The apical complex couples cell fate and cell survival to cerebral cortical development.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Neuron

• Publication date

  2010-04-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuron.2010.03.019PMID 20399730PMCID PMC2872122
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development.

  2010cited by this paper
• Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex.

  2009cited by this paper
• Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex.

  2009cited by this paper
• Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex

  2009cited by this paper
• Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse

  2009cited by this paper
• Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa

  2009cited by this paper
• Behavioral phenotyping strategies for mutant mice.

  2008cited by this paper
• Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis

  2008cited by this paper
• MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex

  2008cited by this paper
• miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex

  2008cited by this paper
• Neural stem cells: balancing self-renewal with differentiation

  2008cited by this paper
• Par-3-mediated Junctional Localization of the Lipid Phosphatase PTEN Is Required for Cell Polarity Establishment*

  2008cited by this paper
• The cell biology of neural stem and progenitor cells and its significance for their proliferation versus differentiation during mammalian brain development.

  2008cited by this paper
• A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression.

  2008cited by this paper
• Patched 1 Regulates Hedgehog Signaling at the Primary Cilium

  2007cited by this paper
• Cilia and developmental signaling.

  2007cited by this paper
• The graded response to Sonic Hedgehog depends on cilia architecture.

  2007cited by this paper
• Evidence for a molecular link between the tuberous sclerosis complex and the Crumbs complex.

  2007influential reference
• Generation of a conditional disruption of the Tsc2 gene

  2007cited by this paper
• Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex

  2007cited by this paper
• PALS1 regulates E-cadherin trafficking in mammalian epithelial cells.

  2007cited by this paper
• Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors

  2007cited by this paper
• Patched1 Regulates Hedgehog Signaling at the Primary Cilium

  2007cited by this paper
• TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.

  2006influential reference
• Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells.

  2006cited by this paper
• Inactivation of aPKCλ results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex

  2006cited by this paper
• Inactivation of aPKCλ results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex

  2006cited by this paper
• p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.

  2006cited by this paper
• Filamin A (FLNA) is required for cell–cell contact in vascular development and cardiac morphogenesis

  2006cited by this paper
• Tuberin activates the proapoptotic molecule BAD

  2006cited by this paper
• Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells.

  2006cited by this paper
• In vivo electroporation in the embryonic mouse central nervous system

  2006cited by this paper
• [p27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex].

  2006cited by this paper
• The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface

  2006cited by this paper
• Loss of Notch Activity in the Developing Central Nervous System Leads to Increased Cell Death

  2006cited by this paper
• Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system.

  2005cited by this paper
• Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling

  2005cited by this paper
• Growing roles for the mTOR pathway.

  2005cited by this paper
• Ephrin signalling controls brain size by regulating apoptosis of neural progenitors

  2005cited by this paper
• Molecular control of cell polarity and asymmetric cell division in Drosophila neuroblasts.

  2005influential reference
• The coordinate regulation of the p53 and mTOR pathways in cells.

  2005cited by this paper
• Developmental cell biology: The cell biology of neurogenesis

  2005cited by this paper
• Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

  2004cited by this paper
• Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice.

  2004cited by this paper
• Asymmetric cell division.

  2004cited by this paper
• Loss of PALS1 expression leads to tight junction and polarity defects.

  2004cited by this paper
• Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis.

  2004cited by this paper
• Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells

  2004cited by this paper
• Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis

  2004cited by this paper
• The hyh mutation uncovers roles for αSnap in apical protein localization and control of neural cell fate

  2004cited by this paper
• Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

  2004cited by this paper
• Faculty Opinions recommendation of The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate.

  2004cited by this paper
• Radial glia serve as neuronal progenitors in all regions of the central nervous system.

  2004cited by this paper
• beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system.

  2003cited by this paper
• Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis.

  2003cited by this paper
• Neurons from radial glia: the consequences of asymmetric inheritance

  2003cited by this paper
• Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

  2003cited by this paper
• Neurons from radial glia: the consequences of asymmetric inheritance.

  2003cited by this paper
• Dividing Precursor Cells of the Embryonic Cortical Ventricular Zone Have Morphological and Molecular Characteristics of Radial Glia

  2002cited by this paper
• Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors

  2002cited by this paper
• Nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina

  2002cited by this paper
• The Carboxyl Terminus of Zona Occludens-3 Binds and Recruits a Mammalian Homologue of Discs Lost to Tight Junctions*

  2002influential reference
• Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage

  2002influential reference
• Progenitor cell maintenance requires numb and numblike during mouse neurogenesis

  2002cited by this paper
• The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost

  2002influential reference
• Developmental structure in brain evolution

  2001cited by this paper
• Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity

  2001influential reference
• Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts

  2001cited by this paper
• Neurons derived from radial glial cells establish radial units in neocortex

  2001cited by this paper
• Radial glia is a progenitor of neocortical neurons in the developing cerebral cortex.

  2001cited by this paper
• Asymmetric inheritance of radial glial fibers by cortical neurons.

