Unpredictable chronic stress model in zebrafish (Danio rerio): behavioral and physiological responses.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Progress in Neuro-psychopharmacology and Biological Psychiatry

• Publication date

  2011-03-30

• Fields of study

  Biology, Medicine, Environmental Science, Psychology

• Identifiers
  DOI 10.1016/j.pnpbp.2010.12.018PMID 21187119
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Shoaling develops with age in Zebrafish (Danio rerio).

  2011cited by this paper
• Analyzing habituation responses to novelty in zebrafish (Danio rerio).

  2010cited by this paper
• Translating rodent behavioral repertoire to zebrafish (Danio rerio): relevance for stress research.

  2010cited by this paper
• Zebrafish antipredatory responses: a future for translational research?

  2010cited by this paper
• The lonely mouse: verification of a separation-induced model of depression in female mice.

  2010cited by this paper
• Physiological and health consequences of social status in zebrafish (Danio rerio).

  2010cited by this paper
• Susceptibility of a potential animal model for pathological anxiety to chronic mild stress.

  2010cited by this paper
• Stress induced cognitive deficit is differentially modulated in BALB/c and C57Bl/6 mice: correlation with Th1/Th2 balance after stress exposure.

  2010cited by this paper
• Anti-stress effects of the "tonic"Ptychopetalum olacoides (Marapuama) in mice.

  2010cited by this paper
• Use of zebrafish as a model to understand mechanisms of addiction and complex neurobehavioral phenotypes.

  2010cited by this paper
• Two tyrosine hydroxylase genes in vertebrates New dopaminergic territories revealed in the zebrafish brain.

  2010cited by this paper
• High-Throughput Behavioral Screens: the First Step towards Finding Genes Involved in Vertebrate Brain Function Using Zebrafish

  2010cited by this paper
• Genetic dissection of dopaminergic and noradrenergic contributions to catecholaminergic tracts in early larval zebrafish

  2009cited by this paper
• The zebrafish stress axis: molecular fallout from the teleost-specific genome duplication event.

  2009cited by this paper
• A one-trial inhibitory avoidance task to zebrafish: rapid acquisition of an NMDA-dependent long-term memory.

  2009cited by this paper
• Evaluation of rapid cooling and tricaine methanesulfonate (MS222) as methods of euthanasia in zebrafish (Danio rerio).

  2009cited by this paper
• Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety.

  2009cited by this paper
• Status of Glucocorticoid Alterations in Post‐traumatic Stress Disorder

  2009cited by this paper
• Zebrafish embryos as models for embryotoxic and teratological effects of chemicals.

  2009cited by this paper
• Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11

  2009cited by this paper
• Psychobiology and molecular genetics of resilience

  2009cited by this paper
• Ontogeny of the corticotropin-releasing factor system in zebrafish.

  2009cited by this paper
• Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish.

  2009influential reference
• Multimetal interactions between Cd, Cu, Ni, Pb, and Zn uptake from water in the zebrafish Danio rerio.

  2009cited by this paper
• Neural regulation of endocrine and autonomic stress responses

  2009cited by this paper
• Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses.

  2009cited by this paper
• Development of the dopamine systems in zebrafish.

  2009cited by this paper
• Development of the corticosteroid stress axis and receptor expression in zebrafish.

  2008cited by this paper
• Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey.

  2008cited by this paper
• The immune and stress responses of Atlantic cod to long-term increases in water temperature.

  2008cited by this paper
• The social zebrafish: behavioral responses to conspecific, heterospecific, and computer animated fish.

  2008cited by this paper
• Adult zebrafish as a model for successful central nervous system regeneration

  2008cited by this paper
• Zebrafish in The Wild: A Review of Natural History And New Notes from The Field

  2007cited by this paper
• The serotonergic phenotype is acquired by converging genetic mechanisms within the zebrafish central nervous system

  2007cited by this paper
• Adenosine deaminase-related genes: molecular identification, tissue expression pattern and truncated alternative splice isoform in adult zebrafish (Danio rerio).

  2007cited by this paper
• Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants

  2007cited by this paper
• Quantification of shoaling behaviour in zebrafish (Danio rerio).

  2007cited by this paper
• Stress mechanisms and metabolic complications.

  2007cited by this paper
• Whole-body cortisol increases after direct and visual contact with a predator in zebrafish, Danio rerio

  2007cited by this paper
• Anxiolytic effects of nicotine in zebrafish.

