Inhibitor of Apoptosis (IAP) proteins in hematological malignancies: molecular mechanisms and therapeutic opportunities

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Leukemia

• Publication date

  2014-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/leu.2014.56PMID 24487414
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Smac mimetic primes apoptosis-resistant acute myeloid leukaemia cells for cytarabine-induced cell death by triggering necroptosis.

  2014cited by this paper
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  2013cited by this paper
• XIAP and P-glycoprotein co-expression is related to imatinib resistance in chronic myeloid leukemia cells.

  2013cited by this paper
• Single-agent Smac-mimetic compounds induce apoptosis in B chronic lymphocytic leukaemia (B-CLL).

  2013cited by this paper
• XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells.

  2013cited by this paper
• Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis

  2013cited by this paper
• Birinapant (TL32711), a Small Molecule Smac Mimetic, Induces Regressions in Childhood Acute Lymphoblastic Leukemia (ALL) Xenografts That Express TNFα and Synergizes with TNFα in Vitro – A Report From the Pediatric Preclinical Testing Program (PPTP)

  2012cited by this paper
• Study of survivin and X-linked inhibitor of apoptosis protein (XIAP) genes in acute myeloid leukemia (AML).

  2012cited by this paper
• RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

  2012cited by this paper
• Targeting IAP proteins for therapeutic intervention in cancer

  2012cited by this paper
• Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34‐positive compartment

  2012cited by this paper
• Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups

  2011cited by this paper
• Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

  2011cited by this paper
• Novel X‐linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL‐mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis

  2011cited by this paper
• Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis.

  2011cited by this paper
• Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis

  2011cited by this paper
• Study of survivin and X-linked inhibitor of apoptosis protein (XIAP) genes in acute myeloid leukemia (AML).

  2011cited by this paper
• Expression of inhibitor of apoptosis protein (IAP) livin/BIRC7 in acute leukemia in adults: correlation with prognostic factors and outcome.

  2011cited by this paper
• Simultaneous targeting of P‐gp and XIAP with siRNAs increases sensitivity of P‐gp overexpressing CML cells to imatinib

  2011cited by this paper
• Safety, pharmacokinetics (PK), and pharmacodynamics (PD) of HGS1029, an inhibitor of apoptosis protein (IAP) inhibitor, in patients (Pts) with advanced solid tumors: Results of a phase I study.

  2011cited by this paper
• Importance of genetics in chronic lymphocytic leukemia.

  2011cited by this paper
• cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

  2011cited by this paper
• Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study.

  2011cited by this paper
• Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

  2011cited by this paper
• Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia.

  2010cited by this paper
• Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients.

  2010cited by this paper
• Targeting mitochondria for cancer therapy

  2010cited by this paper
• XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38− cells in a phase 1/2 study of patients with relapsed/refractory AML

  2010cited by this paper
• Smac mimetics: implications for enhancement of targeted therapies in leukemia

  2010cited by this paper
• Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling

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• XIAP expression is post‐transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T‐cell ALL

  2010cited by this paper
• Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia.

  2009cited by this paper
• Tumor resistance to apoptosis

  2009cited by this paper
• Experimental Therapeutics , Molecular Targets , and Chemical Biology A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic Leukemia

  2009cited by this paper
• Overexpression of X-linked Inhibitor of Apoptosis Protein (XIAP) is an Independent Unfavorable Prognostic Factor in Childhood de Novo Acute Myeloid Leukemia

  2009cited by this paper
• Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95‐induced apoptosis

  2009cited by this paper
• Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance.

  2008cited by this paper
• c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation*

  2008cited by this paper
• Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation

  2008cited by this paper
• cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.

  2008cited by this paper
• Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK

  2008cited by this paper
• Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.

  2008cited by this paper
• Survivin, cancer networks and pathway-directed drug discovery

  2008cited by this paper
• Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

  2008cited by this paper
• Design of small-molecule peptidic and nonpeptidic Smac mimetics.

