Transcription attenuation.

Prokaryotic transcription attenuation mechanisms are described in which different metabolic signals and sensing events are used to regulate transcription termination at sites preceding structural genes. Suggestive eukaryotic examples also are mentioned.

• Publication year

  1988

• Venue

  Journal of Biological Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/9783527678679.dg13481PMID 3275656
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Evidence that a Nucleotide Sequence , ‘ % oxA , ~ ~ Is Involved ‘ in the Action of the NusA Protein

  2004cited by this paper
• Analysis of nutR ; A Region of Phage Lambda Required for Antitermination of Transcription

  2004cited by this paper
• The organization and regulation of the pyrBI operon in E. coli includes a rho-independent attenuator sequence

  2004cited by this paper
• The mtr locus is a two-gene operon required for transcription attenuation in the trp operon of Bacillus subtilis.

  1990cited by this paper
• Antitermination of characterized transcriptional terminators by the Escherichia coli rrnG leader region.

  1990cited by this paper
• Transcription pausing by Escherichia coli RNA polymerase is modulated by downstream DNA sequences.

  1990cited by this paper
• The sacT gene regulating the sacPA operon in Bacillus subtilis shares strong homology with transcriptional antiterminators

  1990cited by this paper
• tRNA(Trp) translation of leader peptide codon 12 and other factors that regulate expression of the tryptophanase operon

  1990influential reference
• The Rhizobium meliloti trpE(G) gene is regulated by attenuation, and its product, anthranilate synthase, is regulated by feedback inhibition

  1990cited by this paper
• Induction of levansucrase in Bacillus subtilis: an antitermination mechanism negatively controlled by the phosphotransferase system

  1990cited by this paper
• Regulation of activity of a transcriptional anti-terminator in E. coli by phosphorylation in vivo.

  1990cited by this paper
• Transcriptional antitermination in the bgl operon of E. coli is modulated by a specific RNA binding protein.

  1990cited by this paper
• Attenuation in the regulation of the pyrBI operon in Escherichia coli. In vivo studies of transcriptional termination.

  1989cited by this paper
• Ribosomal RNA operon anti-termination. Function of leader and spacer region box B-box A sequences and their conservation in diverse micro-organisms.

  1989cited by this paper
• Protein phosphorylation regulates transcription of the beta-glucoside utilization operon in E. coli.

  1989cited by this paper
• Role of the ribosome in suppressing transcriptional termination at the pyrBI attenuator of Escherichia coli K-12.

  1988cited by this paper
• Hyper-regulation of pyr gene expression in Escherichia coli cells with slow ribosomes. Evidence for RNA polymerase pausing in vivo?

  1988cited by this paper
• cis-acting sites in the transcript of the Bacillus subtilis trp operon regulate expression of the operon

  1988cited by this paper
• The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12.

  1987cited by this paper
• Isolation and structural analysis of the Escherichia coli trp leader paused transcription complex.

  1987cited by this paper
• Transcription termination factor rho is an RNA-DNA helicase.

  1987cited by this paper
• Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis.

  1987cited by this paper
• Nucleotide sequence and expression of the pyrC gene of Escherichia coli K-12

  1987cited by this paper
• Evidence that Rho and NusA are involved in termination in the rplL-rpoB intercistronic region

  1987cited by this paper
• Mapping and characterization of transcriptional pause sites in the early genetic region of bacteriophage T7.

  1987cited by this paper
• Specificity of the attenuation response of the threonine operon of Escherichia coli is determined by the threonine and isoleucine codons in the leader transcript.

  1987cited by this paper
• Regulatory elements common to the Bacillus pumilus and Bacillus subtilis trp operons

  1986cited by this paper
• Antitermination mechanisms in rRNA operons of Escherichia coli

  1986cited by this paper
• Promoter domain mediates guanosine tetraphosphate activation of the histidine operon.

  1986cited by this paper
• Intragenic pausing and anti‐sense transcription within the murine c‐myc locus.

  1986cited by this paper
• Complete nucleotide and deduced amino acid sequences of the Brevibacterium lactofermentum tryptophan operon.

