Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Genes & Development

• Publication date

  1993-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/GAD.7.12B.2483PMID 8276233
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

  1993cited by this paper
• The irregular chiasm C-roughest locus of Drosophila, which affects axonal projections and programmed cell death, encodes a novel immunoglobulin-like protein.

  1993cited by this paper
• Determinants of binding-site specificity among yeast C6 zinc cluster proteins.

  1993cited by this paper
• Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

  1993cited by this paper
• The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

  1993cited by this paper
• Solution structure of the POU-specific DNA-binding domain of Oct-1

  1993cited by this paper
• Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival.

  1993cited by this paper
• Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated.

  1993cited by this paper
• A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene.

  1993cited by this paper
• POU-domain proteins: structure and function of developmental regulators.

  1993cited by this paper
• Site-specific HU binding in the Mu transpososome: conversion of a sequence-independent DNA-binding protein into a chemical nuclease.

  1993cited by this paper
• The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain.

  1993cited by this paper
• A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain.

  1992cited by this paper
• A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an alpha 2 dimer.

  1992cited by this paper
• The DNA binding specificity of the bipartite POU domain and its subdomains.

  1992cited by this paper
• Regulation of the mec‐3 gene by the C.elegans homeoproteins UNC‐86 and MEC‐3.

  1992cited by this paper
• Recognition of the surface of a homeo domain protein.

  1992cited by this paper
• NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein.

  1992cited by this paper
• Regulation of transcription and cell identity by POU domain proteins.

  1991cited by this paper
• Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0

  1991cited by this paper
• POU proteins bend DNA via the POU‐specific domain.

  1991cited by this paper
• The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors.

  1991cited by this paper
• POU-domain transcription factors: pou-er-ful developmental regulators.

  1991cited by this paper
• Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions.

  1991cited by this paper
• The mec-3 gene contains cis-acting elements mediating positive and negative regulation in cells produced by asymmetric cell division in Caenorhabditis elegans.

  1991cited by this paper
• Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors.

  1991cited by this paper
• DNA recognition by proteins with the helix-turn-helix motif.

  1990cited by this paper
• A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression.

  1990cited by this paper
• Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

  1990cited by this paper
• Crystal structure of an engrailed homeodomain-DNA complex at 2.8 A resolution: a framework for understanding homeodomain-DNA interactions.

  1990cited by this paper
• Interactions of the Oct-1 POU subdomains with specific DNA sequences and with the HSV alpha-trans-activator protein.

  1990cited by this paper
• Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons

  1990cited by this paper
• Conserved residues make similar contacts in two repressor-operator complexes.

  1990cited by this paper
• The oct-1 homeo domain contacts only part of the octamer sequence and full oct-1 DNA-binding activity requires the POU-specific domain.

  1990cited by this paper
• The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.

  1990cited by this paper
• Contacts between steroid hormone receptors and thymines in DNA: an interference method.

  1990cited by this paper
• Expression of a large family of POU-domain regulatory genes in mammalian brain development

  1989cited by this paper
• The structure and function of the homeodomain.

  1989cited by this paper
• The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors.

  1989cited by this paper
• Expression of a large family of POU-domain regulatory genes in mammalian brain development

  1989cited by this paper
• Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: A hybridization histochemical study in the rat

  1989cited by this paper
• A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype.

  1988cited by this paper
• The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.

  1988cited by this paper
• Homeo boxes in the study of development.

  1987cited by this paper
• Homologous interactions of lambda repressor and lambda Cro with the lambda operator.

  1986cited by this paper
• Chemical and biological characterization of corticotropin releasing factor.

