Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cancer Research

• Publication date

  2006-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-05-3243PMID 16740736PMCID PMC4484848
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells

  2006cited by this paper
• Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase.

  2005cited by this paper
• Limits of predictive models using microarray data for breast cancer clinical treatment outcome.

  2005cited by this paper
• The Src kinase pathway promotes tamoxifen agonist action in Ishikawa endometrial cells through phosphorylation-dependent stabilization of estrogen receptor (alpha) promoter interaction and elevated steroid receptor coactivator 1 activity.

  2005cited by this paper
• Reversible Oxidation of ERK-directed Protein Phosphatases Drives Oxidative Toxicity in Neurons*

  2005cited by this paper
• Molecular classification of tamoxifen-resistant breast carcinomas by gene expression profiling.

  2005cited by this paper
• Phospho-Serine-118 Estrogen Receptor-α Expression Is Associated with Better Disease Outcome in Women Treated with Tamoxifen

  2004cited by this paper
• A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.

  2004cited by this paper
• Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells

  2004cited by this paper
• Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.

  2004cited by this paper
• Phosphorylation of Estrogen Receptor α Blocks Its Acetylation and Regulates Estrogen Sensitivity

  2004cited by this paper
• Prolonged Extracellular Signal-Regulated Kinase 1/2 Activation during Fibroblast Growth Factor 1- or Heregulin β1-Induced Antiestrogen-Resistant Growth of Breast Cancer Cells Is Resistant to Mitogen-Activated Protein/Extracellular Regulated Kinase Kinase Inhibitors

  2004cited by this paper
• Phosphorylation of estrogen receptor alpha blocks its acetylation and regulates estrogen sensitivity.

  2004cited by this paper
• A random variance model for detection of differential gene expression in small microarray experiments

  2003cited by this paper
• Estrogen and antiestrogen regulation of cell cycle progression in breast cancer cells.

  2003cited by this paper
• Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer.

  2003cited by this paper
• Adaptive mechanisms induced by long-term estrogen deprivation in breast cancer cells.

  2002cited by this paper
• Phosphorylation of ERK1/2 mitogen‐activated protein kinase is associated with poor response to anti‐hormonal therapy and decreased patient survival in clinical breast cancer

  2001cited by this paper
• Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application

  2001cited by this paper
• The Human Estrogen Receptor-α Is a Ubiquitinated Protein Whose Stability Is Affected Differentially by Agonists, Antagonists, and Selective Estrogen Receptor Modulators*

  2001cited by this paper
• Mechanisms of tamoxifen-induced apoptosis

  2001cited by this paper
• Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2*

  2001cited by this paper
• Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3*

  2000cited by this paper
• Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity.

  2000cited by this paper
• Dual specificity phosphatases: a gene family for control of MAP kinase function

  2000cited by this paper
• Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells.

  2000cited by this paper
• Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo.

  2000cited by this paper
• A hypersensitive estrogen receptor-alpha mutation in premalignant breast lesions.

  2000cited by this paper
• Proteasome-dependent degradation of the human estrogen receptor.

  1999cited by this paper
• Acquired antiestrogen resistance in MCF-7 human breast cancer sublines is not accomplished by altered expression of receptors in the ErbB-family

  1999cited by this paper
• Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

  1996cited by this paper
• Tyrosine kinase/p21ras/MAP‐kinase pathway activation by estradiol‐receptor complex in MCF‐7 cells.

  1996cited by this paper
• Comparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer.

  1995cited by this paper
• Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

  1995influential reference

• OCT4-mediated upregulation of DUSP6 promotes metastasis in non-small-cell lung cancer

  2025cites this paper
• Dual-Specificity Protein Phosphatases Targeting Extracellular Signal-Regulated Kinases: Friends or Foes in the Biology of Cancer?

  2025cites this paper
• Hormone Signaling in Breast Development and Cancer.

  2025cites this paper
• Metabolomic rewiring promotes endocrine therapy resistance in breast cancer.

  2023cites this paper
• QSAR Study, Molecular Docking/Dynamics Simulations and ADME Prediction of 2-Phenyl-1H-Indole Derivatives as Potential Breast Cancer Inhibitors

  2022cites this paper
• Dual-specificity phosphatases: therapeutic targets in cancer therapy resistance

  2022cites this paper
• Combinatorial treatments of tamoxifen and SM6Met, an extract from Cyclopia subternata Vogel, are superior to either treatment alone in MCF-7 cells

  2022cites this paper
• Cancer stem cell phosphatases.

