The nitrilase superfamily: classification, structure and function

The nitrilase superfamily consists of thiol enzymes involved in natural product biosynthesis and post-translational modification in plants, animals, fungi and certain prokaryotes. On the basis of sequence similarity and the presence of additional domains, the superfamily can be classified into 13 branches, nine of which have known or deduced specificity for specific nitrile- or amide-hydrolysis or amide-condensation reactions. Genetic and biochemical analysis of the family members and their associated domains assists in predicting the localization, specificity and cell biology of hundreds of uncharacterized protein sequences.

• Publication year

  2001

• Venue

  Genome Biology

• Publication date

  2001-01-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1186/gb-2001-2-1-reviews0001PMID 11380987PMCID 150437
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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