Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Human Molecular Genetics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/HMG/DDI007PMID 15525661
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Parkinson's disease].

  2022cited by this paper
• Response to Comment on "S-Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function"

  2005cited by this paper
• The R98Q variation in DJ‐1 represents a rare polymorphism

  2004cited by this paper
• The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily.

  2004cited by this paper
• The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

  2004cited by this paper
• The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

  2004cited by this paper
• Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7)

  2004cited by this paper
• Analysis of an early‐onset Parkinson's disease cohort for DJ‐1 mutations

  2004cited by this paper
• Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells.

  2004cited by this paper
• Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications.

  2004cited by this paper
• Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

  2004cited by this paper
• Pathological properties of the Parkinson’s disease-associated protein DJ-1 in α-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick’s disease

  2004cited by this paper
• Differential Effects of Parkinson's Disease-associated Mutations on Stability and Folding of DJ-1*

  2004cited by this paper
• DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease

  2004cited by this paper
• Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson’s disease

  2004cited by this paper
• DJ‐1 colocalizes with tau inclusions: A link between parkinsonism and dementia

  2004cited by this paper
• S-Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function

  2004cited by this paper
• DJ‐1 has a role in antioxidative stress to prevent cell death

  2004cited by this paper
• Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function*

  2004influential reference
• L166P Mutant DJ-1, Causative for Recessive Parkinson's Disease, Is Degraded through the Ubiquitin-Proteasome System*

  2003cited by this paper
• The Crystal Structure of DJ-1, a Protein Related to Male Fertility and Parkinson's Disease*

  2003cited by this paper
• Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition.

  2003cited by this paper
• The role of pathogenic DJ‐1 mutations in Parkinson's disease

  2003cited by this paper
• Molecular Pathways of Neurodegeneration in Parkinson's Disease

  2003cited by this paper
• Novel Monoclonal Antibodies Demonstrate Biochemical Variation of Brain Parkin with Age*

  2003cited by this paper
• Overview of the genetics of parkinsonism.

  2003cited by this paper
• Crystal Structure of Human DJ-1, a Protein Associated with Early Onset Parkinson's Disease*

  2003cited by this paper
• Crystal structure of DJ‐1/RS and implication on familial Parkinson's disease 1

  2003cited by this paper
• The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes.

  2003cited by this paper
• The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

  2003cited by this paper
• Crystal Structures of Human DJ-1 and Escherichia coli Hsp31, Which Share an Evolutionarily Conserved Domain*

  2003cited by this paper
• The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI.

  2003cited by this paper
• Parkin Facilitates the Elimination of Expanded Polyglutamine Proteins and Leads to Preservation of Proteasome Function*

  2003cited by this paper
• Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

  2003cited by this paper
• Parkin Binds to α/β Tubulin and Increases their Ubiquitination and Degradation

  2003cited by this paper
• Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity.

  2003cited by this paper
• α-Synuclein Locus Triplication Causes Parkinson's Disease

  2003cited by this paper
• α-Synuclein Aggregation: A Link Between Mitochondrial Defects and Parkinson's Disease?

  2003cited by this paper
• The 1.1-Å resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

  2003cited by this paper
• A missense mutation (L166P) in DJ‐1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo‐oligomerization

  2003influential reference
• Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation.

  2003cited by this paper
• Rare genetic mutations shed light on the pathogenesis of Parkinson disease.

  2003cited by this paper
• Early‐onset Parkinson's disease caused by a compound heterozygous DJ‐1 mutation

  2003cited by this paper
• alpha-Synuclein locus triplication causes Parkinson's disease.

  2003cited by this paper
• Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

  2002cited by this paper
• The Herbicide Paraquat Causes Up-regulation and Aggregation of α-Synuclein in Mice

  2002cited by this paper
• Proteasomal degradation of tau protein

  2002cited by this paper
• The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein.

  2002cited by this paper
• An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage

  2002cited by this paper
• Mechanistic Approaches to Parkinson's Disease Pathogenesis

  2002cited by this paper
• CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.

