Laminin α5 guides tissue patterning and organogenesis

Laminins (LM) are extracellular matrix molecules that contribute to and are required for the formation of basement membranes. They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis. Among the LM molecules, the LM α5 chain (LMα5) is one of the most widely distributed LM in the developing and mature organism. Its presence in some basement membranes during embryogenesis is absolutely required for maintenance of basement membrane integrity and thus for proper organogenesis. LMα5 also regulates the expression of genes important for major biological processes, in part by repressing or activating signaling pathways, depending upon the physiological context.

• Publication year

  2013

• Venue

  Cell Adhesion & Migration

• Publication date

  2013-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cam.22236PMID 23076210PMCID 3544791
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Laminin-511 expression is associated with the functionality of feeder cells in human embryonic stem cell culture.

  2012cited by this paper
• Functional Consequences of Cell Type-Restricted Expression of Laminin α5 in Mouse Placental Labyrinth and Kidney Glomerular Capillaries

  2012cited by this paper
• Abnormal Wnt and PI3Kinase Signaling in the Malformed Intestine of lama5 Deficient Mice

  2012influential reference
• The Epidermal Basement Membrane Is a Composite of Separate Laminin- or Collagen IV-containing Networks Connected by Aggregated Perlecan, but Not by Nidogens*

  2012cited by this paper
• Origin and evolution of laminin gene family diversity.

  2012cited by this paper
• Cell–matrix interactions in muscle disease

  2012cited by this paper
• A missense LAMB2 mutation causes congenital nephrotic syndrome by impairing laminin secretion.

  2011cited by this paper
• Basement membranes: cell scaffoldings and signaling platforms.

  2011cited by this paper
• Determinants of laminin polymerization revealed by the structure of the α5 chain amino-terminal region

  2011cited by this paper
• Efficient Differentiation of Embryonic Stem Cells into Hepatic Cells In Vitro Using a Feeder-Free Basement Membrane Substratum

  2011cited by this paper
• Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511

  2010cited by this paper
• Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages

  2010cited by this paper
• Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation

  2010cited by this paper
• Laminin chain assembly is regulated by specific coiled-coil interactions

  2010cited by this paper
• Caught in the Akt: regulation of Wnt signaling in the intestine.

  2010cited by this paper
• The role of the basement membrane as a modulator of intestinal epithelial-mesenchymal interactions.

  2010influential reference
• Maintenance of glomerular filtration barrier integrity requires laminin alpha5.

  2010cited by this paper
• Mutations in the human laminin β2 (LAMB2) gene and the associated phenotypic spectrum a

  2010cited by this paper
• Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis

  2009cited by this paper
• Integrins

  2009cited by this paper
• A role for pericytes as microenvironmental regulators of human skin tissue regeneration.

  2009cited by this paper
• Laminins

  2009cited by this paper
• Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.

  2009cited by this paper
• Laminin‐332 and ‐511 in skin

  2008cited by this paper
• Laminin α5 influences the architecture of the mouse small intestine mucosa

  2008cited by this paper
• Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.

  2008influential reference
• Red cell and endothelial Lu/BCAM beyond sickle cell disease.

  2008cited by this paper
• Genetic inactivation of the laminin alpha5 chain receptor Lu/BCAM leads to kidney and intestinal abnormalities in the mouse.

  2008cited by this paper
• Laminin‐511 but Not ‐332, ‐111, or ‐411 Enables Mouse Embryonic Stem Cell Self‐Renewal In Vitro

  2008cited by this paper
• Partial rescue of glomerular laminin alpha5 mutations by wild-type endothelia produce hybrid glomeruli.

  2007cited by this paper
• Epithelial stem cells: turning over new leaves.

  2007cited by this paper
• The integrins

  2007cited by this paper
• Hedgehog signaling in development and homeostasis of the gastrointestinal tract.

  2007cited by this paper
• Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.

  2007cited by this paper
• The sonic hedgehog signaling network in development and neoplasia.

  2007cited by this paper
• The LG1-3 Tandem of Laminin α5 Harbors the Binding Sites of Lutheran/Basal Cell Adhesion Molecule and α3β1/α6β1 Integrins*

  2007influential reference
• Laminin α5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through β1 integrin signaling

  2007cited by this paper
• Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract

  2007cited by this paper
• Laminin α5 Is Required for Dental Epithelium Growth and Polarity and the Development of Tooth Bud and Shape*

  2006influential reference
• Ligand-binding specificities of laminin-binding integrins: A comprehensive survey of laminin–integrin interactions using recombinant α3β1, α6β1, α7β1 and α6β4 integrins

  2006cited by this paper
• Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.

