Studies on the lumazine synthase/riboflavin synthase complex of Bacillus subtilis: crystal structure analysis of reconstituted, icosahedral beta-subunit capsids with bound substrate analogue inhibitor at 2.4 A resolution.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Journal of Molecular Biology

• Publication date

  1995-10-13

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1006/JMBI.1995.0542PMID 7473709
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ligand-binding studies on heavy riboflavin synthase of Bacillus subtilis.

  2005cited by this paper
• Biosynthesis of riboflavin. Studies on the reaction mechanism of 6,7-dimethyl-8-ribityllumazine synthase.

  1995cited by this paper
• The lumazine synthase/riboflavin synthase complex of Bacillus subtilis. X-ray structure analysis of hollow reconstituted beta-subunit capsids.

  1994cited by this paper
• De novo and inverse folding predictions of protein structure and dynamics

  1993cited by this paper
• Electron microscopy of decorated crystals for the determination of crystallographic rotation and translation parameters in large protein complexes.

  1992cited by this paper
• 1.7 A X-ray structure of the periplasmic ribose receptor from Escherichia coli.

  1992cited by this paper
• Crystal structure of cholesterol oxidase from Brevibacterium sterolicum refined at 1.8 A resolution.

  1991cited by this paper
• The lumazine synthase-riboflavin synthase complex of Bacillus subtilis. Crystallization of reconstituted icosahedral beta-subunit capsids.

  1990cited by this paper
• The calcium-binding site in the galactose chemoreceptor protein. Crystallographic and metal-binding studies.

  1989cited by this paper
• Crystal structure of the p-hydroxybenzoate hydroxylase-substrate complex refined at 1.9 A resolution. Analysis of the enzyme-substrate and enzyme-product complexes.

  1989cited by this paper
• Heavy riboflavin synthase from Bacillus subtilis. Crystal structure analysis of the icosahedral beta 60 capsid at 3.3 A resolution.

  1988cited by this paper
• Refined structure of glutathione reductase at 1.54 A resolution.

  1987cited by this paper
• Heavy riboflavin synthase of Bacillus subtilis. Primary structure of the beta subunit.

  1987cited by this paper
• Analysis of the relationship between side-chain conformation and secondary structure in globular proteins.

  1987cited by this paper
• Comparison of two highly refined structures of bovine pancreatic trypsin inhibitor.

  1987cited by this paper
• Heavy riboflavin synthase from Bacillus subtilis. Particle dimensions, crystal packing and molecular symmetry.

  1986cited by this paper
• Heavy riboflavin synthase from Bacillus subtilis. Quaternary structure and reaggregation.

  1986cited by this paper
• Resolution of phase ambiguity in macromolecular crystallography.

  1985cited by this paper
• Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

  1983cited by this paper
• Riboflavin synthases of Bacillus subtilis. Purification and properties.

  1980cited by this paper
• Structure of the L-arabinose-binding protein from Escherichia coli at 2.4 A resolution.

  1980cited by this paper
• The Protein Data Bank: a computer-based archival file for macromolecular structures.

  1977cited by this paper
• Beta-turns in proteins.

  1977cited by this paper

• Mutations in the riboflavin biosynthesis pathway confer resistance to furazolidone and abolish the synergistic interaction between furazolidone and vancomycin in Escherichia coli

  2025cites this paper
• A Macrocycle-Mediated Protein Cage

  2024cites this paper
• Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo

  2023cites this paper
• Enzymes in riboflavin biosynthesis: Potential antibiotic drug targets.

  2023cites this paper
• Manufacturing of non-viral protein nanocages for biotechnological and biomedical applications

  2023cites this paper
• Inhibitors of riboflavin biosynthetic pathway enzymes as potential antibacterial drugs

  2023influential citation
• Cryo-electron structures of the extreme thermostable enzymes Sulfur Oxygenase Reductase and Lumazine Synthase

  2022cites this paper
• Transcription-dependent confined diffusion of enzymes within subcellular spaces of the bacterial cytoplasm

  2021cites this paper
• Chapter 2 Recent Advances in Ribofl avin Biosynthesis

  2019cites this paper
• Discovery of potential lumazine synthase antagonists for pathogens involved in bacterial meningitis: In silico study

  2019cites this paper
• Understanding the riboflavin biosynthesis pathway for the development of antimicrobial agents

  2019cites this paper
• Tailoring lumazine synthase assemblies for bionanotechnology.

