RNA-binding proteins implicated in the hypoxic response

•  Introduction •  Post‐transcriptional gene regulation by hypoxia ‐  Control of mRNA turnover ‐  mRNA decay ‐  mRNA stabilization ‐  Control of translation ‐  Translational inhibition ‐  Translational activation •  HuR ‐  HIF‐1α mRNA ‐  VEGF mRNA ‐  GLUT1, p53, TGF‐β and c‐myc mRNAs •  PTB ‐  HIF‐1α mRNA ‐  VEGF mRNA ‐  Insulin mRNA •  Other RBPs implicated in the response to hypoxia ‐  IRPs ‐  CPEBs ‐  hnRNPs ‐  TIA‐1, TIAR and RBPs present in SGs ‐  ERBP •  Perspective

• Publication year

  2009

• Venue

  Journal of Cellular and Molecular Medicine

• Publication date

  2009-07-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1582-4934.2009.00842.xPMID 19583805PMCID 2832090
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR.

  2009cited by this paper
• Factors Interacting with HIF-1α mRNA: Novel Therapeutic Targets

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• Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

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• Intermittent hypoxia regulates RNA polymerase II in hippocampus and prefrontal cortex.

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• Ubiquitin‐mediated proteolysis of HuR by heat shock

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• Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression.

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• Factors interacting with HIF-1alpha mRNA: novel therapeutic targets.

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• Diverse molecular functions of Hu proteins

  2008cited by this paper
• miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

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• Hypoxia induces a novel signature of chromatin modifications and global repression of transcription.

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• Large P body-like RNPs form in C. elegans oocytes in response to arrested ovulation, heat shock, osmotic stress, and anoxia and are regulated by the major sperm protein pathway.

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• Biology of hypoxia-inducible factor-2α in development and disease

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• Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein.

  2008influential reference
• Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase Cδ Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA

  2008cited by this paper
• Hypoxic regulation of mRNA expression

  2008influential reference
• Hypoxia‐inducible factor 1 and cancer pathogenesis

  2008cited by this paper
• RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha.

  2008cited by this paper
• The role of hypoxia-inducible factors in tumorigenesis

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• Stress granules: the Tao of RNA triage.

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• Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.

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• Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence

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• Harnessing the hypoxia-inducible factor in cancer and ischemic disease.

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• Protein Kinase Cα-dependent Phosphorylation of the mRNA-stabilizing Factor HuR: Implications for Posttranscriptional Regulation of Cyclooxygenase-2

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• Phosphorylation of HuR by Chk2 regulates SIRT1 expression.

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• NF90 regulates inducible IL-2 gene expression in T cells

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• RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α

  2007influential reference
• P bodies and the control of mRNA translation and degradation.

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• Targeting hypoxia cell signaling for cancer therapy

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• Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia

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• Solving the structure of PTB in complex with pyrimidine tracts: an NMR study of protein-RNA complexes of weak affinities.

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• Hypoxia/reoxygenation and TGF-β increase αB-crystallin expression in human optic nerve head astrocytes

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• The family of iron responsive RNA structures regulated by changes in cellular iron and oxygen

  2007influential reference
• Posttranscriptional Orchestration of an Anti-Apoptotic Program by HuR

  2007cited by this paper
• HIF gene expression in cancer therapy.

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• Hypoxia: A key regulator of angiogenesis in cancer

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• Elucidation of a C-Rich Signature Motif in Target mRNAs of RNA-Binding Protein TIAR

  2007cited by this paper
• Hypoxia-induced and stress-specific changes in chromatin structure and function.

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• Mammalian stress granules and processing bodies.

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• Polyamine Depletion Increases Cytoplasmic Levels of RNA-binding Protein HuR Leading to Stabilization of Nucleophosmin and p53 mRNAs*

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• Hypoxic Regulation of Vascular Endothelial Growth Factor through the Induction of Phosphatidylinositol 3-Kinase/Rho/ROCK and c-Myc*

  2006cited by this paper
• Conformation of polypyrimidine tract binding protein in solution.

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• The regulation of glucose transporter (GLUT1) expression by the RNA binding protein HuR

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• Hypoxia/reoxygenation and TGF-beta increase alphaB-crystallin expression in human optic nerve head astrocytes.

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• In vivo models of angiogenesis

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• RNA granules

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• Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER

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• Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18

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• The polypyrimidine tract-binding protein stimulates HIF-1α IRES-mediated translation during hypoxia

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• Control of the hypoxic response through regulation of mRNA translation.

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• Evidence for an RNA chaperone function of polypyrimidine tract-binding protein in picornavirus translation.

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• Integration of Oxygen Signaling at the Consensus HRE

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• Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.

  2005cited by this paper
• Identification and Functional Outcome of mRNAs Associated with RNA-Binding Protein TIA-1

  2005cited by this paper
• Signalling hypoxia by HIF hydroxylases.

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• Increased expression of polypyrimidine tract binding protein results in higher insulin mRNA levels.

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• Structure of PTB Bound to RNA: Specific Binding and Implications for Splicing Regulation

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• Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis

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• Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay.

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• Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b

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• Cytoplasmic foci are sites of mRNA decay in human cells

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• Poly(A)-binding Protein-interacting Protein 2, a Strong Regulator of Vascular Endothelial Growth Factor mRNA*

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• Role of VHL gene mutation in human cancer.

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• Structure and RNA interactions of the N-terminal RRM domains of PTB.

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• A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization.

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• A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.

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• Identification of a target RNA motif for RNA-binding protein HuR.

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• Oxygen sensing by HIF hydroxylases

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• The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies.

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• The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.

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• c-Jun ARE Targets mRNA Deadenylation by an EDEN-BP (Embryo Deadenylation Element-binding Protein)-dependent Pathway*

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• Angiogenesis therapy in ischemic disease.

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• The mammalian exosome mediates the efficient degradation of mRNAs that contain AU‐rich elements

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• The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.

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• Angiogenesis therapy in ischemic disease.

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• The yin and yang of the exosome.

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• Regulation of glut1 mRNA by Hypoxia-inducible Factor-1

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• Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB).

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• The cap-to-tail guide to mRNA turnover

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• Cooperativity between the Preproinsulin mRNA Untranslated Regions Is Necessary for Glucose-stimulated Translation*

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• mRNA turnover.

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  2019cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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• The role of hypoxia related angiogenesis in uterine smooth muscle tumors

  2015cites this paper
• FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA.

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• Reactive Oxygen Species as Initiators and Mediators of Cellular Signaling Processes

  2015cites this paper
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