  2007cited by this paper
• Evolution of the corticosteroid receptor signalling pathway in fish.

  2007cited by this paper
• The clinical significance of loneliness: a literature review.

  2006cited by this paper
• Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress.

  2006cited by this paper
• Memory Performance in Older Trauma Survivors

  2006cited by this paper
• Common molecular mechanisms in explicit and implicit memory

  2006cited by this paper
• Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice.

  2006cited by this paper
• Social Organization, Grouping, and Domestication in Fish

  2006cited by this paper
• Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS

  2005cited by this paper
• Stress elevates corticotropin-releasing factor (CRF) and CRF-binding protein mRNA levels in rainbow trout (Oncorhynchus mykiss).

  2005cited by this paper
• CRF-related peptides contribute to stress response and regulation of appetite in hypoxic rainbow trout.

  2005cited by this paper
• Glucocorticoids, depression, and mood disorders: structural remodeling in the brain.

  2005cited by this paper
• Appetite-suppressing effects of ammonia exposure in rainbow trout associated with regional and temporal activation of brain monoaminergic and CRF systems

  2005cited by this paper
• Anhedonia and motivational deficits in rats: impact of chronic social stress.

  2005cited by this paper
• The Cost of Chronic Stress: Impacts of a Nonhabituating Stress Response on Metabolic Variables and Swimming Performance in Sturgeon

  2005cited by this paper
• Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming and Exploration

  2004cited by this paper
• Linking genes to brain, behavior and neurological diseases: what can we learn from zebrafish?

  2004cited by this paper
• NMDA receptor-dependent long-term potentiation in the telencephalon of the zebrafish.

  2004cited by this paper
• Teleostean and mammalian forebrains contrasted: Evidence from genes to behavior

  2004cited by this paper
• Corticotropin-releasing factor and neuropeptide Y mRNA levels are elevated in the preoptic area of socially subordinate rainbow trout.

  2003cited by this paper
• Differences in behaviour between rainbow trout selected for high- and low-stress responsiveness.

  2002cited by this paper
• Spatial memory and hippocampal pallium through vertebrate evolution: insights from reptiles and teleost fish.

  2002cited by this paper
• Melatonin promotes sleep-like state in zebrafish.

  2001cited by this paper
• How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.

  2000cited by this paper
• The syntenic relationship of the zebrafish and human genomes.

  2000cited by this paper
• Anxiolytic action on the behavioural inhibition system implies multiple types of arousal contribute to anxiety.

  2000cited by this paper
• The neurobiology of stress: from serendipity to clinical relevance.

  2000cited by this paper
• Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects.

  2000cited by this paper
• Cortisol in teleosts: dynamics, mechanisms of action, and metabolic regulation

  1999cited by this paper
• Natural preference of zebrafish (Danio rerio) for a dark environment.

  1999cited by this paper
• Overview of the Zebrafish system.

  1999cited by this paper
• Shifting the balance between foraging and predator avoidance: the importance of food distribution for a schooling pelagic forager

  1998cited by this paper
• Zebrafish as a Model System for Studying Neuronal Circuits and Behavior a

  1998cited by this paper
• The immediate effects of stress on hormones and plasma lysozyme in rainbow trout.

  1997cited by this paper
• Cortisol and glucose responses after acute stress by net handling in the sparid red porgy previously subjected to crowding stress

  1997cited by this paper
• Quantitative analysis of the distributions of glutamatergic ligand binding sites in goldfish brain.

  1994cited by this paper
• Behaviour of Teleost Fishes

  1992cited by this paper
• The influence of alarm substance and shoal size on the behaviour of zebra danios, Brachydanio rerio (Cyprinidae)

  1988cited by this paper
• Functions of Shoaling Behaviour in Teleosts

  1986cited by this paper
• Oddity and the ‘confusion effect’ in predation

  1986cited by this paper
• A Syndrome produced by Diverse Nocuous Agents

  1936cited by this paper

• Differential adenosine signaling and effects of acute caffeine exposure on alternative stress coping styles in zebrafish (Danio rerio)

  2026influential citation
• Studying the Stress, Gene Expression, and Behavioral Changes Induced by Diazepam and Sertraline in a Zebrafish Model.

  2026cites this paper
• Metabolomic insights into gut-brain axis dysregulation under unpredictable chronic stress in zebrafish.

