Cyclic AMP Sensor EPAC Proteins and Their Role in Cardiovascular Function and Disease.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Circulation Research

• Publication date

  2016-03-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.115.306529PMID 26941424
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.

  2015cited by this paper
• Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.

  2015influential reference
• The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway

  2015cited by this paper
• Blood cells and endothelial barrier function

  2015cited by this paper
• Structure-Guided Design of Selective Epac1 and Epac2 Agonists

  2015influential reference
• The future of EPAC-targeted therapies: agonism versus antagonism

  2015cited by this paper
• Autophagy in cardiovascular biology.

  2015cited by this paper
• Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

  2015cited by this paper
• Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation

  2015cited by this paper
• Rap1 Spatially Controls ArhGAP29 To Inhibit Rho Signaling during Endothelial Barrier Regulation

  2015cited by this paper
• Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes

  2015influential reference
• Exendin-4 promotes endothelial barrier enhancement via PKA- and Epac1-dependent Rac1 activation.

  2015cited by this paper
• Autophagy: an emerging therapeutic target in vascular diseases

  2015cited by this paper
• The Association of Serum IL-33 and sST2 with Breast Cancer

  2015cited by this paper
• The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal

  2015cited by this paper
• The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP

  2015influential reference
• Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”

  2015cited by this paper
• Epac is required for GLP-1R-mediated inhibition of oxidative stress and apoptosis in cardiomyocytes.

  2015cited by this paper
• Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytes.

  2015influential reference
• MicroRNA-133 Modulates the &bgr;1-Adrenergic Receptor Transduction Cascade

  2014cited by this paper
• cAMP controls the restoration of endothelial barrier function after thrombin‐induced hyperpermeability via Rac1 activation

  2014cited by this paper
• Rap1b in Smooth Muscle and Endothelium Is Required for Maintenance of Vascular Tone and Normal Blood Pressure

  2014cited by this paper
• Epac contributes to cardiac hypertrophy and amyloidosis induced by radiotherapy but not fibrosis.

  2014cited by this paper
• cAMP with other signaling cues converges on Rac1 to stabilize the endothelial barrier— a signaling pathway compromised in inflammation

  2014cited by this paper
• Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.

  2014influential reference
• Role of soluble adenylyl cyclase in cell death and growth.

  2014cited by this paper
• Integrated mechanisms of CaMKII-dependent ventricular remodeling

  2014cited by this paper
• β-Agonist-mediated Relaxation of Airway Smooth Muscle Is Protein Kinase A-dependent*

  2014cited by this paper
• Exchange Protein Directly Activated by cAMP Mediates Slow Delayed-Rectifier Current Remodeling by Sustained &bgr;-Adrenergic Activation in Guinea Pig Hearts

  2014cited by this paper
• The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs

  2014cited by this paper
• Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke

  2014cited by this paper
• Allosteric Inhibition of Epac

  2014cited by this paper
• PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production.

  2014cited by this paper
• Inhibition of Egr1 expression underlies the anti-mitogenic effects of cAMP in vascular smooth muscle cells

  2014cited by this paper
• Epac proteins: specific ligands and role in cardiac remodelling.

  2014cited by this paper
• cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).

  2014cited by this paper
• Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy

  2013cited by this paper
• Epac-Inhibitors: Facts and Artefacts

  2013cited by this paper
• Biophysical Techniques for Detection of cAMP and cGMP in Living Cells

  2013cited by this paper
• Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+‐sensitive K+ channels in rat mesenteric artery

  2013cited by this paper
• DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms

  2013cited by this paper
• Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling.

  2013cited by this paper
• Epac activator critically regulates action potential duration by decreasing potassium current in rat adult ventricle.

  2013cited by this paper
• Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias.

  2013cited by this paper
• Enhanced autophagy ameliorates cardiac proteinopathy.

  2013cited by this paper
• Exchange Protein Directly Activated by cAMP (epac): A Multidomain cAMP Mediator in the Regulation of Diverse Biological Functions

  2013cited by this paper
• Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses

  2013cited by this paper
• Antidiabetic Sulfonylureas and cAMP Cooperatively Activate Epac2A

  2013cited by this paper
• Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29

  2013cited by this paper
• The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1).