  1983cited by this paper
• Subject Index

  1981cited by this paper
• Advertisers

  1967cited by this paper

• Transcriptional and Epigenetic Regulation of the Corticotropin-Releasing Hormone System and Genetic Associations With Neuropsychiatric Disorders

  2021cites this paper
• Coexistence of severe developmental delay, epilepsy, and hemangioma in Snijders Blok‐Fisher syndrome suggests the presence of a POU3F3‐related SNIBFIS endophenotype: A case report

  2021cites this paper
• Expression of zebrafish Brn1.2 (Pou3f2) and two Brn-3a (Pou4f1) POU genes in brain and sensory structures

  2021cites this paper
• De Novo Variants Disturbing the Transactivation Capacity of POU3F3 Cause a Characteristic Neurodevelopmental Disorder.

  2019cites this paper
• Isoform-specific regulation of Drosophila gut immunity and regeneration by the POU/Oct transcription factor Nub/Pdm1

  2018cites this paper
• Activation of Six1 Expression in Vertebrate Sensory Neurons

  2015cites this paper
• An Autoregulatory Pathway Establishes the Definitive Chromatin Conformation at the Pit-1 Locus

  2015cites this paper
• Methylation of BDNF in women with bulimic eating syndromes: associations with childhood abuse and borderline personality disorder.

  2014cites this paper
• Hyperphosphorylation Results in Tau Dysfunction in DNA Folding and Protection

  2013cites this paper
• Gbx2 Directly Restricts Otx2 Expression to Forebrain and Midbrain, Competing with Class III POU Factors

  2012cites this paper
• The molecular physiology of CRH neurons.

  2012cites this paper
• TRAFFICKING OF ALPHA SECRETASE ADAM10: NEW INSIGHTS INTO THE MOLECULAR MECHANISM OF MODULATION

  2012cites this paper
• The dynamic expression of Mash1 in the hippocampal subgranular zone after fimbria-fornix transection.

  2012cites this paper
• Régulation transcriptionelle du développement de l'hypothalamus chez l'amphibien

  2011cites this paper
• The lysosomal polypeptide transporter TAPL: more than a housekeeping factor?

  2011cites this paper
• TRAFFICKING OF α-SECRETASE ADAM10: NEW INSIGHTS INTO THE MOLECULAR MECHANISM OF MODULATION

  2011cites this paper
• Genome‐wide analysis of POU3F2/BRN2 promoter occupancy in human melanoma cells reveals Kitl as a novel regulated target gene

  2010cites this paper
• Brn2 Is a Transcription Factor Regulating Keratinocyte Differentiation with a Possible Role in the Pathogenesis of Lichen Planus

  2010cites this paper
• Brn‐4 is upregulated in the deafferented hippocampus and promotes neuronal differentiation of neural progenitors in vitro

  2009cites this paper
• Factors involved in the establishment of hypothalamic neuroendocrine phenotypes

  2009cites this paper
• Structure of human Brn-5 transcription factor in complex with CRH gene promoter.

  2009cites this paper
• Binding to the Minor Groove of the Double-Strand, Tau Protein Prevents DNA from Damage by Peroxidation

  2008cites this paper
• two-in-one DNA-binding domain. The POU domain: versatility in transcriptional regulation by a flexible

  2007influential citation
• Molecular physiology of pituitary development: signaling and transcriptional networks.

  2007cites this paper
• Accuracy and reproducibility of protein-DNA microarray technology.

  2007cites this paper
• epidermal differentiation. Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in

  2007cites this paper
• Tissue-specific regulatory elements in mammalian promoters : Supplementary information

  2006cites this paper
• Identification and functional significance of polymorphisms in the mu-opioid receptor gene (Oprm) promoter of C57BL/6 and DBA/2 mice.

  2006cites this paper
• Control of myelination in Schwann cells: a Krox20 cis‐regulatory element integrates Oct6, Brn2 and Sox10 activities

  2006influential citation
• Determination of transcription factors and their possible roles in the regulation of Pax3 gene expression in the mouse B16 F1 melanoma cell line

  2005cites this paper
• The neuronal POU transcription factor Brn-2 interacts with Jab1, a gene involved in the onset of neurodegenerative diseases.

  2005cites this paper
• Genomic structure and functional characterization of the human ADAM10 promoter

  2005cites this paper
• Expression and role of Brn3 family of transcription factors in human neuroblastomas.

