Biomechanical properties of intermediate filaments: from tissues to single filaments and back

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Bioessays

• Publication date

  2007-01-01

• Fields of study

  Biology, Medicine, Materials Science

• Identifiers
  DOI 10.1002/BIES.20514PMID 17187357
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nanomechanical properties of desmin intermediate filaments.

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• Exploring the mechanical properties of single vimentin intermediate filaments by atomic force microscopy.

  2006influential reference
• Mechanisms of mechanotransduction.

  2006cited by this paper
• Multiple roles of α-smooth muscle actin in mechanotransduction

  2006cited by this paper
• Multiple roles of alpha-smooth muscle actin in mechanotransduction.

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• Mechanical Stretch Stimulates Protein Kinase B/Akt Phosphorylation in Epidermal Cells via Angiotensin II Type 1 Receptor and Epidermal Growth Factor Receptor*

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• Cellular Fluid Mechanics and Mechanotransduction

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• Composition, morphology and mechanics of hagfish slime

  2005cited by this paper
• Severe muscle disease-causing desmin mutations interfere with in vitro filament assembly at distinct stages.

  2005cited by this paper
• Exploring the mechanical behavior of single intermediate filaments.

  2005influential reference
• Tissue Cells Feel and Respond to the Stiffness of Their Substrate

  2005cited by this paper
• Keratin 8 Phosphorylation by Protein Kinase C δ Regulates Shear Stress-mediated Disassembly of Keratin Intermediate Filaments in Alveolar Epithelial Cells*

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• Alternative explanation of stiffening in cross-linked semiflexible networks.

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• Shear Stress Biology of the Endothelium

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• Cell tension, matrix mechanics, and cancer development.

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• Characterization of the elastic properties of the nuclear envelope

  2005cited by this paper
• Investigation of the morphology of intermediate filaments adsorbed to different solid supports.

  2005cited by this paper
• Structural and functional roles of desmin in mouse skeletal muscle during passive deformation.

  2004cited by this paper
• Molecular mechanisms underlying the assembly of intermediate filaments.

  2004cited by this paper
• The biology of desmin filaments: how do mutations affect their structure, assembly, and organisation?

  2004cited by this paper
• Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy.

  2004cited by this paper
• Nonlinear elasticity in biological gels

  2004cited by this paper
• Scaling of F-actin network rheology to probe single filament elasticity and dynamics.

  2004cited by this paper
• Assessing the flexibility of intermediate filaments by atomic force microscopy.

  2004influential reference
• New aspects of the alpha-helix to beta-sheet transition in stretched hard alpha-keratin fibers.

  2004cited by this paper
• Atomic force microscopy imaging and pulling of nucleic acids.

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• New Aspects of the α-Helix to β-Sheet Transition in Stretched Hard α-Keratin Fibers

  2004cited by this paper
• Visualization and mechanical manipulations of individual fibrin fibers suggest that fiber cross section has fractal dimension 1.3.

  2004cited by this paper
• The role of the cytoskeleton in the viscoelastic properties of human articular chondrocytes.

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• Molecular design of the α–keratin composite: insights from a matrix–free model, hagfish slime threads

  2004influential reference
• Isolation, characterization, and in vitro assembly of intermediate filaments.

  2004cited by this paper
• Multiscale modelling of human hair

  2004cited by this paper
• Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes

  2004cited by this paper
• A cryotransmission electron microscopy study of skin barrier formation.

  2003cited by this paper
• Polysaccharide properties probed with atomic force microscopy

  2003cited by this paper
• Intermediate filaments: molecular structure, assembly mechanism, and integration into functionally distinct intracellular Scaffolds.

  2003cited by this paper
• Molecular architecture of intermediate filaments

  2003influential reference
• The mechanical properties of simple epithelial keratins 8 and 18: discriminating between interfacial and bulk elasticities.

  2003cited by this paper
• Mapping mechanical strain of an endogenous cytoskeletal network in living endothelial cells.

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• Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells

  2003cited by this paper
• The mechanical properties of hydrated intermediate filaments: insights from hagfish slime threads.

  2003influential reference
• Mechanics of F-actin characterized with microfabricated cantilevers.

  2002cited by this paper
• A new deformation model of hard alpha-keratin fibers at the nanometer scale: implications for hard alpha-keratin intermediate filament mechanical properties.

  2002cited by this paper
• A New Deformation Model of Hard α-Keratin Fibers at the Nanometer Scale: Implications for Hard α-Keratin Intermediate Filament Mechanical Properties

  2002cited by this paper
• Nanomechanics of microtubules.

  2002cited by this paper
• Characterization of early assembly intermediates of recombinant human keratins.

  2002cited by this paper
• Domain unfolding in neurofilament sidearms: effects of phosphorylation and ATP

  2002cited by this paper
• Beyond structure: do intermediate filaments modulate cell signalling?

  2002cited by this paper
• Mechanics of Motor Proteins and the Cytoskeleton

  2001cited by this paper
• Spatiotemporal analysis of flow-induced intermediate filament displacement in living endothelial cells.

  2001cited by this paper
• Rigidity of Circulating Lymphocytes Is Primarily Conferred by Vimentin Intermediate Filaments

  2001cited by this paper
• The nonhelical tail domain of keratin 14 promotes filament bundling and enhances the mechanical properties of keratin intermediate filaments in vitro

  2001cited by this paper
• Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality

  2000cited by this paper
• Unfolding forces of titin and fibronectin domains directly measured by AFM.

  2000cited by this paper
• Single molecule force spectroscopy in biology using the atomic force microscope.

  2000cited by this paper
• Contribution of intermediate filaments to cell stiffness, stiffening, and growth.

