Reactive Oxygen Species Mediated Sustained Activation of Protein Kinase C α and Extracellular Signal-Regulated Kinase for Migration of Human Hepatoma Cell Hepg2

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular Cancer Research

• Publication date

  2006-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1158/1541-7786.MCR-06-0096PMID 17050668
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.

  2006cited by this paper
• Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2.

  2005influential reference
• Modulation of Apoptosis in HaCaT Keratinocytes via Differential Regulation of ERK Signaling Pathway by Flavonoids*

  2005cited by this paper
• TGFβ-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN

  2005cited by this paper
• Integrin Engagement Differentially Modulates Epithelial Cell Motility by RhoA/ROCK and PAK1*

  2005cited by this paper
• Integrins control motile strategy through a Rho–cofilin pathway

  2005cited by this paper
• TGF-beta1 induces cardiac hypertrophic responses via PKC-dependent ATF-2 activation.

  2005cited by this paper
• G1/S Cell Cycle Arrest Provides Anoikis Resistance through Erk-Mediated Bim Suppression

  2005cited by this paper
• Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression.

  2005cited by this paper
• Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.

  2005cited by this paper
• Molecular requirements for epithelial-mesenchymal transition during tumor progression.

  2005cited by this paper
• Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.

  2005cited by this paper
• PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase.

  2005cited by this paper
• Regulation of Outside-in Signaling in Platelets by Integrin-associated Protein Kinase Cβ*

  2005cited by this paper
• Smad4 Dependency Defines Two Classes of Transforming Growth Factor β (TGF-β) Target Genes and Distinguishes TGF-β-Induced Epithelial-Mesenchymal Transition from Its Antiproliferative and Migratory Responses

  2005cited by this paper
• Reactive oxygen species in tumor progression.

  2005cited by this paper
• MAP kinases and cell migration

  2004cited by this paper
• Protein kinase C modulates negatively the hepatocyte growth factor-induced migration, integrin expression and phosphatidylinositol 3-kinase activation.

  2004cited by this paper
• Extracellular Signal-regulated Kinase (ERK)-dependent Gene Expression Contributes to L1 Cell Adhesion Molecule-dependent Motility and Invasion*

  2004cited by this paper
• Lysophosphatidic acid interacts with transforming growth factor-beta signaling to mediate keratinocyte growth arrest and chemotaxis.

  2004cited by this paper
• Reactive oxygen species amplify protein kinase C signaling in high glucose-induced fibronectin expression by human peritoneal mesothelial cells.

  2004cited by this paper
• Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells.

  2004cited by this paper
• PKC controls HGF‐dependent c‐Met traffic, signalling and cell migration

  2004cited by this paper
• Protein kinase C isozymes as potential targets for anticancer therapy.

  2004cited by this paper
• Integrin signalling during tumour progression

  2004cited by this paper
• Growth factor-dependent activation of the MAPK pathway in human pancreatic cancer: MEK/ERK and p38 MAP kinase interaction in uPA synthesis

  2004cited by this paper
• Protein Kinase C α/β Inhibitor Go6976 Promotes Formation of Cell Junctions and Inhibits Invasion of Urinary Bladder Carcinoma Cells

  2004cited by this paper
• Role of reactive oxygen species in bradykinin-induced proliferation of vascular smooth muscle cells.

  2004cited by this paper
• Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells.

  2004cited by this paper
• Invasive Potential Induced under Long-Term Oxidative Stress in Mammary Epithelial Cells

  2004cited by this paper
• Epithelial-mesenchymal transitions: twist in development and metastasis.

  2004influential reference
• Protein kinase C-epsilon protects PC12 cells against methamphetamine-induced death: possible involvement of suppression of glutamate receptor.

