  2020cites this paper
• Effect of NH2-terminal acetylation on the oxygenation properties of vertebrate haemoglobin.

  2020cites this paper
• Ecology shapes epistasis in a genotype–phenotype–fitness map for stick insect colour

  2020cites this paper
• Adaptive Changes in Hemoglobin Function in High-Altitude Tibetan Canids Were Derived via Gene Conversion and Introgression

  2019cites this paper
• Evolved Mechanisms of Aerobic Performance and Hypoxia Resistance in High-Altitude Natives.

  2019cites this paper
• Adaptive Landscapes in the Age of Synthetic Biology

  2019cites this paper
• Complex pleiotropic genetic architecture of evolved heat stress and oxidative stress resistance in the nematode Caenorhabditis remanei

  2019cites this paper
• The role of mutation bias in adaptive molecular evolution: insights from convergent changes in protein function

  2019cites this paper
• Evolution of physiological performance capacities and environmental adaptation: insights from high-elevation deer mice (Peromyscus maniculatus).

  2019cites this paper
• Life Ascending: Mechanism and Process in Physiological Adaptation to High-Altitude Hypoxia.

  2019cites this paper
• The fitness challenge of studying molecular adaptation.

  2019cites this paper
• Enzyme neo- versus re-functionalization - an epistatic ratchet versus a smooth reversible transition.

  2019cites this paper
• Allosteric mechanisms underlying the adaptive increase in hemoglobin–oxygen affinity of the bar-headed goose

  2018cites this paper
• Mapping mutational e � ects along the evolutionary landscape of H I V envelope

  2018cites this paper
• Evolved changes in breathing and CO2 sensitivity in deer mice native to high altitudes.

  2018cites this paper
• Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants

  2018cites this paper
• Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development

  2018cites this paper
• Tracing whale myoglobin evolution by resurrecting ancient proteins

  2018cites this paper
• The Genome Landscape of Tibetan Sheep Reveals Adaptive Introgression from Argali and the History of Early Human Settlements on the Qinghai–Tibetan Plateau

  2018cites this paper
• Direct coupling analysis of epistasis in allosteric materials

  2018cites this paper
• Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems

  2018cites this paper
• Compensatory mutations and epistasis for protein function.

  2018cites this paper
• A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

  2018cites this paper
• Divergent and parallel routes of biochemical adaptation in high-altitude passerine birds from the Qinghai-Tibet Plateau

  2018cites this paper
• Remodeling Ancestral Phenotypic Plasticity in Local Adaptation: A New Framework to Explore the Role of Genetic Compensation in the Evolution of Homeostasis.

  2018cites this paper
• Proteostasis Environment Shapes Higher-Order Epistasis Operating on Antibiotic Resistance

  2018cites this paper
• Comparative analysis of the blood transcriptomes between wolves and dogs

  2018cites this paper
• Investigation of the differences between the Tibetan and Han populations in the hemoglobin–oxygen affinity of red blood cells and in the adaptation to high-altitude environments

  2018cites this paper
• Control of breathing and ventilatory acclimatization to hypoxia in deer mice native to high altitudes

  2017cites this paper
• Peromyscus transcriptomics: Understanding adaptation and gene expression plasticity within and between species of deer mice.

  2017cites this paper
• Alteration of the α1β2/α2β1 subunit interface contributes to the increased hemoglobin-oxygen affinity of high-altitude deer mice

  2017cites this paper
• Convergent adaptation to dangerous prey proceeds through the same first‐step mutation in the garter snake Thamnophis sirtalis

  2017cites this paper
• Selecting among three basic fitness landscape models: additive, multiplicative and stickbreaking

  2017cites this paper
• Circulatory mechanisms underlying adaptive increases in thermogenic capacity in high-altitude deer mice

  2017cites this paper
• The Complex Role of Sequence and Structure in the Stability and Function of the TIM Barrel Proteins

  2017cites this paper
• Quantifying how the mutational tolerance of HIV's envelope protein shapes its evolution

  2017cites this paper
• Evolution of Hemoglobin Genes in Codfishes Influenced by Ocean Depth

  2017cites this paper
• Evolution of the α2-adrenoreceptors in vertebrates: ADRA2D is absent in mammals and crocodiles

  2017cites this paper
• Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin

  2017cites this paper
• Quantification of heat shock protein 70 and acetylcholinesterase over a time course suggests environmental adaptation in a foundational molluscan species.

  2017cites this paper
• Rapid seasonal evolution in innate immunity of wild Drosophila melanogaster

  2017cites this paper
• Molecular adaptive convergence in the α-globin gene in subterranean octodontid rodents.

  2017cites this paper
• O2 binding and CO2 sensitivity in haemoglobins of subterranean African mole rats

  2017cites this paper
• Molecular basis of hemoglobin adaptation in the high-flying bar-headed goose

  2017cites this paper
• Evolution of the α2-adrenoreceptors in vertebrates: ADRA2D is absent in mammals and crocodiles

  2017cites this paper
• COMPUTATIONAL INVESTIGATIONS OF BIOMOLECULAR MOTIONS AND INTERACTIONS IN GENOMIC MAINTENANCE AND REGULATION

  2017cites this paper
• Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations.

  2017cites this paper