Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Development

• Publication date

  2004-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dev.01200PMID 15201220
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Development of the kidney.

  2014cited by this paper
• 8 The Development of the Kidney

  2008cited by this paper
• Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development

  2003cited by this paper
• The kidney: from normal development to congenital disease

  2003cited by this paper
• The Receptor Tyrosine Kinase Regulator Sprouty1 Is a Target of the Tumor Suppressor WT1 and Important for Kidney Development*

  2003cited by this paper
• hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.

  2003cited by this paper
• Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

  2002cited by this paper
• Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinase.

  2002influential reference
• The GDNF family: Signalling, biological functions and therapeutic value

  2002cited by this paper
• Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

  2002cited by this paper
• Wnt‐6 is expressed in the ureter bud and induces kidney tubule development in vitro

  2002cited by this paper
• mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins.

  2002cited by this paper
• Organogenesis: Coordinating early kidney development: lessons from gene targeting

  2002cited by this paper
• Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene.

  2001cited by this paper
• sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish

  2001cited by this paper
• Characterization of Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives.

  2001cited by this paper
• sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish.

  2001cited by this paper
• Expression of Sprouty genes 1, 2 and 4 during mouse organogenesis.

  2001cited by this paper
• Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis.

  2001cited by this paper
• Vitamin A controls epithelial/mesenchymal interactions through Ret expression

  2001cited by this paper
• Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis.

  2001influential reference
• Induction of ureter branching as a response to Wnt‐2b signaling during early kidney organogenesis

  2001cited by this paper
• Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney.

  2001cited by this paper
• Induced repatterning of type XVIII collagen expression in ureter bud from kidney to lung type: association with sonic hedgehog and ectopic surfactant protein C.

  2001cited by this paper
• Kidney morphogenesis: cellular and molecular regulation.

  2000cited by this paper
• BMP‐4 affects the differentiation of metanephric mesenchyme and reveals an early anterior‐posterior axis of the embryonic kidney

  2000cited by this paper
• Expression of FGFR1, FGFR2 and FGFR3 during early neural development in the chick embryo.

  2000cited by this paper
• Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter.

  2000cited by this paper
• Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene

  1999influential reference
• Sprouty, an intracellular inhibitor of Ras signaling.

  1999cited by this paper
• Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.

  1999cited by this paper
• Transient effect of epidermal growth factor on the motility of an immortalized mammary epithelial cell line

  1999influential reference
• FGF-7 modulates ureteric bud growth and nephron number in the developing kidney.

  1999cited by this paper
• Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme.

  1999cited by this paper
• Wnts as kidney tubule inducing factors.

  1999cited by this paper
• Expression of Fetal Kidney Growth Factors in a Kidney Tumor Line: Role of FGF2 in Kidney Development

  1998cited by this paper
• Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney.

  1998cited by this paper
• Impaired cerebral cortex development and blood pressure regulation in FGF‐2‐deficient mice

  1998cited by this paper
• sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.

  1998cited by this paper
• Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium.

  1997influential reference
• Ureteric bud cells secrete multiple factors, including bFGF, which rescue renal progenitors from apoptosis.

  1997cited by this paper
• Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4.

  1997cited by this paper
• Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung.

  1997influential reference
• GDNF induces branching and increased cell proliferation in the ureter of the mouse.

  1997influential reference
• Expression of fibroblast growth factors and their receptors in rat glomeruli.

  1997cited by this paper
• Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos

  1997cited by this paper
• Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips.

  1996cited by this paper
• GDNF is required for kidney development and enteric innervation.

  1996cited by this paper
• GDNF signalling through the Ret receptor tyrosine kinase

  1996cited by this paper
• Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.

  1996influential reference
• Fibroblast growth factor signalling in the hair growth cycle: Expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle

  1996cited by this paper
• Development

  1996cited by this paper
• Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

  1996influential reference
• Renal and neuronal abnormalities in mice lacking GDNF

  1996influential reference
• Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis.

  1996cited by this paper
• Expression and Biological Activity of Mouse Fibroblast Growth Factor-9 (*)

  1996cited by this paper
• Pax-2 controls multiple steps of urogenital development.

  1995cited by this paper
• Repression of Pax-2 by WT1 during normal kidney development.

  1995influential reference
• The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo.

  1995influential reference
• Bromodeoxyuridine: a diagnostic tool in biology and medicine, Part II: Oncology, chemotherapy and carcinogenesis

  1995cited by this paper
• Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal‐epithelial interactions

  1995cited by this paper
• Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

  1995cited by this paper
• HNF-3 beta as a regulator of floor plate development.

  1994influential reference
• FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions.

  1994cited by this paper
• Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas.

  1994cited by this paper
• HNF-3β as a regulator of floor plate development

  1994influential reference
• Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

  1994cited by this paper
• Nephron underdosing: a programmed cause of chronic renal allograft failure.

  1993cited by this paper
• Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development.

  1993cited by this paper
• WT-1 is required for early kidney development.

  1993influential reference
• Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.

  1993influential reference
• Total numbers of glomeruli and individual glomerular cell types in the normal rat kidney

  1992cited by this paper
• Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system.

