Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Physical Chemistry B

• Publication date

  2012-01-25

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/jp2108126PMID 22217000PMCID PMC4342054
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997cited by this paper
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  1994cited by this paper
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