The evolutionary origin of genetic instability in cancer development.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Seminars in Cancer Biology

• Publication date

  2005-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.SEMCANCER.2004.09.008PMID 15613288
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Carcinogen-specific targeting of chromosome 12 for loss of heterozygosity in mouse lung adenocarcinomas: implications for chromosome instability and tumor progression

  2004cited by this paper
• Linear Model of Colon Cancer Initiation

  2004cited by this paper
• Secondary malignant neoplasms of the bladder after cyclophosphamide treatment for childhood acute lymphocytic leukemia

  2004cited by this paper
• Control of oncogenesis and cancer therapy resistance

  2004cited by this paper
• Cancer without disease

  2004cited by this paper
• Resolving the evolutionary paradox of genetic instability: a cost–benefit analysis of DNA repair in changing environments

  2004cited by this paper
• Apoptosis in cancer--implications for therapy.

  2004cited by this paper
• Cancer Statistics, 2004

  2004cited by this paper
• Can better prescribing turn the tide of resistance?

  2004cited by this paper
• DNA repair and cancer: Lessons from mutant mouse models

  2004cited by this paper
• Inactivation of hCDC4 can cause chromosomal instability

  2004cited by this paper
• Reproductive epigenetics

  2004cited by this paper
• Aneuploidy, the Primary Cause of the Multilateral Genomic Instability of Neoplastic and Preneoplastic Cells

  2004cited by this paper
• Telomeres and chromosomal instability

  2004cited by this paper
• Toxic effects of ultraviolet radiation on the skin.

  2004cited by this paper
• The history of cancer epigenetics

  2004cited by this paper
• Chromosome instability in cancer: how, when, and why?

  2003cited by this paper
• On the Ordinality of Causes in Complex Autocatalytic Systems

  2003cited by this paper
• The Human Mutator Gene Homolog MSHP and Its Association with Hereditary Nonpolyposis Colon Cancer

  2003cited by this paper
• The significance of unstable chromosomes in colorectal cancer

  2003cited by this paper
• Genomic instability — the engine of tumorigenesis?

  2003cited by this paper
• Response to environmental carcinogens in DNA-repair-deficient disorders.

  2003cited by this paper
• Specification of germ cell fate in mice.

  2003cited by this paper
• Cancer as an evolutionary process at the cell level: an epidemiological perspective.

  2003cited by this paper
• Food mutagens.

  2003cited by this paper
• Evolution of mutational robustness.

  2003cited by this paper
• Untangling the roots of cancer.

  2003cited by this paper
• The Directed Mutation Controversy in an Evolutionary Context

  2003cited by this paper
• Natural selection of tumor variants in the generation of “tumor escape” phenotypes

  2002cited by this paper
• Genealogical evidence for epidemics of selfish genes

  2002cited by this paper
• Genetic insights into familial cancers-- update and recent discoveries.

  2002cited by this paper
• Exploring and Exploiting Instability

  2002cited by this paper
• Gastrointestinal cancer of the microsatellite mutator phenotype pathway

  2002cited by this paper
• The mechanism and regulation of chromosomal V(D)J recombination.

  2002cited by this paper
• The role of chromosomal instability in tumor initiation

  2002cited by this paper
• Fitness evolution and the rise of mutator alleles in experimental Escherichia coli populations.

  2002cited by this paper
• Unraveling DNA Repair in Human: Molecular Mechanisms and Consequences of Repair Defect

  2001cited by this paper
• How carcinogens (or telomere dysfunction) induce genetic instability: associated‐selection model

  2001cited by this paper
• Different mechanisms in the tumorigenesis of proximal and distal colon cancers

  2001cited by this paper
• Self-Organization of Template-Replicating Polymers and the Spontaneous Rise of Genetic Information

  2001cited by this paper
• Humans as the world's greatest evolutionary force.

  2001cited by this paper
• Carcinogen-specific induction of genetic instability

  2001cited by this paper
• Malignant neoplasms: discordance between clinical diagnoses and autopsy findings in 3,118 cases

  2001cited by this paper
• Second tumours.

  2001cited by this paper
• Don't stop for repairs in a war zone: Darwinian evolution unites genes and environment in cancer development

  2001cited by this paper
• The evolution of mutation rates: separating causes from consequences

  2000cited by this paper
• Evolution of Biological Complexity

  2000cited by this paper
• Molecular interactions in the Vogelstein model of colorectal carcinoma

  2000cited by this paper
• Human lung cancer and p53: the interplay between mutagenesis and selection.

