Gastrins, iron homeostasis and colorectal cancer.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2011-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bbamcr.2011.02.007PMID 21320535PMCID PMC3078979
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• HFE C282Y homozygotes are at increased risk of breast and colorectal cancer

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• Stimulation of proliferation in the colorectal mucosa by gastrin precursors is blocked by desferrioxamine.

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• Iron: an emerging factor in colorectal carcinogenesis.

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• Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor

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• Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

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• Annexin II binds progastrin and gastrin-like peptides, and mediates growth factor effects of autocrine and exogenous gastrins on colon cancer and intestinal epithelial cells

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• Overexpression of Glycine-Extended Gastrin Inhibits Parietal Cell Loss and Atrophy in the Mouse Stomach

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• Divergent roles for ferric ions in the biological activity of amidated and non-amidated gastrins.

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• Regulation of transferrin receptor 2 protein levels by transferrin.

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• Biological activity and ferric ion binding of fragments of glycine-extended gastrin.

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• A Novel Effect of Bismuth Ions

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• Ferric Ions Are Essential for the Biological Activity of the Hormone Glycine-extended Gastrin*

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• Biologically Active Recombinant Human Progastrin6–80Contains a Tightly Bound Calcium Ion*

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• Selective, high-affinity binding of ferric ions by glycine-extended gastrin(17).

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• A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload*

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• Short term infusion of glycine‐extended gastrin17 stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa

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• The gastrins: their production and biological activities.

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• Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

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• Iron transport.

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• The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22

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• Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

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• Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation.

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• CCK2 receptor antagonists: pharmacological tools to study the gastrin-ECL cell-parietal cell axis.

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• Glycine-extended gastrin regulates HEK cell growth.

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• Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux.

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• Gastrin and colorectal cancer: a prospective study.

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• Iron absorption in patients with Zollinger–Ellison syndrome treated with long‐term gastric acid antisecretory therapy

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• Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice.

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• Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line.

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• Abnormal gastric histology and decreased acid production in cholecystokinin-B/gastrin receptor-deficient mice.

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• BRIEF REVIEW BIOLOGY OF GUT CHOLECYSTOKININ AND GASTRIN RECEPTORS

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