Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Acta Pharmacologica Sinica

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1745-7254.2008.00725.xPMID 18158873
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Magnolol suppresses NF-kappaB activation and NF-kappaB regulated gene expression through inhibition of IkappaB kinase activation.

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• Protective effects of magnolol against oxidized LDL-induced apoptosis in endothelial cells

  2007cited by this paper
• Magnolol suppresses NF-κB activation and NF-κB regulated gene expression through inhibition of IkappaB kinase activation

  2007cited by this paper
• Honokiol, a Natural Plant Product, Inhibits Inflammatory Signals and Alleviates Inflammatory Arthritis1

  2007cited by this paper
• Targeting Signal‐Transducer‐and‐Activator‐of‐Transcription‐3 for Prevention and Therapy of Cancer

  2006cited by this paper
• Honokiol causes the p21WAF1‐mediated G(1)‐phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells

  2006cited by this paper
• Honokiol Reduces Oxidative Stress, c-jun-NH2-Termial Kinase Phosphorylation and Protects against Glycochenodeoxycholic Acid-Induced Apoptosis in Primary Cultured Rat Hepatocytes

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• Protein Kinase C Negatively Regulates Akt Activity and Modifies UVC-induced Apoptosis in Mouse Keratinocytes*

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• Honokiol Potentiates Apoptosis, Suppresses Osteoclastogenesis, and Inhibits Invasion through Modulation of Nuclear Factor-κB Activation Pathway

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• Cytotoxic neolignans: an SAR study.

  2005cited by this paper
• The NF-kappaB pathway.

  2005cited by this paper
• Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.

  2005cited by this paper
• Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation.

  2005cited by this paper
• Enhanced v-Src-induced oncogenic transformation in the absence of focal adhesion kinase is mediated by phosphatidylinositol 3-kinase.

  2005cited by this paper
• Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling.

  2005cited by this paper
• Macrophages in inflammation.

  2005cited by this paper
• Honokiol inhibits TNF-α-stimulated NF-κB activation and NF-κB-regulated gene expression through suppression of IKK activation

  2005cited by this paper
• PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathways.

  2004cited by this paper
• [Pharmacokinetics of honokiol in rats].

  2004cited by this paper
• Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis.

  2004cited by this paper
• IκB kinases: key regulators of the NF-κB pathway

  2004cited by this paper
• IkappaB kinases: key regulators of the NF-kappaB pathway.

  2004cited by this paper
• Isolation and purification of honokiol and magnolol from cortex Magnoliae officinalis by high-speed counter-current chromatography.

  2004cited by this paper
• In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp.

  2004cited by this paper
• Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production.

  2003cited by this paper
• CD98-dependent homotypic aggregation is associated with translocation of protein kinase Cdelta and activation of mitogen-activated protein kinases.

  2003cited by this paper
• Phosphatidylinositol 3‐kinase is involved in Toll‐like receptor 4‐mediated cytokine expression in mouse macrophages

  2003cited by this paper
• The anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production.

  2003cited by this paper
• Anti-inflammatory properties of lipid oxidation products

  2003cited by this paper
• Regulation of CD43-induced U937 homotypic aggregation.

  2003cited by this paper
• Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo*

  2003cited by this paper
• cAMP Inhibition of Akt Is Mediated by Activated and Phosphorylated Rap1b*

  2002cited by this paper
• Salicylate Suppresses Macrophage Nitric-oxide Synthase-2 and Cyclo-oxygenase-2 Expression by Inhibiting CCAAT/Enhancer-binding Protein-β Binding via a Common Signaling Pathway*

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• Macrophage-Mediated Innate Host Defense Against Protozoan Parasites

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• Redox signaling in vascular angiogenesis.

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• Nuclear factor-kappa B and cancer: its role in prevention and therapy.

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• Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation.

  2001cited by this paper
• The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation.

  2001cited by this paper
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  2001cited by this paper
• In vitro inhibitory effect of protopanaxadiol Ginsenosides on tumor necrosis factor (TNF)-α production and its modulation by known TNF-α antagonists

  2001cited by this paper
• Effects of constituents from the bark of Magnolia obovata on nitric oxide production in lipopolysaccharide-activated macrophages.

  2001cited by this paper
• In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists.

  2001cited by this paper
• Role of the NF-kappaB pathway in the pathogenesis of human disease states.

  2001cited by this paper
• Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria.

  2000cited by this paper
• Antifungal activity of magnolol and honokiol

  2000cited by this paper
• Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages.

  2000cited by this paper
• In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica.

  2000cited by this paper
• In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa.

  2000cited by this paper
• The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro

  1999cited by this paper
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  1999cited by this paper
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  1976cited by this paper

• Assembly of thioether analogs from 2‐mercaptobenzoxazole‐fused honokiol and heterocyclic scaffolds and evaluation of their agrochemical potential

  2025cites this paper
• A comprehensive review of anti-cancer mechanisms of polyphenol honokiol and nano carrier-based approaches to enhance its therapeutic potential

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• Novel Pesticide Candidates Inspired by Natural Neolignan: Preparation and Insecticidal Investigation of Honokiol Analogs Containing 2-Aminobenzoxazole-Fused Core Scaffold.

  2024cites this paper
• The anti-inflammatory effect of a magnoliae cortex and Zea mays L. extract mixture in a canine model of ligature-induced periodontitis

  2024cites this paper
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  2024cites this paper
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