  2003cited by this paper
• Integrin-specific signaling pathways controlling focal adhesion formation and cell migration

  2003cited by this paper
• Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer

  2003cited by this paper
• Activation of RAF-1 through Ras and Protein Kinase Cα Mediates 1α,25(OH)2-Vitamin D3 Regulation of the Mitogen-activated Protein Kinase Pathway in Muscle Cells*

  2003cited by this paper
• Elucidation of Molecular Events Leading to Neutrophil Apoptosis following Phagocytosis

  2003cited by this paper
• Multiple cis-Elements Mediate the Transcriptional Activation of Human fra-1 by 12-O-Tetradecanoylphorbol-13-acetate in Bronchial Epithelial Cells*

  2003cited by this paper
• Distinct Mechanisms of Receptor and Nonreceptor Tyrosine Kinase Activation by Reactive Oxygen Species in Vascular Smooth Muscle Cells: Role of Metalloprotease and Protein Kinase C-δ

  2003cited by this paper
• The Ets-1 transcription factor is involved in the development and invasion of malignant melanoma

  2003cited by this paper
• Oxidant‐induced hepatocyte injury from menadione is regulated by ERK and AP‐1 signaling

  2003cited by this paper
• Phorbol ester-induced migration of HepG2 cells is accompanied by intensive stress fibre formation, enhanced integrin expression and transient down-regulation of p21-activated kinase 1.

  2003cited by this paper
• ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a

  2003cited by this paper
• Epithelial-mesenchymal transitions in development and pathologies.

  2003cited by this paper
• α-Tocopherol Decreases Superoxide Anion Release in Human Monocytes Under Hyperglycemic Conditions Via Inhibition of Protein Kinase C-α

  2002cited by this paper
• Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases

  2002cited by this paper
• Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha.

  2002cited by this paper
• Role of integrins in cell invasion and migration

  2002cited by this paper
• Mechanism of silica-induced ROS generation in Rat2 fibroblast cells.

  2002cited by this paper
• Erk Is Essential for Growth, Differentiation, Integrin Expression, and Cell Function in Human Osteoblastic Cells*

  2001cited by this paper
• Induction of β3-Integrin Gene Expression by Sustained Activation of the Ras-Regulated Raf–MEK–Extracellular Signal-Regulated Kinase Signaling Pathway

  2001cited by this paper
• A differential role of extracellular signal-regulated kinase in stimulated PC12 pheochromocytoma cell movement.

  2001cited by this paper
• Signaling Events Mediating the Additive Effects of Oleic Acid and Angiotensin II on Vascular Smooth Muscle Cell Migration

  2001cited by this paper
• Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells.

  2001cited by this paper
• Phorbol Ester-induced Generation of Reactive Oxygen Species Is Protein Kinase Cβ-dependent and Required for SAPK Activation*

  2000cited by this paper
• Phorbol ester-induced U-937 differentiation: effects on integrin alpha(5) gene transcription.

  2000cited by this paper
• JunB suppresses cell proliferation by transcriptional activation of p16INK4a expression

  2000cited by this paper
• Extracellular-Regulated Kinase Activation and Cas/Crk Coupling Regulate Cell Migration and Suppress Apoptosis during Invasion of the Extracellular Matrix

  2000cited by this paper
• Cellular Response to Oncogenic Ras Involves Induction of the Cdk4 and Cdk6 Inhibitor p15INK4b

  2000cited by this paper
• Protein kinase C-mediated regulation of the cell cycle.

  2000cited by this paper
• Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion.

  2000cited by this paper
• Protein kinase C signaling and oxidative stress.

  2000cited by this paper
• Phorbol ester-induced U-937 differentiation: Effects on integrin α5 gene transcription

  2000cited by this paper
• Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis.

  1999cited by this paper
• Activation of Protein Kinase C by Phorbol Esters Modulates α2β1Integrin on MCF-7 Breast Cancer Cells

  1999cited by this paper
• Activation of protein kinase C by phorbol esters modulates alpha2beta1 integrin on MCF-7 breast cancer cells.

  1999cited by this paper
• Regulation of Cell Contraction and Membrane Ruffling by Distinct Signals in Migratory Cells

  1999cited by this paper
• Protein kinase C--a question of specificity.

