Selective suppression of cerebellar GABAergic transmission by an autoantibody to glutamic acid decarboxylase

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Annals of Neurology

• Publication date

  1999-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/1531-8249(199908)46:2<263::AID-ANA19>3.0.CO;2-0PMID 10443895
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Monoaminergic long-term facilitation of GABA-mediated inhibitory transmission at cerebellar synapses.

  1999cited by this paper
• Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndrome.

  1998cited by this paper
• Inhibition of γ‐aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff‐man syndrome

  1998cited by this paper
• Identification and characterization of an anti-glial fibrillary acidic protein antibody with a unique specificity in a demented patient with an autoimmune disorder

  1997cited by this paper
• Expression of recombinant human glutamic acid decarboxylase (GAD) in myeloma cells and enzyme-linked immunosorbent assay (ELISA) for autoantibodies to GAD.

  1997cited by this paper
• Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus, and polyendocrine autoimmunity

  1997cited by this paper
• Glutamic acid decarboxylase autoantibodies in stiff-man syndrome and insulin-dependent diabetes mellitus exhibit similarities and differences in epitope recognition.

  1996cited by this paper
• The clinical significance of an autoimmune response against glutamic acid decarboxylase

  1996cited by this paper
• Anti-gabaergic neuron autoantibodies in a patient with stiff-man syndrome and ataxia.

  1996cited by this paper
• Autoantibodies to glutamate decarboxylase in a patient with cerebellar cortical atrophy, peripheral neuropathy, and slow eye movements.

  1995cited by this paper
• Enhancement by serotonin of GABA-mediated inhibitory synaptic currents in rat cerebellar Purkinje cells.

  1994cited by this paper
• Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus

  1994cited by this paper
• Heterogeneity of autoantibodies in stiff‐man syndrome

  1993cited by this paper
• Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus.

  1991cited by this paper
• The preferential release of newly synthesized transmitter by a sympathetic ganglion

  1969cited by this paper

• Exploring Potential Mechanisms for Epilepsy After mRNA COVID‐19 Vaccination: An Extremely Rare Side‐Effect

  2025cites this paper
• Stiff Person Syndrome and GAD Antibody–Spectrum Disorders

  2024cites this paper
• Stiff-person syndrome and related disorders — diagnosis, mechanisms and therapies

  2024cites this paper
• Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies

  2023cites this paper
• Disorders related to antineuronal antibodies: Autoimmune epilepsy

  2023cites this paper
• General features, pathogenesis, and laboratory diagnostics of autoimmune encephalitis

  2023cites this paper
• An update on malignant tumor-related stiff person syndrome spectrum disorders: clinical mechanism, treatment, and outcomes

  2023cites this paper
• Immune Mechanisms in Epileptogenesis: Update on Diagnosis and Treatment of Autoimmune Epilepsy Syndromes

  2023cites this paper
• Pathophysiological Effects of Autoantibodies in Autoimmune Encephalitides

  2023cites this paper
• Functional changes in neuronal circuits due to antibody-driven autoimmune response.

  2023cites this paper
• Autoimmune Epilepsy - Novel Multidisciplinary Analysis, Discoveries and Insights

  2022cites this paper
• Advances in the Pathogenesis of Auto-antibody-Induced Cerebellar Synaptopathies

  2022influential citation
• A Breakdown of Immune Tolerance in the Cerebellum

  2022cites this paper
• Stiff-person Syndrome and GAD Antibody-spectrum Disorders: GABAergic Neuronal Excitability, Immunopathogenesis and Update on Antibody Therapies

  2022cites this paper
• Stiff-Eye Syndrome—Anti-GAD Ataxia Presenting with Isolated Ophthalmoplegia: A Case Report

  2021cites this paper
• Treatment of Anti-GAD65 Autoimmune Encephalitis With Methylprednisolone

  2021cites this paper
• GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions

  2021cites this paper
• Immune-Mediated Cerebellar Ataxias: Clinical Diagnosis and Treatment Based on Immunological and Physiological Mechanisms.