  2001cited by this paper
• Molecular Cloning and Characterization of Pals, Proteins Associated with mLin-7*

  2000cited by this paper
• Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons.

  1999cited by this paper
• Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12)

  1999cited by this paper
• Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

  1999cited by this paper
• Asymmetric cell division

  1998cited by this paper
• Acute tolerance to spinally administered morphine compares mechanistically with chronically induced morphine tolerance.

  1997cited by this paper
• The Leaving or Q Fraction of the Murine Cerebral Proliferative Epithelium: A General Model of Neocortical Neuronogenesis

  1996influential reference
• Numbers, time and neocortical neuronogenesis: a general developmental and evolutionary model

  1995cited by this paper
• Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.

  1994cited by this paper
• Visual capacity in the hemianopic field following a restricted occipital ablation.

  1974cited by this paper
• VISUAL INTENSITY DISCRIMINATION IN CATS AFTER SERIAL TECTAL AND CORTICAL LESIONS.

  1965cited by this paper

• Functional Divergence of NOTCH1 and NOTCH2 in Human Cerebral Organoids Reveals Receptor-Specific Roles in Early Corticogenesis

  2025cites this paper
• Orchestrating Neural Development Through mRNA Translation Regulation

  2025cites this paper
• Shared Disease Mechanisms in Neurodevelopmental Disorders: A Cellular and Molecular Biology Perspective

  2025cites this paper
• Perturbed cell cycle phase-dependent positioning and nuclear migration of retinal progenitors along the apico-basal axis underlie global retinal disorganization in the LCA8-like mouse model.

  2024cites this paper
• PALS1-dependent modulations of mRNA profiles in MDCK II cells grown in non-confluent monolayers and three-dimensional cysts

  2024cites this paper
• Profiling metabolome of mouse embryonic cerebrospinal fluid following maternal immune activation

  2024cites this paper
• Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy

  2024influential citation
• Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations

  2024cites this paper
• Entosis implicates a new role for P53 in microcephaly pathogenesis, beyond apoptosis

  2024cites this paper
• Dissecting Gene Expression Networks in the Developing Hippocampus through the Lens of NEIL3 Depletion.

  2024cites this paper
• Copper-deficiency is associated with impairments in social behavior and oligodendrocyte development via mTOR signaling pathway

  2023cites this paper
• Neuronal atg1 Coordinates Autophagy Induction and Physiological Adaptations to Balance mTORC1 Signalling

  2023cites this paper
• Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation.

  2023cites this paper
• PATJ inhibits histone deacetylase 7 to control tight junction formation and cell polarity

  2023cites this paper
• An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis

  2023cites this paper
• Metabolomics of Mouse Embryonic CSF Following Maternal Immune Activation

  2023cites this paper
• Progenitor-Based Cell Biological Aspects of Neocortex Development and Evolution

  2022cites this paper
• Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy

  2022cites this paper
• RAB6 and dynein drive post‐Golgi apical transport to prevent neuronal progenitor delamination

  2022cites this paper
• Impact of Pals1 on Expression and Localization of Transporters Belonging to the Solute Carrier Family

  2022cites this paper
• Asymmetric Notch activity by differential inheritance of lysosomes in human neural stem cells

  2022cites this paper
• Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke

  2021cites this paper
• Primary Cilia and Centrosomes in Neocortex Development

  2021cites this paper
• Cytokinetic Abscission Regulation in Neural Stem Cells and Tissue Development

  2021cites this paper
• Stick around: Cell–Cell Adhesion Molecules during Neocortical Development

  2021cites this paper
• Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures

  2021cites this paper
• Crumbs proteins stabilize the cone mosaics of photoreceptors and improve vision in zebrafish.

  2021cites this paper
• Key Role for CRB2 in the Maintenance of Apicobasal Polarity in Retinal Pigment Epithelial Cells

  2021cites this paper
• Regulation of neuronal progenitor delamination by dynein-driven post-Golgi apical transport

  2021cites this paper
• Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice.

  2020cites this paper
• De novo variants in MPP5 cause global developmental delay and behavioral changes.

  2020cites this paper
• SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity

  2020cites this paper
• Stick around: Cell-Cell Adhesion Molecules during Neocortical Development

  2020cites this paper
• Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival

  2020cites this paper
• Molecular mechanisms of cell polarity in a range of model systems and in migrating neurons.

  2020cites this paper
• Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly

  2020cites this paper
• The sifting of visual information in the superior colliculus

  2020cites this paper
• Adherens Junctions: Guardians of Cortical Development

  2020cites this paper
• Cytokinetic and post-abscission midbody remnants are regulated during mammalian brain development

  2019cites this paper
• Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.

  2019cites this paper
• Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly.