  1994cited by this paper

• CAT and CXCL8 are crucial cofactors for the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma, the immune infiltration and prognosis of hepatocellular carcinoma

  2025cites this paper
• Reactive Oxygen Species: A Double-Edged Sword in the Modulation of Cancer Signaling Pathway Dynamics

  2025cites this paper
• Role of NOX1 and NOX5 in protein kinase C/reactive oxygen species‑mediated MMP‑9 activation and invasion in MCF‑7 breast cancer cells

  2024cites this paper
• ERK1/2-SOX9/FOXL2 axis regulates ovarian steroidogenesis and favors the follicular–luteal transition

  2023cites this paper
• Distinct Protein Kinase C isoforms drive the cell cycle re-entry of two separate populations of neonatal rat ventricular cardiomyocytes.

  2023cites this paper
• Nfe2l2 Regulates Metabolic Rewiring and Epigenetic Reprogramming in Mediating Cancer Protective Effect by Fucoxanthin

  2022cites this paper
• Epithelial-mesenchymal transition: When tumor cells meet myeloid-derived suppressor cells.

  2021cites this paper
• Browsing the oldest antioxidant enzyme: catalase and its multiple regulation in cancer.

  2021cites this paper
• Calcium Dobesilate Modulates PKCδ-NADPH Oxidase- MAPK-NF-κB Signaling Pathway to Reduce CD14, TLR4, and MMP9 Expression during Monocyte-to-Macrophage Differentiation: Potential Therapeutic Implications for Atherosclerosis

  2021cites this paper
• Playing the Devil’s Advocate: Should We Give a Second Chance to mTOR Inhibition in Renal Clear Cell Carcinoma? – ie Strategies to Revert Resistance to mTOR Inhibitors

  2021cites this paper
• Interplay of Immunometabolism and Epithelial–Mesenchymal Transition in the Tumor Microenvironment

  2021cites this paper
• Antioxidant of Pleurotus ostreatus (Jacq.) P. Kumn and lymphoid cancer cells

  2021cites this paper
• PKCδ mediates mitochondrial ROS generation and oxidation of HSP60 to relieve RKIP inhibition on MAPK pathway for HCC progression.

  2020cites this paper
• MitoTEMPO provides an antiarrhythmic effect in aged-rats through attenuation of mitochondrial reactive oxygen species.

  2020cites this paper
• The Role of Calcium Signaling in Regulation of Epithelial-Mesenchymal Transition

  2020cites this paper
• Therapeutic resistance in breast cancer cells can result from deregulated EGFR signaling.

  2020cites this paper
• Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival

  2019cites this paper
• Hydrogen peroxide inducible clone-5 sustains NADPH oxidase-dependent reactive oxygen species-c-jun N-terminal kinase signaling in hepatocellular carcinoma

  2019cites this paper
• Oleanolic Acid, a Novel Endothelin A Receptor Antagonist, Alleviated High Glucose-Induced Cardiomyocytes Injury.

  2018cites this paper
• Protein kinase C Inhibitors selectively modulate dynamics of cell adhesion molecules and cell death in human colon cancer cells

  2018cites this paper
• Oxidative stress in carcinogenesis

  2018cites this paper
• The molecular functions of protein kinase C (PKC) isoforms

  2018cites this paper
• Utilization of Different Omic Approaches to Unravel Stress Response Mechanisms in the Parasite Entamoeba histolytica

  2018cites this paper
• miR‐330‐3p promotes lung cancer cells invasion, migration, and metastasis by directly targeting hSOD2b

  2018cites this paper
• MZF-1/Elk-1/PKCα is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma

  2017cites this paper
• PKC ζ ‐ dependent upregulation of p 27 kip 1 contributes to oxidative stress induced retinal pigment epithelial cell

  2017cites this paper
• Andrographolide Inhibits Proliferation and Metastasis of SGC7901 Gastric Cancer Cells

  2017cites this paper
• PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation

  2017cites this paper
• Constrained inference of protein interaction networks for invadopodium formation in cancer.

  2016cites this paper
• Proteomic Identification of Oxidized Proteins in Entamoeba histolytica by Resin-Assisted Capture: Insights into the Role of Arginase in Resistance to Oxidative Stress

  2016cites this paper
• MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Cα-based triple-negative breast cancer cells

  2016cites this paper
• Oxidation of heat shock protein 60 and protein disulfide isomerase activates ERK and migration of human hepatocellular carcinoma HepG2

  2016influential citation
• Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species

  2016cites this paper
• Hispolon inhibits breast cancer cell migration by reversal of epithelial-to-mesenchymal transition via suppressing the ROS/ERK/Slug/E-cadherin pathway.

