Chronic obstructive pulmonary disease • 3: Experimental animal models of pulmonary emphysema

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Thorax

• Publication date

  2002-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1136/thorax.57.10.908PMID 12324680PMCID PMC1746206
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The effect of lathyrogens on the evolution of elastase-induced emphysema.

  2015cited by this paper
• Pulmonary emphysema with special reference to vascular changes.

  2015cited by this paper
• Hereditary emphysema in the tight-skin mouse. Evaluation of pathogenesis.

  2015cited by this paper
• Pre- and postnatal lung development, maturation, and plasticity - Temporal/spatial expression of retinoid binding proteins and RAR isoforms in the postnatal lung

  2002cited by this paper
• Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response.

  2002cited by this paper
• Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice.

  2002cited by this paper
• Severity of Elastase-Induced Emphysema Is Decreased in Tumor Necrosis Factor-α and Interleukin-1β Receptor-Deficient Mice

  2002cited by this paper
• Fibulin-5/DANCE is essential for elastogenesis in vivo

  2002cited by this paper
• Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3).

  2001cited by this paper
• Transcription factors in mouse lung development and function.

  2001cited by this paper
• Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema.

  2001cited by this paper
• Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor.

  2001cited by this paper
• Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension.

  2001cited by this paper
• Surfactant Protein D Regulates NF-κB and Matrix Metalloproteinase Production in Alveolar Macrophages via Oxidant-Sensitive Pathways1

  2001cited by this paper
• The Importance of Ultramicroscopic Emphysema in Cigarette Smoke-Induced Lung Disease

  2001cited by this paper
• Dose-dependent lung remodeling in transgenic mice expressing transforming growth factor-alpha.

  2001cited by this paper
• End-stage chronic obstructive pulmonary disease: the cigarette is burned out but inflammation rages on.

  2001cited by this paper
• Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis.

  2001cited by this paper
• Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema.

  2001cited by this paper
• Identification of a Novel Lipopolysaccharide-Inducible Gene with Key Features of Both a Kinase Anchor Proteins and chs1/beige Proteins1

  2001cited by this paper
• Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema.

  2000cited by this paper
• New Insights into the Assembly of Extracellular Microfibrils from the Analysis of the Fibrillin 1 Mutation in the Tight skin Mouse

  2000cited by this paper
• Impaired distal airway development in mice lacking elastin.

  2000cited by this paper
• Interferon γ Induction of Pulmonary Emphysema in the Adult Murine Lung

  2000cited by this paper
• Inhibition of VEGF receptors causes lung cell apoptosis and emphysema.

  2000cited by this paper
• Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by alpha1-antitrypsin.

  2000cited by this paper
• Retinoic acid treatment partially rescues failed septation in rats and in mice.

  2000cited by this paper
• The challenge of providing better care for patients with chronic obstructive pulmonary disease: the poor relation of airways obstruction?

  2000cited by this paper
• Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers.

  2000cited by this paper
• The molecular basis of lung morphogenesis.

  2000cited by this paper
• Retinoic acid receptor-β: an endogenous inhibitor of the perinatal formation of pulmonary alveoli

  2000cited by this paper
• Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung.

  2000cited by this paper
• Animal models for COPD.

  2000cited by this paper
• Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life.

  2000cited by this paper
• The prepro vasoactive intestinal contractor (VIC)/endothelin-2 gene (EDN2): structure, evolution, production, and embryonic expression.

  2000cited by this paper
• Emphysematous lesions, inflammation, and fibrosis in the lungs of transgenic mice overexpressing platelet-derived growth factor.

  1999cited by this paper
• The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency

  1999cited by this paper
• The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis.

  1999cited by this paper
• VEGF is required for growth and survival in neonatal mice.

  1999cited by this paper
• Ultrastructure of lung elastin and collagen in mouse models of spontaneous emphysema.

  1999cited by this paper
• FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung.

  1998cited by this paper
• Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.

  1997cited by this paper
• Mighty mice: transgenic technology "knocks out" questions of matrix metalloproteinase function.

  1997cited by this paper
• Identification of the homologous beige and Chediak–Higashi syndrome genes

  1997cited by this paper
• Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice.

  1997cited by this paper
• Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats

  1997cited by this paper
• Further investigation of the use of intratracheally administered hyaluronic acid to ameliorate elastase-induced emphysema.

  1997cited by this paper
• Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development.

  1997cited by this paper
• A scanning electron microscopic investigation of genetic emphysema in tight-skin, pallid, and beige mice, three different C57 BL/6J mutants.

  1996cited by this paper
• PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.

  1996cited by this paper
• Compound mutants for retinoic acid receptor (RAR) beta and RAR alpha 1 reveal developmental functions for multiple RAR beta isoforms.

  1996cited by this paper
• Mineral dusts cause elastin and collagen breakdown in the rat lung: a potential mechanism of dust-induced emphysema.