  2013cited by this paper
• GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

  2013cited by this paper
• Ca(2+) fluxes involvement in gene expression during cardiac hypertrophy.

  2013cited by this paper
• Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling.

  2013cited by this paper
• Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist.

  2013cited by this paper
• Epac2 Mediates Cardiac &bgr;1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca2+ Leak and Arrhythmia

  2013influential reference
• Epac in cardiac calcium signaling.

  2013cited by this paper
• Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

  2013cited by this paper
• A Novel EPAC-Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion

  2013cited by this paper
• Anchoring Proteins as Regulators of Signaling Pathways

  2012cited by this paper
• 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP.

  2012cited by this paper
• Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.

  2012cited by this paper
• cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane

  2012influential reference
• HIF-1α binding to the Epac1 promoter recruits hematopoietic stem cells to the ischemic brain following stroke.

  2012cited by this paper
• Isoform-specific antagonists of exchange proteins directly activated by cAMP

  2012cited by this paper
• Sustained Epac activation induces calmodulin dependent positive inotropic effect in adult cardiomyocytes.

  2012influential reference
• Epac2: a sulfonylurea receptor?

  2012cited by this paper
• Anti-Inflammatory Role of the cAMP Effectors Epac and PKA: Implications in Chronic Obstructive Pulmonary Disease

  2012cited by this paper
• Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac*

  2012cited by this paper
• Electrical Coupling and Propagation in Engineered Ventricular Myocardium With Heterogeneous Expression of Connexin43

  2012cited by this paper
• Epac enhances excitation-transcription coupling in cardiac myocytes.

  2012influential reference
• A Fluorescence-Based High-Throughput Assay for the Discovery of Exchange Protein Directly Activated by Cyclic AMP (EPAC) Antagonists

  2012cited by this paper
• PDEs create local domains of cAMP signaling.

  2012cited by this paper
• cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A

  2011cited by this paper
• Exchange Protein Directly Activated by Cyclic AMP Isoform 2 Is Not a Direct Target of Sulfonylurea Drugs

  2011cited by this paper
• Epidemiology and risk profile of heart failure

  2011cited by this paper
• AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties.

  2011cited by this paper
• Epac as a novel effector of airway smooth muscle relaxation

  2011cited by this paper
• CaMKII in myocardial hypertrophy and heart failure.

  2011cited by this paper
• A₂B receptors mediate the induction of early genes and inhibition of arterial smooth muscle cell proliferation via Epac.

  2011cited by this paper
• Treatment of chronic heart failure with β-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiology.

  2011influential reference
• PKA and Epac synergistically inhibit smooth muscle cell proliferation

  2011cited by this paper
• New Perspectives in cAMP-Signaling Modulation

  2011cited by this paper
• The cAMP-responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity*

  2011cited by this paper
• Epac: defining a new mechanism for cAMP action.

  2010influential reference
• Spatial Regulation of Cyclic AMP-Epac1 Signaling in Cell Adhesion by ERM Proteins

  2010cited by this paper
• Epac stimulation induces rapid increases in connexin43 phosphorylation and function without preconditioning effect

  2010cited by this paper
• cAMP Analogs and Their Metabolites Enhance TREK-1 mRNA and K+ Current Expression in Adrenocortical Cells

  2010cited by this paper
• Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway.

  2010influential reference
• Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability*

  2010cited by this paper
• Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells.

  2010cited by this paper
• β-Arrestin–dependent activation of Ca2+/calmodulin kinase II after β1–adrenergic receptor stimulation

  2010cited by this paper
• Differential Roles of Epac in Regulating Cell Death in Neuronal and Myocardial Cells*

  2010cited by this paper
• Inhibition of the Equilibrative Nucleoside Transporter 1 and Activation of A2A Adenosine Receptors by 8-(4-Chlorophenylthio)-modified cAMP Analogs and Their Hydrolytic Products*

  2009cited by this paper
• Exchange protein activated by cAMP (Epac) mediates cAMP‐dependent but protein kinase A‐insensitive modulation of vascular ATP‐sensitive potassium channels

  2009cited by this paper
• The cAMP binding protein Epac regulates cardiac myofilament function

  2009cited by this paper
• The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs

  2009cited by this paper
• Epac and Phospholipase Cϵ Regulate Ca2+ Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II*

  2009cited by this paper
• Direct Spatial Control of Epac1 by Cyclic AMP

  2009cited by this paper
• Critical role of the N‐terminal cyclic AMP‐binding domain of Epac2 in its subcellular localization and function

  2009influential reference
• Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin‐induced barrier breakdown

  2009cited by this paper

• Natural Glycosides from Cistanche deserticola Alleviate Hepatic Ischemia-Reperfusion Injury via a cAMP-Mediated Signaling Pathway.