  2008cited by this paper
• New wirings in the survivin networks

  2008cited by this paper
• Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

  2008cited by this paper
• IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.

  2007cited by this paper
• Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.

  2007cited by this paper
• Guest Editor

  2007cited by this paper
• Activated intrinsic apoptosis pathway is a key related prognostic parameter in acute myeloid leukemia.

  2007cited by this paper
• Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

  2007cited by this paper
• A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling.

  2007cited by this paper
• Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells

  2007cited by this paper
• Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia.

  2007cited by this paper
• IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

  2007cited by this paper
• Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.

  2007cited by this paper
• XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.

  2007cited by this paper
• Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes.

  2006cited by this paper
• Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis

  2006cited by this paper
• The Inhibitor of Apoptosis Protein Fusion c-IAP2·MALT1 Stimulates NF-κB Activation Independently of TRAF1 AND TRAF2*

  2006cited by this paper
• Expression of Smac/DIABLO in B-cell non-Hodgkin and Hodgkin lymphomas.

  2006cited by this paper
• Apoptotic effect of fludarabine is independent of expression of IAPs in B-cell chronic lymphocytic leukemia

  2006cited by this paper
• XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack.

  2006cited by this paper
• Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

  2006cited by this paper
• Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

  2006cited by this paper
• Apoptosis-based therapies for hematologic malignancies.

  2005cited by this paper
• Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia.

  2005cited by this paper
• Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis.

  2005cited by this paper
• Expression of IAP‐family proteins in adult acute mixed lineage leukemia (AMLL)

  2005cited by this paper
• Expression of C‐IAP1, C‐IAP2 and SURVIVIN discriminates different types of lymphoid malignancies

  2005cited by this paper
• Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

  2005cited by this paper
• XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis.

  2004cited by this paper
• Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.

  2004cited by this paper
• High Expression Levels of X-Linked Inhibitor of Apoptosis Protein and Survivin Correlate with Poor Overall Survival in Childhood de Novo Acute Myeloid Leukemia

  2004cited by this paper
• Bcl10 activates the NF-κB pathway through ubiquitination of NEMO

  2004cited by this paper
• Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).

  2004cited by this paper
• Characteristics of the caspase-like catalytic domain of human paracaspase

  2004cited by this paper
• Uncoupling of the Signaling and Caspase-inhibitory Properties of X-linked Inhibitor of Apoptosis*

  2004cited by this paper
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  2003cited by this paper
• Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma.

  2003cited by this paper
• Mechanism of XIAP-mediated inhibition of caspase-9.

  2003cited by this paper
• The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays.

  2003cited by this paper
• XIAP-mediated Caspase Inhibition in Hodgkin's Lymphoma–derived B Cells

  2003cited by this paper
• Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia

  2003cited by this paper
• Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis.

  2002cited by this paper
• SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP)*

  2002cited by this paper
• Structural basis for the inhibition of caspase-3 by XIAP.

  2001cited by this paper
• A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

  2001cited by this paper
• xIAP Induces Cell-Cycle Arrest and Activates Nuclear Factor-&kgr;B: New Survival Pathways Disabled by Caspase-Mediated Cleavage During Apoptosis of Human Endothelial Cells

  2001cited by this paper
• Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern

  2001cited by this paper
• Structural basis of caspase-7 inhibition by XIAP.

  2001cited by this paper
• Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.

  2001cited by this paper
• X-linked Inhibitor of Apoptosis Protein Functions as a Cofactor in Transforming Growth Factor-β Signaling*

  2001cited by this paper
• Livin, a Novel Inhibitor of Apoptosis Protein Family Member*

  2001cited by this paper
• Activation of NF-κB by XIAP, the X Chromosome-linked Inhibitor of Apoptosis, in Endothelial Cells Involves TAK1*

  2000cited by this paper
• Structural and biochemical basis of apoptotic activation by Smac/DIABLO

  2000cited by this paper
• Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

  2000cited by this paper
• ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.

  2000cited by this paper
• The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas.

  1999cited by this paper

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