  2000cited by this paper
• Mutators and sex in bacteria: conflict between adaptive strategies.

  2000cited by this paper
• A simple model for carcinogenesis of colorectal cancers with microsatellite instability.

  2000cited by this paper
• Genomic instability, DNA methylation, and natural selection in colorectal carcinogenesis.

  1999cited by this paper
• Carcinogenesis and natural selection: a new perspective to the genetics and epigenetics of colorectal cancer.

  1999cited by this paper
• Genetic instability and darwinian selection in tumours.

  1999cited by this paper
• Ultimate physical limits to computation

  1999cited by this paper
• Tobacco smoke carcinogens and lung cancer.

  1999cited by this paper
• Cell damage, aging and transformation: a multilevel analysis of carcinogenesis.

  1999cited by this paper
• Cancer cells exhibit a mutator phenotype.

  1998cited by this paper
• Foulds' dangerous idea revisited: the multistep development of tumors 40 years later.

  1998cited by this paper
• Microsatellite instability in human solid tumors

  1998cited by this paper
• Genetic instabilities in human cancers

  1998cited by this paper
• Microsatellite instability in human solid tumors.

  1997cited by this paper
• The objects of selection.

  1997cited by this paper
• Different genetic pathways to proximal and distal colorectal cancer influenced by sex‐related factors

  1997cited by this paper
• Mutation for survival.

  1997cited by this paper
• Genetic instability in colorectal cancers

  1997cited by this paper
• Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype

  1997cited by this paper
• Introduction To Artificial Life

  1997cited by this paper
• Cancer-susceptibility genes. Gatekeepers and caretakers.

  1997cited by this paper
• Microsatellite instability and mutations of p53 and TGF-beta RII genes in gastric cancer.

  1996cited by this paper
• Genomic instability and tolerance to alkylating agents.

  1996cited by this paper
• Microsatellite instability and mutations of p53 and TGF-‚RII genes in gastric cancer

  1996cited by this paper
• Cell cycle. Why don't plants get cancer?

  1996cited by this paper
• Why don't plants get cancer?

  1996cited by this paper
• DNA repair fine structure and its relations to genomic instability.

  1995cited by this paper
• Darwin's Dangerous Idea

  1995cited by this paper
• DNA chaperones: a solution to a persistence problem?

  1994cited by this paper
• The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.

  1994cited by this paper
• The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.

  1993cited by this paper
• Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.

  1993cited by this paper
• Genomic instability occurs in colorectal carcinomas but not in adenomas

  1993cited by this paper
• Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

  1993cited by this paper
• The multistep nature of cancer.

  1993cited by this paper
• Mutator phenotype may be required for multistage carcinogenesis.

  1991cited by this paper
• Chlamydia

  1990cited by this paper
• The selfish gene (2nd edn)

  1990cited by this paper
• A genetic model for colorectal tumorigenesis.

  1990cited by this paper
• Cancer statistics

  1989cited by this paper
• Pathologic basis of disease

  1974cited by this paper
• NATURAL history of cancer.

  1963cited by this paper
• The natural history of cancer.

  1958cited by this paper
• The Natural History of Cancer

  1905cited by this paper

• Exploring Biocomplexity in Cancer: A Comprehensive Review

  2024cites this paper
• Peto’s “Paradox” and Six Degrees of Cancer Prevalence

  2024influential citation
• Viral carcinogenesis: A concise review

  2023cites this paper
• Co nás učí nádory. Paralely v chování buněk a lidí

  2021cites this paper
• Evaluation of the Genotoxicity of Endodontic Materials for Deciduous Teeth Using the Comet Assay

  2021cites this paper
• The UnderstAnding of Enigmas Related to Cancer: Cancer Origin and Progression- A Review

  2021cites this paper
• Aspirin and the chemoprevention of cancers: A mathematical and evolutionary dynamics perspective

  2020cites this paper
• The evolution of metapopulation dynamics and the number of stem cells in intestinal crypts and other tissue structures in multicellular bodies

  2020cites this paper
• The Etiology of Cancer

  2020cites this paper
• Development versus Evolution in Cancer Biology.

