Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

K. Steinbach,I. Vincenti,M. Kreutzfeldt,Nicolas Page,A. Muschaweckh,Ingrid Wagner,I. Drexler,D. Pinschewer,T. Korn,D. Merkler

Published 2016 in Journal of Experimental Medicine

ABSTRACT

During viral infections, brain tissue–resident memory T cells (bTRM) prevent fatal brain infection after acquiring perforin- and IFN-γ–dependent effector functions through a pathway that involves presentation of cognate antigen on MHC-I.

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