  2021cites this paper
• Stiff-person syndrome: an atypical presentation and a review of the literature

  2021cites this paper
• Neurological Syndromes Associated with Anti-GAD Antibodies

  2020cites this paper
• GAD antibodies in neurological disorders — insights and challenges

  2020cites this paper
• Fundamental Mechanisms of Autoantibody-Induced Impairments on Ion Channels and Synapses in Immune-Mediated Cerebellar Ataxias

  2020cites this paper
• Distinct Effects of Stereotactically Injected Human Cerebrospinal Fluid Containing Glutamic Acid Decarboxylase Antibodies into the Hippocampus of Rats on the Development of Spontaneous Epileptic Activity

  2020cites this paper
• Predictive value of high titer of GAD65 antibodies in a case of limbic encephalitis.

  2019cites this paper
• The neurological syndromes associated with glutamic acid decarboxylase antibodies.

  2019cites this paper
• Anti-GAD Antibodies and the Cerebellum: Where Do We Stand?

  2018cites this paper
• Endocrine disorders and the cerebellum: from neurodevelopmental injury to late-onset ataxia.

  2018cites this paper
• Pathogenic role of autoantibodies against inhibitory synapses.

  2018cites this paper
• EXPLORING THE CLINICAL SPECTRUM OF GLUTAMIC ACID DECARBOXYLASE ANTIBODIES IN NEUROLOGICAL PATIENTS, THROUGH THE VALIDATION OF AN ENZYME-LINKED IMMUNOSORBENT ASSAY

  2018cites this paper
• Immune-mediated Cerebellar Ataxias: Practical Guidelines and Therapeutic Challenges

  2018cites this paper
• GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets

  2018cites this paper
• Cerebellar disease associated with anti-glutamic acid decarboxylase antibodies: review

  2017cites this paper
• Immune-mediated cerebellar ataxias: from bench to bedside

  2017influential citation
• Acute Cerebellar Ataxia Associated with Anti-glutamic Acid Decarboxylase Antibodies Mimicking Miller Fisher Syndrome

  2017cites this paper
• Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar Ataxias

  2017cites this paper
• Anti-glutamic acid decarboxylase antibody positive neurological syndromes

  2016cites this paper
• Efficacy of oral corticosteroids therapy in anti-glutamic acid decarboxylase antibodies cerebellar ataxia.

  2016cites this paper
• Autoantibody-mediated encephalitis: Not just paraneoplastic, not just limbic, and not untreatable

  2016cites this paper
• Anti-GAD65 Containing Cerebrospinal Fluid Does not Alter GABAergic Transmission

  2016cites this paper
• Autoantibody-mediated encephalitis: Not just paraneoplastic, not just limbic, and not untreatable

  2015cites this paper
• Serum from a Patient with GAD65 Antibody-Associated Limbic Encephalitis Did Not Alter GABAergic Neurotransmission in Cultured Hippocampal Networks

  2015cites this paper
• Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions

  2015cites this paper
• Guidelines for treatment of immune-mediated cerebellar ataxias

  2015cites this paper
• Autoantibody-mediated encephalitis: Not just paraneoplastic, not just limbic, and not untreatable

  2015cites this paper
• GABAergic Pharmacotherapy in the Treatment of Motor Disorders of the Central Nervous System.

  2015cites this paper
• Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission – Analyzing Antibody-Induced Effects ex vivo

  2015cites this paper
• The Role of Pathogenic Autoantibodies in Autoimmunity

  2015cites this paper
• Square-Wave Ocular Oscillation and Ataxia in an Anti-GAD-Positive Individual With Hypothyroidism.

  2015cites this paper
• Autoantibody-mediated encephalitis: Not just paraneoplastic, not just limbic, and not untreatable

  2015cites this paper
• Targeting B Cells in Neurological Autoimmune Diseases

  2014cites this paper
• The GABAergic septohippocampal pathway is directly involved in internal processes related to operant reward learning.

  2014cites this paper
• Cerebellar ataxia and glutamic acid decarboxylase antibodies: immunologic profile and long-term effect of immunotherapy.

  2014cites this paper
• Involvement of the GABAergic Septo-Hippocampal Pathway in Brain Stimulation Reward

  2014cites this paper
• Chapter 57 – Encephalomyelopathies

  2014cites this paper
• Stiff-Man Syndrome

  2014cites this paper
• GABA-A receptor impairment in cerebellar ataxia with anti-glutamic acid decarboxylase antibodies

  2013influential citation
• Novel use of dual immunomodulation for treating stiff‐person syndrome, cerebellar variant

  2013cites this paper
• Is Anti-Gliadin Antibody Pathogenic in Gluten Ataxia? Analysis using Rat Cerebellar Slices and Patch-Clamp Recording

  2013cites this paper
• Review article Immunological perspectives of temporal lobe seizures

  2013cites this paper
• Immunological perspectives of temporal lobe seizures.

