Current status of lupus genetics

Over the past 40 years more than 100 genetic risk factors have been defined in systemic lupus erythematosus through a combination of case studies, linkage analyses of multiplex families, and case-control analyses of single genes. Multiple investigators have examined patient cohorts gathered from around the world, and although we doubt that all of the reported associations will be replicated, we have probably already discovered many of the genes that are important in lupus pathogenesis, including those encoding human leukocyte antigen-DR, Fcγ receptor 3A, protein tyrosine phosphatase nonreceptor 22, cytotoxic T lymphocyte associated antigen 4, and mannose-binding lectin. In this review we will present what is known, what is disputed, and what remains to be discovered in the world of lupus genetics.

• Publication year

  2007

• Venue

  Arthritis Research & Therapy

• Publication date

  2007-05-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/ar2176PMID 17509159PMCID 2206359
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Arthritis Research & Therapy

  2009cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004influential reference
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  2003cited by this paper
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  2003cited by this paper
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  2003influential reference
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  2003cited by this paper
• Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: Methods and power analysis.

  2003cited by this paper
• Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus.

  2002cited by this paper
• Stratification of pedigrees multiplex for systemic lupus erythematosus and for self-reported rheumatoid arthritis detects a systemic lupus erythematosus susceptibility gene (SLER1) at 5p15.3.

  2002cited by this paper
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  2002influential reference
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002influential reference
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002influential reference
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  2001cited by this paper
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  2001cited by this paper
• Mutation of DNASE1 in people with systemic lupus erythematosus

  2001cited by this paper
• Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients.

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• PARP alleles and SLE: failure to confirm association with disease susceptibility.

  2000influential reference
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000influential reference
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  2000cited by this paper
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  1999cited by this paper
• C1q Knock-Out Mice for the Study of Complement Deficiency in Autoimmune Disease

  1999cited by this paper
• The combination of polymorphisms within interferon‐γ receptor 1 and receptor 2 associated with the risk of systemic lupus erythematosus

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Poly(ADP-ribose) polymerase alleles in French Caucasians are associated neither with lupus nor with primary antiphospholipid syndrome

  1999cited by this paper
• PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus.

  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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• Potential Therapeutic Targets of Resveratrol in the Prevention and Treatment of Pulmonary Fibrosis.

  2023cites this paper
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• T follicular helper cells, interleukin‐21 and systemic lupus erythematosus

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  2014cites this paper
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  2012influential citation
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• Male-only Systemic Lupus

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