  2006cited by this paper
• Abnormalities in neural crest cell migration in laminin alpha5 mutant mice.

  2006cited by this paper
• The Lutheran glycoprotein: a multifunctional adhesion receptor

  2006cited by this paper
• Abnormalities in neural crest cell migration in laminin α5 mutant mice

  2006cited by this paper
• Trophoblast cells exhibit differential responses to laminin isoforms.

  2006cited by this paper
• Ligand-binding specificities of laminin-binding integrins: a comprehensive survey of laminin-integrin interactions using recombinant alpha3beta1, alpha6beta1, alpha7beta1 and alpha6beta4 integrins.

  2006cited by this paper
• Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier.

  2006cited by this paper
• Functional Sites in the Laminin Alpha Chains

  2005cited by this paper
• Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung.

  2005cited by this paper
• Generation of a conditionally null allele of the laminin α1 gene

  2005cited by this paper
• Review: Lutheran/B-CAM: A Laminin Receptor on Red Blood Cells and in Various Tissues

  2005cited by this paper
• A simplified laminin nomenclature.

  2005cited by this paper
• Compositional and structural requirements for laminin and basement membranes during mouse embryo implantation and gastrulation

  2004influential reference
• Molecular Dissection of the α-Dystroglycan- and Integrin-binding Sites within the Globular Domain of Human Laminin-10*

  2004cited by this paper
• Syndecans: proteoglycan regulators of cell-surface microdomains?

  2003cited by this paper
• Laminin‐10 is crucial for hair morphogenesis

  2003influential reference
• Laminin alpha5 chain is required for intestinal smooth muscle development.

  2003influential reference
• Role for laminin-α5 chain LG4 module in epithelial branching morphogenesis

  2003cited by this paper
• Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin α5 in the glomerular basement membrane

  2003cited by this paper
• Role for laminin-alpha5 chain LG4 module in epithelial branching morphogenesis.

  2003cited by this paper
• Opposing roles of integrin alpha6Abeta1 and dystroglycan in laminin-mediated extracellular signal-regulated kinase activation.

  2003cited by this paper
• Beta1 integrin and alpha-dystroglycan binding sites are localized to different laminin-G-domain-like (LG) modules within the laminin alpha5 chain G domain.

  2003cited by this paper
• Laminin α5 chain is required for intestinal smooth muscle development

  2003cited by this paper
• Genomic analysis of neural crest induction

  2002cited by this paper
• Laminin 10/11: an alternative adhesive ligand for epidermal keratinocytes with a functional role in promoting proliferation and migration

  2002cited by this paper
• Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells.

  2002cited by this paper
• Laminin α5 Chain Adhesion and Signaling in Conjunctival Epithelial Cells

  2002cited by this paper
• Complete sequence, recombinant analysis and binding to laminins and sulphated ligands of the N-terminal domains of laminin alpha3B and alpha5 chains.

  2002cited by this paper
• Laminin-10/11 and Fibronectin Differentially Prevent Apoptosis Induced by Serum Removal via Phosphatidylinositol 3-Kinase/Akt- and MEK1/ERK-dependent Pathways*

  2002cited by this paper
• Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung.

  2002cited by this paper
• Laminin gamma2 chain as a stromal cell marker of the human bone marrow microenvironment.

  2002cited by this paper
• Laminin alpha5 chain adhesion and signaling in conjunctival epithelial cells.

  2002cited by this paper
• Complete sequence, recombinant analysis and binding to laminins and sulphated ligands of the N-terminal domains of laminin α3B and α5 chains

  2002cited by this paper
• Laminin γ2 chain as a stromal cell marker of the human bone marrow microenvironment

  2002cited by this paper
• Identification of the Binding Site for the Lutheran Blood Group Glycoprotein on Laminin α5 through Expression of Chimeric Laminin Chains in Vivo *

  2002influential reference
• Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo.

  2001cited by this paper
• Domain IVa of laminin α5 chain is cell‐adhesive and binds β1 and αVβ3 integrins through Arg‐Gly‐Asp

  2001cited by this paper
• Domain IVa of laminin alpha5 chain is cell-adhesive and binds beta1 and alphaVbeta3 integrins through Arg-Gly-Asp.