  2026cites this paper
• Biological Validation of Cortisol in Zebrafish Trunk, Skin Mucus, and Water as a Biomarker of Acute or Chronic Stress

  2026cites this paper
• Responses of zebrafish to chronic environmental stressors: anxiety-like behavior and its persistence

  2025cites this paper
• Laser‐Induced Olfactory Bulbectomy in Adult Zebrafish as a Novel Putative Model for Affective Syndrome: A Research Tribute to Brian Leonard

  2025cites this paper
• The number of conspecific alarm substance donors notably influences the behavioural responses of zebrafish subjected to a traumatic stress procedure

  2025cites this paper
• Habituation with apparatus and group testing improves assessment of fish preferences

  2025cites this paper
• Differential effects of chronic unpredictable stress on behavioral and molecular (cortisol and microglia-related neurotranscriptomic) responses in adult leopard (leo) zebrafish

  2025cites this paper
• Anxiogenic and anxiolytic modulators differentially affect thigmotaxis and thrashing behavior in adult zebrafish during habituation to the open field test.

  2025cites this paper
• Early Life Adversity and Adult Attention-Deficit/Hyperactivity Disorder (ADHD): Pathways to Persistence and Adult Susceptibility.

  2025cites this paper
• The Path to Resilience: Improving Welfare in Aquaculture Through Physical Exercise and Stressor Predictability Training

  2025cites this paper
• Molecular regulation of chronic stress responses in European sea bass, Dicentrarchus labrax

  2025cites this paper
• Effect of Feeding Frequency on Anxiety-Like Behavior and Cortisol Levels in Group-Housed Zebrafish (Danio rerio)

  2025cites this paper
• There is no Smoke Without Fire: Evaluation of Water eDNA Profile of Yersinia ruckeri to Assess Enteric Redmouth Disease Pathogenesis in Rainbow Trout (Oncorhynchus mykiss)

  2025cites this paper
• Unpredictable chronic stress does not alter social behavior in zebrafish

  2025cites this paper
• Assessing adult zebrafish despair-like behaviors in the small vertical cylinder immobility test (VCIT).

  2025cites this paper
• Misbehaving Fish: The role of these simple vertebrates in the analysis of human brain function and dysfunction.

  2025cites this paper
• Experimental modeling of Alzheimer's disease: Translational lessons from cross‐taxon analyses

  2025cites this paper
• The maintenance conditions of the zebrafish (Danio rerio) breeding stock affect the survival and behavior of their offspring

  2025cites this paper
• Zebrafish as a Model Organism for Post-Traumatic Stress Disorder: Insights into Stress Mechanisms and Behavioral Assays

  2025cites this paper
• Modeling Stress‐Related Disorders in Zebrafish Using Prolonged Predator Exposure and Prolonged Unpredictable Stress

  2025cites this paper
• Experimental PTSD Models in Zebrafish: A Systematic Review of Behavioral, Neurochemical, and Molecular Outcomes

  2025cites this paper
• Zebrafish models: Charting promising platform and illuminating the depths of depression.

  2025cites this paper
• Cognitive Bias in Adult Zebrafish (Danio rerio): A Systematic Review

  2025cites this paper
• Tricaine, eugenol and etomidate for repetitive procedural anesthesia in adult zebrafish, Danio rerio: effect on stress and behavior

  2025cites this paper
• Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies.

  2024cites this paper
• Epidermal oxysterols function as alarm substances in zebrafish

  2024cites this paper
• Parental preconception stress in zebrafish induces long-lasting anxiety in offspring.

  2024cites this paper
• Zebrafish—A Suitable Model for Rapid Translation of Effective Therapies for Pediatric Cancers

  2024cites this paper
• Developing Peripheral Biochemical Biomarkers of Brain Disorders: Insights from Zebrafish Models

  2024cites this paper
• Zebrafish Model in Illuminating the Complexities of Post-Traumatic Stress Disorders: A Unique Research Tool

  2024cites this paper
• “Why (Zebra)fish May Get Ulcers”: Cognitive and Social Modulation of Stress in Fish

  2024cites this paper
• Zebrafish models for studying cognitive enhancers.

  2024cites this paper
• Stress-resilient effect of Spirulina platensis on zebrafish chronic unpredictable stress model.