  1986cited by this paper
• A block to elongation is largely responsible for decreased transcription of c-myc in differentiated HL60 cells

  1986cited by this paper
• Novel form of transcription attenuation regulates expression the Bacillus subtilis tryptophan operon

  1986cited by this paper
• Role of leader peptide synthesis in tryptophanase operon expression in Escherichia coli K-12

  1986cited by this paper
• Transcription attenuation in Salmonella typhimurium: the significance of rare leucine codons in the leu leader.

  1986cited by this paper
• Escherichia coli tryptophan operon directs the in vivo synthesis of a leader peptide

  1986cited by this paper
• Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression.

  1986cited by this paper
• Mutational studies with the trp repressor of Escherichia coli support the helix-turn-helix model of repressor recognition of operator DNA.

  1985cited by this paper
• Autogenous control of Escherichia coli threonyl-tRNA synthetase expression in vivo.

  1985cited by this paper
• Analysis of in vivo RNA transcription products of the ilvGEDA attenuator region of Escherichia coli K12.

  1985cited by this paper
• Translation activates the paused transcription complex and restores transcription of the trp operon leader region.

  1985cited by this paper
• Role of translation and attenuation in the control of pyrBI operon expression in Escherichia coli K-12

  1985cited by this paper
• Analysis of the requirements for transcription pausing in the tryptophan operon.

  1985cited by this paper
• Starvation for ilvB operon leader amino acids other than leucine or valine does not increase acetohydroxy acid synthase activity in Escherichia coli

  1985cited by this paper
• Structure of ribosome-bound messenger RNA as revealed by enzymatic accessibility studies.

  1985cited by this paper
• Regulation of aspartate transcarbamoylase synthesis in Escherichia coli: analysis of deletion mutations in the promoter region of the pyrBI operon.

  1985cited by this paper
• Pausing of RNA polymerase during in vitro transcription through the ilvB and ilvGEDA attenuator regions of Escherichia coli K12.

  1985cited by this paper
• Evidence for transcription antitermination control of tryptophanase operon expression in Escherichia coli K-12

  1985cited by this paper
• Mutations that convert the four leucine codons of the Salmonella typhimurium leu leader to four threonine codons

  1985cited by this paper
• Attenuation control of the Escherichia coli phenylalanyl-tRNA synthetase operon.

  1985cited by this paper
• Attenuation of late simian virus 40 mRNA synthesis is enhanced by the agnoprotein and is temporally regulated in isolated nuclear systems

  1985cited by this paper
• Structure of the Escherichia coli pyrE operon and control of pyrE expression by a UTP modulated intercistronic attentuation.

  1984cited by this paper
• Evidence for the transcript secondary structures predicted to regulate transcription attenuation in the trp operon.

  1984cited by this paper
• Translational attenuation: the regulation of bacterial resistance to the macrolide-lincosamide-streptogramin B antibiotics.

  1984cited by this paper
• Regulation of the synthesis of ribosomes and ribosomal components.

  1984cited by this paper
• Comparison of regulatory and structural regions of genes of tryptophan metabolism.

  1984cited by this paper
• Repression is relieved before attenuation in the trp operon of Escherichia coli as tryptophan starvation becomes increasingly severe

  1984cited by this paper
• Genetic analysis of the tryptophan operon regulatory region using site-directed mutagenesis.

  1984cited by this paper
• Evidence for antitermination in Escherichia coli RRNA transcription

  1984cited by this paper
• Stability of an RNA secondary structure affects in vitro transcription pausing in the trp operon leader region.

  1984cited by this paper
• Mechanism of UTP‐modulated attenuation at the pyrE gene of Escherichia coli: an example of operon polarity control through the coupling of translation to transcription.

  1984cited by this paper
• Nucleotide sequence of the ilvB multivalent attenuator region of Escherichia coli K12

  1983cited by this paper
• Escherichia coli phenylalanyl-tRNA synthetase operon is controlled by attenuation in vivo.

  1983cited by this paper
• Synthesis of aspartate transcarbamoylase in Escherichia coli: transcriptional regulation of the pyrB-pyrI operon.

  1983cited by this paper
• Linkage map of Escherichia coli K-12, edition 7

  1983cited by this paper
• Release of transcript and template during transcription termination at the trp operon attenuator.