  1996cited by this paper
• Compound mutants for retinoic acid receptor (RAR)β and RARα1 reveal developmental functions for multiple RARβ isoforms

  1996cited by this paper
• Identification of the homologous beige and Chediak–Higashi syndrome genes

  1996cited by this paper
• A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation.

  1996cited by this paper
• Modulation of airspace enlargement in elastase-induced emphysema by intratracheal instillment of hyaluronidase and hyaluronic acid.

  1995cited by this paper
• Effect of oxidant air pollutants on the respiratory system: insights from experimental animal research.

  1995cited by this paper
• Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

  1995cited by this paper
• Pallid mice with genetic emphysema. Neutrophil elastase burden and elastin loss occur without alteration in the bronchoalveolar lavage cell population.

  1995cited by this paper
• Mutations in the murine homologue of the Menkes gene in dappled and blotchy mice

  1994cited by this paper
• The pallid mouse. A model of genetic alpha 1-antitrypsin deficiency.

  1993cited by this paper
• Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema.

  1992cited by this paper
• Prevention of leucocyte elastase-induced emphysema in mice by heparin fragments.

  1991cited by this paper
• Cigarette smoke causes physiologic and morphologic changes of emphysema in the guinea pig.

  1990cited by this paper
• Cadmium-chloride-induced air-space enlargement with interstitial pulmonary fibrosis is not associated with destruction of lung elastin. Implications for the pathogenesis of human emphysema.

  1988cited by this paper
• Structural crosslinking of lung connective tissue collagen in the blotchy mouse.

  1987cited by this paper
• Animal models of emphysema.

  1986cited by this paper
• Lung fibrosis and emphysema: divergent responses to a common injury?

  1982cited by this paper
• Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema.

  1981cited by this paper
• Chemotactic activity of elastin-derived peptides.

  1980cited by this paper
• Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton.

  1976cited by this paper
• Emphysema-like changes in the lungs of the blotchy mouse.

  1976cited by this paper
• The induction of emphysema with elastase. II. Changes in connective tissue.

  1976cited by this paper
• Pulmonary intravascular leukocyte sequestration. A potential mechanism of lung injury.

  1974cited by this paper
• EXPERIMENTAL EMPHYSEMA: ITS PRODUCTION WITH PAPAIN IN NORMAL AND SILICOTIC RATS.

  1965cited by this paper

• Animal models of chronic obstructive pulmonary disease and their role in drug discovery and development: a critical review

  2025cites this paper
• Alpha-7 Nicotinic Receptor Agonist Protects Mice Against Pulmonary Emphysema Induced by Elastase

  2024cites this paper
• Characterization of a spontaneous mouse model of mild, accelerated aging via ECM degradation in emphysematous lungs

  2023cites this paper
• A novel inactivated whole-cell Pseudomonas aeruginosa vaccine that acts through the cGAS-STING pathway

  2021cites this paper
• Benefit of Physiologically Variable Over Pressure-Controlled Ventilation in a Model of Chronic Obstructive Pulmonary Disease: A Randomized Study

  2021cites this paper
• The Influence of the Heat-not-burn Cigarettes on Alveolus and Cytokine ─The Analysis of Chronic Obstructive Pulmonary Disease (COPD) and Skeletal Muscle Atrophy Model Mice─

  2021cites this paper
• Spontaneous pulmonary emphysema in mice lacking all three nitric oxide synthase isoforms

  2021cites this paper
• CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis

  2020cites this paper
• Differential lung inflammation and injury with tobacco smoke exposure in Wistar Kyoto and spontaneously hypertensive rats

  2020cites this paper
• LJ-529, a partial peroxisome proliferator-activated receptor gamma (PPARγ) agonist and adenosine A3 receptor agonist, ameliorates elastase-induced pulmonary emphysema in mice

  2020cites this paper
• Pseudomonas aeruginosa induced acute emphysema through bacterial secretion in mice

  2020cites this paper
• Preventive and therapeutic effect of anti IL-17 in an experimental model of elastase-induced lung injury in C57Bl6 mice.

  2020cites this paper
• LJ-2698, an Adenosine A3 Receptor Antagonist, Alleviates Elastase-Induced Pulmonary Emphysema in Mice

  2020cites this paper
• NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks

  2019cites this paper
• Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance

  2019cites this paper
• Emphysema-associated Autoreactive Antibodies Exacerbate Post-Lung Transplant Ischemia-Reperfusion Injury.

  2019cites this paper
• Animal models of emphysema

  2019cites this paper
• Microenvironmental stimuli induce different macrophage polarizations in experimental models of emphysema

  2019cites this paper
• Basophils trigger emphysema development in a murine model of COPD through IL-4–mediated generation of MMP-12–producing macrophages

  2018cites this paper
• Bone Marrow-Derived Mononuclear Cell Therapy in Papain-Induced Experimental Pulmonary Emphysema

  2018cites this paper
• The tick-derived rBmTI-A protease inhibitor attenuates the histological and functional changes induced by cigarette smoke exposure.

