Inhibitors of 17 beta-hydroxysteroid dehydrogenases.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Current Medicinal Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 12570693
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of Cadmium on 17ß‐Hydroxysteroid Dehydrogenase in Toad Testis

  2009cited by this paper
• Affinity labeling of arginyl residues at the catalytic region of estradiol 17 beta-dehydrogenase from human placenta by 16-oxoestrone.

  2005cited by this paper
• Synthesis and optimization of a new family of type 3 17 beta-hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry.

  2002cited by this paper
• A multidetachable sulfamate linker successfully used in a solid-phase strategy to generate libraries of sulfamate and phenol derivatives.

  2002cited by this paper
• Some Coumarins and Triphenylethene Derivatives as Inhibitors of Human Testes Microsomal 17β-hydroxysteroid Dehydrogenase (17β-HSD Type 3): Further Studies with Tamoxifen on the Rat Testes Microsomal Enzyme

  2002cited by this paper
• Androsterone Derivatives Substituted at Position 16: Chemical Synthesis, Inhibition of Type 3 17β-hydroxysteroid Dehydrogenase, Binding Affinity for Steroid Receptors and Proliferative/antiproliferative Activity on Shionogi (AR +) Cells

  2002cited by this paper
• Effect of nickel sulfate on testicular steroidogenesis in rats during protein restriction.

  2002cited by this paper
• Chemical synthesis of 16beta-propylaminoacyl derivatives of estradiol and their inhibitory potency on type 1 17beta-hydroxysteroid dehydrogenase and binding affinity on steroid receptors.

  2001cited by this paper
• Structure-based focusing using pharmacophores derived from the active site of 17beta-hydroxysteroid dehydrogenase.

  2001cited by this paper
• A guide to 17beta-hydroxysteroid dehydrogenases.

  2001cited by this paper
• Type 5 17beta-hydroxysteroid dehydrogenase: its role in the formation of androgens in women.

  2001cited by this paper
• Analysis and characteristics of multiple types of human 17beta-hydroxysteroid dehydrogenase.

  2001cited by this paper
• Inhibitors of human and rat testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD) as potential agents for prostatic cancer.

  2001cited by this paper
• Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities.

  2001cited by this paper
• Evaluation of 7-Hydroxy-Flavones as Inhibitors of Oestrone and Oestradiol Biosynthesis

  2001cited by this paper
• The selective estrogen enzyme modulator (SEEM) in breast cancer.

  2001cited by this paper
• Inhibitors of type II 17beta-hydroxysteroid dehydrogenase.

  2001cited by this paper
• Parallel solid-phase synthesis of 3beta-peptido-3alpha-hydroxy-5alpha-androstan-17-one derivatives for inhibition of type 3 17beta-hydroxysteroid dehydrogenase.

  2001cited by this paper
• Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).

  2001cited by this paper
• Inhibition of Rat Testicular Androgenesis by a Polychlorinated Biphenyl Mixture Aroclor 12481

  2000cited by this paper
• Inhibition of testosterone secretion by S-petasin in rat testicular interstitial cells.

  2000cited by this paper
• Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease.

  2000cited by this paper
• Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain.

  2000cited by this paper
• N-Butyl-N-methyl-11-(3'-hydroxy-21', 17'-carbolactone-19'-nor-17'alpha-pregna-1',3', 5'(10')-trien-7'alpha-yl)-undecanamide: an inhibitor of type 2 17beta-hydroxysteroid dehydrogenase that does not have oestrogenic or androgenic activity.

  2000cited by this paper
• Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells.

  2000cited by this paper
• 17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes.

  1999cited by this paper
• Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase.

  1999cited by this paper
• Effects of Org OD14 (Livial) and its metabolites on 17 beta-hydroxysteroid dehydrogenase activity in hormone-dependent MCF-7 and T-47D breast cancer cells.

  1999cited by this paper
• Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry.

  1999cited by this paper
• Characterization of molecular and catalytic properties of intact and truncated human 17beta-hydroxysteroid dehydrogenase type 2 enzymes: intracellular localization of the wild-type enzyme in the endoplasmic reticulum.

  1999cited by this paper
• Reduction of serum testosterone in men by licorice.

  1999cited by this paper
• Effect of Medrogestone on 17beta-hydroxysteroid dehydrogenase activity in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines.