  1983cited by this paper
• Escherichia coli phenylalanyl-tRNA synthetase operon region. Evidence for an attenuation mechanism. Identification of the gene for the ribosomal protein L20.

  1983cited by this paper
• A complementary DNA oligomer releases a transcription pause complex.

  1983cited by this paper
• Efficient read-through of Tn9 and IS1 by RNA polymerase molecules that initiate at rRNA promoters

  1983cited by this paper
• Transcription analyses with heteroduplex trp attenuator templates indicate that the transcript stem and loop structure serves as the termination signal.

  1983cited by this paper
• The leader mRNA of the histidine attenuator region resembles tRNAHis: possible general regulatory implications.

  1983cited by this paper
• Transcription of the S10 ribosomal protein operon is regulated by an attenuator in the leader.

  1983cited by this paper
• Transcription termination in vitro at the tryptophan operon attenuator is controlled by secondary structures in the leader transcript.

  1983cited by this paper
• REGULATION OF AN ELEVEN GENE RIBOSOMAL PROTEIN OPERON

  1982cited by this paper
• Effects of DNA base analogs on transcription termination at the tryptophan operon attenuator of EScherichia coli.

  1982cited by this paper
• ATTENUATION IN THE CONTROL OF TRYPTOPHAN OPERON EXPRESSION

  1982cited by this paper
• Regulation of tryptophan operon expression by attenuation in cell-free extracts of Escherichia coli.

  1982cited by this paper
• Attenuation regulation in the thr operon of Escherichia coli K-12: molecular cloning and transcription of the controlling region

  1982cited by this paper
• Initiation, pausing, and termination of transcription in the threonine operon regulatory region of Escherichia coli.

  1982cited by this paper
• Autogenous control: ribosomal protein L10‐L12 complex binds to the leader sequence of its mRNA.

  1982cited by this paper
• Transcript secondary structures regulate transcription termination at the attenuator of S. marcescens tryptophan operon

  1982cited by this paper
• Nucleotide sequence of the ilvB promoter-regulatory region: a biosynthetic operon controlled by attenuation and cyclic AMP.

  1982cited by this paper
• Regulation of phenylalanine biosynthesis in Escherichia coli K-12: control of transcription of the pheA operon

  1982cited by this paper
• Transcription termination at the tryptophan operon attenuator is decreased in vitro by an oligomer complementary to a segment of the leader transcript.

  1982cited by this paper
• Chromosomal locations of the genes for rRNA in Escherichia coli K-12

  1982cited by this paper
• The E. coli beta-lactamase attenuator mediates growth rate-dependent regulation.

  1981cited by this paper
• Molecular basis of valine resistance in Escherichia coli K-12.

  1981cited by this paper
• Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information

  1981cited by this paper
• In vivo and in vitro detection of the leader RNA of the histidine operon of Escherichia coli K-12.

  1981cited by this paper
• Pausing of RNA polymerase during in vitro transcription of the tryptophan operon leader region.

  1981cited by this paper
• Regulation of the histidine operon: translation-controlled transcription termination (a mechanism common to several biosynthetic operons).

  1981cited by this paper
• A direct effect of guanosine tetraphosphate on pausing of Escherichia coli RNA polymerase during RNA chain elongation.

  1981cited by this paper
• Control of leu operon expression in Escherichia coli by a transcription attenuation mechanism.

  1981cited by this paper
• Codon catalog usage is a genome strategy modulated for gene expressivity

  1981cited by this paper
• Rifampin resistance mutations that alter the efficiency of transcription termination at the tryptophan operon attenuator

  1981cited by this paper
• Attenuation in the control of expression of bacterial operons

  1981cited by this paper
• Nucleotide sequence of the structural gene for tryptophanase of Escherichia coli K-12

  1981cited by this paper
• An aminoacyl tRNA synthetase binds to a specific DNA sequence and regulates its gene transcription

  1981cited by this paper
• Pausing and termination of transcription within the early region of bacteriophage T7 DNA in vitro.

  1981cited by this paper
• E. coli ribosomal protein L4 is a feedback regulatory protein.

