Atomic structure of the RuvC resolvase: A holliday junction-specific endonuclease from E. coli

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Cell

• Publication date

  1994-09-23

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0092-8674(94)90280-1PMID 7923356
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The processing of recombination intermediates: mechanistic insights from studies of bacterial proteins.

  1994cited by this paper
• Structural requirements of substrate DNA for binding to and cleavage by RuvC, a Holliday junction resolvase.

  1994influential reference
• Resolution of recombination intermediates by a mammalian activity functionally analogous to Escherichia coli RuvC resolvase.

  1994cited by this paper
• Preliminary crystallographic study of Escherichia coli RuvC protein. An endonuclease specific for Holliday junctions.

  1994cited by this paper
• Biochemistry of homologous recombination in Escherichia coli.

  1994cited by this paper
• Similarity of the yeast RAD51 filament to the bacterial RecA filament.

  1993cited by this paper
• Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA

  1993cited by this paper
• Resolution of Holliday junctions by RuvC resolvase: cleavage specificity and DNA distortion.

  1993influential reference
• RuvA and RuvB proteins of Escherichia coli exhibit DNA helicase activity in vitro.

  1993cited by this paper
• A mouse homolog of the Escherichia coli recA and Saccharomyces cerevisiae RAD51 genes.

  1993cited by this paper
• Development of pseudoenergy potentials for assessing protein 3-D-1-D compatibility and detecting weak homologies.

  1993cited by this paper
• Crystal structure of Escherichia coli RNase HI in complex with Mg2+ at 2.8 Å resolution: Proof for a single Mg2+‐binding site

  1993cited by this paper
• Dissociation of synthetic Holliday junctions by E. coli RecG protein.

  1993cited by this paper
• Enzymes and molecular mechanisms of genetic recombination.

  1992cited by this paper
• Fluorescence resonance energy transfer analysis of the structure of the four-way DNA junction.

  1992cited by this paper
• Escherichia coli RuvA and RuvB proteins specifically interact with Holliday junctions and promote branch migration.

  1992cited by this paper
• Identification and characterization of yeast mutants and the gene for a cruciform cutting endonuclease.

  1992cited by this paper
• Structural details of ribonuclease H from Escherichia coli as refined to an atomic resolution.

  1992cited by this paper
• Improving multiple isomorphous replacement phasing by heavy-atom refinement using solvent-flattened phases.

  1992cited by this paper
• Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein.

  1992cited by this paper
• ATP-dependent branch migration of Holliday junctions promoted by the RuvA and RuvB proteins of E. coli.

  1992cited by this paper
• Presto(protein Engineering Simulator): A Vectorized Molecular Mechanics Program for Biopolymers

  1992cited by this paper
• Heavy-atom refinement against solvent-flattened phases.

  1992cited by this paper
• DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression.

  1992cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• A program to produce both detailed and schematic plots of protein structures

  1991influential reference
• Structural basis for the 3′‐5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

  1991cited by this paper
• Molecular analysis of the Escherichia coli ruvC gene, which encodes a Holliday junction-specific endonuclease

  1991cited by this paper
• X-ray diffraction data collection system for modern protein crystallography with a Weissenberg camera and an imaging plate using synchrotron radiation

  1991influential reference
• Resolution of Holliday junctions in Escherichia coli: identification of the ruvC gene product as a 19-kilodalton protein

  1991cited by this paper
• Formation and resolution of recombination intermediates by E. coliRecA and RuvC proteins

  1991cited by this paper
• Escherichia coli RuvC protein is an endonuclease that resolves the Holliday structure.

  1991cited by this paper
• Model for the interaction of DNA junctions and resolving enzymes.

  1991cited by this paper
• Resolution of synthetic Holliday junctions in DNA by an endonuclease activity from calf thymus.

  1990cited by this paper
• The stereochemistry of a four-way DNA junction: a theoretical study.

  1990influential reference
• Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein.

  1990cited by this paper
• An automatic diffraction data collection system with an imaging plate

  1990cited by this paper
• Three-dimensional structure of ribonuclease H from E. coli

  1990cited by this paper
• The processing of diffraction data taken on a screenless Weissenberg camera for macromolecular crystallography

  1989cited by this paper
• Overproduction and preliminary crystallographic study of ribonuclease H from Escherichia coli.