  2019cites this paper
• Functional architecture of motion direction in the mouse superior colliculus

  2019cites this paper
• CRB2 controls primary ciliogenesis in association with PAR6α, HOOK2 and RAB8A

  2019cites this paper
• Knockdown of the ADHD Candidate Gene Diras2 in Murine Hippocampal Primary Cells

  2019cites this paper
• Transcriptome Study of Brain Nerve Impairment Induced by Pb Exposure

  2019cites this paper
• HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development.

  2019cites this paper
• ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration.

  2019cites this paper
• Linking Cell Polarity to Cortical Development and Malformations

  2019cites this paper
• The Role of Merlin and Apicobasal Polarity in Endometrial Development and Homeostasis

  2018cites this paper
• The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development

  2018cites this paper
• Cortical progenitor biology: key features mediating proliferation versus differentiation

  2018cites this paper
• The Genetics of Primary Microcephaly.

  2018cites this paper
• Regulation of spermatid polarity by the actin- and microtubule (MT)-based cytoskeletons.

  2018cites this paper
• Expression and localization of the polarity protein CRB2 in adult mouse brain: a comparison with the CRB1rd8 mutant mouse model

  2018cites this paper
• Neural blastocyst complementation enables mouse forebrain organogenesis

  2018cites this paper
• Spermatid polarity is regulated by the actin- and microtubule (MT)-based cytoskeletons

  2018cites this paper
• Neural Stem Cell Plasticity: Advantages in Therapy for the Injured Central Nervous System

  2017cites this paper
• Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.

  2017cites this paper
• Neuronal Polarity in the Embryonic Mammalian Cerebral Cortex

  2017cites this paper
• Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder

  2017cites this paper
• Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation.

  2017cites this paper
• Molecular components and polarity of radial glial cells during cerebral cortex development

  2017cites this paper
• Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia

  2017cites this paper
• Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development

  2017influential citation
• Two Stories of Neurodevelopment: Exosome-Mediated Secretion of Sonic Hedgehog and Somatic Mutation in Disorders of DNA Damage Repair

  2016cites this paper
• Vascular regulation of embryonic neurogenesis

  2016cites this paper
• Role of skeletal muscle in motor neuron development.

  2016cites this paper
• The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state

  2016cites this paper
• Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon.

  2016cites this paper
• Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.

  2016cites this paper
• The mammalian Target of Rapamycin ( mTOR ) regulates T helper cell differentiation through the selective activation of mTORC 1 and mTORC 2 signaling

  2016cites this paper
• VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation

  2016cites this paper
• Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus

  2016cites this paper
• CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium

  2015cites this paper
• The Polarity Protein Pals1 Regulates Radial Sorting of Axons

  2015influential citation
• Expression of Polarity Genes in Human Cancer

  2015cites this paper
• CB1 Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex.

  2015cites this paper
• Short report Open Access

  2015cites this paper
• Rbm8a Haploinsufficiency Disrupts Embryonic Cortical Development Resulting in Microcephaly

  2015cites this paper
• Mechanistic insights into the role of mTOR signaling in neuronal differentiation

  2015cites this paper
• Neurobiology of Disease Rbm 8 a Haploinsufficiency Disrupts Embryonic Cortical Development Resulting in Microcephaly

  2015cites this paper
• ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination

  2015cites this paper
• The Crumbs3 Complex

  2015cites this paper
• The Role and Mechanisms of Dlg5 in the Regulation of the Hippo Signaling Pathway

  2015cites this paper
• The cell biology of neurogenesis: toward an understanding of the development and evolution of the neocortex.

  2014cites this paper
• Progenitor genealogy in the developing cerebral cortex

  2014cites this paper
• The CRB1 and adherens junction complex proteins in retinal development and maintenance.

  2014influential citation
• THE APICAL POLARITY COMPLEX PROTEIN, PALS1, REGULATES CELL FATE IN THE DEVELOPMENT OF CEREBELLUM AND NEOCORTEX

  2014cites this paper
• The Dissection of Signaling Cascades in Neural Stem Cell Proliferation & GBM Promotion

  2014influential citation
• IL RUOLO DELL'HUNTINGTINA NELLA FISIOLOGIA DEL DIFFERENZIAMENTO NEURONALE E NELLA PATOLOGIA

  2014cites this paper
• Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates

  2014cites this paper
• p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex

  2014cites this paper
• The Crumbs Complex in the Retina:: From animal models to function

  2014cites this paper
• Roles of imprinted genes in neural stem cells.

  2014cites this paper
• Shaping our minds: stem and progenitor cell diversity in the mammalian neocortex.

  2013cites this paper
• Non-cell autonomous effects on integrin signalling on neurogenesis in the chick embryonic CNS

  2013cites this paper
• MPP3 Is Required for Maintenance of the Apical Junctional Complex, Neuronal Migration, and Stratification in the Developing Cortex

  2013influential citation
• Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

  2013cites this paper
• Microarray and Morphological Analysis of Early Postnatal CRB2 Mutant Retinas on a Pure C57BL/6J Genetic Background

  2013cites this paper
• The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in Development, Disease, and Therapy

  2013cites this paper