  2018cites this paper
• Understanding shared pathogenesis between chronic obstructive pulmonary disease (COPD) and lung cancer by means of cell specific genomics

  2018cites this paper
• Experimental animal models for COPD: a methodological review

  2017cites this paper
• Anatomical and functional lung imaging with MRI

  2017cites this paper
• Native matrix-based human lung alveolar tissue model in vitro: studies of the reparatory actions of mesenchymal stem cells

  2017cites this paper
• A murine model of elastase- and cigarette smoke-induced emphysema

  2017cites this paper
• Animal Models of Alpha-1-Antitrypsin Deficiency

  2017cites this paper
• One-year Prevalence, Comorbidities, and Cost of Hospitalizations for Alpha-1 Antitrypsin Deficiency among Patients with Chronic Obstructive Pulmonary Disease in the United States

  2017cites this paper
• Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice

  2017influential citation
• Compensatory lung growth after bilobectomy in emphysematous rats

  2017cites this paper
• A Plant Proteinase Inhibitor from Enterolobium contortisiliquum Attenuates Pulmonary Mechanics, Inflammation and Remodeling Induced by Elastase in Mice

  2017cites this paper
• Variable Susceptibility to Cigarette Smoke‐Induced Emphysema in 34 Inbred Strains of Mice Implicates Abi3bp in Emphysema Susceptibility

  2017cites this paper
• Elucidating the dynamics and role of macrophages in a murine model of elastase-induced emphysema

  2016cites this paper
• Chronic Obstructive Lung Disease, Stem Cells and Telocytes: Review of Therapeutic

  2016cites this paper
• Assessing the Relationship between Lung Density and Function with Oxygen-Enhanced Magnetic Resonance Imaging in a Mouse Model of Emphysema

  2016cites this paper
• The Plant-Derived Bauhinia bauhinioides Kallikrein Proteinase Inhibitor (rBbKI) Attenuates Elastase-Induced Emphysema in Mice

  2016cites this paper
• Novel insights into the genetic basis of chronic obstructive pulmonary disease

  2016cites this paper
• Alpha-1 Antitrypsin Investigations Using Animal Models of Emphysema.

  2016cites this paper
• Imagerie quantitative du dépôt d’aérosols dans les voies aériennes du petit animal par résonance magnétique

  2015cites this paper
• A Novel Mouse Model of Spontaneous Pulmonary Emphysema: Mayumi-Emphysema Mouse

  2015cites this paper
• Estudo das fibras constituintes da matriz extracelular e da expressão de metaloproteases durante o desenvolvimento do enfisema pulmonar induzido por elastase em camundongos

  2015cites this paper
• Experimental progressive emphysema in BALB/cJ mice as a model for chronic alveolar destruction in humans.

  2015cites this paper
• Biomarkers in Lung Diseases : from Pathogenesis to Prediction to New Therapies Experimental progressive emphysema in BALB / cJ mice as a model for chronic alveolar destruction in humans

  2015cites this paper
• Oxidative and proteolysis‐related parameters of skeletal muscle from hamsters with experimental pulmonary emphysema: a comparison between papain and elastase induction

  2015cites this paper
• Novel aspects of pathogenesis and regeneration mechanisms in COPD

  2015cites this paper
• The Receptor for Advanced Glycation End Products (RAGE) Contributes to the Progression of Emphysema in Mice

  2015cites this paper
• Comparison between cigarette smoke-induced emphysema and cigarette smoke extract-induced emphysema

  2015cites this paper
• A novel nonhuman primate model of cigarette smoke-induced airway disease.

  2015cites this paper
• Animal Models of Chronic Obstructive Pulmonary Disease

  2015cites this paper
• Preclinical murine models of Chronic Obstructive Pulmonary Disease.

  2015cites this paper
• Levels of Cobalt and Chromium in Cigarette Smokers , Khartoum State

  2015cites this paper
• Three‐dimensional accurate detection of lung emphysema in rats using ultra‐short and zero echo time MRI

  2015cites this paper
• A Novel Mouse Model of Spontaneous Pulmonary Emphysema : Mayumi-Emphysema Mouse

  2015cites this paper
• Animal models of chronic obstructive pulmonary disease.

  2015cites this paper
• Functional Proton MRI in Emphysematous Rats

  2015cites this paper
• Efeitos pulmonares da fumaça de cigarro associada ao particulado de diesel exaurido (DEP) em camundongos

  2015cites this paper
• Effects of postnatal dexamethasone treatment on mRNA expression profiles of genes related to alveolar development in an emphysema model in mice.