  2018cites this paper
• Biomedical Applications of Lumazine Synthase.

  2018cites this paper
• Nanotechnology for Synthetic Biology: Crossroads Throughout Spatial Confinement

  2017cites this paper
• Encapsulation and Controlled Release of Protein Guests by the Bacillus subtilis Lumazine Synthase Capsid.

  2017cites this paper
• The C-terminal peptide of Aquifex aeolicus riboflavin synthase directs encapsulation of native and foreign guests by a cage-forming lumazine synthase

  2017cites this paper
• Design of a hyperstable 60-subunit protein icosahedron

  2016cites this paper
• Industrial Production of Vitamin B2 by Microbial Fermentation

  2016cites this paper
• Protein cages and synthetic polymers: a fruitful symbiosis for drug delivery applications, bionanotechnology and materials science.

  2016cites this paper
• Crystallographic and kinetic study of riboflavin synthase from Brucella abortus, a chemotherapeutic target with an enhanced intrinsic flexibility.

  2014cites this paper
• An In Vitro Deletion in ribE Encoding Lumazine Synthase Contributes to Nitrofurantoin Resistance in Escherichia coli

  2014cites this paper
• Recent advances in riboflavin biosynthesis.

  2014cites this paper
• MAIN software for density averaging, model building, structure refinement and validation

  2013cites this paper
• O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase.

  2012cites this paper
• Biosynthesis of Vitamin B2 (Riboflavin) : Studies on the Reaction Mechanism of Riboflavin Synthase.

  2012cites this paper
• Unusual arginine formations in protein function and assembly: rings, strings, and stacks.

  2012cites this paper
• Nanoreactors by programmed enzyme encapsulation inside the capsid of the bacteriophage P22.

  2012cites this paper
• Reactions inside nanoscale protein cages.

  2011cites this paper
• Selective and Responsive Nanoreactors

  2011cites this paper
• Crystal structure analysis of icosahedral lumazine synthase from Salmonella typhimurium, an antibacterial drug target.

  2011influential citation
• Biosynthesis of Vitamin B2: A Unique Way to Assemble a Xylene Ring

  2011cites this paper
• Biosynthesis of Vitamin B2 and Flavocoenzymes in Plants

  2011cites this paper
• Sensing the dissociation of a polymeric enzyme by means of an engineered intrinsic probe

  2011cites this paper
• Estudio de Lumazina Sintasa de Brucella como proteína transportadora de antígenos: relación entre estructura, estabilidad e inmunogenicidad

  2011cites this paper
• Amyloid Assemblies: Protein Legos at a Crossroads in Bottom‐Up Synthetic Biology

  2010cites this paper
• Rol del metabolismo de flavinas en la virulencia de Brucella abortus

  2010cites this paper
• 7.02 – Riboflavin Biosynthesis

  2010cites this paper
• Visual proteomics.

  2010cites this paper
• Some Enzymes Just Need a Space of Their Own

  2010cites this paper
• Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase.

  2010cites this paper
• Discovery and development of a small molecule library with lumazine synthase inhibitory activity.

  2009cites this paper
• Biosynthesis of riboflavin

  2009cites this paper
• Survey of large protein complexes in D. vulgaris reveals great structural diversity

  2009cites this paper
• CSSP (Consensus Secondary Structure Prediction): a web-based server for structural biologists

  2009cites this paper
• Metastable Mesoscopic Phases in Concentrated Protein Solutions

  2009cites this paper
• Biosynthesis of vitamin B2: Structure and mechanism of riboflavin synthase.

  2008cites this paper
• Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of tetrahydrodipicolinate-N-succinyltransferase (Rv1201c) from Mycobacterium tuberculosis.

  2008cites this paper
• Improvement of the quality of lumazine synthase crystals by protein engineering.

  2008cites this paper
• Structural basis of enzyme encapsulation into a bacterial nanocompartment

  2008cites this paper
• Metastable liquid clusters in super- and undersaturated protein solutions.

  2007cites this paper
• Lumazine Synthase from Candida albicans as an Anti-fungal Target Enzyme

  2007cites this paper
• Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase.

  2007cites this paper
• Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales.

  2007cites this paper
• Coenzyme biosynthesis: enzyme mechanism, structure and inhibition.