  2026cites this paper
• Deciphering pro-arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes.

  2025cites this paper
• Genistein ameliorates thoracic aortic dissection by inhibiting CB1 receptor hyperactivation and modulating its-mediated cAMP-PKA signaling.

  2025cites this paper
• Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives

  2025cites this paper
• Selective Epac2 antagonist attenuates cerebral infarction induced by secondary brain injury in rats

  2025cites this paper
• A SUMO-interacting motif in the guanine nucleotide exchange factor EPAC1 is required for subcellular targeting and function

  2025cites this paper
• Pharmacological inhibition of Epac1 protects against pulmonary fibrosis by blocking FoxO3a neddylation

  2025cites this paper
• Role of exchange proteins directly activated by cAMP signaling in vascular remodeling.

  2025cites this paper
• The machinery of healthy vasodilatation: an overview

  2025cites this paper
• Reduced blood EPAC1 protein levels as a marker of severe coronary artery disease: the role of hypoxic foam cell-transformed smooth muscle cells

  2025cites this paper
• Knocking Out Rap1a Attenuates Cardiac Remodeling and Fibrosis in a Male Murine Model of Angiotensin II-Induced Hypertension

  2025cites this paper
• A SUMO-interacting motif in the guanine nucleotide exchange factor EPAC1 is required for subcellular targeting and function

  2025cites this paper
• Sex-specific molecular drivers of cardiac fibrosis in aging hearts

  2025cites this paper
• DIFFERENTIAL CELLULAR RESPONSES TO ω-3 AND ω-6 FATTY ACIDS MEDIATED BY FFAR4 RECEPTOR IN LARGE YELLOW CROAKER (LARIMICHTHYS CROCEA)

  2025cites this paper
• Canonical or non‐canonical, all aspects of G protein‐coupled receptor kinase 2 in heart failure

  2025cites this paper
• QiShenYiQi dripping pills ameliorate post-myocardial infarction cardiac fibrosis via modulation of the cAMP/Rap1 and PI3K/Akt signaling pathways.

  2025cites this paper
• D-Ala2-GIP (1-30) promotes angiogenesis by facilitating endothelial cell migration via the Epac/Rap1/Cdc42 signaling pathway.

  2025cites this paper
• Epac2 Deficiency Compromises Adaptation to Dietary Acidification by Decreasing H+ Transport in the Renal Nephron

  2025cites this paper
• Nuclear α1A-Adrenergic Receptor Regulation of cAMP Production by an Inside-Out MAP Kinase Signaling Pathway in Cardiac Myocytes

  2025cites this paper
• Regulation of β-adrenergic receptors on cardiomyocyte calcium signaling

  2024cites this paper
• Protective effect of ginsenoside Rb1 against aconitine cardiotoxicity studied by myocardial injury, action potential, and calcium signaling.

  2024cites this paper
• Adenylyl cyclase isoforms 5 and 6 in the cardiovascular system: complex regulation and divergent roles

  2024cites this paper
• Epac activation reduces trans-endothelial migration of undifferentiated neuroblastoma cells and cellular differentiation with a CDK inhibitor further enhances Epac effect

  2024cites this paper
• Intracellular cAMP signaling-induced Ca2+ influx mediated by calcium homeostasis modulator 1 (CALHM1) in human odontoblasts

  2024cites this paper
• Signaling through cAMP-Epac1 induces metabolic reprogramming to protect podocytes in glomerulonephritis.