  1980cited by this paper

• A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics

  2025cites this paper
• Insights into Ligand-Mediated Activation of an Oligomeric Ring-Shaped Gene-Regulatory Protein from Solution- and Solid-State NMR

  2024cites this paper
• Escherichia coli non-coding regulatory regions are highly conserved

  2024cites this paper
• Functional characteristics and research trends of PDE11A in human diseases

  2022cites this paper
• Factor-stimulated intrinsic termination: getting by with a little help from some friends

  2022cites this paper
• Transcriptome architecture and regulation at environmental transitions in flavobacteria: the case of an important fish pathogen

  2021cites this paper
• Global Transcriptional Response of Methylorubrum extorquens to Formaldehyde Stress Expands the Role of EfgA and Is Distinct from Antibiotic Translational Inhibition

  2021cites this paper
• Minigene as a Novel Regulatory Element in Toxin-Antitoxin Systems

  2021cites this paper
• Sequence-Specific DNA Binding Protein

  2020cites this paper
• Structure-seq2 probing of RNA structure upon amino acid starvation reveals both known and novel RNA switches in Bacillus subtilis

  2020influential citation
• Bioinformatic prediction reveals posttranscriptional regulation of the chromosomal replication initiator gene dnaA by the attenuator sRNA rnTrpL in Escherichia coli

  2020cites this paper
• Structural Basis for the Ac tion of an All-Purpose Transcription Anti-termination Factor Graphical

  2019cites this paper
• Regulation of Bacterial Gene Expression by Transcription Attenuation

  2019cites this paper
• The Integrator complex terminates promoter-proximal transcription at protein-coding genes

  2019cites this paper
• Two Old Dogs, One New Trick: A Review of RNA Polymerase and Ribosome Interactions during Transcription-Translation Coupling

  2019cites this paper
• Identifying Small Proteins by Ribosome Profiling with Stalled Initiation Complexes

  2019cites this paper
• A link between transcription fidelity and pausing in vivo

  2017cites this paper
• Mg2+-dependent translational speed bump acts to regulate gene transcription

  2016cites this paper
• A Two-Way Street: Regulatory Interplay between RNA Polymerase and Nascent RNA Structure.

  2016cites this paper
• A Search for Ribonucleic Antiterminator Sites in Bacterial Genomes: Not Only Antitermination

  2015cites this paper
• Identification of tRNA modifications in T. thermophilus: wild type HB8 and mutant DTTHA1897 by LC-UV-MS/MS

  2015cites this paper
• Studies on the role of aminoacyl-tRNA synthesis in the regulation of ribosomal and exo-ribosomal protein synthesis in pathogens

  2015cites this paper
• Ribosomal protein L10(L12)4 autoregulates expression of the Bacillus subtilis rplJL operon by a transcription attenuation mechanism

  2015cites this paper
• Translation initiation factor 3 families: what are their roles in regulating cyanobacterial and chloroplast gene expression?

  2015cites this paper
• Metabolic De-Isotoping for Improved LC-MS Characterization of Modified RNAs

  2014cites this paper
• G673 could be a novel mutational hot spot for intragenic suppressors of pheS5 lesion in Escherichia coli

  2014cites this paper
• Evolution of a Genome-Encoded Bias in Amino Acid Biosynthetic Pathways Is a Potential Indicator of Amino Acid Dynamics in the Environment

  2014cites this paper
• Kinetics of promoter Pol II on Hsp70 reveal stable pausing and key insights into its regulation

  2014cites this paper
• Conditional gene expression using ribozymes : Post-transcriptional control of amino acid identity in protein synthesis and temperature-dependent gene expression

  2013cites this paper
• Unique role for translation initiation factor 3 in the light color regulation of photosynthetic gene expression

  2013cites this paper
• Post-transcriptional regulation on a global scale: form and function of Csr/Rsm systems.

