The Five Families of DNA Repair Proteins and their Functionally Relevant Ubiquitination

The process of DNA repair, be it a response to replication dysfunction or genotoxic insult, is critical for the resolution of strand errors and the avoidance of DNA mismatches that could result in various molecular pathologies, including carcinogenic development. Here, we will describe the five main mechanisms by which DNA avoids mutation, namely the processes of base excision repair, mismatch repair, nucleotide excision repair, homologous recombination, and nonhomologous end joining. In particular, we will dis-sect the functional significance of various posttranslational modifications of the essential proteins within these pathways, including but not limited to ubiquitination, acetylation, and phosphorylation.

• Publication year

  2017

• Venue

  Ubiquitination Governing DNA Repair - Implications in Health and Disease

• Publication date

  2017-12-20

• Fields of study

  Biology, Chemistry

• Identifiers
  DOI 10.5772/INTECHOPEN.71537
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997influential reference

• No citing papers are available for this paper.