  2014cites this paper
• EFFECT OF CHRONIC CIGARETTES SMOKING ON SERUM TESTOSTERONE, LUTINIZING HORMONE AND PROLACTIN LEVELS AMONG SUDANESE SMOKERS

  2014cites this paper
• Histopathological characteristics of pulmonary emphysema in experimental model

  2014cites this paper
• High intensity exercise training worsens alveolar destruction in pulmonary emphysema rats

  2014cites this paper
• An increased ratio of serum miR-21 to miR-181a levels is associated with the early pathogenic process of chronic obstructive pulmonary disease in asymptomatic heavy smokers.

  2014cites this paper
• 20. Lung Diseases

  2014cites this paper
• Pathological changes in the COPD lung mesenchyme--novel lessons learned from in vitro and in vivo studies.

  2014cites this paper
• Participación de las metaloproteinasas de matriz extracelular en la EPOC

  2014cites this paper
• Animal models in chronic obstructive pulmonary disease—an overview

  2014cites this paper
• Enhanced proliferation and growth of human lung epithelial cells on gelatin microparticle loaded with ephedra extracts

  2013cites this paper
• NAD(P)H:QUINONE OXIOREDUCTASE 1 PROTECTS LUNGS FROM OXIDANT-INDUCED EMPHYSEMA IN MICE

  2013cites this paper
• New experimental model of exposure to environmental tobacco smoke.

  2013cites this paper
• Emprego de células mononucleares da medula óssea em terapia experimental do enfisema pulmonar

  2013cites this paper
• A comparative study of extracellular matrix remodeling in two murine models of emphysema.

  2013cites this paper
• Cigarette Smoke Exposure as a Model of Inflammation Associated with COPD

  2013cites this paper
• Effect of a cysteinyl leukotriene receptor antagonist on experimental emphysema and asthma combined with emphysema.

  2013cites this paper
• Engineering three-dimensional macroporous hydroxyethyl methacrylate-alginate-gelatin cryogel for growth and proliferation of lung epithelial cells

  2013cites this paper
• Recent advances in pre-clinical mouse models of COPD

  2013cites this paper
• lterations in pulmonary structure by elastase administration n a model of emphysema in mice is associated with functional isturbances

  2013cites this paper
• SerpinB1 deficiency is not associated with increased susceptibility to pulmonary emphysema in mice.

  2013cites this paper
• Influence of chronic Cigarette Smoking on Serum Biochemical Profile among Sudanese smokers

  2013cites this paper
• New experimental model of exposure to environmental tobacco smoke 1

  2013cites this paper
• Modelo experimental de indução de enfisema pulmonar por exposição à fumaça de cigarro.

  2012cites this paper
• Effects of perinatal nicotine exposure on the development of albino rat’s alveoli with special reference to the role of the vascular endothelial growth factor

  2012cites this paper
• Inflammatory responses of the rat lungs in cold-dryness syndrome in the northwest of China.

  2012cites this paper
• Imbalance of Apoptosis and Cell Proliferation Contributes to the Development and Persistence of Emphysema

  2012cites this paper
• Crackle sounds and lung recruitment PhD Thesis

  2012cites this paper
• RETRACTED: NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice.

  2012cites this paper
• Cell Therapy in Chronic Obstructive Pulmonary Disease: State of the Art and Perspectives

  2012cites this paper
• Genetically manipulated mouse models of lung disease: potential and pitfalls.

  2012cites this paper
• Animal models of COPD

  2012cites this paper
• The Respiratory Tract

  2012cites this paper
• A review of α1-antitrypsin deficiency.

  2012cites this paper
• The Immunopathogenesis of Chronic Obstructive Pulmonary Disease

  2012cites this paper
• Improvement of animal models of COPD and identification of new therapeutic intervention principles therein

  2012cites this paper
• Modelo experimental de indução de enfisema pulmonar por exposição à fumaça de cigarro

  2012cites this paper
• Cell Therapy with Bone Marrow Mononuclear Cells in Elastase-Induced Pulmonary Emphysema

  2012cites this paper
• Alterations in pulmonary structure by elastase administration in a model of emphysema in mice is associated with functional disturbances.

  2012cites this paper
• Regional function-structure relationships in lungs of an elastase murine model of emphysema.

  2012cites this paper
• Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance.

  2011cites this paper
• Respiratory mechanics do not always mirror pulmonary histological changes in emphysema

  2011cites this paper
• Short-term exposure of mice to cigarette smoke and/or residual oil fly ash produces proximal airspace enlargements and airway epithelium remodeling.

  2011cites this paper
• Development of a robust LC-MS/MS method for determination of desmosine and isodesmosine in human urine.

  2010cites this paper
• Modelo de cámara inhaladora para los estudios controlados sobre la toxicidad del humo del tabaco en los roedores

  2010cites this paper