The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Clinical Cancer Research

• Publication date

  2000-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 11156244
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000influential reference
• Is angiogenesis inhibition the Holy Grail of cancer therapy?

  2000cited by this paper
• SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

  2000cited by this paper
• Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors.

  2000cited by this paper
• New paradigms for the treatment of cancer: the role of anti-angiogenesis agents.

  2000cited by this paper
• Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

  1999cited by this paper
• Inhibition of p56(lck) tyrosine kinase by isothiazolones.

  1999cited by this paper
• Molecular and biological properties of vascular endothelial growth factor

  1999cited by this paper
• Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy.

  1999cited by this paper
• Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization

  1999cited by this paper
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  1999cited by this paper
• Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor.

  1999cited by this paper
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  1999cited by this paper
• Inhibition of p56lckTyrosine Kinase by Isothiazolones

  1999cited by this paper
• The rationale and strategy used to develop a series of highly potent, irreversible, inhibitors of the epidermal growth factor receptor family of tyrosine kinases.

  1999cited by this paper
• Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785).

  1999cited by this paper
• Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.

  1999cited by this paper
• Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy

  1998cited by this paper
• Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival.

  1998cited by this paper
• Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.

  1998cited by this paper
• Angiogenesis and tumor metastasis.

  1998cited by this paper
• Extracellular Signal-regulated Protein Kinase/Jun Kinase Cross-talk Underlies Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation*

  1998cited by this paper
• Tumor angiogenesis as a major prognostic factor in stage I lung adenocarcinoma.

  1997cited by this paper
• Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases.

  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.

  1996cited by this paper
• Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121.

  1995cited by this paper
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  1995cited by this paper
• Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool.

  1995cited by this paper
• Inhibition of basic fibroblast growth factor-mediated tyrosine phosphorylation and protein synthesis by PD 145709, a member of the 2-thioindole class of tyrosine kinase inhibitors.

  1995cited by this paper
• Association of Vascular Endothelial Growth Factor Expression with Tumor Angiogenesis and with Early Relapse in Primary Breast Cancer

  1994cited by this paper
• Quantification of angiogenesis as an independent predictor of prognosis in invasive bladder carcinomas.

  1994cited by this paper
• Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

  1994cited by this paper
• Tumor angiogenesis as a prognostic factor in oral cavity tumors.

  1994cited by this paper
• Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

  1993cited by this paper
• Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites.

  1991cited by this paper
• New colorimetric cytotoxicity assay for anticancer-drug screening.

  1990cited by this paper
• Irreversible inhibition of v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds.

  1989cited by this paper
• Prolonged tumor dormancy by prevention of neovascularization in the vitreous.

  1976cited by this paper
• Anti‐Angiogenesis: New Concept for Therapy of Solid Tumors

  1972cited by this paper
• THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

  1949cited by this paper

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• [Correlation between expressions of VEGF and TRPC6 and their roles in podocyte injury in rats with diabetic nephropathy].

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• VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review).

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• Growth factors, Cytokines and VEGF in human neoplastic and inflammatory pathologies

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