Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Gastroenterology

• Publication date

  2010-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1053/j.gastro.2010.02.049PMID 20193684
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanisms of hepatic fibrogenesis.

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• Mouse Models of Liver Fibrosis

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• Oncosis represents the main type of cell death in mouse models of cholestasis.

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• Lack of gp130 expression results in more bacterial infection and higher mortality during chronic cholestasis in mice

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• Erratum: Liver fibrosis (Journal of Clinical Investigation (2005) 115 (209-218) DOI:10.1172/JCI200524282)

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• Liver fibrosis.

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• Liver fibrosis

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• Bile Acids Stimulate cFLIP Phosphorylation Enhancing TRAIL-mediated Apoptosis*

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• Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes.

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• Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms.

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• STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration*

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• Activation of the Raf‐1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes

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• Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver.

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• Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis.

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• Proinflammatory cytokines inhibit secretion in rat bile duct epithelium.

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• Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.

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• Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver

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• Erratum: Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation in the liver (Molecular and Cellcular Biology (2001) 21 (S) 1621-1632)

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• Hepatocyte‐specific expression of Cre recombinase

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• The development and compensation of biliary cirrhosis in interleukin-6-deficient mice.

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• Lactucin reverses liver fibrosis by inhibiting TGF-β1/STAT3 signaling pathway and regulating short-chain fatty acids metabolism

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• The Role of Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitors in The Attenuation of CCl4-Induced Liver Fibrosis in Rats

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• The Origin and Fate of Liver Myofibroblasts

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• Response to treatment of murine schistosomiasis with recombinant IL-22 under different circadian timing

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• Stat3 role in the protective effect of FXR Agonist in parenteral nutrition-associated cholestasis

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• Tamoxifen Ameliorates Cholestatic Liver Fibrosis in Mice: Upregulation of TGFβ and IL6 Is a Potential Protective Mechanism

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• Nifuroxazide-loaded cubosomes exhibit an advancement in pulmonary delivery and attenuate bleomycin-induced lung fibrosis by regulating the STAT3 and NF-κB signaling: A new challenge for unmet therapeutic needs.

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• The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury

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• Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response

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• MicroRNA-92b-3p promotes the progression of liver fibrosis by targeting CREB3L2 through the JAK/STAT signaling pathway.

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• Targeting Certain Interleukins as Novel Treatment Options for Liver Fibrosis

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• The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis

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• Multiple Roles of IL6 in Hepatic Injury, Steatosis, and Senescence Aggregate to Suppress Tumorigenesis

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• Molecular mechanisms of hepatic fibrosis in chronic liver diseases

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• STAT3 Contributes to Radioresistance in Cancer

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• Bile acid‐induced apoptosis and bile acid synthesis are reduced by over‐expression of Augmenter of Liver Regeneration (ALR) in a STAT3‐dependent mechanism

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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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• Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein.

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• p19ARF/p14ARF controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma

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