  2024cites this paper
• Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

  2023cites this paper
• The GLP-1-mediated gut-kidney cross talk in humans: mechanistic insight

  2023cites this paper
• Rap1 in the Context of PCSK9, Atherosclerosis, and Diabetes

  2023cites this paper
• Receptor-Specific Inside-Out cAMP Signaling Regulates Cardiomyocyte Fate.

  2023cites this paper
• A low androgen state impairs erectile function by suppressing EPAC1 in rat penile corpus cavernosum

  2023cites this paper
• Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis

  2023cites this paper
• CD44 regulates Epac1-mediated β-adrenergic-receptor-induced Ca2+-handling abnormalities: implication in cardiac arrhythmias

  2023cites this paper
• Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development

  2023cites this paper
• Mutations in phosphodiesterase 3A (PDE3A) Cause Hypertension Without Cardiac Damage.

  2023cites this paper
• Differential changes in cyclic adenosine 3′‐5′ monophosphate (cAMP) effectors and major Ca2+ handling proteins during diabetic cardiomyopathy

  2023cites this paper
• Epac as a tractable therapeutic target.

  2023cites this paper
• Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation

  2023cites this paper
• GLP−1 Promotes Cortical and Medullary Perfusion in the Human Kidney and Maintains Renal Oxygenation During NaCl Loading

  2023cites this paper
• EPAC1 Pharmacological Inhibition with AM-001 Prevents SARS-CoV-2 and Influenza A Virus Replication in Cells

  2023cites this paper
• Journal Pre-proof Inhibition of Exchange Proteins Directly Activated by cAMP (EPAC) as a Strategy for Broad-Spectrum Antiviral Development

  2023influential citation
• Journal Pre-proof Inhibition of Exchange Proteins Directly Activated by cAMP (EPAC) as a Strategy for Broad-Spectrum Antiviral Development

  2023influential citation
• Journal Pre-proof Inhibition of Exchange Proteins Directly Activated by cAMP (EPAC) as a Strategy for Broad-Spectrum Antiviral Development

  2023influential citation
• The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells

  2022cites this paper
• Host Cell Rap1b mediates cAMP-dependent invasion by Trypanosoma cruzi

  2022cites this paper
• Epac1 activation by cAMP regulates cellular SUMOylation and promotes the formation of biomolecular condensates

  2022cites this paper
• Proteomic Analysis of the Role of the Adenylyl Cyclase–cAMP Pathway in Red Blood Cell Mechanical Responses

  2022cites this paper
• DP1 (Prostaglandin D2 Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II–Induced Hypertension in Mice

  2022cites this paper
• Epac, a positive or negative signaling molecule in cardiovascular diseases.

  2022cites this paper
• Mechanisms of Lian-Gui-Ning-Xin-Tang in the treatment of arrhythmia: Integrated pharmacology and in vivo pharmacological assessment.

  2022cites this paper
• Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation

  2022cites this paper
• Phosphodiesterase-1 in the cardiovascular system.

  2022cites this paper
• Epac1 regulates cellular SUMOylation by promoting the formation of SUMO-activating nuclear condensates

  2022influential citation
• Role of Takeda G protein‑coupled receptor 5 in microvascular endothelial cell dysfunction in diabetic retinopathy (Review)

  2022cites this paper
• Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure

  2022cites this paper
• Mitochondrial a Kinase Anchor Proteins in Cardiovascular Health and Disease: A Review Article on Behalf of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology

  2022cites this paper
• Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections

  2021cites this paper
• Visualization and bibliometric analysis of cAMP signaling system research trends and hotspots in cancer

  2021cites this paper
• GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure

  2021cites this paper
• Impact of Aldosterone on the Failing Myocardium: Insights from Mitochondria and Adrenergic Receptors Signaling and Function

  2021cites this paper
• Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy

  2021cites this paper
• cAMP signaling through protein kinase A and Epac2 induces substance P release in the rat spinal cord.

  2021cites this paper
• Bicarbonate, carbon dioxide and pH sensing via mammalian bicarbonate-regulated soluble adenylyl cyclase

  2021cites this paper
• PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective

  2021cites this paper
• Integrated Pharmacogenetics Analysis of the Three Fangjis Decoctions for Treating Arrhythmias Based on Molecular Network Patterns

  2021cites this paper
• Epac1–/– and Epac2–/– mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation

  2021cites this paper
• Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis

  2021cites this paper
• Sympatho-adrenergic mechanisms in heart failure: new insights into pathophysiology

  2021cites this paper
• Physiological And Pathological Roles Of Protein Kinase A In The Heart.