  2007cites this paper
• Crystal Structure of an Archaeal Pentameric Riboflavin Synthase in Complex with a Substrate Analog Inhibitor

  2006cites this paper
• Biosynthesis of vitamin B 2 in plants

  2006cites this paper
• Multiple assembly states of lumazine synthase: a model relating catalytic function and molecular assembly.

  2006cites this paper
• Multiple extrema in the intermolecular potential and the phase diagram of protein solutions.

  2006cites this paper
• Coupling artificial actin cortices to biofunctionalized lipid monolayers.

  2006cites this paper
• Biosynthesis of vitamin B2 in plants

  2006cites this paper
• Riboflavin analogs and inhibitors of riboflavin biosynthesis

  2006cites this paper
• A metastable prerequisite for the growth of lumazine synthase crystals.

  2005cites this paper
• Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors.

  2005cites this paper
• Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase.

  2005cites this paper
• Crystallographic studies on decameric Brucella spp. Lumazine synthase: a novel quaternary arrangement evolved for a new function?

  2005cites this paper
• Biomimetic magnetic nanoparticles

  2005cites this paper
• Biosynthesis of flavocoenzymes.

  2005cites this paper
• Structure of the molybdenum-cofactor biosynthesis protein MoaB of Escherichia coli.

  2004cites this paper
• High Order Quaternary Arrangement Confers Increased Structural Stability to Brucella sp. Lumazine Synthase*

  2004cites this paper
• Sequence determinants of quaternary structure in lumazine synthase.

  2004influential citation
• Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase.

  2004cites this paper
• Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase.

  2004cites this paper
• Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes.

  2004cites this paper
• Biosynthesis of riboflavin in Archaea

  2003cites this paper
• Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase.

  2003cites this paper
• Temperature-dependent Presteady State Kinetics of Lumazine Synthase from the Hyperthermophilic Eubacterium Aquifex aeolicus*

  2003cites this paper
• Examination of a reaction intermediate in the active site of riboflavin synthase.

  2003cites this paper
• A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus.

  2003cites this paper
• Biosynthesis of riboflavin in archaea. 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii.

  2003cites this paper
• Biosynthesis of riboflavin. Single turnover kinetic analysis of 6,7-dimethyl-8-ribityllumazine synthase.

  2003cites this paper
• The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase.

  2002cites this paper
• Investigation of the binding of epimer A of the covalent hydrate of 6,7-bis(trifluoromethyl)-8-D-ribityllumazine to a recombinant F22W Bacillus subtilis lumazine synthase mutant by (15)N[(19)F] REDOR NMR.

  2002cites this paper
• Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.

  2002cites this paper
• Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase.

  2002cites this paper
• Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase.

  2002cites this paper
• Formation of metal nanoclusters on specific surface sites of protein molecules.

  2002cites this paper
• Biosynthesis of riboflavin.

  2001cites this paper
• Solution structure and backbone dynamics of the human DNA ligase IIIalpha BRCT domain.

  2001cites this paper
• Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of riboflavin biosynthesis.

  2001cites this paper
• Design of biofunctional assemblies on solids through recombinant spherical bacterial protein lumazine synthase.

  2001cites this paper
• 19F NMR ligand perturbation studies on 6,7-bis(trifluoromethyl)-8-ribityllumazine-7-hydrates and the lumazine synthase complex of Bacillus subtilis. Site-directed mutagenesis changes the mechanism and the stereoselectivity of the catalyzed haloform-type reaction.

  2001cites this paper
• Design, synthesis, and evaluation of 9-D-ribityl-1,3,7-trihydro-2,6,8-purinetrione, a potent inhibitor of riboflavin synthase and lumazine synthase.

  2001cites this paper
• Crystal structure of riboflavin synthase.

  2001cites this paper
• Channeling of substrates and intermediates in enzyme-catalyzed reactions.

  2001cites this paper
• Synthesis of Nanophase Iron Oxide in Lumazine Synthase Capsids.

  2001cites this paper
• Metabolism of Aromatic Compounds and Nucleic Acid Bases

  2001cites this paper
• A method for soluble overexpression of the α7 nicotinic acetylcholine receptor extracellular domain

  2001cites this paper
• X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons.

  2001cites this paper
• Structural, functional and immunological studies on a polymeric bacterial protein.

  2000cites this paper
• Electron microscopic observations on protein crystallization : adsorption layers, aggregates and crystal defects

  2000cites this paper