  1989cited by this paper
• Numerical Calculations of Electrostatic Potentials of Protein-Solvent Systems by the Self Consistent Boundary Method

  1987cited by this paper
• Generalized method of determining heavy-atom positions using the difference Patterson function

  1987cited by this paper
• A reciprocal-space method for calculating a molecular envelope using the algorithm of B. C. Wang.

  1987cited by this paper
• Cleavage of cruciform DNA structures by an activity from Saccharomyces cerevisiae.

  1985cited by this paper
• Partial purification of an enzyme from Saccharomyces cerevisiae that cleaves Holliday junctions.

  1985cited by this paper
• Resolution of phase ambiguity in macromolecular crystallography.

  1985cited by this paper
• Enzymes and sites of genetic recombination: studies with gene-3 endonuclease of phage T7 and with site-affinity mutants of phage lambda.

  1984cited by this paper
• Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

  1983cited by this paper
• T4 endonuclease VII cleaves holliday structures.

  1982cited by this paper
• The application of MULTAN to the analysis of isomorphous derivatives in protein crystallography

  1978cited by this paper
• Methods and programs for direct‐space exploitation of geometric redundancies

  1976cited by this paper
• The application of direct methods to the analysis of heavy‐atom derivatives

  1974cited by this paper

• Identification and purification of a novel bacteriophage T7 endonuclease from the Kogelberg Biosphere Reserve (KBR) biodiversity hotspot

  2025cites this paper
• Mycobacterium smegmatis putative Holliday junction resolvases RuvC and RuvX play complementary roles in the processing of branched DNA structures

  2024influential citation
• Structural mechanism of bridge RNA-guided recombination

  2024cites this paper
• Engineering CRISPR/Cas9 therapeutics for cancer precision medicine

  2024cites this paper
• The CRISPR Cas patent files, part 2: Is Cpf1/Cas12a a less conflict- prone alternative to Cas9 ?

  2024cites this paper
• Prokaryotic DNA Crossroads: Holliday Junction Formation and Resolution

  2024cites this paper
• Twisting and swiveling domain motions in Cas9 to recognize target DNA duplexes, make double-strand breaks, and release cleaved duplexes

  2023cites this paper
• Holliday junction resolution by At-HIGLE: an SLX1 lineage endonuclease from Arabidopsis thaliana with a novel in-built regulatory mechanism

  2022cites this paper
• Computational biophysics and structural biology of proteins—a Special Issue in honor of Prof. Haruki Nakamura’s 70th birthday

  2022cites this paper
• Crystal structure and initial characterization of a novel archaeal-like Holliday junction-resolving enzyme from Thermus thermophilus phage Tth15-6

  2022cites this paper
• Biochemical and Structural Study of RuvC and YqgF from Deinococcus radiodurans

  2022cites this paper
• Novel insights into ATP-stimulated cleavage of branched DNA and RNA substrates through structure-guided studies of the Holliday junction resolvase RuvX.

  2021cites this paper
• Single bacterial resolvases first exploit, then constrain intrinsic dynamics of the Holliday junction to direct recombination

  2021influential citation
• Microsoft Word-Ray_et_al_NAR_SI_2ndRevision_Final

  2021influential citation
• Active-Site Models of Streptococcus pyogenes Cas9 in DNA Cleavage State

  2021cites this paper
• Direct unfolding of RuvA-HJ complex at the single-molecule level.

  2021cites this paper
• Biochemical and structural characterization of the Holliday junction resolvase RuvC from Pseudomonas aeruginosa.