  1999cited by this paper
• Two non-reactive ternary complexes of estrogenic 17beta-hydroxysteroid dehydrogenase: crystallization and preliminary structural analysis.

  1999cited by this paper
• Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+.

  1999cited by this paper
• Spironolactone-related inhibitors of type II 17beta-hydroxysteroid dehydrogenase: chemical synthesis, receptor binding affinities, and proliferative/antiproliferative activities.

  1999cited by this paper
• Crystallization and preliminary crystal structure of the complex of 17β-hydroxysteroid dehydrogenase with a dual-site inhibitor

  1999cited by this paper
• 17beta-hydroxysteroid dehydrogenases: physiological roles in health and disease.

  1998cited by this paper
• Unusual Charge Stabilization of NADP+ in 17β-Hydroxysteroid Dehydrogenase*

  1998cited by this paper
• A 6beta-(thiaheptanamide) derivative of estradiol as inhibitor of 17beta-hydroxysteroid dehydrogenase type 1.

  1998cited by this paper
• Inhibition of 17beta-hydroxysteroid oxidoreductase by flavonoids in breast and prostate cancer cells.

  1998cited by this paper
• Overview of a rational approach to design type I 17beta-hydroxysteroid dehydrogenase inhibitors without estrogenic activity: chemical synthesis and biological evaluation.

  1998cited by this paper
• Oxidative activity of the type 2 isozyme of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) predominates in human sebaceous glands.

  1998cited by this paper
• Effect of tibolone (Org OD14) and its metabolites on estrone sulphatase activity in MCF-7 and T-47D mammary cancer cells.

  1997cited by this paper
• Intracellular regulation of 17 beta-hydroxysteroid dehydrogenase type 2 catalytic activity in A431 cells.

  1997cited by this paper
• Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution.

  1997cited by this paper
• The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology.

  1997cited by this paper
• The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.

  1996cited by this paper
• Synthesis and evaluation of estradiol derivatives with 16 alpha-(bromoalkylamide), 16 alpha-(bromoalkyl) or 16 alpha-(bromoalkynyl) side chain as inhibitors of 17 beta-hydroxysteroid dehydrogenase type 1 without estrogenic activity.

  1996cited by this paper
• Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol.

  1996cited by this paper
• Effect of nomegestrol acetate on estrone-sulfatase and 17beta-hydroxysteroid dehydrogenase activities in human breast cancer cells.

  1996cited by this paper
• Steroidal spiro-gamma-lactones that inhibit 17 beta-hydroxysteroid dehydrogenase activity in human placental microsomes.

  1995cited by this paper
• Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition.

  1995cited by this paper
• Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution.

  1995cited by this paper
• Estrogen-Specific 17β-Hydroxysteroid Oxidoreductase Type 1 (E.C. 1.1.1.62) as a Possible Target for the Action of Phytoestrogens

  1995cited by this paper
• Synthesis and biological activities of thioether derivatives related to the antiestrogens tamoxifen and ICI 164384.

  1995cited by this paper
• Substrate Specificity, Gene Structure, and Tissue-specific Distribution of Multiple Human 3α-Hydroxysteroid Dehydrogenases (*)

  1995cited by this paper
• Synthesis of 16-(bromoalkyl)-estradiols having inhibitory effect on human placental estradiol 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD type 1).

  1995cited by this paper
• N-butyl, N-methyl, 11-[3',17' beta-(dihydroxy)-1',3',5'(10')-estratrien-16' alpha-yl]-9(R/S)-bromo undecanamide: synthesis and 17 beta-HSD inhibiting, estrogenic and antiestrogenic activities.

  1994cited by this paper
• The short-chain alcohol dehydrogenase superfamily: variations on a common theme.

  1994cited by this paper
• Inhibition of microsomal 17 beta-hydroxysteroid oxidoreduction activities in rat liver by all-trans-, 9-cis- and 13-cis-retinoic acid.

  1994cited by this paper
• In vitro studies on the inhibition of testosterone synthesis in the human testis by atamestane.

  1993cited by this paper
• Crystallization and preliminary X-ray diffraction analysis of the complex of human placental 17 beta-hydroxysteroid dehydrogenase with NADP+.

  1993cited by this paper
• Novel compounds inhibit estrogen formation and action.

  1992cited by this paper
• Licorice-induced hypermineralocorticoidism.

  1991cited by this paper
• Hydrogen bonding in steroidogenesis: studies on new heterocyclic analogs of estrone that inhibit human estradiol 17 beta-dehydrogenase.