  2005cites this paper
• Oct-3/4 Maintains the Proliferative Embryonic Stem Cell State via Specific Binding to a Variant Octamer Sequence in the Regulatory Region of the UTF1 Locus

  2005cites this paper
• Molecular regulation of the CRF system

  2005cites this paper
• Multiple POU-binding motifs, recognized by tissue-specific nuclear factors, are important for Dll1 gene expression in neural stem cells.

  2004cites this paper
• The Brn-2 Transcription Factor Links Activated BRAF to Melanoma Proliferation

  2004cites this paper
• Characteristic patterns of N Oct-3 binding to a set of neuronal promoters.

  2004cites this paper
• Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity.

  2003cites this paper
• Adenoviral-mediated over-expression of Brn2 in the rat paraventricular nucleus: no effect on vasopressin or corticotrophin releasing factor RNA levels.

  2003cites this paper
• Hormones, Obesity, Learning, and Breathing — the Many Functions of Mammalian Single-Minded Genes

  2003cites this paper
• Promoter analysis and transcriptional regulation of the CMT1A-disease gene peripheral myelin protein PMP22

  2003cites this paper
• Research Article Microtubule associated protein tau binds to double-stranded but not single-stranded DNA

  2003cites this paper
• Microtubule associated protein tau binds to double-stranded but not single-stranded DNA

  2003cites this paper
• Distinct elements of the peripheral myelin protein 22 (PMP22) promoter regulate expression in Schwann cells and sensory neurons.

  2003cites this paper
• Identification of the Downstream Targets of SIM1 and ARNT2, a Pair of Transcription Factors Essential for Neuroendocrine Cell Differentiation*

  2003cites this paper
• Sequence and Positional Requirements for DNA Sites in a Mu Transpososome*

  2002cites this paper
• Regulation of gene promoters of hypothalamic peptides.

  2002cites this paper
• Molecular cloning and genomic analysis of mouse glucuronyltransferase involved in biosynthesis of the HNK-1 epitope.

  2002cites this paper
• Characterisation of cis-acting sequences reveals a biphasic, axon-dependent regulation of Krox20 during Schwann cell development.

  2002cites this paper
• Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS.

  2002cites this paper
• Nucleus and gene expression

  2002cites this paper
• Effect of phosphorylation and aggregation on tau binding to DNA.

  2002cites this paper
• Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: a role for POU homeodomain transcription factors.

  2002cites this paper
• Transcriptional Regulation of Cortical Neuron Migration by POU Domain Factors

  2002cites this paper
• qBrn-2, a POU III gene in quail: distinct developmental expression revealed by a specific antibody.

  2001cites this paper
• High copy arrays containing a sequence upstream of mec-3 alter cell migration and axonal morphology in C. elegans

  2001cites this paper
• Atypical binding of the neuronal POU protein N-Oct3 to noncanonical DNA targets. Implications for heterodimerization with HNF-3 beta.

  2001cites this paper
• Alternative promoters drive the expression of the gene encoding the mouse axonal glycoprotein F3/contactin.

  2001cites this paper
• Novel control motif cluster in the IgH delta-gamma 3 interval exhibits B cell-specific enhancer function in early development.

  2001cites this paper
• Constitutive Expression of MHC Class II Genes in Melanoma Cell Lines Results from the Transcription of Class II Transactivator Abnormally Initiated from Its B Cell-Specific Promoter1

  2001cites this paper
• Novel Control Motif Cluster in the IgH δ-γ3 Interval Exhibits B Cell-Specific Enhancer Function in Early Development1

  2001cites this paper
• Defective development of secretory neurones in the hypothalamus of Arnt2‐knockout mice

  2001cites this paper
• POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease.

  2001cites this paper
• Developmental expression of the POU transcription factor qBrn-2 during somitic myogenesis in quail.

  2001cites this paper
• Identification of DNA-protein interactions in the 5' flanking and 5' untranslated regions of the human multidrug resistance protein (MRP1) gene: evaluation of a putative antioxidant response element/AP-1 binding site.