  2002cited by this paper
• An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.

  2001cited by this paper
• Putative Transmembrane Polypeptide , which Can Lead to Endoplasmic Reticulum Stress , Is a Substrate of Parkin

  2001cited by this paper
• The parkin gene and its phenotype. Italian PD Genetics Study Group, French PD Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease.

  2001cited by this paper
• α‐Synuclein metabolism and aggregation is linked to ubiquitin‐independent degradation by the proteasome

  2001cited by this paper
• Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

  2001cited by this paper
• Parkin and Parkinson's disease

  2001cited by this paper
• The parkin gene and its phenotype

  2001cited by this paper
• Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat

  2001cited by this paper
• DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin

  2001cited by this paper
• Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease

  2001cited by this paper
• Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

  2000cited by this paper
• Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.

  2000cited by this paper
• Oxidative stress and genetics in the pathogenesis of Parkinson's disease.

  2000cited by this paper
• Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity*

  2000cited by this paper
• Chronic systemic pesticide exposure reproduces features of Parkinson's disease

  2000cited by this paper
• Immunohistochemical and subcellular localization of parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients

  1999cited by this paper
• Parkinson's disease. Second of two parts.

  1998cited by this paper
• Molecular genetic analysis of a novel Parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: Evidence for variable homozygous deletions in the Parkin gene in affected individuals

  1998cited by this paper
• AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

  1998cited by this paper
• Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.

  1998cited by this paper
• Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

  1998cited by this paper
• Parkinson's disease. First of two parts.

  1998cited by this paper
• alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.

  1998cited by this paper
• α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies

  1998cited by this paper
• First of two parts

  1997cited by this paper
• Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.

  1997cited by this paper

• Redox modulatory role of DJ-1 in Parkinson’s disease

  2025cites this paper
• Neuroprotective role and mechanistic insights of DJ-1 dimerization in Parkinson’s disease

  2025cites this paper
• DJ-1: Potential target for treatment of myocardial ischemia-reperfusion injury.

  2024cites this paper
• Signaling Pathways Concerning Mitochondrial Dysfunction: Implications in Neurodegeneration and Possible Molecular Targets

  2024cites this paper
• Therapeutic Implications and Regulations of Protein Post-translational Modifications in Parkinsons Disease

  2024influential citation
• Exploring the Role of Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease

  2024cites this paper
• Recent progress and challenges in the application of molecularly imprinted polymers for early-stage screening of neurodegenerative diseases-related protein biomarkers

  2023cites this paper
• Peculiarities of some candidate gene polymorphisms in Parkinson’s disease

  2023influential citation
• A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson’s disease

  2023cites this paper
• Progressive Motor and Non-Motor Symptoms in Park7 Knockout Zebrafish

  2023cites this paper
• C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain

  2023cites this paper
• Autophagy in Parkinson’s Disease

  2023cites this paper
• PARK7/DJ-1 in microglia: implications in Parkinson’s disease and relevance as a therapeutic target

  2023influential citation
• Robustness of the Krebs Cycle under Physiological Conditions and in Cancer: New Clues for Evaluating Metabolism-Modifying Drug Therapies

  2022cites this paper
• Modeling Parkinson's disease‐related symptoms in alpha‐synuclein overexpressing mice

  2022cites this paper
• Pathogenetic factors in Parkinson disease and novel experimental therapies

  2022cites this paper
• Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies

  2021influential citation
• DJ-1 in neurodegenerative diseases: pathogenesis and clinical application.

  2021cites this paper
• Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models

  2021cites this paper
• A Potential Innovative Therapy for Parkinson’s Disease: Selective Destruction of the Pathological Assemblies of Alpha-Synuclein

  2021cites this paper
• Single-synapse analyses of Alzheimer’s disease implicate pathologic tau, DJ1, CD47, and ApoE

  2021cites this paper
• DJ-1 and Parkinson's disease

  2021cites this paper
• Genes Implicated in Familial Parkinson’s Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage

  2021cites this paper
• PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia

  2021cites this paper
• DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits.