  1991cited by this paper
• Trifluoromethylacetylenic alcohols as affinity labels: inactivation of estradiol dehydrogenase by a trifluoromethylacetylenic secostradiol.

  1990cited by this paper
• Solid-state NMR observation of cysteine and lysine Michael adducts of inactivated estradiol dehydrogenase.

  1988cited by this paper
• Human placental estradiol 17 beta-dehydrogenase: evidence for inverted substrate orientation ("wrong-way" binding) at the active site.

  1988cited by this paper
• Enhancement of estradiol potency by the 17 beta-hydroxysteroid dehydrogenase inhibitor, 16-methylene E2 in vivo.

  1988cited by this paper
• Inhibitory effect of glycyrrhetinic acid on testosterone production in rat gonads.

  1988cited by this paper
• Inhibition of 3(17)beta-hydroxysteroid dehydrogenase from Pseudomonas testosteroni by steroidal A ring fused pyrazoles.

  1987cited by this paper
• The affinity alkylators, 11 alpha-bromoacetoxyprogesterone and estrone 3-bromoacetate, modify a common histidyl residue in the active site of human placental 17 beta,20 alpha-hydroxysteroid dehydrogenase.

  1986cited by this paper
• Human placental estradiol 17 beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region.

  1986cited by this paper
• Mechanism-based inactivation of 17 beta,20 alpha-hydroxysteroid dehydrogenase by an acetylenic secoestradiol.

  1986cited by this paper
• 17 beta-hydroxysteroid and 20 alpha-hydroxysteroid dehydrogenase activities of human placental microsomes: kinetic evidence for two enzymes differing in substrate specificity.

  1985cited by this paper
• Inactivation of soluble 17 beta-hydroxysteroid dehydrogenase of human placenta by fatty acids.

  1985cited by this paper
• Affinity labeling of the cofactor-binding site of estradiol 17 beta-dehydrogenase of human placenta by 5'-p-fluorosulfonylbenzoyl adenosine.

  1985cited by this paper
• Inhibition of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activities of human placenta by steroids and non-steroidal hormone agonists and antagonists.

  1984cited by this paper
• Photochemical inactivation of human placental estradiol 17 beta-dehydrogenase in the presence of 2,3-butanedione.

  1983cited by this paper
• Inactivation of human placental 17 beta,20 alpha-hydroxysteroid dehydrogenase by 16-methylene estrone, an affinity alkylator enzymatically generated from 16-methylene estradiol-17 beta.

  1983cited by this paper
• Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Studies with 6 beta-bromoacetoxyprogesterone.

  1983cited by this paper
• Inhibition of testosterone synthesis in the canine testis in vitro.

  1983cited by this paper
• Fast kinetic study of yeast phenylalanyl-tRNA synthetase: an efficient discrimination between tyrosine and phenylalanine at the level of the aminoacyladenylate-enzyme complex.

  1983cited by this paper
• Isolation of histidyl peptides of the steroid-binding site of human placental estradiol 17 beta-dehydrogenase.

  1982cited by this paper
• Inactivation of human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase with active site-directed 17 beta-propynyl-substituted progestin analogs.

  1982cited by this paper
• Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site.

  1981cited by this paper
• Photoaffinity labeling of human placental estradiol dehydrogenase with 3-(arylazido-beta-alanine)estrone.

  1980cited by this paper
• Synthesis of 2-bromoacetamidoestrone methyl ether and study of the steroid-binding site of human placental estradiol 17 beta-dehydrogenase.

  1980cited by this paper
• Inactivation of alcohol dehydrogenase by 3-butyn-1-ol.

  1979cited by this paper
• Synthesis of 4-bromoacetamidoestrone methyl ether and study of the steroid binding site of human placental estradiol 17beta-dehydrogenase.

  1978cited by this paper
• Inhibiton of human placental 17 beta-hydroxysteroid dehydrogenase by steroids and nonsteroidal alcohols: aspects of inhibitor structure and binding specificity.

  1978cited by this paper
• Alkylation of estradiol 17beta-dehydrogenase from human placenta with 3-chloroacetylpyridine--adenine dinucleotide.

  1976cited by this paper
• Synthesis of 16alpha-bromoacetoxyestradiol 3-methyl ether and study of the steroid binding site of human placental estradiol 17beta-dehydrogenase.

