Inactivation of a serotonin-gated ion channel by a polypeptide toxin from marine snails.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Science

• Publication date

  1998-07-24

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1126/SCIENCE.281.5376.575PMID 9677203
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Charybdotoxin Family of K+ Channel-Blocking Peptides Review

  2003cited by this paper
• Molecular neurobiology and genetics: investigation of neural function and dysfunction.

  1998cited by this paper
• The structure and signalling properties of 5-HT receptors: an endless diversity?

  1998cited by this paper
• E.E. Just Lecture, 1996. Conus venom peptides, receptor and ion channel targets, and drug design: 50 million years of neuropharmacology.

  1997cited by this paper
• A Novel Post-translational Modification Involving Bromination of Tryptophan

  1997cited by this paper
• Bromocontryphan: post-translational bromination of tryptophan.

  1997cited by this paper
• Strategy for rapid immobilization of prey by a fish-hunting marine snail

  1996cited by this paper
• Contryphan Is a D-Tryptophan-containing Conus Peptide*

  1996cited by this paper
• The charybdotoxin family of K+ channel-blocking peptides.

  1995cited by this paper
• Serotonin receptors: subtypes, functional responses and therapeutic relevance.

  1995cited by this paper
• Combinatorial peptide libraries in drug design: lessons from venomous cone snails.

  1995cited by this paper
• New players in the 5-HT receptor field: genes and knockouts.

  1995cited by this paper
• New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

  1994cited by this paper
• Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

  1993cited by this paper
• Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha.

  1993cited by this paper
• A new wave of serotonin receptors.

  1993cited by this paper
• Substitution of three amino acids switches receptor specificity of Gqα to that of Giα

  1993cited by this paper
• 5-Hydroxytryptamine receptors.

  1992cited by this paper
• Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel.

  1991cited by this paper
• Conotoxins.

  1991cited by this paper
• The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.

  1990cited by this paper
• Diversity of Conus neuropeptides.

  1990cited by this paper
• The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: β4

  1989cited by this paper
• The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: beta 4.

  1989cited by this paper
• Molecular characterization of a functional cDNA encoding the serotonin 1c receptor.

  1988cited by this paper
• Molecular Biology of Nicotinic Acetylcholine Receptors

  1987cited by this paper
• Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family.

  1987cited by this paper
• Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

  1973cited by this paper

• In silico toxicology investigation of μ-conotoxin KIIIA on human Na+ channel Nav1.2.

  2025cites this paper
• Structural characterisation of a cysteine-rich conotoxin, sigma(σ)S-GVIIIA, extracted from the defensive venom of the marine cone snail Conus geographus

  2025influential citation
• Advances in the synthesis and engineering of conotoxins.

  2024cites this paper
• Predatory and Defensive Strategies in Cone Snails

  2024cites this paper
• Nobel somatosensations and pain

  2022cites this paper
• Venomics Reveals a Non-Compartmentalised Venom Gland in the Early Diverged Vermivorous Conus distans

  2022cites this paper
• Translational Informatics for Natural Products as Antidepressant Agents

  2022cites this paper
• A Review on the Antidiabetic and Anticancer Activities of Conus Venom Peptides

  2021cites this paper
• Toxinology of Marine Venomous Snails

  2021cites this paper
• Post-translationally modified conopeptides: Biological activities and pharmacological applications.

  2021cites this paper
• Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research

  2020cites this paper
• Comparative transcriptomics of the venoms of continental and insular radiations of West African cones

  2020cites this paper
• Human health and snails

  2020cites this paper
• The Therapeutic Prospects of Naturally Occurring and Synthetic Indole Alkaloids for Depression and Anxiety Disorders

  2020cites this paper
• Determinación computacional de la relación estructura-actividad en las conotoxinas cal29b y xm11a, y su unión a los receptores farmacológicos en Mycobacterium tuberculosis.

  2019cites this paper
• Bromotryptophan and its Analogs in Peptides from Marine Animals.