  2021cites this paper
• Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis

  2021cites this paper
• Overexpression of DUSP6 enhances chemotherapy-resistance of ovarian epithelial cancer by regulating the ERK signaling pathway

  2020cites this paper
• Somatic alterations of TP53, ERBB2, PIK3CA and CCND1 are associated with chemosensitivity for breast cancers

  2019cites this paper
• Nuclear-Biased DUSP6 Expression is Associated with Cancer Spreading Including Brain Metastasis in Triple-Negative Breast Cancer

  2019cites this paper
• Pharmacological inhibition of DUSP6 suppresses gastric cancer growth and metastasis and overcomes cisplatin resistance.

  2018cites this paper
• Dual-specificity phosphatase 6 (DUSP6): a review of its molecular characteristics and clinical relevance in cancer

  2018cites this paper
• Tracking evolution of aromatase inhibitor resistance with circulating tumour DNA analysis in metastatic breast cancer

  2018cites this paper
• Triethylenetetramine Synergizes with Pharmacologic Ascorbic Acid in Hydrogen Peroxide Mediated Selective Toxicity to Breast Cancer Cell

  2017cites this paper
• The Role of the Androgen Receptor Signaling in Breast Malignancies.

  2017cites this paper
• Phosphatases and solid tumors: focus on glioblastoma initiation, progression and recurrences.

  2017cites this paper
• Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification.

  2017cites this paper
• Regulation and Function of MAP Kinases in PDGF Signaling

  2016cites this paper
• Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival.

  2016cites this paper
• Genomic and transcriptomic profiles and in vitro resistance to mitoxantrone and idarubicin in pediatric acute leukemias

  2016cites this paper
• Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer

  2016cites this paper
• Regulatory Roles of MAPK Phosphatases in Cancer

  2016cites this paper
• Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer

  2016cites this paper
• Dual-Specificity Map Kinase (MAPK) Phosphatases (MKPs) and Their Involvement in Cancer

  2016cites this paper
• Identification of novel roles and new modes of regulation for the atypical MAP kinases ERK3 and ERK4

  2015cites this paper
• Prognostic value of dual-specificity phosphatase 6 expression in non-small cell lung cancer

  2015cites this paper
• Androgen receptor promotes tamoxifen agonist activity by activation of EGFR in ERα-positive breast cancer

  2015cites this paper
• Breast Cancer and Oxidative Stress

  2015cites this paper
• Dual-Specificity Phosphatases as Molecular Targets for Inhibition in Human Disease

  2014cites this paper
• Gene expression profile of peripheral blood in colorectal cancer.

  2014cites this paper
• Estrogen receptor (ER) α mutations in breast cancer: hidden in plain sight

  2014cites this paper
• Progress in study on DUSP6 in the tumor

  2014cites this paper
• The kinome associated with estrogen receptor-positive status in human breast cancer.

  2014cites this paper
• mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma

  2014cites this paper
• Anomalies moléculaires de la voie MAPK et cancer papillaire de la thyroïde : étude de deux phosphatases spécifiques de ERK, DUSP5 et DUSP6

  2014cites this paper
• Fonctions antitumorales de la voie ERK/MAPK et développement rationnel de nouvelles stratégies thérapeutiques

  2014cites this paper
• Verification of gene expression profiles for colorectal cancer using 12 internet public microarray datasets.

  2014cites this paper
• Targeting DUSPs in glioblastomas – wielding a double‐edged sword?

  2014cites this paper
• RETROSPECTIVE STUDY Verification of gene expression profiles for colorectal cancer using 12 internet public microarray datasets

  2014cites this paper
• Retraction Retracted : Chemistry and Biology of Essential Oils of Genus Boswellia Evidence-Based Complementary and Alternative Medicine

  2014cites this paper
• Control of Sty1 MAPK activity through stabilisation of the Pyp2 MAPK phosphatase

  2013cites this paper
• GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancer

  2013cites this paper
• DUSP6, a tumor suppressor, is involved in differentiation and apoptosis in esophageal squamous cell carcinoma

  2013cites this paper
• Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer.

  2013cites this paper
• Chemistry and Biology of Essential Oils of Genus Boswellia

  2013cites this paper
• A Common Docking Domain in Progesterone Receptor-B links DUSP6 and CK2 signaling to proliferative transcriptional programs in breast cancer cells

  2013cites this paper
• Dual-specificity phosphatase 6 (Dusp6), a negative regulator of FGF2/ERK1/2 signaling, enhances 17β-estradiol-induced cell growth in endometrial adenocarcinoma cell.