  2020cites this paper
• Biotechnological and Therapeutic Applications of Natural Nucleic Acid Structural Motifs

  2020cites this paper
• DNA Nanotechnology: From Structure to Functionality

  2020cites this paper
• Structural insights into sequence-dependent Holliday junction resolution by the chloroplast resolvase MOC1

  2020cites this paper
• Genome editing of algal species by CRISPR Cas9 for biofuels

  2020cites this paper
• Correction du gène de la dystrophine avec la méthode CRISPR induced deletion (CinDel)

  2019cites this paper
• Acidic residues and a predicted, highly conserved α‐helix are critical for the endonuclease/strand separation functions of bacteriophage λ’s TerL

  2019cites this paper
• A bacterial resolvase first exploits, then constrains intrinsic dynamics of the Holliday junction to direct recombination

  2019cites this paper
• Comprehensive Classification of the RNase H-like domain-containing Proteins in Plants

  2019cites this paper
• The path towards functional nanoparticle-DNA origami composites

  2019cites this paper
• Cas12a trans-cleavage can be modulated in vitro and is active on ssDNA, dsDNA, and RNA

  2019cites this paper
• RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution

  2019cites this paper
• Homologous Recombination under the Single-Molecule Fluorescence Microscope

  2019cites this paper
• Identification of Holliday junction resolvases crucial for the chloroplast nucleoid morphology and segregation

  2018cites this paper
• Protein Hydration Waters Are Susceptible to Unfavorable Perturbations.

  2018cites this paper
• Construction of a Holliday Junction in Small Circular DNA Molecules for Stable Motifs and Two‐Dimensional Lattices

  2018cites this paper
• Nucleoprotein Intermediates in HIV-1 DNA Integration: Structure and Function of HIV-1 Intasomes.

  2018cites this paper
• Applications of the CRISPR/Cas system beyond gene editing

  2018cites this paper
• DNA Unwinding Is the Primary Determinant of CRISPR-Cas9 Activity.

  2018cites this paper
• DNA unwinding is the primary determinant of CRISPR-Cas9 activity

  2017cites this paper
• Holliday junction‐resolving enzymes—structures and mechanisms

  2017cites this paper
• Holliday junction resolvases mediate chloroplast nucleoid segregation

  2017cites this paper
• Structure of the large terminase from a hyperthermophilic virus reveals a unique mechanism for oligomerization and ATP hydrolysis

  2017cites this paper
• Structural and biochemical studies of the large terminase protein from thermophilic viruses

  2017cites this paper
• Resolution of single and double Holliday junction recombination intermediates by GEN1

  2017cites this paper
• The Gene cloning and biochemical and genetic analysis of the ribonuclease HI from Mycobacterium smegmatis

  2017cites this paper
• The chemistry of Cas9 and its CRISPR colleagues

  2017cites this paper
• Current status and perspectives of genome editing technology for microalgae

  2017cites this paper
• C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism.

  2017cites this paper
• Mechanism of Transcription Anti-termination in Human Mitochondria.

  2017cites this paper
• C 2 c 1-sgRNA Complex Stru cture Reveals RNA-Guided DNA Cleavage Mechanism Graphical Abstract Highlights

  2016cites this paper
• Mycobacterium tuberculosis RuvX is a Holliday junction resolvase formed by dimerisation of the monomeric YqgF nuclease domain

  2016cites this paper
• A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron protein

  2016cites this paper
• Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase

  2016cites this paper
• Structure and Metal Binding Properties of a Poxvirus Resolvase*

  2016cites this paper
• Analysis of DNA mismatch repair system from Neisseria meningitidis

  2016cites this paper
• Structural insights into dynamics of RecU–HJ complex formation elucidates key role of NTR and stalk region toward formation of reactive state

  2016cites this paper
• Sleeping Beauty Transposition

  2015cites this paper
• GEN1 promotes Holliday junction resolution by a coordinated nick and counter-nick mechanism

  2015cites this paper
• Crystal structure of E. coli endonuclease V, an essential enzyme for deamination repair

  2015cites this paper
• ISC, a Novel Group of Bacterial and Archaeal DNA Transposons That Encode Cas9 Homologs

  2015cites this paper
• Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I

  2015cites this paper
• Structural basis for incision at deaminated adenines in DNA and RNA by endonuclease V.

  2015cites this paper
• Single-Molecule Imaging Reveals that Argonaute Re-Shapes the Properties of its Nucleic Acid Guides: A Dissertation

  2015cites this paper
• Atomistic details of the molecular recognition of DNA-RNA hybrid duplex by ribonuclease H enzyme

  2015cites this paper
• Inhibitors of Nucleotidyltransferase Superfamily Enzymes Suppress Herpes Simplex Virus Replication

  2014cites this paper
• Crystal structure of Cas9 in complex with guide RNA and target DNA.