  2019cites this paper
• Conotoxins: Chemistry and Biology.

  2019cites this paper
• Selecting Potential Neuronal Drug Leads from Conotoxins of Various Venomous Marine Cone Snails in Bali, Indonesia

  2019cites this paper
• Les cônes marins, une ressource naturelle d’antalgiques venue du fond des mers : au-delà du ziconotide ?

  2019cites this paper
• Structural and Functional Analyses of Cone Snail Toxins

  2019cites this paper
• Natural product modulators of human sensations and mood: molecular mechanisms and therapeutic potential.

  2018cites this paper
• Discovery Methodology of Novel Conotoxins from Conus Species

  2018cites this paper
• Recent Developments and Chemical Diversity of Cone Snails with Special Reference to Indian Cone Snails

  2018cites this paper
• Mass spectrometric identification of bromotryptophan containing conotoxin sequences from the venom of C. amadis

  2018cites this paper
• A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus)

  2017cites this paper
• Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (CaV) Channels

  2017cites this paper
• Pharmacology of predatory and defensive venom peptides in cone snails.

  2017cites this paper
• Diversity in sequences, post‐translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting‐edge proteomics, transcriptomics and bioinformatics

  2017cites this paper
• Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study

  2017cites this paper
• The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea

  2017cites this paper
• Pharmacological screening technologies for venom peptide discovery

  2017cites this paper
• Formation and reductive ring opening reactions of indolyl bicyclic-isoxazolidines-II:7 access to novel natural product analogs

  2016cites this paper
• High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing

  2016cites this paper
• Prey-Capture Strategies of Fish-Hunting Cone Snails: Behavior, Neurobiology and Evolution

  2016cites this paper
• Immunomodulatory and Therapeutic Potential of Zootoxins (Venom and Toxins) on the Way Towards Designing and Developing Novel Drugs/Medicines: An Overview

  2016cites this paper
• Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications

  2016cites this paper
• Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks

  2015influential citation
• αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors.

  2015cites this paper
• High Conopeptide Diversity in Conus tribblei Revealed Through Analysis of Venom Duct Transcriptome Using Two High-Throughput Sequencing Platforms

  2015cites this paper
• Prey-Capture Strategies of Fish-Hunting Cone Snails: Behavior, Neurobiology and Evolution

  2015cites this paper
• Prey-Capture Strategies of Fish-Hunting Cone Snails : Behavior , Neurobiology and Evolution

  2015influential citation
• Conotoxins: Modulators of Ion Channel and their Applications

  2014cites this paper
• Characterization of a Novel Conus bandanus Conopeptide Belonging to the M-Superfamily Containing Bromotryptophan

  2014cites this paper
• Conotoxins and Other Conopeptides

  2014cites this paper
• Diversity of Conotoxin Gene Superfamilies in the Venomous Snail, Conus victoriae

  2014cites this paper
• Conotoxins and their regulatory considerations.

  2014cites this paper
• Conotoxin Gene Superfamilies

  2014cites this paper
• Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors.

  2013cites this paper
• Diversity of Conus peptides that target the nicotinic acetylcholine receptors

  2013cites this paper
• Rapid mass spectrometric determination of disulfide connectivity in peptides and proteins.

  2013cites this paper
• A Novel Inhibitor of α9α10 Nicotinic Acetylcholine Receptors from Conus vexillum Delineates a New Conotoxin Superfamily

  2013cites this paper
• Conus Venom Peptide Pharmacology

  2012cites this paper
• Development and Application of Membrane-Tethered Toxins for Genetic Analyses of Neuronal Circuits

  2012cites this paper
• Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct

  2012cites this paper
• Conotoxins: From the biodiversity of gastropods to new drugs

  2012cites this paper
• Therapeutic potential of cone snail venom peptides (conopeptides).

  2012cites this paper
• Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes

  2012cites this paper
• 9.3 KDa components of the injected venom of Conus purpurascens define a new five‐disulfide conotoxin framework

  2011cites this paper
• From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

  2011cites this paper
• Conotoxin-based leads in drug design

  2011cites this paper
• Conopeptide characterization and classifications: an analysis using ConoServer.