  2000cited by this paper
• A critical review of the structural mechanics of wool and hair fibres.

  2000cited by this paper
• Elastic and shear moduli of single-walled carbon nanotube ropes

  1999cited by this paper
• Keratin Filament Suspensions Show Unique Micromechanical Properties*

  1999cited by this paper
• Desmin filaments studied by quasi-elastic light scattering.

  1999cited by this paper
• Neurofilament‐L homopolymers are less mechanically stable than native neurofilaments

  1998cited by this paper
• Intermediate filament assembly: fibrillogenesis is driven by decisive dimer-dimer interactions.

  1998cited by this paper
• Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure.

  1997cited by this paper
• Effect of strain on human keratinocytes in vitro

  1997cited by this paper
• Simple epithelium keratins are required for maintenance of hepatocyte integrity.

  1997cited by this paper
• Intermediate filament-mediated stretch-induced changes in chromatin: a hypothesis for growth initiation in cardiac myocytes.

  1996cited by this paper
• Torsional rigidity of single actin filaments and actin-actin bond breaking force under torsion measured directly by in vitro micromanipulation.

  1996cited by this paper
• Flexural rigidity of microtubules measured with the use of optical tweezers.

  1996cited by this paper
• Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant

  1995cited by this paper
• Buckling of a single microtubule by optical trapping forces: direct measurement of microtubule rigidity.

  1995cited by this paper
• Direct measurement of stiffness of single actin filaments with and without tropomyosin by in vitro nanomanipulation.

  1994cited by this paper
• An unusual intermediate filament subunit from the cytoskeletal biopolymer released extracellularly into seawater by the primitive hagfish (Eptatretus stouti).

  1994cited by this paper
• Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape

  1993cited by this paper
• Mid-gestational lethality in mice lacking keratin 8.

  1993cited by this paper
• Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis.

  1992cited by this paper
• Identification of a nonapeptide motif in the vimentin head domain involved in intermediate filament assembly.

  1992cited by this paper
• Assembly and structure of calcium-induced thick vimentin filaments.

  1991cited by this paper
• Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease.

  1991cited by this paper
• Keratin-like components of gland thread cells modulate the properties of mucus from hagfish (Eptatretus stouti)

  1991cited by this paper
• Viscoelastic properties of vimentin compared with other filamentous biopolymer networks

  1991cited by this paper
• Mechano-chemical control of human endothelium orientation and size

  1989cited by this paper
• Maturation of hagfish gland thread cells: composition and characterization of intermediate filament polypeptides.

  1988cited by this paper
• The hagfish slime gland thread cell. I. A unique cellular system for the study of intermediate filaments and intermediate filament- microtubule interactions

  1984cited by this paper
• Thread Cells from the Slime Glands of Hagfish (Myxinidae)

  1981cited by this paper
• Threads in the hagfish slime gland thread cells: organization, biochemical features, and length.

  1981cited by this paper
• The hagfish slime gland: a model system for studying the biology of mucus.

  1981cited by this paper
• Intermediate filaments as mechanical integrators of cellular space

  1980cited by this paper
• Ten-nanometer filaments of hamster BHK-21 cells and epidermal keratin filaments have similar structures.

  1978cited by this paper
• The macroheterogeneity of type I tyrosine-rich proteins of merine wool.

  1974cited by this paper
• Rheology of stratum corneum--I: A molecular interpretation of the stress-strain curve

  1972cited by this paper
• Keratins: their composition, structure, and biosynthesis,

  1972cited by this paper
• Physical Properties of Textile Fibres

  1962cited by this paper
• A Quantitative X-Ray Diffraction Study of the Alpha-Beta Transformation in Wool Keratin

  1960cited by this paper
• The Change in Stress on Wetting and Drying Wool Fibers

  1959cited by this paper
• A Two-Phase Structure for Keratin Fibers

  1959cited by this paper
• Is α-Keratin a Coiled Coil?

  1952cited by this paper
• Is alpha-keratin a coiled coil?

  1952cited by this paper
• The structure of hair, muscle, and related proteins.

  1951cited by this paper
• X-Ray Studies of the Structure of Hair, Wool, and Related Fibres. II. The Molecular Structure and Elastic Properties of Hair Keratin

  1934cited by this paper
• X-Ray Studies of the Structure of Hair, Wool, and Related Fibres. I. General

  1932cited by this paper

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• Mechanics of cell sheets: plectin as an integrator of cytoskeletal networks

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• Excessive Glycine Loop Variations in the Keratin 10 Tail Domain and Implications for Skin Fragility.

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• Worsened axonal injury and gliosis following diffuse brain injury in male and female mice with neurofilament light gene deletion.

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• A keratin bundling transition uncages the nucleus in stretched epithelia

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• Control across scales: signals, information, and adaptive biological mechanical function

  2025cites this paper
• Are the Head and Tail Domains of Intermediate Filaments Really Unstructured Regions?

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• Real‐time imaging of intracellular deformation dynamics in vibrated adherent cell cultures

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• Quest for environmentally sustainable materials: A case for animal-based fillers and fibers in polymeric biocomposites

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• Molecular structure of soluble vimentin tetramers

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• Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics

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• Evolution of a remarkable intracellular polymer and extreme cell allometry in hagfishes.

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• Finite Element Modelling of Single Cell Based on Atomic Force Microscope Indentation Method

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• Structure and Nanomechanics of Dry and Hydrated Intermediate Filament Films and Fibers Produced from Hagfish Slime Fibers.

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• Hagfish slime and mucin flow properties and their implications for defense

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• A Natural Approach To Tomorrow ’ s High Performance Fibers : Hagfish Slime Fibers

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• The axon as a physical structure in health and acute trauma.

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