Biological regulation: controlling the system from within

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Biology & Philosophy

• Publication date

  2016-03-01

• Fields of study

  Biology

• Identifiers
  DOI 10.1007/S10539-015-9497-8
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Alvaro Moreno and Matteo Mossio. 2015. Biological autonomy: a philosophical and theoretical enquiry

  2017influential reference
• The Second Law

  2016cited by this paper
• The role of regulation in the origin and synthetic modelling of minimal cognition

  2016cited by this paper
• The systems perspective at the crossroads between chemistry and biology.

  2015cited by this paper
• Biological organisation as closure of constraints.

  2015cited by this paper
• Biological Autonomy: A Philosophical and Theoretical Enquiry

  2015influential reference
• Organizational requirements for multicellular autonomy: insights from a comparative case study

  2014cited by this paper
• Fundamentals of enzyme kinetics.

  2014cited by this paper
• The ensemble nature of allostery

  2014cited by this paper
• Understanding allosteric and cooperative interactions in enzymes

  2014cited by this paper
• Emergence, Closure and Inter-level Causation in Biological Systems

  2013cited by this paper
• Simulating a Model of Metabolic Closure

  2013cited by this paper
• Interplay between gene expression noise and regulatory network architecture.

  2012cited by this paper
• On the Emergence of Biology from Chemistry: A Discontinuist Perspective from the Point of View of Stability and Regulation

  2012influential reference
• What history tells us. XXVII. A new life for allostery.

  2012cited by this paper
• A loop conjecture for metabolic closure

  2011cited by this paper
• Two Different Template Replicators Coexisting in the Same Protocell: Stochastic Simulation of an Extended Chemoton Model

  2011cited by this paper
• Advances in Artificial Life, ECAL 2011

  2011cited by this paper
• A Theory of Circular Organization and Negative Feedback: Defining Life in a Cybernetic Context

  2010influential reference
• A Minimal Model of Metabolism-Based Chemotaxis

  2010cited by this paper
• Organisational closure in biological organisms.

  2010cited by this paper
• Genetic Regulatory Mechanisms

  2010cited by this paper
• Principles of Life

  2010influential reference
• A Simple Self-Maintaining Metabolic System: Robustness, Autocatalysis, Bistability

  2010cited by this paper
• A letter to Darwin

  2009cited by this paper
• The origin of allosteric functional modulation: multiple pre-existing pathways.

  2009cited by this paper
• Seeking the chemical roots of darwinism: bridging between chemistry and biology.

  2009cited by this paper
• Stochastic Simulation of the Chemoton

  2009cited by this paper
• An Organizational Account of Biological Functions

  2009cited by this paper
• On the origin of systems

  2009influential reference
• Gánti’s Chemoton Model and Life Criteria

  2008influential reference
• Biological robustness

  2008cited by this paper
• Protocells : bridging nonliving and living matter

  2008cited by this paper
• Introduction à l'étude de la médecine expérimentale

  2008cited by this paper
• Biological mechanisms: organized to maintain autonomy

  2007cited by this paper
• The Evolutionary origins of volition

  2007cited by this paper
• Distributed Cognition and the Will: Individual Volition and Social Context

  2007cited by this paper
• A hitchhiker's guide through advances and conceptual changes in chemotaxis

  2007cited by this paper
• Organizational invariance and metabolic closure: analysis in terms of (M,R) systems.

  2006cited by this paper
• Feedback dynamics and cell function: Why systems biology is called Systems Biology.

  2005cited by this paper
• Autopoiesis, Adaptivity, Teleology, Agency

  2005cited by this paper
• Basic Autonomy as a Fundamental Step in the Synthesis of Life

  2004cited by this paper
• Making sense of it all: bacterial chemotaxis

  2004cited by this paper
• The hidden genetic program of complex organisms.

  2004cited by this paper
• Bridging Nonliving and Living Matter

  2003cited by this paper
• Untangling the wires: A strategy to trace functional interactions in signaling and gene networks

  2002cited by this paper
• Control, exploitation and tolerance of intracellular noise

  2002cited by this paper
• The Process Dynamics of Normative Function

  2002cited by this paper
• Foundations of systems biology

  2001cited by this paper
• Cybernetic formulation of the definition of life.

  2001cited by this paper
• Regulating the cellular economy of supply and demand

  2000influential reference
• Making sense of life : explaining biological development with models, metaphors, and machines

  1999cited by this paper
• Fundamentally different logic of gene regulation in eukaryotes and prokaryotes.

  1999cited by this paper
• ON THE CHEMOTON THEORY

  1997influential reference
• Understanding the Control of Metabolism

  1996cited by this paper
• The Regulation of Cellular Systems

  1996influential reference
• The control of flux.

  1995cited by this paper
• Histoire de la biologie moléculaire

  1994cited by this paper
• Quantitative assessment of regulation in metabolic systems.

  1991cited by this paper
• Life Itself: A Comprehensive Inquiry Into the Nature, Origin, and Fabrication of Life

  1991cited by this paper
• A SIMULATION STUDY ON THE CHEMOTON

  1984cited by this paper
• Autopoiesis and Cognition : The Realization of the Living (Boston Studies in the Philosophy of Scie

  1980cited by this paper
• Autopoiesis and Cognition

  1980cited by this paper
• Biochemical systems analysis: A study of function and design in molecular biology

  1978cited by this paper
• DYNAMIC AND LINGUISTIC MODES OF COMPLEX SYSTEMS

  1977cited by this paper
• Biochemical Systems Analysis: A Study of Function and Design in Molecular Biology

  1976cited by this paper
• Organization of chemical reactions into dividing and metabolizing units: the chemotons.