  2021cites this paper
• Signature network-based survey of the effects of a traditional Chinese medicine on heart failure.

  2021cites this paper
• Microvascular Sex- and Age- Dependent Phosphodiesterase Expression

  2021cites this paper
• Cyclic nucleotide signaling and pacemaker activity.

  2021cites this paper
• The renal extraction and the natriuretic action of GLP-1 in humans depend on interaction with the GLP-1 receptor.

  2020cites this paper
• Correlative Study on Impaired Prostaglandin E2 Regulation in Epicardial Adipose Tissue and Its Role in Maladaptive Cardiac Remodeling via EPAC2 and ST2 Signaling in Overweight Cardiovascular Disease Subjects

  2020cites this paper
• Ion channels as effectors of cyclic nucleotide pathways: Functional relevance for arterial tone regulation.

  2020cites this paper
• cAMP sensitive nanochannels driven by conformational transition of a tripeptide-based smart polymer.

  2020cites this paper
• Integration of Rap1 and Calcium Signaling

  2020cites this paper
• A high-content, in vitro cardiac fibrosis assay for high-throughput, phenotypic identification of compounds with anti-fibrotic activity.

  2020cites this paper
• Epac-mediated relaxation in murine basilar arteries depends on membrane permeability of cyclic nucleotide analogues and endothelial aging.

  2020influential citation
• Synthesis and Biochemical Evaluation of Non-Cyclic Nucleotide Exchange Protein Directly Activated by cAMP 1 (EPAC1) Regulators.

  2020cites this paper
• Epac Proteins and Their Role in the Physiological and Pathological Processes in the Cardiovascular System. Part 1: The Role of Epac Proteins in the Physiological and Pathological Processes of the Vasculature

  2020cites this paper
• Investigating cardiac β-adrenergic nuclear signaling with FRET-based biosensors.

  2020cites this paper
• G Protein-Coupled Receptors in the Mammalian Blood-Brain Barrier

  2020cites this paper
• Risk assessment of cardiotoxicity to zebrafish (Danio rerio) by environmental exposure to triclosan and its derivatives.

  2020cites this paper
• Novel anti-thrombotic mechanisms mediated by Mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems

  2020cites this paper
• Identification of novel Epac2 antagonists through in silico and in vitro analyses.

  2020cites this paper
• EPAC in Vascular Smooth Muscle Cells

  2020cites this paper
• The cyclic adenosine monophosphate elevating medicine, forskolin, reduces neointimal formation and atherogenesis in mice

  2020cites this paper
• Molecular and Mechanical Mechanisms Regulating Ductus Arteriosus Closure in Preterm Infants

  2020cites this paper
• Role of EPAC1 Signalosomes in Cell Fate: Friends or Foes?

  2020cites this paper
• P2Y Purinergic Receptors, Endothelial Dysfunction, and Cardiovascular Diseases

  2020cites this paper
• Nitration of protein phosphatase 2A increases via Epac1/PLCε/CaMKII/HDAC5/iNOS cascade in human endometrial stromal cell decidualization

  2020cites this paper
• Exchange protein directly activated by cAMP (Epac) mediates cardiac repolarization and arrhythmogenesis during chronic heart failure.

  2020cites this paper
• Epac: new emerging cAMP-binding protein

  2020cites this paper
• Corticotropin-Releasing Hormone Family and Their Receptors in the Cardiovascular System.

  2019cites this paper
• Hepatic Glucagon Signaling Regulates PCSK9 and Low-Density Lipoprotein Cholesterol

  2019cites this paper
• Epac agonist improves barrier function in iPSC-derived endothelial colony forming cells for whole organ tissue engineering.

  2019cites this paper
• Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress.

  2019cites this paper
• Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1: A Functional GLP-1-Renal Axis in Man.

  2019cites this paper
• Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

  2019cites this paper
• Glucagon-Like Peptide-1 Receptors in the Kidney: Impact on renal autoregulation.

  2019cites this paper