  1975cited by this paper
• Synthesis and study of the estrogenic activity of 2,4-bis(bromomethyl)estradiol-17 beta 3-methyl ether.

  1975cited by this paper
• Synthesis and antiestrogenic activity of 2,4-bis(bromomethyl)-estrone methyl ether: a bifunctional alkylating steroid.

  1974cited by this paper
• Allyl alcohol-induced irreversible inhibition of yeast alcohol dehydrogenase.

  1974cited by this paper
• Danazol--a synthetic steroid derivative with interesting physiologic properties.

  1971cited by this paper
• A souble 17 beta-hydroxysteroid dehydrogenase from human placenta. The binding of pyridine nucleotides and steroids.

  1969cited by this paper
• INHIBITION OF BETA-HYDROXYSTEROID DEHYDROGENASE. I. STRUCTURAL CHARACTERISTICS OF SOME STEROIDAL INHIBITORS.

  1963cited by this paper
• Human placental estradiol-17 beta dehydrogenase. II. Kinetics and substrate specificities.

  1959cited by this paper

• Benzophenone UV-filters: Inhibition on Human and Rat 17β-hydroxysteroid Dehydrogenase 1 - Insights from 3D-QSAR and Docking Studies.

  2025cites this paper
• Suppression of human and rat 17β-hydroxysteroid dehydrogenase 1 by salicylate preservatives: 3D quantitative structure-activity relationship and in silico docking analysis.

  2025cites this paper
• Demethoxylation of curcumin enhances its inhibition on human and rat 17β-hydroxysteroid dehydrogenase 3: QSAR structure-activity relationship and in silico docking analysis.

  2024cites this paper
• Reproductive toxicity of bisphenol A and nitro-bisphenol A in male zebrafish at environmentally relevant concentrations.

  2024cites this paper
• Modification of B-Nor Steroids Mediated by Filamentous Fungus Fusarium culmorum: Focus on 15α-Hydroxylase Activity

  2024cites this paper
• Recent advances in the development of 17beta-hydroxysteroid dehydrogenase inhibitors.

  2024cites this paper
• Effects of Different Levels of Antarctic Krill Oil on the Ovarian Development of Macrobrachium rosenbergii

  2024cites this paper
• Light-switchable diazocines as potential inhibitors of testosterone-synthesizing 17β-hydroxysteroid dehydrogenase 3.

  2024cites this paper
• Chemical Synthesis and Biological Evaluation of 3-Substituted Estrone/Estradiol Derivatives as 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Acting via a Reverse Orientation of the Natural Substrate Estrone

  2023cites this paper
• Biotransformation of Δ1-Progesterone Using Selected Entomopathogenic Filamentous Fungi and Prediction of Its Products’ Bioactivity

  2023cites this paper
• Phenylpropiolic acid isolated in cryogenic nitrogen and xenon matrices: NIR and UV-induced study.

  2023cites this paper
• VenomPred 2.0: A Novel In Silico Platform for an Extended and Human Interpretable Toxicological Profiling of Small Molecules

  2023cites this paper
• Mechanism of 17β-estradiol degradation by Rhodococcus equi via the 4,5-seco pathway and its key genes.

  2022cites this paper
• Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis.

  2022cites this paper
• Short-time intensive insulin therapy upregulates 3 beta- and 17 beta-hydroxysteroid dehydrogenase levels in men with newly diagnosed T2DM

  2022cites this paper
• Reduction of photoswitched, nitrogen bridged N-acetyl diazocines limits inhibition of 17βHSD3 activity in transfected human embryonic kidney 293 cells.

  2022cites this paper
• Combined 4D-QSAR and target-based approaches for the determination of bioactive Isatin derivatives

  2021cites this paper
• Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 3

  2021influential citation
• Temperature-Dependent Dynamical Evolution in Coum/SBE-β-CD Inclusion Complexes Revealed by Two-Dimensional FTIR Correlation Spectroscopy (2D-COS)

  2021cites this paper
• Synthesis of 16β-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17β-ol as inhibitors of 17β-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases.

