Characterization of Apelin, the Ligand for the APJ Receptor

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Neurochemistry

• Publication date

  2000-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1471-4159.2000.0740034.xPMID 10617103
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Levels of angiotensin and molecular biology of the tissue renin angiotensin systems.

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