  2010cites this paper
• 2.15 – Natural Peptide Toxins

  2010cites this paper
• Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844.

  2010cites this paper
• Drugs from slugs--past, present and future perspectives of omega-conotoxin research.

  2010cites this paper
• Marine indole alkaloids: potential new drug leads for the control of depression and anxiety.

  2010cites this paper
• Detailed atomistic molecular dynamics simulations of alpha-conotoxin AuIB in water.

  2009cites this paper
• Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily.

  2009cites this paper
• Chapter 36 – Biology and Pharmacology of Conotoxins

  2009cites this paper
• Dissertation zur Erlangung des Grades eines Doktors der Naturwissenschaften

  2009cites this paper
• Identification of a novel S-superfamily conotoxin from vermivorous Conus caracteristicus.

  2008cites this paper
• Folding of Conotoxins: Formation of the Native Disulfide Bridges During Chemical Synthesis and Biosynthesis of Conus Peptides

  2008cites this paper
• Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins.

  2008cites this paper
• Antifouling activity of a dibrominated cyclopeptide from the marine sponge Geodia barretti.

  2008cites this paper
• A rational nomenclature for naming peptide toxins from spiders and other venomous animals.

  2008cites this paper
• The five bromotryptophans

  2007cites this paper
• Chemical modification of conotoxins to improve stability and activity.

  2007cites this paper
• Isolation and characterization of a T-superfamily conotoxin from Conus litteratus with targeting tetrodotoxin-sensitive sodium channels.

  2007cites this paper
• Photoactivatable derivatives of peptide and protein ligands in the study of neuroreceptor structure

  2007cites this paper
• Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands.

  2006cites this paper
• Modification of tryptophan and tryptophan residues in proteins by reactive nitrogen species.

  2006cites this paper
• Identification of a Novel Class of Nicotinic Receptor Antagonists

  2006cites this paper
• Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus.

  2006cites this paper
• Conus Peptides: Biodiversity-based Discovery and Exogenomics*

  2006cites this paper
• Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 32 Bioactive Compounds from the Marine Sponge Geodia barretti Characterization , Antifouling Activity and Molecular Targets

  2006cites this paper
• Conotoxins: Therapeutic Potential and Application

  2006cites this paper
• Antifouling activity of synthesized peptide analogs of the sponge metabolite barettin.

  2006cites this paper
• NMR of conotoxins: structural features and an analysis of chemical shifts of post‐translationally modified amino acids

  2006cites this paper
• Conotoxins down under.

  2006cites this paper
• The Tarantula Toxin Psalmotoxin 1 Inhibits Acid-sensing Ion Channel (ASIC) 1a by Increasing Its Apparent H+ Affinity

  2005cites this paper
• Alpha S-conotoxin RVIIIA: a structurally unique conotoxin that broadly targets nicotinic acetylcholine receptors.

  2005cites this paper
• Molecular prospecting for drugs from the sea. Isolating therapeutic peptides and proteins from cone snail venom.

  2005cites this paper
• Sequence diversity of T-superfamily conotoxins from Conus marmoreus.

  2005cites this paper
• Natural products as tools for studies of ligand-gated ion channels.

  2005cites this paper
• A novel conotoxin from Conus delessertii with posttranslationally modified lysine residues.

  2005cites this paper
• Molecular prospecting for drugs from the sea

  2005cites this paper
• Conantokins: peptide antagonists of NMDA receptors.

  2004cites this paper
• Drugs from the sea: conopeptides as potential therapeutics.

  2004cites this paper
• Venom effects on monoaminergic systems

  2004cites this paper
• Determining sequences and post-translational modifications of novel conotoxins in Conus victoriae using cDNA sequencing and mass spectrometry.

  2004cites this paper
• Conotoxins and structural biology: a prospective paradigm for drug discovery.

  2004cites this paper