  2024cites this paper
• Unpredictable Repeated Stress in Rainbow Trout (Oncorhynchus mykiss) Shifted the Immune Response against a Fish Parasite

  2024cites this paper
• Neuro-protective effects of increased O-GlcNAcylation by glucosamine in an optic tectum traumatic brain injury model of adult zebrafish.

  2024cites this paper
• Deep Learning Dives: Predicting Anxiety in Zebrafish Through Novel Tank Assay Analysis.

  2024cites this paper
• Knockout in zebrafish reveals the role of the glucocorticoid receptor in shaping behavioral syndromes.

  2024cites this paper
• Optimistic and pessimistic cognitive judgement bias modulates the stress response and cancer progression in zebrafish

  2024cites this paper
• Minocycline reduces neurobehavioral deficits evoked by chronic unpredictable stress in adult zebrafish.

  2024cites this paper
• Posttraumatic anxiety-like behaviour in zebrafish is dose-dependently attenuated by the alpha-2A receptor agonist, guanfacine

  2024cites this paper
• Anxiety modulators elicit different behavioral outcomes in adult zebrafish: Emphasis on homebase-related parameters and spatio-temporal exploration.

  2024cites this paper
• Acute Stress Modulates Social Approach and Social Maintenance in Adult Zebrafish

  2023cites this paper
• Glucosyl hesperidin exhibits more potent anxiolytic activity than hesperidin accompanied by the attenuation of noradrenaline induction in a zebrafish model

  2023cites this paper
• Zebrafish as a Promising Model in Translational Neurobiology and Biomedicine

  2023cites this paper
• Systematic review and meta-analysis of 10 years of unpredictable chronic stress in zebrafish

  2023cites this paper
• Long-term stress induced cortisol downregulation, growth reduction and cardiac remodeling in Atlantic salmon

  2023cites this paper
• The Mechanism of Anxiolytic Effects of Moringa oleifera Leaf Extracts Associated with Significant Differential Expression of Crhb, Faah2a, Mao, and Pah Genes in Danio rerio

  2023cites this paper
• Current State of Modeling Human Psychiatric Disorders Using Zebrafish

  2023cites this paper
• miR-29a Is Downregulated in Progenies Derived from Chronically Stressed Males

  2023cites this paper
• Novel Epidermal Oxysterols Function as Alarm Substances in Zebrafish

  2023cites this paper
• Atorvastatin and gemfibrozil alter zebrafish behavior

  2023cites this paper
• Life-threatening, high-intensity trauma- and context-dependent anxiety in zebrafish and its modulation by epinephrine.

  2023cites this paper
• Environmental change or choice during early rearing improves behavioural adaptability in laying hen chicks

  2023cites this paper
• Metabolic constraints and individual variation shape the trade-off between physiological recovery and antipredator responses in adult sockeye salmon.

  2023cites this paper
• Antidepressant evaluation of Andrographis paniculata Nees extract and andrographolide in chronic unpredictable stress zebrafish model.

  2023cites this paper
• Evaluation of the effects of exogenous cortisol manipulation and the glucocorticoid antagonist, RU486, on the exploratory tendency of bluegill sunfish (Lepomis macrochirus)

  2023cites this paper
• Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways

  2023cites this paper
• Advances in Zebrafish as a Comprehensive Model of Mental Disorders

  2023cites this paper
• Role of Spirulina in Structural Remodeling of Synapse in Telencephalon of Chronic Unpredictable Stress Model of Zebrafish

  2023cites this paper
• Expanding the use of homebase-related parameters to investigate how distinct stressful conditions affect zebrafish behaviors.

  2023cites this paper
• Zebrafish as an experimental model for the simulation of neurological and craniofacial disorders

  2022cites this paper
• Behavioral and cortisol analysis of the anti-stress effect of Polygonum minus (Huds) extracts in chronic unpredictable stress (CUS) zebrafish model.

  2022cites this paper
• Alcohol exposure and environmental enrichment effects on contextual fear conditioning in zebrafish.