  2016cites this paper
• Sulforaphane inhibits TGF-β-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway.

  2016cites this paper
• Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells

  2016cites this paper
• Regulation of pancreatic β-cell death and cancer cell migration by TPRM2 channels

  2016influential citation
• Significance of kinase activity in the dynamic invadosome.

  2016influential citation
• Bi-Module Sensing Device to In Situ Quantitatively Detect Hydrogen Peroxide Released from Migrating Tumor Cells

  2015cites this paper
• Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways.

  2015cites this paper
• Hydrogen peroxide inducible clone-5 mediates reactive oxygen species signaling for hepatocellular carcinoma progression

  2015cites this paper
• PKCα promotes generation of reactive oxygen species via DUOX2 in hepatocellular carcinoma.

  2015cites this paper
• High-Throughput, Label-Free Isolation of Cancer Stem Cells on the Basis of Cell Adhesion Capacity.

  2015cites this paper
• Regulation of catalase expression in healthy and cancerous cells.

  2015cites this paper
• Microfluidic cytometric analysis of cancer cell transportability and invasiveness

  2015cites this paper
• SCUOLA DI DOTTORATO DI RICERCA IN BIOSCIENZE E BIOTECNOLOGIE INDIRIZZO DI NEUROBIOLOGIA CICLO 27° ROLE OF MITOCHONDRIAL Ca UPTAKE IN BREAST CANCER CELL MIGRATION AND INVASIVENESS

  2015cites this paper
• Emerging strategies to overcome the resistance to current mTOR inhibitors in renal cell carcinoma.

  2014cites this paper
• Cell Signaling and Gene Regulation by Oxidative Stress

  2014cites this paper
• Src tyrosine kinase mediates platelet-derived growth factor BB-induced and redox-dependent migration in metanephric mesenchymal cells.

  2014cites this paper
• Atrazine represses S100A4 gene expression and TPA-induced motility in HepG2 cells.

  2014cites this paper
• Proliferation and migration of hepatoblastoma cells are mediated by IRS-4 via PI3K/Akt pathways.

  2014cites this paper
• Protein Kinase C (PKC) Isozymes and Cancer

  2014cites this paper
• Lipoperoxyl Radical Scavenging and Antioxidative Effects of Red Beet Pigments

  2013cites this paper
• Reactive oxygen species in cancer biology and anticancer therapy.

  2013cites this paper
• Redox regulation of cancer cell migration and invasion.

  2013cites this paper
• ROS-mediated regulation of CXCR4 in cancer

  2013cites this paper
• Cell Signaling and Cancer: Integrated, Fundamental Approach Involving Electron Transfer, Reactive Oxygen Species, and Antioxidants

  2012cites this paper
• A possible role for oxidation stress in lymphoid leukaemias and therapeutic failure.

  2012cites this paper
• Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells.

  2012cites this paper
• Spatiotemporal regulation of Src and its substrates at invadosomes.

  2012cites this paper
• Oxidative stress and metal carcinogenesis.

  2012cites this paper
• The regulatory role of ROS on CXCR4 expression andfunction in prostate cancer cells

  2012cites this paper
• Oxidative stress and oxidative damage in chemical carcinogenesis.

  2011cites this paper
• VEGFR1 and PKC&agr; signaling control melanoma vasculogenic mimicry in a VEGFR2 kinase-independent manner

  2011cites this paper
• Metabolic memory and individual treatment aims in type 2 diabetes--outcome-lessons learned from large clinical trials.

  2011cites this paper
• The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

  2011cites this paper
• Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation.

  2011cites this paper
• New insights into redox-modulated cell signaling.

  2011cites this paper
• EGF‐induced ERK‐activation downstream of FAK requires rac1‐NADPH oxidase

  2011cites this paper
• Liver Regeneration Associated Protein (ALR) Exhibits Antimetastatic Potential in Hepatocellular Carcinoma

  2011influential citation
• Reactive oxygen species-mediated PKC and integrin signaling promotes tumor progression of human hepatoma HepG2

  2011cites this paper
• Targeting tissue oxidative damage by means of cell signaling modulators: the antioxidant concept revisited.