  2001cites this paper
• The human complement C9 gene: structural analysis of the 5' gene region and genetic polymorphism studies.

  2001cites this paper
• Structure of the mouse metalloprotease meprin beta gene (Mep1b): alternative splicing in cancer cells.

  2000cites this paper
• Complex Interactions between Epidermal POU Domain and Activator Protein 1 Transcription Factors Regulate the Expression of the Profilaggrin Gene in Normal Human Epidermal Keratinocytes*

  2000cites this paper
• Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors.

  2000cites this paper
• Alteration of the levels of the M-type 6-phosphofructo-1-kinase mRNA isoforms during neonatal maturation of heart, brain, and muscle

  2000cites this paper
• Identification of Amino Acid Residues in the Caenorhabditis elegans POU Protein UNC-86 That Mediate UNC-86–MEC-3–DNA Ternary Complex Formation

  2000cites this paper
• Myocyte Enhancer Factors-2B and -2C Are Required for Adhesion Related Kinase Repression of Neuronal Gonadotropin Releasing Hormone Gene Expression*

  2000cites this paper
• Genomic organization and alternative transcripts of the human PQBP-1 gene.

  2000cites this paper
• The POU Domain Transcription Factor Tst-1 Activates Somatostatin Receptor 1 Gene Expression in Pancreatic β-Cells*

  2000cites this paper
• Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene.

  2000cites this paper
• The virtuoso of versatility: POU proteins that flex to fit.

  2000cites this paper
• Regulation and expression of gonadotropin-releasing hormone gene differs in brain and gonads in rainbow trout.

  1999cites this paper
• The SKN-1 Amino-Terminal Arm Is a DNA Specificity Segment

  1999cites this paper
• Autoregulatory Sequences are Revealed by Complex Stability Screening of the Mouse brn-3.0 Locus

  1999cites this paper
• An octamer-binding site is crucial for the activity of an enhancer active at the embryonic met-/mesencephalic junction.

  1999cites this paper
• A requirement for the POU transcription factor, Brn-2, in corticotropin-releasing hormone expression in a neuronal cell line.

  1999influential citation
• The role of POU domain proteins in the regulation of mammalian pituitary and nervous system development.

  1999cites this paper
• Expression of brain-2 in the developing olfactory bulb.

  1999cites this paper
• A role for the POU‐III transcription factor Brn‐4 in the regulation of striatal neuron precursor differentiation

  1999cites this paper
• RAV1, a novel DNA-binding protein, binds to bipartite recognition sequence through two distinct DNA-binding domains uniquely found in higher plants.

  1999cites this paper
• Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene.

  1999cites this paper
• Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes*

  1998cites this paper
• Neuronal Expression of the 5HT3 Serotonin Receptor Gene Requires Nuclear Factor 1 Complexes

  1998cites this paper
• Transcriptional regulatory region of Brn-2 required for its expression in developing olfactory epithelial cells.

  1998cites this paper
• Cooperative Function of POU Proteins and SOX Proteins in Glial Cells*

  1998cites this paper
• Identification of a New Binding Motif for the Paired Domain of Pax-3 and Unusual Characteristics of Spacing of Bipartite Recognition Elements on Binding and Transcription Activation*

  1998cites this paper
• Recruitment of Octamer Transcription Factors to DNA by Glucocorticoid Receptor

  1998cites this paper
• Zinc-finger transcription factors in plants

  1998cites this paper
• OCA-B Is a Functional Analog of VP16 but Targets a Separate Surface of the Oct-1 POU Domain

  1998cites this paper
• Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1.

  1998cites this paper
• Transgenic and Transcriptional Studies on Neurosecretory Cell Gene Expression

  1998cites this paper
• A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome.

  1998cites this paper
• Characterization of a human-specific regulator of placental corticotropin-releasing hormone.

  1998cites this paper
• The structures of the mouse and human urocortin genes (Ucn and UCN).

  1998cites this paper