  2018cites this paper
• Article Title: Multi-target Analysis of Neoplasms for the Evaluation of Tumor Progression: Stochastic Approach of Biologic Processes

  2018influential citation
• Une approche multi-échelle des processus écologiques et évolutifs impliqués dans le cancer

  2017cites this paper
• Stochastic model of contact inhibition and the proliferation of melanoma in situ

  2017cites this paper
• Non-cell-autonomous effects yield lower clonal diversity in expanding tumors

  2017cites this paper
• Tumor Dormancy and Relapse: From a Natural Byproduct of Evolution to a Disease State.

  2017cites this paper
• Human 8-oxoguanine DNA glycosylase gene polymorphism (Ser326Cys) and cancer risk: updated meta-analysis

  2017cites this paper
• Effect of cell cycle duration on somatic evolutionary dynamics

  2017cites this paper
• Evaluation of the genotoxicity and cytotoxicity of filling pastes used for pulp therapy on deciduous teeth using the micronucleus test on bone marrow from mice (Mus musculus).

  2016cites this paper
• Treatment Induced Autophagy Associated with Tumor Dormancy and Relapse

  2016cites this paper
• Origin of Cancer: An Information, Energy, and Matter Disease

  2016cites this paper
• An Evolutionary Genetic Perspective on Cancer Biology

  2016cites this paper
• Pathological Bases for a Robust Application of Cancer Molecular Classification

  2015cites this paper
• UNIVERSIDADE ESTADUAL DE FEIRA DE SANTANA PROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA

  2015cites this paper
• Single-Cell Next-Generation Sequencing and Its Applications in Cancer Biology

  2015cites this paper
• Avaliação da participação de grânulos de estresse na resposta a agentes antineoplásicos em linhagens celulares de tumores cerebrais

  2015cites this paper
• Who has misled Trond Mohn?

  2015cites this paper
• Caracterização do genoma de tumores bem diferenciados da tireóide por hibridização genômica comparativa em matriz (aCGH)

  2014cites this paper
• Evolution of Cancer: A Quantum Mechanical Approach

  2014cites this paper
• Fastest Time to Cancer by Loss of Tumor Suppressor Genes

  2014cites this paper
• Analysis of novel mutations in BRCA1 in Iranian families with breast cancer.

  2014cites this paper
• Low-fidelity compensatory backup alternative DNA repair pathways may unify current carcinogenesis theories.

  2014cites this paper
• Understanding Cancer via Cell Evolution

  2014cites this paper
• Recognizing Cancer via Somatic and Organic Evolution

  2014cites this paper
• Fastest Time to Cancer by Loss of Tumor Suppressor Genes

  2014cites this paper
• Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution

  2013cites this paper
• Oral squamous cell carcinoma in relation to field precancerisation: pathobiology

  2013cites this paper
• Mechanisms and insights into drug resistance in cancer

  2013cites this paper
• [The cancer riddle is outdated].

  2013cites this paper
• Assessment of exposure to organochlorine pesticides and levels of DNA damage in mother–infant pairs of an agrarian community

  2013cites this paper
• Methylation kinetics and CpG-island methylator phenotyope status in colorectal cancer cell lines

  2013cites this paper
• Chemical biology approaches for the identification of novel p53 regulatory signalling pathways

  2013cites this paper
• STAGE T 1 URINARY BLADDER CARCINOMA : INVESTIGATION OF A POPULATION-BASED COHORT

  2012cites this paper
• Molecular profile of colorectal cancer in Indonesia: is there another pathway?

  2012influential citation
• Tumor Heterogeneity: Mechanisms and Bases for a Reliable Application of Molecular Marker Design

  2012influential citation
• MOLECULAR PROFILE OF COLORECTAL CANCER IN INDONESIA: IS THERE ANOTHER PATHWAY? (REVIEW ARTICLE)

  2012cites this paper
• Stage T1 Urinary Bladder Carcinoma : Investigation of A Population-Based Cohort

  2012cites this paper
• CONTRIBUTIONS OF EVOLUTIONARY BIOLOGY TO THE UNDERSTANDING OF CANCER

  2012cites this paper
• Germ cell DNA-repair systems—possible tools in cancer research?

  2012cites this paper
• Early events during neoplastic progression in Barrett's esophagus

  2011cites this paper
• Bile acids and Barrett's oesophagus : the development of a functional siRNA screen to identify novel therapeutic targets

  2011cites this paper
• The origins of cancer robustness and evolvability.

  2011cites this paper
• Molecular biology and riddle of cancer: the ‘Tom & Jerry’ show

  2011influential citation
• Evolutionary mechanisms and diversity in cancer.

  2011cites this paper
• Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis

  2010cites this paper
• What has happened to human fertility?