  2010cites this paper
• Reactive Oxygen Species Are Required for Maintenance and Differentiation of Primary Lung Fibroblasts in Idiopathic Pulmonary Fibrosis

  2010cites this paper
• Reversible conversion of epithelial and mesenchymal phenotypes in SV40 large T antigen-immortalized rat liver cell lines

  2010cites this paper
• Redox Control of Protein Kinase C: Cell- and Disease-Specific Aspects

  2010cites this paper
• Lysophosphatidic Acid Induces MDA-MB-231 Breast Cancer Cells Migration through Activation of PI3K/PAK1/ERK Signaling

  2010cites this paper
• Oligonol a low molecular weight polyphenol of lychee fruit extract inhibits proliferation of influenza virus by blocking reactive oxygen species-dependent ERK phosphorylation.

  2010cites this paper
• Signaling mechanism(s) of reactive oxygen species in Epithelial-Mesenchymal Transition reminiscent of cancer stem cells in tumor progression.

  2010cites this paper
• Polyphenol-rich extracts from Solanum nigrum attenuated PKC alpha-mediated migration and invasion of hepatocellular carcinoma cells.

  2010cites this paper
• The Role of ROS Signaling in Tumor Progression

  2010cites this paper
• The Role of Mitochondrial Reactive Oxygen Species in Cancer

  2010cites this paper
• Signal Cross Talks for Sustained MAPK Activation and Cell Migration Mediated by Reactive Oxygen Species: The Involvement in Tumor Progression

  2010cites this paper
• Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells

  2009cites this paper
• Role for protein kinase C-alpha in keratinocyte growth arrest.

  2009cites this paper
• Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells.

  2009cites this paper
• In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells.

  2009cites this paper
• Cytoskeletal changes during epithelial-to-fibroblastoid conversion as a crucial mechanism of des-gamma-carboxy prothrombin production in hepatocellular carcinoma.

  2009cites this paper
• Reactive oxygen species regulate the generation of urokinase plasminogen activator in human hepatoma cells via MAPK pathways after treatment with hepatocyte growth factor

  2009cites this paper
• Expression of functional metallothionein isoforms in papillary thyroid cancer.

  2009cites this paper
• Gene Expression via Nrf 2 MAPK UpRegulates Heme Oxygenase-1 Inhibition and Genetic Deficiency of p 38 Kietzmann and

  2009cites this paper
• The role of "metabolic memory" in the natural history of diabetes mellitus.

  2009cites this paper
• Inhibition and Genetic Deficiency of p38 MAPK Up-Regulates Heme Oxygenase-1 Gene Expression via Nrf21

  2009cites this paper
• Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9

  2008cites this paper
• Impairment of clathrin-mediated endocytosis via cytoskeletal change by epithelial to fibroblastoid conversion in HepG2 cells: a possible mechanism of des-gamma-carboxy prothrombin production in hepatocellular carcinoma.

  2008influential citation
• The Spanish flu as a worst case scenario

  2008cites this paper
• Peroxisome proliferator‐activated receptor gamma coactivator‐1 alpha (PGC‐1α) upregulated E‐cadherin expression in HepG2 cells

  2008cites this paper
• Inhibition of NADPH Oxidase Prevents Advanced Glycation End Product–Mediated Damage in Diabetic Nephropathy Through a Protein Kinase C-α–Dependent Pathway

  2008cites this paper
• PIOGLITAZONE INHIBITS HOMOCYSTEINE‐INDUCED MIGRATION OF VASCULAR SMOOTH MUSCLE CELLS THROUGH A PEROXISOME PROLIFERATOR‐ACTIVATED RECEPTOR γ‐INDEPENDENT MECHANISM

  2008cites this paper
• Migratory activity of human breast cancer cells is modulated by differential expression of xanthine oxidoreductase

  2008cites this paper
• RAC 1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NF j B-dependent mechanism

  2008cites this paper