  2001cited by this paper
• Localization of Lutheran, a novel laminin receptor, in normal, knockout, and transgenic mice suggests an interaction with laminin α5 in vivo

  2001influential reference
• Identification of Cell-binding Sites on the Laminin α5 N-terminal Domain by Site-directed Mutagenesis*

  2001cited by this paper
• Expression patterns of laminin alpha1 and alpha5 in human lung during development.

  2000cited by this paper
• Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins.

  2000cited by this paper
• Laminins: Structure and genetic regulation

  2000cited by this paper
• Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.

  2000cited by this paper
• Expression Patterns of Laminin α 1 and α 5 in Human Lung during Development

  2000cited by this paper
• Developmental Expression and Cellular Origin of the Laminin α2, α4, and α5 Chains in the Intestine

  1999cited by this paper
• Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.

  1999cited by this paper
• Developmental expression and cellular origin of the laminin alpha2, alpha4, and alpha5 chains in the intestine.

  1999influential reference
• Adhesion of Cultured Bovine Aortic Endothelial Cells to Laminin-1 Mediated by Dystroglycan*

  1999cited by this paper
• Expression of laminin alpha3, alpha4, and alpha5 chains by alveolar epithelial cells and fibroblasts.

  1998cited by this paper
• Expression of Laminin α3, α4, and α5 Chains by Alveolar Epithelial Cells and Fibroblasts

  1998cited by this paper
• Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus

  1998cited by this paper
• Roles for Laminin in Embryogenesis: Exencephaly, Syndactyly, and Placentopathy in Mice Lacking the Laminin α5 Chain

  1998influential reference
• Differential expression of laminin alpha chains during murine tooth development.

  1997cited by this paper
• Differential expression of laminin α chains during murine tooth development

  1997cited by this paper
• Molecular Cloning of a Novel Laminin Chain, α5, and Widespread Expression in Adult Mouse Tissues (*)

  1995cited by this paper
• Cellular origin of the dermal‐epidermal basement membrane

  1993cited by this paper
• Laminin in lung development: effects of anti-laminin antibody in murine lung morphogenesis.

  1990cited by this paper
• Interactions of migrating neural crest cells with fibronectin.

  1986cited by this paper
• Turning over New Leaves

  1889cited by this paper

• The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis

  2025cites this paper
• LAMA5 deficiency disrupts ECM–WNT crosstalk in chondrogenesis and contributes to idiopathic short stature

  2025cites this paper
• Structure and Function of the Extracellular Matrix in Normal and Pathological Conditions: Looking at the Bicuspid Aortic Valve

  2025cites this paper
• Patterned integrin–laminin adhesion coordinates epithelial collective cell migration

  2025cites this paper
• Optimizing the in vitro neuronal microenvironment to mitigate phototoxicity in live-cell imaging

  2025cites this paper
• MALDI mass spectrometry imaging of extracellular matrix proteins.

  2025cites this paper
• Caveolin 1 and 2 enhance the proliferative capacity of BCAM-positive corneal progenitors

  2025cites this paper
• Identification of molecular signatures defines the differential proteostasis response in induced spinal and cranial motor neurons

  2024cites this paper
• Metalloproteinases are involved in the regulation of prenatal tooth morphogenesis.

  2024cites this paper
• External Scaffold for Strengthening the Pulmonary Autograft in the Ross Procedure

  2024cites this paper
• Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes

  2024cites this paper
• Alterations of Matrisome Gene Expression in Naturally Aged and Photoaged Human Skin In Vivo

  2024cites this paper
• Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes

  2024cites this paper
• Proteomic analysis of extracellular vesicles from tick hemolymph and uptake of extracellular vesicles by salivary glands and ovary cells

  2023cites this paper
• Novel homozygous LAMB1 in‐frame deletion in a pediatric patient with brain anomalies and cerebrovascular event

  2023cites this paper
• Extracellular matrix: A regenerative conduit in dentistry

  2023cites this paper
• LAMA5: A new pathogenic gene for non-syndromic cleft lip with or without cleft palate

  2023cites this paper
• Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection

  2023cites this paper
• Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin α5/FAK signaling

  2022cites this paper
• Laminin N-terminus (LaNt) proteins, laminins and basement membrane regulation

  2022cites this paper
• Using whole exome sequencing to identify susceptibility genes associated with nonsyndromic cleft lip with or without cleft palate

  2022cites this paper
• A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects

  2022cites this paper
• Junctional epithelium and hemidesmosomes: Tape and rivets for solving the “percutaneous device dilemma” in dental and other permanent implants

  2022cites this paper
• Kidney development and function: ECM cannot be ignored.

