Ketamine, at a Dose that Disrupts Motor Behavior and Latent Inhibition, Enhances Prefrontal Cortex Synaptic Efficacy and Glutamate Release in the Nucleus Accumbens

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Neuropsychopharmacology

• Publication date

  2007-03-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1038/sj.npp.1301057PMID 16525415
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
• Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior

  2005cited by this paper
• Ketamine Induces Dopamine-Dependent Depression of Evoked Hippocampal Activity in the Nucleus Accumbens in Freely Moving Rats

  2005influential reference
• Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization.

  2005cited by this paper
• The Effects of a Serotoninergic Substrate of the Nucleus Accumbens on Latent Inhibition

  2004cited by this paper
• Dopaminergic Modulation of Prefrontal Cortical Input to Nucleus Accumbens Neurons In Vivo

  2004cited by this paper
• NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex.

  2004cited by this paper
• Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

  2003cited by this paper
• Systemic administration of MK-801 produces an abnormally persistent latent inhibition which is reversed by clozapine but not haloperidol

  2003cited by this paper
• Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings.

  2003cited by this paper
• Activation of Glutamate Neurotransmission in the Prefrontal Cortex Sustains the Motoric and Dopaminergic Effects of Phencyclidine

  2003cited by this paper
• The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment

  2003cited by this paper
• Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia

  2003cited by this paper
• Latent inhibition disruption by MK-801 in a conditioned taste-aversion paradigm.

  2003cited by this paper
• Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down.

  2003influential reference
• Modulation of Hippocampal and Amygdalar-Evoked Activity of Nucleus Accumbens Neurons by Dopamine: Cellular Mechanisms of Input Selection

  2001cited by this paper
• The delayed effects of DTG and MK-801 on latent inhibition in a conditioned taste-aversion paradigm.

  2000cited by this paper
• Gating of information flow within the limbic system and the pathophysiology of schizophrenia.

  2000influential reference
• The pharmacology of latent inhibition as an animal model of schizophrenia.

  2000influential reference
• Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia.

  2000cited by this paper
• The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats.

  1999cited by this paper
• The Neuropsychopharmacology of Phencyclidine: From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

  1999cited by this paper
• Neurotransmitter interactions in schizophrenia--therapeutic implications.

  1999cited by this paper
• Corticolimbic Dopamine Neurotransmission Is Temporally Dissociated from the Cognitive and Locomotor Effects of Phencyclidine

  1998influential reference
• Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil.

  1998cited by this paper
• Prefrontal cortex activity in people with schizophrenia and control subjects

  1998cited by this paper
• Hippocampal morphometry in schizophrenia by high dimensional brain mapping.

  1998cited by this paper
• Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort.

  1998cited by this paper
• Impaired recruitment of the hippocampus during conscious recollection in schizophrenia

  1998cited by this paper
• Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats.

  1998cited by this paper
• Ketamine-Induced Exacerbation of Psychotic Symptoms and Cognitive Impairment in Neuroleptic-Free Schizophrenics

  1997cited by this paper
• Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

  1997cited by this paper
• Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method.

  1997cited by this paper
• NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers

  1996cited by this paper
• Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

  1996cited by this paper
• Phencyclidine‐induced stereotyped behaviour and social isolation in rats: a possible animal model of schizophrenia

  1996influential reference
• Enhanced temporal resolution for the microdialysis monitoring of catecholamines and excitatory amino acids using capillary electrophoresis with laser-induced fluorescence detection. Analytical developments and in vitro validations.

  1996cited by this paper
• MK‐801 increases locomotor activity without elevating extracellular dopamine levels in the nucleus accumbens

  1996cited by this paper
• NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine

  1996cited by this paper
• Subanesthetic Doses of Ketamine Stimulate Psychosis in Schizophrenia

  1995cited by this paper
• Involvement of N-methyl-D-aspartate (NMDA) receptors in noncompetitive NMDA receptor antagonist-induced hyperlocomotion in mice.

  1995influential reference
• Glutamate receptor dysfunction and schizophrenia.

  1995cited by this paper
• Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.

  1994cited by this paper
• Effects of the NMDA receptor antagonist ketamine on flavor memory: conditioned aversion, latent inhibition, and habituation of neophobia.

  1994cited by this paper
• Phencyclidine disrupts acquisition and retention performance within a spatial continuous recognition memory task.

  1993cited by this paper
• Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Assessment with xenon 133 single-photon emission computed tomography and the Tower of London.

  1992cited by this paper
• On the significance of subterritories in the "accumbens" part of the rat ventral striatum.

  1992influential reference
• Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.

  1991cited by this paper
• Recent advances in the phencyclidine model of schizophrenia.

  1991cited by this paper
• The effect of NMDA antagonists in the radial arm maze task with an interposed delay.

  1990cited by this paper
• In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other.

  1990influential reference
• Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence.

  1986cited by this paper
• Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention, and mental effort.

  1986cited by this paper
• Basal ganglia and limbic system pathology in schizophrenia. A morphometric study of brain volume and shrinkage.

  1985cited by this paper
• Basal Ganglia and Limbic System Pathology in Schizophrenia: A Morphometric Study of Brain Volume and Shrinkage

  1985cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983influential reference
• From motivation to action: functional interface between the limbic system and the motor system.

  1980cited by this paper
• Distribution of putative neurotransmitters in the neocortex.

  1979cited by this paper
• Study of a new schizophrenomimetic drug; sernyl.

  1959cited by this paper

• Psychosis: The Utility of Ketamine as a Pharmacological Model of Psychotic-like Symptoms in Rodents: A Review of Dosage Regimens

  2026influential citation
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  2025cites this paper
• Impaired contingency judgement in mice under ketamine: an implication for an altered sense of agency in schizophrenia.

  2025cites this paper
• Increased sensitivity to psychomotor effects of ketamine enantiomers in the Wistar-Kyoto depression model.

  2025cites this paper
• The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats

  2024cites this paper
• Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.

  2024cites this paper
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  2024cites this paper
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  2024cites this paper
• Ketamine’s rapid antidepressant effects are mediated by Ca2+-permeable AMPA receptors

  2023cites this paper
• [Ketamine: a neuropsychotropic drug with an innovative mechanism of action].

  2023cites this paper
• Behavioral changes of food allergic model mice during light and dark period.

  2023cites this paper
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  2023cites this paper
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  2023cites this paper
• Adjunctive dopaminergic enhancement of esketamine in treatment-resistant depression.

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2020cites this paper
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• Brain NMDA Receptors in Schizophrenia and Depression

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