  2022cites this paper
• Silver nanoparticles modify the hypothalamic–pituitary–interrenal axis and block cortisol response to an acute stress in zebrafish, Danio rerio

  2022cites this paper
• Baicalein prevents stress-induced anxiety behaviors in zebrafish model

  2022cites this paper
• The Effect of Unpredictable Chronic Stress on Rare Minnow (Gobiocypris rarus): Growth, Behaviour and Physiology

  2022cites this paper
• Evolutionarily conserved gene expression patterns for affective disorders revealed using cross-species brain transcriptomic analyses in humans, rats and zebrafish

  2022cites this paper
• Early life exposure to chronic unpredictable stress induces anxiety-like behaviors and increases the excitability of cerebellar neurons in zebrafish.

  2022cites this paper
• Hatchery and wild larval lake sturgeon experience effects of captivity on stress reactivity, behavior and predation risk

  2022cites this paper
• An insight on chronic unpredictable stress in association with pathophysiology, neurotransmitters, and experimental models

  2022cites this paper
• Assessment of general locomotor activity and anxiety in zebrafish (Danio rerio) in the light-dark box (tank), the shoaling test, in the novel tank and the open field tests

  2022cites this paper
• Ninjinyoeito improves social behavior disorder in neuropeptide Y deficient zebrafish

  2022cites this paper
• Zebrafish - The Neurobehavioural Model in Trend.

  2022cites this paper
• Supervised machine learning aided behavior classification in pigeons

  2022cites this paper
• Influence of acute and unpredictable chronic stress on spatio-temporal dynamics of exploratory activity in zebrafish with emphasis on homebase-related behaviors.

  2022cites this paper
• Structural environmental enrichment and the way it is offered influence cognitive judgement bias and anxiety-like behaviours in zebrafish

  2022cites this paper
• Modeling neurodegenerative disorders in zebrafish.

  2022cites this paper
• Towards translational modeling of behavioral despair and its treatment in zebrafish.

  2022cites this paper
• Neuroprotective and antioxidant effects of pitaya fruit on Cu-induced stress in adult zebrafish.

  2022cites this paper
• Learning Deficits and Attenuated Adaptive Stress Response After Early-Life Seizures in Zebrafish

  2022cites this paper
• Age-Dependent Effects of Chronic Stress on Zebrafish Behavior and Regeneration

  2022cites this paper
• Pessimistic cognitive bias is associated with enhanced reproductive investment in female zebrafish

  2022cites this paper
• Suppression of Chronic Unpredictable Stress-Persuaded Increased Monoamine Oxidase Activity by Taurine Promotes Significant Neuroprotection in Zebrafish Brain

  2022cites this paper
• Sound stimulus effects on dusky damselfish behavior and cognition.

  2022cites this paper
• Evidence of an antidepressant-like effect of xylopic acid mediated by serotonergic mechanisms

  2021cites this paper
• Behavioural and molecular effects of alcohol in the stress model of zebrafish

  2021cites this paper
• Micronized Curcumin Causes Hyperlocomotion in Zebrafish Larvae

  2021cites this paper
• Effects of Atlantic salmon (Salmo salar) fed low- and high HUFA diets on growth and midgut intestinal health

  2021cites this paper
• The Effect of Ethanol Extract of Arabica Coffee (Coffea Arabica Linn) on the Number of Adult Pyramidal Pallium Zebrafish (Danio rerio) Neurons exposed to Stress Method UCS (Unpredictable Chronic Stress)

  2021cites this paper
• Predictable chronic stress modulates behavioral and neuroendocrine phenotypes of zebrafish: Influence of two homotypic stressors on stress-mediated responses.

  2021cites this paper
• Anti-stress effects of the glucagon-like peptide-1 receptor agonist liraglutide in zebrafish

  2021cites this paper
• Zebrafish Tools for Deciphering Habenular Network-Linked Mental Disorders

  2021cites this paper
• Stress and the Gut-Brain Axis: Implications for Cancer, Inflammation and Sepsis.

  2021cites this paper
• Temporal exposure to chronic unpredictable stress induces precocious neurobehavioral deficits by distorting neuromorphology and glutathione biosynthesis in zebrafish brain.

  2021cites this paper
• Tank cleaning temporarily increases stress and decreases affiliative behavior in zebrafish

  2021cites this paper
• Different Influences of Anxiety Models, Environmental Enrichment, Standard Conditions and Intraspecies Variation (sex, personality and strain) on Stress and Quality of life in Adult and Juvenile Zebrafish: A Systematic Review.

  2021cites this paper
• A Reliable High-Throughput Screening Model for Antidepressant

  2021cites this paper
• Zebrafish Models for Stress Research

  2021cites this paper