  1990influential reference
• Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development.

  1989influential reference
• Microinjecting DNA into mouse ova to study DNA replication and gene expression and to produce transgenic animals.

  1988cited by this paper
• Organogenesis of the kidney

  1987influential reference
• Manipulating the mouse embryo: A laboratory manual

  1986cited by this paper
• Formation of basement membranes in the embryonic kidney: an immunohistological study

  1981cited by this paper

• A Novel lncRNA MSTRG.16386.1 as ceRNA Promotes Kidney Injury Induced by Deep Hypothermic Circulatory Arrest via Mediating miR‐466b‐5p/Spry2 Axis

  2026cites this paper
• Self-organization, error-correction and homeorhesis in renal development.

  2025cites this paper
• The genetics and pathogenesis of CAKUT

  2023cites this paper
• Nephron progenitors rhythmically alternate between renewal and differentiation phases that synchronize with kidney branching morphogenesis

  2023cites this paper
• Temporally and Spatially Regulated Collagen XVIII Isoforms Are Involved in Ureteric Tree Development Via the TSP1-like Domain.

  2023cites this paper
• Effect of Hypoxia on Branching Characteristics and Cell Subpopulations during Kidney Organ Culture

  2022cites this paper
• Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor

  2021cites this paper
• Pre-natal Development of the Kidneys and Urinary Tract

  2021cites this paper
• Mouse Models of Congenital Kidney Anomalies.

  2020cites this paper
• https://researchopenworld.com/analysis-of-copy-number-variations-and-knockdown-in-zebrafish-pronephros-identifies-novel-candidate-cakut-genes/#

  2020cites this paper
• Biallelic Pathogenic GFRA1 Variants Cause Autosomal Recessive Bilateral Renal Agenesis.

  2020cites this paper
• Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.

  2020cites this paper
• Nephron progenitor maintenance is controlled through FGFs and Sprouty1 Interaction

  2020cites this paper
• MAPK/ERK Signaling in Regulation of Renal Differentiation

  2019cites this paper
• Perfusion culture maintained with an air-liquid interface to stimulate epithelial cell organization in renal organoids in vitro

  2019cites this paper
• Cellular and molecular determinants of normal and abnormal kidney development

  2019cites this paper
• Developmental pathology of congenital kidney and urinary tract anomalies

  2018cites this paper
• Regulation of Renal Differentiation by Trophic Factors

  2018cites this paper
• Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.

  2017cites this paper
• 4 – Regulation of Embryogenesis

  2017cites this paper
• Renal Branching Morphogenesis

  2017cites this paper
• Chapter 8 MIG-6 and SPRY 2 in the Regulation of Receptor Tyrosine Kinase Signaling : Balancing Act via Negative Feedback Loops

  2017cites this paper
• Feedback regulation of RTK signaling in development.

  2017cites this paper
• Mechanisms of fibroblast growth factor signaling in the ovarian follicle.

  2016cites this paper
• Fibrosis in the lens. Sprouty regulation of TGFβ-signaling prevents lens EMT leading to cataract.

  2016cites this paper
• Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling.

  2016cites this paper
• Embryonic Development of the Kidney

  2016cites this paper
• Structural Development of the Kidney

  2016cites this paper
• Frizzled Receptors in Development and Disease.

  2016cites this paper
• Developmental Roles of the Stroma

  2016cites this paper
• Sprouty2 Protein Regulates Hypoxia-inducible Factor-α (HIFα) Protein Levels and Transcription of HIFα-responsive Genes*

  2016cites this paper
• Epithelial Wnt/βcatenin signalling is essential for epididymal coiling.

  2016cites this paper
• Sprouty2 mediated tuning of signalling is essential for somite myogenesis

  2015cites this paper
• Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation

  2015cites this paper
• Sprouty gain of function disrupts lens cellular processes and growth by restricting RTK signaling.

  2015cites this paper
• The ureteric bud epithelium: Morphogenesis and roles in metanephric kidney patterning

  2015cites this paper
• Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.

  2014cites this paper
• Renal branching morphogenesis: morphogenetic and signaling mechanisms.

  2014cites this paper
• Development of the Kidney and Lower Urinary Tract

  2014cites this paper
• Four miniature kidneys: supernumerary kidney and multiple organ system anomalies.

  2014cites this paper
• Cell fates in nephrogenesis and spermatogenesis

  2014cites this paper
• The developing story of Sprouty and cancer

  2014cites this paper
• Kif3a Controls Murine Nephron Number Via GLI3 Repressor, Cell Survival, and Gene Expression in a Lineage-Specific Manner

  2013cites this paper
• GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling

  2013influential citation
• PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.

  2013cites this paper
• MIG-6 and SPRY2 in the Regulation of Receptor Tyrosine Kinase Signaling: Balancing Act via Negative Feedback Loops

  2013cites this paper
• Expression and Functional Role of Sprouty-2 in Breast Morphogenesis

  2013cites this paper
• Stromal Expression of Decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in Developing Prostate and Decreased Levels of Decorin in Prostate Cancer

  2012cites this paper
• Sprouty/FGF signaling regulates the proximal-distal feather morphology and the size of dermal papillae.