  1975cited by this paper
• Simulation of kinetics of proliferating chemical systems.

  1975cited by this paper
• Regulation of the Synthesis of the Lactose Repressor

  1974cited by this paper
• De máquinas y seres vivos: Una teoría sobre la organización biológica

  1973cited by this paper
• Dynamical System Theory in Biology. Vol. 1. Stability Theory and Its Applications

  1972influential reference
• Chapter 4 – SOME RELATIONAL CELL MODELS: THE METABOLISM-REPAIR SYSTEMS

  1972cited by this paper
• Basic ideas in biology

  1971cited by this paper
• Le hasard et la nécessité

  1970cited by this paper
• Stability theory and its applications

  1970cited by this paper
• Dynamical System Theory in Biology

  1970cited by this paper
• Biochemical systems analysis. II. The steady-state solutions for an n-pool system using a power-law approximation.

  1969cited by this paper
• Dynamics of Development: Experiments and Inferences; Selected Papers on Developmental Biology

  1968cited by this paper
• Comparison of experimental binding data and theoretical models in proteins containing subunits.

  1966cited by this paper
• Analytical Biology

  1966cited by this paper
• ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.

  1965influential reference
• Dynamics of development

  1964cited by this paper
• Allosteric proteins and cellular control systems.

  1963cited by this paper
• Genetic regulatory mechanisms in the synthesis of proteins.

  1961influential reference
• A relational theory of biological systems II

  1958cited by this paper
• An Introduction to Cybernetics

  1957cited by this paper
• Cybernetics, or Control and Communication in the Animal and the Machine.

  1949cited by this paper
• Cybernetics.

  1948cited by this paper
• ORGANIZATION FOR PHYSIOLOGICAL HOMEOSTASIS

  1929cited by this paper
• Leçons sur les phénomènes de la vie communs aux animaux et aux végétaux

  year unknowncited by this paper

• Wetware network-based AI: a chemical approach to embodied cognition for robotics and artificial intelligence

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• A Category Theory Model for Human Communication and Experience

  2026cites this paper
• Multi-Scale Temporal Homeostasis Enables Efficient and Robust Neural Networks

  2026cites this paper
• Autonomy and development: distinguishing teleological development from teleological physiology

  2026influential citation
• Autonomous Change

  2026cites this paper
• Homeostatic set-points are physical and foundational to organism autonomy

  2025cites this paper
• Continual decision-making dynamics across biological organisms.

  2025cites this paper
• A photoprotection dial maps holistic light-stress response in diatoms

  2025cites this paper
• Regulation in ecological systems: an overview

  2025influential citation
• Gaia: the Earth is an organism (not a Darwinian individual)

  2025cites this paper
• Homeostasis and Health: From Balance to Change

  2025cites this paper
• Structure-performance relationships for catalysis-driven molecular machinery

  2025cites this paper
• Modelling the prebiotic origins of regulation and agency in evolving protocell ecologies

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• Arousal as a universal embedding for spatiotemporal brain dynamics

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• Naturalizing biological agency: constitutive and dynamical strategies

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• The Units of Life

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• The evolution of human-type consciousness – a by-product of mammalian innovation mechanism – a preliminary hypothesis

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• Organizational Accounts of Malfunction: The Dual-Order Approach and the Normative Field Alternative

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• Explanatory Particularism in Scientific Practice

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• How Physical Information Underlies Causation and the Emergence of Systems at all Biological Levels

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• An Investigation Into the Notion of Complex Systems

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• Constitutive and Regulatory Responses of Arabidopsis thaliana to Harmonically Oscillating Light

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• Transformative creativity in life: an epigenetic perspective based on biological autonomy

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• A Mechanistic Account of Biological Computation

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• Biological Organization

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• The teleological modal profile and subjunctive background of organic generation and growth

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• Systems theory, thermodynamics and life: Integrated thinking across ecology, organization and biological evolution

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• Biodynamic Lighting: Reviewing Foundational Considerations for ‘Life-centric’ Lighting

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• A functional approach to homeostatic regulation

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• Organisational teleology 2.0: Grounding biological purposiveness in regulatory control

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• Using neurons to maintain autonomy: Learning from C. elegans

  2023cites this paper
• How biological codes break causal chains to enable autonomy for organisms

  2023cites this paper
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• Organisms, Life Relations, and Evolution: Inter-Dependencies after Kropotkin's Mutual Aid

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• Affordances and organizational functions

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• Integrating Multicellular Systems: Physiological Control and Degrees of Biological Individuality

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• Between Samir Amin and Claude Ake: towards a roadmap for Africa’s development

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• Ecosystem health and malfunctions: an organisational perspective

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• Organizational normativity and teleology: a critique

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• Control mechanisms: Explaining the integration and versatility of biological organisms

  2022influential citation
• A constraints-based theory of the primary cause of senescence: imbalance of epigenetic and non-epigenetic information in histone crosstalk

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• Organization needs organization: Understanding integrated control in living organisms.

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• Self, Agency and Autonomy in Dynamical Living Systems

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  2020cites this paper
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  2020cites this paper
• Plurality of Explanatory Strategies in Biology: Mechanisms and Networks

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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• An Organisational Approach to Biological Communication

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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