Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Cancer Research

• Publication date

  1991-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 1675933
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• [Cancer of the exocrine pancreas].

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