  2013cites this paper
• Expression And Regulation Of Map Kinase Phosphatases 1 And 2 In Breast Cancer Tamoxifen Sensitivity

  2013cites this paper
• Investigating epigenetic mechanisms of acquired endocrine resistance in an in vitro model of breast cancer

  2013cites this paper
• Downregulation of insulin-like growth factor-binding protein 7 in cisplatin-resistant non-small cell lung cancer

  2012cites this paper
• Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics

  2012cites this paper
• DUSP6 is a novel transcriptional target of p53 and regulates p53‐mediated apoptosis by modulating expression levels of Bcl‐2 family proteins

  2012cites this paper
• Determining the Roles that DICER1 and Noncoding RNAs Play in Endometrial Tumorigenesis

  2012cites this paper
• The Role of Redox Signaling in the Molecular Mechanism of Tamoxifen Resistance in Breast Cancer

  2012cites this paper
• A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons

  2012cites this paper
• Efecto de la doxorubicina sobre MKP-1 en el cáncer de mama humano y asociación entre la expresión de MKP-1 y la evolución de las pacientes

  2012cites this paper
• Tumor suppressor dual‐specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial‐mesenchymal transition (EMT)‐associated phenotype

  2012cites this paper
• The role of FOXO3a in the cellular stress response and metabolism of breast cancer cells

  2012cites this paper
• MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis.

  2012cites this paper
• Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α.

  2011cites this paper
• Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas

  2011influential citation
• Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells

  2011cites this paper
• The genetic association of DUSP6 with bipolar disorder and its effect on ERK activity.

  2011cites this paper
• Signalling pathways in basal-like breast carcinomas: a clue on pathogenesis and therapeutical targets.

  2011cites this paper
• Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells

  2011influential citation
• Resveratrol, through NF‐Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor α gene expression via p38MAPK/CK2 signaling in human breast cancer cells

  2011cites this paper
• 4-hydroxy estradiol-induced oxidant-mediated signaling is involved in the development of breast cancer

  2011cites this paper
• Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer.

  2011cites this paper
• “Overcoming breast cancer drug resistance with mTOR inhibitors”. Could it be a myth or a real possibility in the short-term future?

  2011cites this paper
• Dual-specificity MAP kinase phosphatases as targets of cancer treatment.

  2011cites this paper
• Dual roles of estrogen metabolism in mammary carcinogenesis.

  2011cites this paper
• Free radicals in breast carcinogenesis, breast cancer progression and cancer stem cells. Biological bases to develop oxidative-based therapies.

  2011cites this paper
• Mitogen activated protein kinase phosphatases and cancer

  2010cites this paper
• Ron receptor tyrosine kinase activation confers resistance to tamoxifen in breast cancer cell lines.

  2010cites this paper
• Unliganded estrogen receptor-beta regulation of genes is inhibited by tamoxifen.

  2010cites this paper
• The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment

  2010cites this paper
• Protein Kinase C as an Apoptosis Regulator and a Potential Prognostic Marker in Breast Cancer

  2010cites this paper
• BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

  2010cites this paper
• Investigation of the effects of adenosine and purine nucleoside analogues on the viability of human breast cancer cells

  2010cites this paper
• Protein Kinase C as an Apoptosis Regulator and a Potential Prognostic Factor in Breast Cancer

  2010cites this paper
• Jostling for Position: Optimizing Linker Location in the Design of Estrogen Receptor‐Targeting PROTACs

  2010cites this paper
• The dual-specificity MAP kinase phosphatases: critical roles in development and cancer.

  2010influential citation
• Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling

  2010cites this paper
• A phosphorylation code for oestrogen receptor-alpha predicts clinical outcome to endocrine therapy in breast cancer.

  2010cites this paper
• Expression and functional role of negative signalling regulators in tumour development and progression

  2010cites this paper
• Infrequent methylation of the DUSP6 phosphatase in endometrial cancer.

  2010cites this paper
• Differential Up-regulation of MAP Kinase Phosphatases MKP3/DUSP6 and DUSP5 by Ets2 and c-Jun Converge in the Control of the Growth Arrest Versus Proliferation Response of MCF-7 Breast Cancer Cells to Phorbol Ester*

  2010cites this paper
• Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells

  2010influential citation
• Mitogen-Activated Protein Kinase Phosphatase-1 in Human Breast Cancer Independently Predicts Prognosis and Is Repressed by Doxorubicin

  2009cites this paper
• A systems biological approach suggests that transcriptional feedback regulation by dual‐specificity phosphatase 6 shapes extracellular signal‐related kinase activity in RAS‐transformed fibroblasts

  2009cites this paper
• Protein Modifications as Potential Biomarkers in Breast Cancer

  2009cites this paper
• Estrogen Regulation of MicroRNA Expression

  2009influential citation
• Dual-specificity phosphatases: critical regulators with diverse cellular targets.

  2009cites this paper
• Phase II multicenter, uncontrolled trial of sorafenib in patients with metastatic breast cancer

  2009cites this paper
• FOXO transcription factors: from cell fate decisions to regulation of human female reproduction.

  2009cites this paper
• Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer

  2008cites this paper
• Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3.

  2008cites this paper
• Rational management of endocrine resistance in breast cancer

  2008cites this paper