  2022cites this paper
• A comprehensive survey on optimal components of extracellular matrix for kidney development and function

  2021cites this paper
• A guide to the composition and functions of the extracellular matrix

  2021cites this paper
• Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

  2020cites this paper
• Laminin α5 modulates fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway

  2020cites this paper
• Astrocytes increase exosomal secretion of oligodendrocyte precursor cells to promote their proliferation via integrin β4-mediated cell adhesion.

  2020cites this paper
• A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder.

  2020cites this paper
• Collagen and Endothelial Cell Coculture Improves β-Cell Functionality and Rescues Pancreatic Extracellular Matrix

  2020cites this paper
• Whole exome sequencing identifies the potential for genetic rescue in iconic and critically endangered Panamanian harlequin frogs

  2020cites this paper
• Evolutionary conserved networks of human height identify multiple Mendelian causes of short stature

  2019cites this paper
• Laminin 521 Alters the SNAI1, ZNF708 and GRN Gene Expression in BeWo b30 Cells and Creates Physiological Conditions for the Placental Barrier

  2019cites this paper
• Extracellular matrix constitution and function for tissue regeneration and repair

  2018cites this paper
• Laminin-511: a key regulator of breast cancer metastasis

  2018influential citation
• Nephrotic Syndrome and Glomerular Basement Membrane: Genetic Defect of the Laminin α5 Chain

  2018cites this paper
• LAMA5 promotes human umbilical vein endothelial cells migration, proliferation, and angiogenesis and is decreased in preeclampsia

  2018cites this paper
• A comprehensive analysis of differentially ex- pressed transcripts during hematopoietic stem cell aging in the mouse

  2018cites this paper
• Immunohistochemical Study of the Laminin α5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands

  2018cites this paper
• Adaptive adhesion systems mediate glioma cell invasion in complex environments

  2018cites this paper
• De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders

  2018cites this paper
• Down-Regulation of Laminin (LN)- α5 is Associated with Preeclampsia and Impairs Trophoblast Cell Viability and Invasiveness Through PI3K Signaling Pathway

  2018cites this paper
• Identification of the first dominant mutation of LAMA5 gene causing a complex multisystem syndrome due to dysfunction of the extracellular matrix

  2017cites this paper
• Gene expression profiles of brain endothelial cells during embryonic development at bulk and single-cell levels

  2017cites this paper
• Association of the Laminin, Alpha 5 (LAMA5) rs4925386 with height and longevity in an elderly population from Southern Italy.

  2016cites this paper
• Immunohistochemical Evaluation of the Effects of Nitrate in Drinking Water on Laminin Alpha-5 Expression in Rat Renal Glomeruli

  2016cites this paper
• Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction.

  2016cites this paper
• Requirement for basement membrane laminin α5 during urethral and external genital development.

  2016cites this paper
• Effect of Tunicamycin on Glycosaminoglycans and Laminins in Embryonic and Postnatal Thymic Tissues.

  2015cites this paper
• Identifying a molecular and cellular phenotype of mesenchymal stem cells mobilized from substance P in the peripheral blood

  2015cites this paper
• Invadopodia and basement membrane invasion in vivo

  2014cites this paper
• Picking up the threads: extracellular matrix signals in epithelial morphogenesis.

  2014cites this paper
• Changes in Laminin Chain Expression in Pre- and Postnatal Rat Pituitary Gland

  2014cites this paper
• Novel insights into the development and maintenance of the blood–brain barrier

  2014cites this paper
• The Lutheran/Basal Cell Adhesion Molecule Promotes Tumor Cell Migration by Modulating Integrin-mediated Cell Attachment to Laminin-511 Protein*

  2013cites this paper
• Characterization of the ubiquitin-like protein Hub1 and its role in pre-mRNA splicing in human cells

  2013cites this paper
• Skin Basement Membrane: The Foundation of Epidermal Integrity—BM Functions and Diverse Roles of Bridging Molecules Nidogen and Perlecan

  2013cites this paper
• Discarded human kidneys as a source of ECM scaffold for kidney regeneration technologies.

  2013cites this paper
• The laminin family

  2013cites this paper