  2010cites this paper
• Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis

  2010cites this paper
• The (non)malignancy of cancerous amino acidic substitutions

  2010cites this paper
• Cancer models, genomic instability and somatic cellular Darwinian evolution

  2010cites this paper
• Genetic and epigenetic heterogeneity in cancer: the ultimate challenge for drug therapy.

  2010cites this paper
• Cancer models, genomic instability and somatic cellular Darwinian evolution

  2010cites this paper
• Concomitant loss of heterozygosity at the BRCA1 and FHIT genes as a prognostic factor in sporadic breast cancer.

  2010cites this paper
• Expression of NF-kappaB and COX-2 in young versus older patients with sporadic colorectal cancer.

  2009cites this paper
• Complex event types for agent-based simulation

  2009cites this paper
• Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma.

  2009cites this paper
• Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice

  2009cites this paper
• Chromosome 3 p 12 . 3p 14 . 2 and 3 q 26 . 2q 26 . 32 Are Genomic Markers for Prognosis of Advanced Nasopharyngeal Carcinoma

  2009cites this paper
• Spontaneous regression of human cancer cells in vitro: potential role of disruption of Cdk1/Cdk4 co-expression.

  2009cites this paper
• Stem Cells in Marine Organisms

  2009cites this paper
• Stem Cells: Autonomy Interactors that Emerge as Causal Agents and Legitimate Units of Selection

  2009cites this paper
• Chromosome 3p12.3-p14.2 and 3q26.2-q26.32 Are Genomic Markers for Prognosis of Advanced Nasopharyngeal Carcinoma

  2009cites this paper
• Expression of NF-κB and COX-2 in Young Versus Older Patients with Sporadic Colorectal Cancer: 433

  2009cites this paper
• A darwinian perspective: right premises, questionable conclusion. A commentary on Niall Shanks and Rebecca Pyles' "Evolution and medicine: the long reach of "Dr. Darwin""

  2008cites this paper
• Programmed Genetic Instability: A Tumor-Permissive Mechanism for Maintaining the Evolvability of Higher Species through Methylation-Dependent Mutation of DNA Repair Genes in the Male Germ Line

  2008cites this paper
• A stochastic carcinogenesis model incorporating multiple types of genomic instability fitted to colon cancer data.

  2008cites this paper
• Selective pressures for and against genetic instability in cancer: a time-dependent problem

  2008cites this paper
• The microenvironments of multistage carcinogenesis.

  2008cites this paper
• Characterization of Bone Morphogenetic protein 7 in Breast Cancer

  2008cites this paper
• Evolutionary Dynamics of Genes and Environment in Cancer Development

  2008cites this paper
• Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis

  2008cites this paper
• Cell lineage analysis of a mouse tumor.

  2008cites this paper
• Beyond the Oncogene Paradigm: Understanding Complexity in Cancerogenesis

  2008cites this paper
• The use of animals in biomedical research

  2007cites this paper
• Multistage carcinogenesis in Barrett's esophagus.

  2007cites this paper
• Mouse Models for Gastrointestinal Cancer

  2007cites this paper
• Exposure to the tobacco smoke constituent 4-aminobiphenyl induces chromosomal instability in human cancer cells.

  2007cites this paper
• Variation, "evolution", immortality and genetic instabilities in tumour cells.

  2007cites this paper
• Genetic susceptibility for breast cancer: how many more genes to be found?

  2007cites this paper
• Proteome characterization of a human urothelial cell line resistant to the bladder carcinogen 4-aminobiphenyl

  2007cites this paper
• Cancer genome sequencing: the challenges ahead.

  2007cites this paper
• Random mutations, selected mutations: A PIN opens the door to new genetic landscapes

  2006cites this paper
• Positive selection in the evolution of cancer 409

  2006influential citation
• Chromosome aberrations in solid tumors have a stochastic nature.

  2006cites this paper
• Chromosome Instability in Carcinomas

  2006cites this paper
• Stochastic modelling of colon cancer: is there a role for genomic instability?

  2006cites this paper
• Somatic Evolution of Cells and the Development of Cancer

  2006cites this paper
• Genetic instability and clonal expansion.

  2006cites this paper
• Is there a Solution to the Cancer Problem

  2006cites this paper
• Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis

  2006cites this paper
• The population dynamics of cancer: a Darwinian perspective.

  2006cites this paper
• Cancer as an evolutionary and ecological process

  2006cites this paper