  2013cites this paper
• Tandem attenuators control expression of the Salmonella mgtCBR virulence operon

  2012cites this paper
• NasT-Mediated Antitermination Plays an Essential Role in the Regulation of the Assimilatory Nitrate Reductase Operon in Azotobacter vinelandii

  2012cites this paper
• Regulation of bacterial transcription elongation

  2011cites this paper
• Structural and functional characterisation of the interaction of the gene regulatory protein C.Esp1396I with its DNA recognition sites

  2011cites this paper
• Effects on Transcription of Mutations in ygjD, yeaZ, and yjeE Genes, Which Are Involved in a Universal tRNA Modification in Escherichia coli

  2011cites this paper
• Regulatory RNAs in Prokaryotes

  2011cites this paper
• Positions of Trp Codons in the Leader Peptide-Coding Region of the at Operon Influence Anti-Trap Synthesis and trp Operon Expression in Bacillus licheniformis

  2010cites this paper
• Tiny abortive initiation transcripts exert antitermination activity on an RNA hairpin-dependent intrinsic terminator

  2010cites this paper
• A regulatory RNA required for antitermination of biofilm and capsular polysaccharide operons in Bacillales

  2010cites this paper
• Exploitation of prokaryotic expression systems based on the salicylate-dependent control circuit encompassing nahR/Psal

  2010cites this paper
• A bacterial mRNA leader that employs different mechanisms to sense disparate intracellular signals.

  2010cites this paper
• Self-organisation and emergence in artificial life: concepts and illustrations

  2009cites this paper
• Diversity of promoter elements in a Geobacter sulfurreducens mutant adapted to disruption in electron transfer

  2009cites this paper
• The structure of bacterial RNA polymerase in complex with the essential transcription elongation factor NusA

  2009cites this paper
• Genesis, effects and fates of repeats in prokaryotic genomes.

  2009cites this paper
• Translational Control of the Antibiotic Inducibility of the PA5471 Gene Required for mexXY Multidrug Efflux Gene Expression in Pseudomonas aeruginosa

  2009cites this paper
• Mechanisms and Evolution of Control Logic in Prokaryotic Transcriptional Regulation

  2009cites this paper
• Correct Timing of dnaA Transcription and Initiation of DNA Replication Requires trans Translation

  2009cites this paper
• A 5′ Leader Sequence Regulates Expression of Methanosarcinal CO Dehydrogenase/Acetyl Coenzyme A Synthase

  2009cites this paper
• In vivo dynamics of intracistronic transcriptional polarity.

  2009cites this paper
• Biochemical Features and Functional Implications of the RNA-Based T-Box Regulatory Mechanism

  2009cites this paper
• Comparative genomic analysis of T-box regulatory systems in bacteria.

  2008cites this paper
• Regulation of bacterial gene expression by the NTP substrates of transcription initiation

  2008cites this paper
• Transcription of Corynebacterium glutamicum Genes Involved in Tricarboxylic Acid Cycle and Glyoxylate Cycle

  2008cites this paper
• Physiological Effects of Anti-TRAP Protein Activity and tRNATrp Charging on trp Operon Expression in Bacillus subtilis

  2008cites this paper
• Caractérisation de 2 transporteurs ABC (“ATP-Binding Cassette”) bactériens de fonction inconnue : YheI/YheH de Bacillus subtilis et Rv1747 de Mycobacterium tuberculosis

  2008cites this paper
• Transcription factor dynamics.

  2008cites this paper
• Regulation of Pyrimidine Biosynthetic Gene Expression in Bacteria: Repression without Repressors

  2008cites this paper
• Biosynthesis of the Aromatic Amino Acids

  2008cites this paper
• Structural features of metabolite-sensing riboswitches.

  2007cites this paper
• The rate of TRAP binding to RNA is crucial for transcription attenuation control of the B. subtilis trp operon.

  2007cites this paper
• Transcriptional Analysis of the Genetic Element pSSVx: Differential and Temporal Regulation of Gene Expression Reveals Correlation between Transcription and Replication

  2007cites this paper
• Modeling Classic Attenuation Regulation of gene Expression in bacteria

  2007influential citation
• Mechanism of mRNA destabilization by the glmS ribozyme.