  2020cites this paper
• Mitophagy and Its Contribution to Metabolic and Aging-Associated Disorders

  2020cites this paper
• The DJ-1 gene and protein: links with Parkinson's disease

  2020cites this paper
• The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis

  2020cites this paper
• Keeping α-Synuclein at Bay: A More Active Role of Molecular Chaperones in Preventing Mitochondrial Interactions and Transition to Pathological States?

  2020cites this paper
• Chaperones and Proteostasis: Role in Parkinson’s Disease

  2020cites this paper
• C Terminus of DJ-1 Determines Its Homodimerization, Deglycation Activity and Suppression of Ferroptosis

  2020cites this paper
• The multi‐faceted role of mitochondria in the pathology of Parkinson’s disease

  2020cites this paper
• "Analysis of the Associated Mutations of DJ-1 Gene to Parkinson’s Patients in Vietnam"

  2020cites this paper
• Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases

  2019cites this paper
• Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson’s Disease

  2019cites this paper
• Pathology, Prevention and Therapeutics of Neurodegenerative Disease

  2019cites this paper
• Mutations in Parkinson's Disease Associated Protein DJ-1 Alter the Energetics of DJ-1 Dimerization

  2019cites this paper
• Dopamine β Hydroxylase (DBH) is a potential modifier gene associated with Parkinson's disease in Eastern India.

  2019cites this paper
• PARK2 and PARK7 Gene Polymorphisms as Risk Factors Associated with Serum Element Concentrations and Clinical Symptoms of Parkinson’s Disease

  2019cites this paper
• Genetic risk factors for movement disorders in Finland

  2019cites this paper
• Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease

  2019cites this paper
• Mesenchymal Stem Cells-derived Exosomes: A New Possible Therapeutic Strategy for Parkinson’s Disease?

  2019cites this paper
• The deglycase activity of DJ‐1 mitigates &agr;‐synuclein glycation and aggregation in dopaminergic cells: Role of oxidative stress mediated downregulation of DJ‐1 in Parkinson's disease

  2019cites this paper
• The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis

  2019cites this paper
• Inhibitory effect of tartrate against phosphate-induced DJ-1 aggregation.

  2018cites this paper
• Dopamine and Early Onset Parkinson’s Disease

  2018cites this paper
• Molecular Mechanisms of Neurodegeneration: Insights from the Studies of Genetic Model of Parkinson’s Disease

  2018cites this paper
• Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease.

  2018cites this paper
• Chapter 2 Dopamine and Early Onset Parkinson ’ s Disease

  2018cites this paper
• DJ-1 based peptide, ND-13, promote functional recovery in mouse model of focal ischemic injury

  2018cites this paper
• Dopamine and Early Onset Parkinson’s Disease Dopamine and Early Onset Parkinson ’ s Disease

  2018cites this paper
• 2 Aetiology and Pathogenesis of Parkinson ’ s Disease

  2018cites this paper
• PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5

  2018influential citation
• Parkin and mitophagy in cancer

  2017cites this paper
• DJ-1, a Parkinson's disease related protein, aggregates under denaturing conditions and co-aggregates with α-synuclein through hydrophobic interaction.

  2017cites this paper
• microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches

  2017cites this paper
• Examining Parkinson’s Disease Linked DJ-1 and its Interaction with Autophagy Related ATG5 and ATG12 & Understanding PINK1’s Functional Interaction with Mitochondrial m-AAA Protease AFG3L2

  2017cites this paper
• Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models.

  2017cites this paper
• Expression of DJ-1 in Neurodegenerative Disorders.

  2017cites this paper
• BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage

  2017cites this paper
• Development of a small alpha-synuclein-knockdown peptide as a potential therapy for Parkinson’s disease

  2016cites this paper
• Transcription Modulation of Mitochondrial Function and Related Pathways as a Therapeutic Opportunity in Parkinson’s Disease

  2016cites this paper
• Neuronal oscillations: A physiological correlate for targeting mitochondrial dysfunction in neurodegenerative diseases?