  2014influential citation
• Structure of human endonuclease V as an inosine-specific ribonuclease.

  2014cites this paper
• Holliday junction resolvases.

  2014cites this paper
• The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification

  2014cites this paper
• Simplex Virus Replication Superfamily Enzymes Suppress Herpes Inhibitors of Nucleotidyltransferase

  2014cites this paper
• Crystal ‘Unengineering’: Reducing the Crystallisability of Sulfolobus solfataricus Hjc

  2014cites this paper
• Density functional study of the phosphate diester hydrolysis of RNA in RNA/DNA hybrid by RNase HI

  2014cites this paper
• The structure of the herpes simplex virus DNA-packaging terminase pUL 15 nuclease domain suggests an evolutionary lineage among eukaryotic and prokaryotic viruses by Sundaresan

  2014influential citation
• Inosine in DNA and RNA.

  2014cites this paper
• Bacterial insertion sequences: their genomic impact and diversity

  2014cites this paper
• The Structure of the Herpes Simplex Virus DNA-Packaging Terminase pUL15 Nuclease Domain Suggests an Evolutionary Lineage among Eukaryotic and Prokaryotic Viruses

  2013influential citation
• Mutants of phage bIL67 RuvC with enhanced Holliday junction binding selectivity and resolution symmetry

  2013influential citation
• Crystal structure of RuvC resolvase in complex with Holliday junction substrate

  2013cites this paper
• The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes

  2013cites this paper
• Dualities in the analysis of phage DNA packaging motors

  2012cites this paper
• DprB Facilitates Inter- and Intragenomic Recombination in Helicobacter pylori

  2012cites this paper
• Structural asymmetry in the Thermus thermophilus RuvC dimer suggests a basis for sequential strand cleavages during Holliday junction resolution

  2012cites this paper
• Soluble expression, purification and characterization of the full length IS2 Transposase

  2011cites this paper
• Structure and Function of the Small MutS-Related Domain

  2011cites this paper
• Relics from the Past: Molecular Biology and Genetic Applications of Resurrected DNA Transposons in Vertebrates

  2011cites this paper
• Crystal structure of a novel non-Pfam protein PF2046 solved using low resolution B-factor sharpening and multi-crystal averaging methods

  2010cites this paper
• Molecular Mechanisms of the Whole DNA Repair System: A Comparison of Bacterial and Eukaryotic Systems

  2010cites this paper
• ORF157 from the Archaeal Virus Acidianus Filamentous Virus 1 Defines a New Class of Nuclease (cid:1)

  2010cites this paper
• ORF157 from the Archaeal Virus Acidianus Filamentous Virus 1 Defines a New Class of Nuclease

  2010cites this paper
• Nucleases: diversity of structure, function and mechanism

  2010cites this paper
• Branch migration of Holliday junction in RuvA tetramer complex studied by umbrella sampling simulation using a path‐search algorithm

  2010cites this paper
• Integrating prokaryotes and eukaryotes: DNA transposases in light of structure

  2010cites this paper
• Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain

  2010cites this paper
• Retroviral integrase superfamily: the structural perspective

  2009cites this paper
• Structural basis for the nuclease activity of a bacteriophage large terminase

  2009cites this paper
• Four-Way Helical Junctions in DNA Molecules

  2009cites this paper
• The search for a human Holliday junction resolvase.

  2009cites this paper
• Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair

  2009cites this paper
• Ribonuclease H: molecular diversities, substrate binding domains, and catalytic mechanism of the prokaryotic enzymes

  2009cites this paper
• Crystal Structure and RNA Binding of the Tex Protein from Pseudomonas aeruginosa

  2008cites this paper
• Functional insight into Maelstrom in the germline piRNA pathway: a unique domain homologous to the DnaQ-H 3'–5' exonuclease, its lineage-specific expansion/loss and evolutionarily active site switch

  2008cites this paper
• Group I intron mediated trans-splicing of highly conserved dengue virus sequences & a mutational analysis of the piggyBac transposase

  2008cites this paper
• New insight into the recognition of branched DNA structure by junction-resolving enzymes.

  2008cites this paper