The Drosophila Polycomb Group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Development

• Publication date

  1998-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 9693151
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster.

  1998influential reference
• The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1.

  1998cited by this paper
• Interaction of Mouse Polycomb-Group (Pc-G) Proteins Enx1 and Enx2 with Eed: Indication for Separate Pc-G Complexes

  1998cited by this paper
• The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.

  1998cited by this paper
• The Distribution of Polycomb-Group Proteins During Cell Division and Development in Drosophila Embryos: Impact on Models for Silencing

  1998cited by this paper
• Characterization of Interactions between the Mammalian Polycomb-Group Proteins Enx1/EZH2 and EED Suggests the Existence of Different Mammalian Polycomb-Group Protein Complexes

  1998cited by this paper
• The Drosophila Polycomb Group Protein Psc Contacts ph and Pc through Specific Conserved Domains

  1998cited by this paper
• Changes in Chromosomal Localization of Heterochromatin-binding Proteins during the Cell Cycle in Drosophila

  1998cited by this paper
• The Drosophila esc and E(z) Proteins Are Direct Partners in Polycomb Group-Mediated Repression

  1998cited by this paper
• Maternal control of embryogenesis by MEDEA, a polycomb group gene in Arabidopsis.

  1998cited by this paper
• Molecular characterization of the

  1997influential reference
• RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor

  1997cited by this paper
• The polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes

  1997cited by this paper
• Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed.

  1997cited by this paper
• PcG complexes and chromatin silencing.

  1997cited by this paper
• A Polycomb-group gene regulates homeotic gene expression in Arabidopsis

  1997cited by this paper
• Mammalian homologues of the Polycomb‐group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S.cerevisiae telomeres

  1997influential reference
• Residues in the WD repeats of Tup1 required for interaction with alpha2

  1997cited by this paper
• A silencer is required for maintenance of transcriptional repression throughout Drosophila development.

  1997cited by this paper
• A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex.

  1997cited by this paper
• Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.

  1997cited by this paper
• Co‐localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression

  1997cited by this paper
• The Embryonic Development of Drosophila melanogaster

  1997influential reference
• The product of the murine homolog of the Drosophila extra sex combs gene displays transcriptional repressor activity

  1997cited by this paper
• Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein

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  1997cited by this paper
• Hunchback‐independent silencing of late Ubx enhancers by a Polycomb Group Response Element.

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• Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene.

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• Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression

  1996cited by this paper
• In vivo assay for protein-protein interactions using Drosophila chromosomes

  1996cited by this paper
• Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.

  1996cited by this paper
• The 2.0 Å crystal structure of a heterotrimeric G protein

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• G protein heterodimers: new structures propel new questions.

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• Positional cloning of a global regulator of anterior–posterior patterning in mice

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• Crystal structure of a G-protein beta gamma dimer at 2.1A resolution.

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• The structure of the G protein heterotrimer Giα1β1γ2

  1995cited by this paper
• Comparison of germline mosaics of genes in the Polycomb group of Drosophila melanogaster.

  1995cited by this paper
• The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.

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  1995influential reference
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  1995cited by this paper
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  1995cited by this paper
• Molecular characterisation of the Polycomblike gene of Drosophila melanogaster, a trans-acting negative regulator of homeotic gene expression.

  1994cited by this paper
• The ancient regulatory-protein family of WD-repeat proteins

  1994influential reference
• Screen for enhancers of Polycomb and Polycomblike in Drosophila melanogaster.

  1994cited by this paper
• The Trithorax-like gene encodes the Drosophila GAGA factor

  1994cited by this paper
• White gene expression, repressive chromatin domains and homeotic gene regulation in Drosophila

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• PHD - an automatic mail server for protein secondary structure prediction

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• The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb.

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• Genetic analysis of the additional sex combs locus of Drosophila melanogaster.

  1992cited by this paper
• The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

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• Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster.

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• Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila.

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• Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products.

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• The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.

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• Interactions of thePolycomb group of genes with homeotic loci ofDrosophila

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• Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

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• Regulatory elements of the bithorax complex that control expression along the anterior‐posterior axis.

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• Mutations in polycombeotic, a Drosophila polycomb-group gene, cause a wide range of maternal and zygotic phenotypes.

  1990cited by this paper
• Developmental distribution of RNA and protein products of the Drosophila α-tubulin gene family

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• Developmental distribution of RNA and protein products of the Drosophila alpha-tubulin gene family.

  1989cited by this paper
• Genes controlling essential cell-cycle functions in Drosophila melanogaster.

  1989influential reference
• Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs.

  1986cited by this paper
• Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila.

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• Maternal expression of genes that regulate the bithorax complex of Drosophila melanogaster.

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• Cloning of the extra sex combs gene of Drosophila and its identification by P‐element‐mediated gene transfer

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• Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila.

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• A group of genes controlling the spatial expression of the bithorax complex in Drosophila

  1985cited by this paper
• Role of the esc+ gene product in ensuring the selective expression of segment-specific homeotic genes in Drosophila.

  1983cited by this paper
• Early role of the esc+ gene product in the determination of segments in Drosophila.

  1982cited by this paper
• Genes involved in the activation of the bithorax complex ofDrosophila

  1981cited by this paper

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