  2021cites this paper
• A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models

  2021cites this paper
• Prospective evaluation of the association between varicocele and benign prostatic hyperplasia in men over 40 years of age

  2021cites this paper
• A novel hybrid method named electron conformational genetic algorithm as a 4D QSAR investigation to calculate the biological activity of the tetrahydrodibenzazosines

  2020cites this paper
• Molecular characterization and expression profiling of 17-beta-hydroxysteroid dehydrogenase 2 and spermatogenesis associated protein 2 genes in endangered catfish, Clarias magur (Hamilton, 1822)

  2020cites this paper
• A Novel Mechanism of Monoethylhexyl Phthalate in Lipid Accumulation via Inhibiting Fatty Acid Beta-Oxidation on Hepatic Cells.

  2020cites this paper
• A Hybrid In Silico/In Vitro Target Fishing Study to Mine Novel Targets of Urolithin A and B: A Step Towards a Better Comprehension of their Estrogenicity.

  2020cites this paper
• Inhibitors of 17β-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challenges.

  2019cites this paper
• Hybrid in silico/in vitro target fishing to assign function to "orphan" compounds of food origin - The case of the fungal metabolite atromentin.

  2019cites this paper
• Current evidence for the involvement of sex steroid receptors and sex hormones in benign prostatic hyperplasia

  2019cites this paper
• Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1

  2019cites this paper
• Expression and role of 17BETA-hydroxysteroid dehydrogenase type 1, 5 and 7 in epithelial ovarian cancer

  2018cites this paper
• Chemical synthesis of C3‐oxiranyl/oxiranylmethyl‐estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17&bgr;‐hydroxysteroid dehydrogenase type 1

  2018cites this paper
• Covalent Immobilization of Human Placental 17β-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications

  2017cites this paper
• Virtual screening applications in short-chain dehydrogenase/reductase research.

  2017cites this paper
• Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study.

  2017cites this paper
• THERAPEUTICALLY ACTIVE TRAZOLES AND THEIR USE CROSS REFERENCE TO RELATED APPLICATION

  2017influential citation
• METHODS OF MAKING AND USING THERAPEUTICALLY ACTIVE THOPHENEPYRIMIDINONE COMPOUNDS CROSS REFERENCE TO RELATED APPLICATION

  2017cites this paper
• Development of 17β-hydroxysteroid dehydrogenase type 3 as a target in hormone-dependent prostate cancer therapy.

  2017cites this paper
• Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives

  2017cites this paper
• Suppression of rat and human androgen biosynthetic enzymes by apigenin: Possible use for the treatment of prostate cancer.

  2016cites this paper
• First Structure-Activity Relationship of 17β-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme.

  2016cites this paper
• Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1).

  2016cites this paper
• Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1

  2016cites this paper
• The Effect of Post-exercise Ethanol Consumption on the Acute Hormonal Response to Heavy Resistance Exercise in Women

  2015cites this paper
• Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases

  2015cites this paper
• Identification of fused 16β,17β-oxazinone-estradiol derivatives as a new family of non-estrogenic 17β-hydroxysteroid dehydrogenase type 1 inhibitors.

  2015cites this paper
• 6‐Hydroxybenzothiophene Ketones: Potent Inhibitors of 17β‐Hydroxysteroid Dehydrogenase Type 1 (17β‐HSD1) Owing to Favorable Molecule Geometry and Conformational Preorganization

  2014cites this paper
• Discovery of a non-estrogenic irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 from 3-substituted-16β-(m-carbamoylbenzyl)-estradiol derivatives.

  2014cites this paper
• Molecular cloning and expression analysis of 17b-hydroxysteroid dehydrogenase 1 and 12 during gonadal development, recrudescence and after in vivo hCG induction in catfish, Clarias batrachus.

  2014cites this paper
• A challenge for medicinal chemistry by the 17β-hydroxysteroid dehydrogenase superfamily: an integrated biological function and inhibition study.

  2013cites this paper
• Viability screen on pediatric low grade glioma cell lines unveils a novel anti-cancer drug of the steroid biosynthesis inhibitor family.

  2013cites this paper
• A safe and practical method for the preparation of 7α-thioether and thioester derivatives of spironolactone.

  2013cites this paper
• Medical treatment improves social behavior in a primate endometriosis model (Callithrix jacchus)

  2013cites this paper
• Chemical synthesis, characterisation and biological evaluation of lactonic-estradiol derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1.

  2013cites this paper
• A New Nonestrogenic Steroidal Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type I Blocks the Estrogen-Dependent Breast Cancer Tumor Growth Induced by Estrone

  2012cites this paper
• Discovery of potent and orally bioavailable 17β-hydroxysteroid dehydrogenase type 3 inhibitors.

