Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cancer Research

• Publication date

  2005-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-05-0651PMID 16267019
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Advances in Biology and Therapy of Multiple Myeloma

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• Enhanced radiation-induced apoptosis of cancer cell lines after treatment with resveratrol.

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• Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma

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  2004cited by this paper
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• Regulation of Human Skeletal Stem Cells Differentiation by Dlk1/Pref‐1

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• Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis.

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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using ‘real-time’ quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) – a Europe against cancer program

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• Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review).

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• Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents.

  2003cited by this paper
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  2003cited by this paper
• Nutrient Interactions and Toxicity Research Communication The Daily Oral Administration of High Doses of trans-Resveratrol to Rats for 28 Days Is Not Harmful

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to induce osteoclastogenesis and is dependent on osteoclast activity

  2002cited by this paper
• Metabolism and Disposition of Resveratrol in Rats: Extent of Absorption, Glucuronidation, and Enterohepatic Recirculation Evidenced by a Linked-Rat Model

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• Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.

  2002cited by this paper
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• Human, Rat, and Mouse Metabolism of Resveratrol

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  2001cited by this paper
• Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma.

  2001cited by this paper
• Nutrition and Cancer Resveratrol Isolated from Polygonum cuspidatum Root Prevents Tumor Growth and Metastasis to Lung and Tumor-Induced Neovascularization in Lewis Lung Carcinoma-Bearing Mice

  2001cited by this paper
• Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats.

  2000cited by this paper
• Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression.

  2000cited by this paper
• The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts

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  1998influential reference
• Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells.

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  1998cited by this paper
• Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells.

  1998cited by this paper
• Aggregation of mononucleated precursors triggers cell surface expression of alphavbeta3 integrin, essential to formation of osteoclast-like multinucleated cells.

  1998cited by this paper
• Bone stem cells

  1998cited by this paper
• Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice.

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• Transcriptional activation through the vitamin D receptor in osteoblasts.

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• Requirement for NF-kappaB in osteoclast and B-cell development.

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• Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

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• Requirement for NF-κB in osteoclast and B-cell development

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• Real time quantitative PCR.

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• Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin.

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• The effects of bisphosphonates on the resorption cycle of isolated osteoclasts

  1994cited by this paper
• Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.

  1993cited by this paper
• Growth factors to stimulate bone formation

  1993cited by this paper
• Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption

  1992influential reference
• Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies.

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• Real time

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• Anti-Osteoporosis and Bone Protective Effects of Resveratrol in Rats With Chronic Kidney Disease-Induced Osteoporosis.

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