  2016cites this paper
• Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer’s Disease

  2016cites this paper
• Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7

  2016cites this paper
• Identification of parkin interactions: implications for Parkinson’s disease

  2015cites this paper
• Laboratory-Scale Automated Polymer Solar Cell Fabrication via Slot Die Coating

  2015cites this paper
• SG2NA enhances cancer cell survival by stabilizing DJ-1 and thus activating Akt.

  2015cites this paper
• Modeling Neuronal Pathology in Yeast: Insights into the Molecular Basis of Parkinson’s Disease

  2015cites this paper
• Inhibitors of leucine-rich repeat kinase 2 (LRRK2): progress and promise for the treatment of Parkinson's disease.

  2015cites this paper
• 6-OHDA-Induced Changes in Parkinson`s Disease-Related Gene Expression are not Affected by the Overexpression of PGAM5 in In Vitro Differentiated Embryonic Mesencephalic Cells

  2015cites this paper
• Evidence for a common biological pathway linking three Parkinson's disease‐causing genes: parkin, PINK1 and DJ‐1

  2015cites this paper
• Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection

  2015cites this paper
• Therapeutic strategies in Parkinson's disease: what we have learned from animal models

  2015cites this paper
• Activation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1.

  2015cites this paper
• Parkinson’s Disease in Saudi Patients: A Genetic Study

  2015cites this paper
• Identification of the underlying mechanism of the c.192G>C mutation in the DJ-1 gene and functional characterisation in patient-based cellular models of Parkinson’s disease ex vivo

  2015cites this paper
• Myricitrin alleviates MPP⁺-induced mitochondrial dysfunction in a DJ-1-dependent manner in SN4741 cells.

  2015cites this paper
• Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.

  2014cites this paper
• Deuterium Protection of Polyunsaturated Fatty Acids against Lipid Peroxidation: A Novel Approach to Mitigating Mitochondrial Neurological Diseases

  2014cites this paper
• Mechanistic Studies of the E3 Ubiquitin Ligases SCF(Fbx4) and Parkin

  2014cites this paper
• Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

  2014cites this paper
• The paths to neurodegeneration in genetic Parkinson's disease.

  2014cites this paper
• Genetic mutations in early‐onset Parkinson's disease Mexican patients: Molecular testing implications

  2014cites this paper
• PRAK Interacts with DJ-1 and Prevents Oxidative Stress-Induced Cell Death

  2014cites this paper
• Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease.

  2014cites this paper
• RBR E3 ubiquitin ligases: new structures, new insights, new questions

  2014cites this paper
• Effect of DJ-1 overexpression on the proliferation, apoptosis, invasion and migration of laryngeal squamous cell carcinoma SNU-46 cells through PI3K/AKT/mTOR.

  2014cites this paper
• [The causative gene of Parkinsonism and its medical treatment strategy].

  2014cites this paper
• Protects against Metal-induced Parkinson Disease Protein DJ-1 Binds Molecular Bases of Disease :

  2013influential citation
• Parkinson Disease Protein DJ-1 Binds Metals and Protects against Metal-induced Cytotoxicity*

  2013influential citation
• A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson’s Research

  2013cites this paper
• Advances in the mechanisms of Parkinson's disease.

  2013cites this paper
• Cellular function and toxicity of the Parkinson’s disease-related genes α-synuclein and catp-6 in C. elegans

  2013cites this paper
• In Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells*

  2013cites this paper
• Evidence of oxidative stress in young and aged DJ‐1‐deficient mice

  2013cites this paper
• Mitochondrial dysfunction and oxidative stress in Parkinson's disease.

  2013cites this paper
• ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1

  2013influential citation
• An emerging role of PARK2 in cancer

  2013cites this paper
• Evaluation of a-Synuclein Degradation Pathways in a Budding Yeast Model

  2013cites this paper