  2012cites this paper
• (Iso)flav(an)ones, chalcones, catechins, and theaflavins as anticarcinogens: mechanisms, anti-multidrug resistance and QSAR studies.

  2012cites this paper
• Therapeutic Discovery A New Nonestrogenic Steroidal Inhibitor of 17 b-Hydroxysteroid Dehydrogenase Type I Blocks the Estrogen-Dependent Breast Cancer TumorGrowth Induced by Estrone

  2012cites this paper
• The design and synthesis of novel 17β hydroxysteroid dehydrogenase inhibitors as anti-cancer agents

  2012cites this paper
• Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily

  2012cites this paper
• Lead optimization of 17β-HSD1 inhibitors of the (hydroxyphenyl)naphthol sulfonamide type for the treatment of endometriosis.

  2012cites this paper
• Hydroxybenzothiazoles as New Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)

  2012cites this paper
• Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitors.

  2012cites this paper
• Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol

  2011cites this paper
• Introduction of an electron withdrawing group on the hydroxyphenylnaphthol scaffold improves the potency of 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors.

  2011cites this paper
• Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3).

  2011cites this paper
• Design and synthesis of substrate mimetics based on an indole scaffold: potential inhibitors of 17β-HSD type 1

  2011cites this paper
• Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.

  2011cites this paper
• Contribution to the development of inhibitors of 17β-hydroxysteroid dehydrogenase types 1 and 7: key tools for studying and treating estrogen-dependent diseases.

  2011cites this paper
• Activité biologique in vitro et in vivo de dérivés stéroïdiens pour le traitement du cancer

  2011cites this paper
• 17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.

  2011cites this paper
• Identification of chemically diverse, novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening.

  2011cites this paper
• New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.

  2011cites this paper
• Chemical synthesis, characterisation and biological evaluation of furanic-estradiol derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1.

  2011cites this paper
• Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: structure-function studies and inhibitor development.

  2011cites this paper
• Synthesis and biological evaluation of (6- and 7-phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1.

  2011cites this paper
• Chemical synthesis of the 17-propanamide derivatives of stereoisomeric Δ14-17α- and 17β-estradiols: potential 17β-hydroxysteroid dehydrogenase inhibitors.

  2011cites this paper
• Species Used for Drug Testing Reveal Different Inhibition Susceptibility for 17beta-Hydroxysteroid Dehydrogenase Type 1

  2010cites this paper
• Predicting Putative Inhibitors of 17β‐HSD1

  2010cites this paper
• Preparation of 16β-Estradiol Derivative Libraries as Bisubstrate Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Using the Multidetachable Sulfamate Linker

  2010cites this paper
• 17β-Hydroxysteroid dehydrogenase inhibitors: a patent review

  2010cites this paper
• A powerful combination of computational methods on the road toward potent non-steroidal inhibitors of steroidogenic enzymes involved in hormone-dependent diseases

  2010cites this paper
• 17β‐Hydroxysteroid Dehydrogenases in Human Breast Cancer

  2009cites this paper
• Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities.

  2009cites this paper
• Relative involvement of three 17beta-hydroxysteroid dehydrogenases (types 1, 7 and 12) in the formation of estradiol in various breast cancer cell lines using selective inhibitors.

  2009cites this paper
• Reductive 17beta-hydroxysteroid dehydrogenases in the sulfatase pathway: critical in the cell proliferation of breast cancer.

  2009cites this paper
• Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core.

  2009cites this paper
• Steroid-converting enzymes in human ovarian carcinomas.

  2009cites this paper
• Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

  2009cites this paper
• The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-Hydroxysteroid Dehydrogenase (17beta-HSD) type 1 and type 2.

  2009cites this paper
• Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy.

  2009cites this paper
• Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors.

  2009cites this paper
• Synthesis of aryl sulfamate and phenol small peptide derivatives using a multidetachable sulfamate linker strategy.

  2009cites this paper
• Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.

  2009cites this paper
• Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17beta-hydroxysteroid dehydrogenase type 1.

  2009cites this paper
• The design of novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors.

  2009cites this paper
• Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.

  2009cites this paper
• Perspectives in Understanding the Role of Human 17β‐Hydroxysteroid Dehydrogenases in Health and Disease

  2009cites this paper
• Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone.

  2009cites this paper
• Charakterisierung neuer Mitglieder der Short-Chain-Dehydrogenase/Reduktase-Proteinfamilie

  2009cites this paper