  2007cites this paper
• A Mg 2 +-responding RNA That Controls the Expression of a Mg 2 + Transporter

  2007cites this paper
• Systematic mutagenesis of the thymidine tract of the pyrBI attenuator and its effects on intrinsic transcription termination in Escherichia coli

  2007cites this paper
• Direct Versus Limited-step Reconstitution Reveals Key Features of an RNA Hairpin-stabilized Paused Transcription Complex*

  2007cites this paper
• RNAmodel Web Server: Modeling Classic Attenuation in Bacteria

  2007cites this paper
• Non-coding-RNA regulators of RNA polymerase II transcription

  2006cites this paper
• Cloning and characterization of a novel gene involved in nitrogen fixation in Heliobacterium chlorum: a possible regulatory gene

  2006cites this paper
• Sequence-resolved detection of pausing by single RNA polymerase molecules.

  2006cites this paper
• From Ribosome to Riboswitch: Control of Gene Expression in Bacteria by RNA Structural Rearrangements

  2006cites this paper
• Subcellular Partitioning of Transcription Factors in Bacillus subtilis

  2006cites this paper
• Síntese Computacional de Fenômenos Naturais: Vida Artifi cial e Geometria Fractal Parte 1: Síntese Comportamental

  2006cites this paper
• Thermodynamics of tryptophan-mediated activation of the trp RNA-binding attenuation protein.

  2006cites this paper
• In vivo and in vitro studies of Chlamydia trachomatis TrpR:DNA interactions

  2006cites this paper
• Sensing metabolic signals with nascent RNA transcripts: the T box and S box riboswitches as paradigms.

  2006cites this paper
• Single-Molecule, Motion-Based DNA Sequencing Using RNA Polymerase

  2006cites this paper
• Biosynthesis and Regulation of the Branched-Chain Amino Acids†

  2006cites this paper
• COMPARISON OF PROTEIN AND MRNA PROFILES OF ESCHERICHIA COLI : DATA VISUALIZATION AND ANALYSIS OF SPECIFIC GENE GROUPS

  2006cites this paper
• Mutations affecting transcription pausing in the Bacillus subtilis pyr operon

  2005cites this paper
• Translational Recoding and RNA Modifications

  2005cites this paper
• What Makes Ribosome-Mediated Transcriptional Attenuation Sensitive to Amino Acid Limitation?

  2005influential citation
• The multifarious short‐term regulation of ammonium assimilation of Escherichia coli: dissection using an in silico replica

  2005cites this paper
• A new generation of vectors with increased induction ratios by overimposing a second regulatory level by attenuation

  2005cites this paper
• Function of wobble nucleoside modification in transfer RNA of S . enterica serovar Typhimurium

  2004cites this paper
• The rates of macromolecular chain elongation modulate the initiation frequencies for transcription and translation inEscherichia coli

  2004cites this paper
• Molecules in Time and Space

  2004cites this paper
• DISSECTION DU MÉCANISME DE TERMINAISON/ANTITERMINAISON AU NIVEAU DU TERMINATEUR TRI DU PHAGE LAMBDA : APPLICATION A L'ÉTUDE DES COMPLEXES ARN-PROTÉINE IN VIVO

  2004influential citation
• Attenuation regulation of amino acid biosynthetic operons in proteobacteria: comparative genomics analysis.

  2004cites this paper
• Leader region of the gene encoding DNA polymerase III of Bacillus subtilis

  2004cites this paper
• Mutational analysis of feedback inhibition and catalytic sites of prephenate dehydratase from Corynebacterium glutamicum

  2004cites this paper
• Isolation and characterization of Pseudobutyrivibrio ruminis gene promoters

  2004cites this paper
• Analysis of HutP‐dependent transcription antitermination in the Bacillus subtilis hut operon: identification of HutP binding sites on hut antiterminator RNA and the involvement of the N‐terminus of HutP in binding of HutP to the antiterminator RNA

  2004cites this paper
• The riboswitch control of bacterial metabolism.

  2004cites this paper
• Riboswitches: the oldest mechanism for the regulation of gene expression?

  2004cites this paper
• Ubiquitous transcriptional pausing is independent of RNA polymerase backtracking.

  2003cites this paper
• Transcriptional Pausing in the Bacillus subtilis pyr Operon In Vitro: a Role in Transcriptional Attenuation?

  2003cites this paper
• Transcription of Clostridium cellulovorans Cellulosomal Cellulase and Hemicellulase Genes

  2003cites this paper