  2012cites this paper
• Control of nephrogenesis by Wnt4 signaling : mechanisms of gene regulation and targeting of specific lineage cells by tissue engineering tools

  2012cites this paper
• Novel Genes in Mesodermal Development

  2012influential citation
• Role of FGFs/FGFRs in skeletal development and bone regeneration

  2012cites this paper
• Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney

  2011cites this paper
• A Secreted BMP Antagonist, Cer1, Fine Tunes the Spatial Organization of the Ureteric Bud Tree during Mouse Kidney Development

  2011cites this paper
• Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.

  2011cites this paper
• WNTs in the Neonatal Mouse Uterus: Potential Regulation of Endometrial Gland Development1

  2011cites this paper
• Non‐canonical wnt signals antagonize and canonical wnt signals promote cell proliferation in early kidney development

  2011cites this paper
• Plexin B2 in mouse and zebrafish development

  2011cites this paper
• Dact2 is expressed in the developing ureteric bud/collecting duct system of the kidney and controls morphogenetic behavior of collecting duct cells.

  2010cites this paper
• Dact 2 is expressed in the developing ureteric bud / collecting duct system of the kidney and controls morphogenetic behavior of collecting duct cells

  2010cites this paper
• Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development

  2010influential citation
• Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression.

  2010cites this paper
• Sprouty4 regulates the balance between pluripotency and trophectoderm differentiation in mouse embryonic stem cells

  2010cites this paper
• Sprouty2 Interacts with Protein Kinase Cδ and Disrupts Phosphorylation of Protein Kinase D1*

  2009cites this paper
• Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis

  2009cites this paper
• Three-dimensional culture models of mammary gland

  2009cites this paper
• Suppression Subtractive Hybridization Analysis of Gene Expression during Late Kidney Development Identifies the Developmentally Regulated Gene rPEA3

  2009cites this paper
• The many faces of RET dysfunction in kidney

  2009cites this paper
• Cell and molecular biology of kidney development.

  2009cites this paper
• Xenopus Wnt11b is identified as a potential pronephric inducer

  2009cites this paper
• Structure-Function Studies of GDNF Family Ligand-RET signalling

  2009cites this paper
• Genetic and developmental basis for urinary tract obstruction

  2009cites this paper
• Intermolecular Interactions of Sprouty Proteins and Their Implications in Development and Disease

  2009cites this paper
• A Novel Role of Sprouty 2 in Regulating Cellular Apoptosis*

  2008cites this paper
• MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths.

  2008influential citation
• Patterning Mechanisms of Branched Organs

  2008cites this paper
• Gata3 Acts Downstream of β-Catenin Signaling to Prevent Ectopic Metanephric Kidney Induction

  2008cites this paper
• Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development.

  2008cites this paper
• Gene Expression in mESC Deficient in FGFR Signalling and the Identification of the Novel Gene Ened

  2008cites this paper
• Semaphorin3a inhibits ureteric bud branching morphogenesis.

  2008cites this paper
• CHAPTER 6 – Structural and Functional Development of the Kidney

  2008cites this paper
• Glial cell-derived neurotrophic factor independent ureteric bud outgrowth from the Wolffian duct.

  2007cites this paper
• Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF‐β1 signaling and EGF as well as FGF receptor tyrosine kinase‐ERK pathways in mesenchymal cells

  2007cites this paper
• Down-Regulation of Sprouty 2 in Non – Small Cell Lung Cancer Contributes to Tumor Malignancy via Extracellular Signal-Regulated Kinase Pathway-Dependent and-Independent Mechanisms

  2007cites this paper
• Down-Regulation of Sprouty2 in Non–Small Cell Lung Cancer Contributes to Tumor Malignancy via Extracellular Signal-Regulated Kinase Pathway-Dependent and -Independent Mechanisms

  2007cites this paper
• Petri Itäranta WNT 4 AND WNT 6 SECRETED GROWTH AND DIFFERENTIATION FACTORS AND NEURAL CREST IN THE CONTROL OF KIDNEY DEVELOPMENT

  2007cites this paper
• Kidney Induction: Control by Notch, Wnt and GDNF/Ret signalling

  2007cites this paper
• Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases

  2007cites this paper
• Renal abnormalities and their developmental origin

  2007cites this paper
• Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

  2007cites this paper
• Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival

  2007cites this paper
• Down the tube of obstructive nephropathies: the importance of tissue interactions during ureter development.

  2007cites this paper
• Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma.

  2006cites this paper
• Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.

  2006cites this paper
• Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis.

  2006cites this paper
• Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney.

  2006cites this paper
• Sprouty and cancer: the first terms report.

  2006cites this paper
• Specific roles of Wnt11 and Fgf8 for palatogenesis in mouse embryo

  2006cites this paper
• Critical and distinct roles for key RET tyrosine docking sites in renal development.

  2006cites this paper
• Renal branching morphogenesis: concepts, questions, and recent advances.

  2006cites this paper