  2013cites this paper
• Autoimmune stiff person syndrome and related myelopathies: Understanding of electrophysiological and immunological processes

  2012influential citation
• Neurochemistry and Neuropharmacology of the Cerebellar Ataxias

  2012influential citation
• Sporadic adult-onset ataxia of unknown etiology.

  2012cites this paper
• Stiff Person Syndrome and Other Anti-GAD–Associated Neurologic Disorders

  2012cites this paper
• Immune-mediated acquired ataxias.

  2012cites this paper
• Autoimmune limbic encephalitis

  2011cites this paper
• GAD antibody‐associated neurological illness and its relationship to gluten sensitivity

  2011cites this paper
• The immunological basis for treatment of stiff person syndrome.

  2011cites this paper
• Chapter 11 – Stiffness syndromes

  2011cites this paper
• Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia

  2011cites this paper
• Clinical presentation of immune-mediated cerebellar ataxia.

  2011cites this paper
• Central Nervous System Destruction Mediated by Glutamic Acid Decarboxylase-Specific CD4+ T Cells

  2010cites this paper
• Effects of the glutamic acid decarboxylase (GAD) inhibitor semicarbazide and anti-GAD autoantibodies-containing immunoglobulin G on neuronal network activity within the motor cortex

  2010cites this paper
• A critical update on the immunopathogenesis of Stiff Person Syndrome

  2010cites this paper
• T Cells + Decarboxylase-Specific CD4 Mediated by Glutamic Acid Central Nervous System Destruction

  2010cites this paper
• CNS Destruction Mediated by GAD-Specific CD4+ T Cells1

  2010cites this paper
• Qualitative and quantitative evidence of anti-glutamic acid decarboxylase-specific intrathecal antibody synthesis in patients with stiff person syndrome.

  2010cites this paper
• Stiff person syndrome.

  2009cites this paper
• Increased spontaneous activity of a network of hippocampal neurons in culture caused by suppression of inhibitory potentials mediated by anti-gad antibodies

  2008influential citation
• [Steroid treatment in four cases of anti-GAD cerebellar ataxia].

  2008cites this paper
• Auto-immune cerebellar ataxia with anti-GAD antibodies accompanied by de novo late-onset type 1 diabetes mellitus.

  2008cites this paper
• Advances in the pathogenesis and treatment of patients with stiff person syndrome

  2008cites this paper
• Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies

  2008cites this paper
• Reversibility of cerebellar GABAergic synapse impairment induced by anti-glutamic acid decarboxylase autoantibodies.

  2008cites this paper
• [Which role of antineural autoantibodies in central nervous system diseases?].

  2008cites this paper
• Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association.

  2008influential citation
• [An update on neurochemistry and pharmacological therapy of the cerebellar ataxias].

  2007cites this paper
• Effects of anti–glutamic acid decarboxylase antibodies associated with neurological diseases

  2007cites this paper
• Anti-GAD antibody cerebellar ataxia mimicking Creutzfeldt-Jakob disease.

  2007cites this paper
• EFFECTS OF ANTI-GAD ANTIBODIES ASSOCIATED WITH NEUROLOGICAL DISEASES

  2007cites this paper
• Sporadic adult onset ataxia of unknown etiology

  2007cites this paper
• Rigidity and spasms from autoimmune encephalomyelopathies: Stiff‐person syndrome

  2006cites this paper
• Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies

  2006cites this paper
• Selective loss of Purkinje cells in a patient with anti-glutamic acid decarboxylase antibody-associated cerebellar ataxia

  2006cites this paper
• A rare saccade velocity profile in Stiff-Person Syndrome with cerebellar degeneration.

  2006cites this paper
• Intravenous immunoglobulin in patients with anti-GAD antibody-associated neurological diseases and patients with inflammatory myopathies

  2005cites this paper
• Immunopharmacology--antibodies for specific modulation of proteins involved in neuronal function.

  2005cites this paper
• The role of IVIg in the treatment of patients with stiff person syndrome and other neurological diseases associated with anti-GAD antibodies

  2005cites this paper
• Stiff-person syndromes

  2004cites this paper
• Treatment of Ataxia in Cortical Cerebellar Atrophy with the GABAergic Drug Gabapentin

  2004cites this paper