A defined locus control region determinant links chromatin domain acetylation with long-range gene activation.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Molecules and Cells

• Publication date

  2002-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S1097-2765(02)00447-1PMID 11864603
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Locus control regions.

  2002cited by this paper
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• The murine β-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes

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• Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus.

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• Patterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region

  2000cited by this paper
• Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain.

  2000cited by this paper
• Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration.

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• The Human Growth Hormone Gene Cluster Locus Control Region Supports Position-independent Pituitary- and Placenta-specific Expression in the Transgenic Mouse*

  2000cited by this paper
• Locus control regions: coming of age at a decade plus.

  1999cited by this paper
• Pit-1 Binding Sites at the Somatotrope-specific DNase I Hypersensitive Sites I, II of the Human Growth Hormone Locus Control Region Are Essential for in Vivo hGH-N Gene Activation*

  1999influential reference
• A new logic for DNA engineering using recombination in Escherichia coli

  1998cited by this paper
• Signal-specific co-activator domain requirements for Pit-1 activation

  1998cited by this paper
• Recombinogenic targeting: a new approach to genomic analysis--a review.

  1998cited by this paper
• Histone acetylation and transcriptional regulatory mechanisms.

  1998cited by this paper
• Roles of histone acetyltransferases and deacetylases in gene regulation

  1998cited by this paper
• DNase I-hypersensitive sites I and II of the human growth hormone locus control region are a major developmental activator of somatotrope gene expression.

  1998cited by this paper
• Physical linkage of the human growth hormone gene cluster and the CD79b (Ig beta/B29) gene.

  1998cited by this paper
• Homologous recombination based modification in Esherichia coli and germline transmission in transgenic mice of a bacterial artificial chromsome

  1997cited by this paper
• Histone acetylation in chromatin structure and transcription

  1997cited by this paper
• What's up and down with histone deacetylation and transcription?

  1997cited by this paper
• Immunoprecipitation of chromatin.

  1996cited by this paper
• Chromatin structure and gene expression.

  1996cited by this paper
• Determinants of thyrotrope-specific thyrotropin beta promoter activation. Cooperation of Pit-1 with another factor.

  1996cited by this paper
• Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation

  1996cited by this paper
• Molecular biology of the growth hormone-prolactin gene system.

  1995cited by this paper
• Physical linkage of the human growth hormone gene cluster and the skeletal muscle sodium channel alpha-subunit gene (SCN4A) on chromosome 17.

  1995cited by this paper
• The human growth hormone gene is regulated by a multicomponent locus control region

  1995influential reference
• Core histone hyperacetylation co‐maps with generalized DNase I sensitivity in the chicken beta‐globin chromosomal domain.

  1994cited by this paper
• Growth Hormone What is it and what does it do?

  1992cited by this paper
• The human growth hormone locus: nucleotide sequence, biology, and evolution.

  1989cited by this paper
• Dissection of functional domains of the pituitary-specific transcription factor GHF-1

  1989cited by this paper
• Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension.

  1989cited by this paper
• Construction of large DNA segments in Escherichia coli.

  1989cited by this paper
• New method for generating deletions and gene replacements in Escherichia coli

  1989cited by this paper
• Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene.

  1988cited by this paper
• Human growth hormone gene and the highly homologous growth hormone variant gene display different splicing patterns.

  1988cited by this paper
• Position-independent, high-level expression of the human beta-globin gene in transgenic mice.

  1987cited by this paper
• A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells.

  1987cited by this paper
• Tissue‐specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans‐acting factor.

  1987cited by this paper
• Selection for loss of tetracycline resistance by Escherichia coli

  1981cited by this paper
• Positive selection for loss of tetracycline resistance

  1980cited by this paper

• Evidence for Pituitary Repression of the Human Growth Hormone-Related Placental Lactogen Genes and a Role for P Sequences

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  2020cites this paper
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  2020influential citation
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  2018cites this paper
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  2018cites this paper
• Activation of Mouse Tcrb: Uncoupling RUNX1 Function from Its Cooperative Binding with ETS1

  2017influential citation
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  2017influential citation
• Asymmetry between Activation and Deactivation during a Transcriptional Pulse

  2017cites this paper
• Growth hormone and growth hormone gene of the American mink (Neovison vison) – the current state of knowledge of one of the key hormones in one of the most intensively economically exploited species

  2017cites this paper
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  2016cites this paper
• Chapter 5 – Development of the Pituitary∗

  2016cites this paper
• Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.

  2016cites this paper
• Evidence for a Circadian Effect on the Reduction of Human Growth Hormone Gene Expression in Response to Excess Caloric Intake*

  2016cites this paper
• Long-range looping of a locus control region drives tissue-specific chromatin packing within a multigene cluster

  2016cites this paper
• The Hierarchy of Transcriptional Activation: From Enhancer to Promoter.

  2015cites this paper
• Autonomous actions of the human growth hormone long-range enhancer

  2015influential citation
• An Autoregulatory Pathway Establishes the Definitive Chromatin Conformation at the Pit-1 Locus

  2015cites this paper
• Characterization of the human TCAM1P pseudogene and its activation by a potential dual promoter–enhancer: Comparison with a protein‐coding mouse orthologue

  2015cites this paper
• A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA.

  2014cites this paper
• Energy homeostasis targets chromosomal reconfiguration of the human GH1 locus.

  2014cites this paper
• Normal Physiology of ACTH and GH Release in the Hypothalamus and Anterior Pituitary in Man

  2014cites this paper
• Tissue specific CTCF occupancy and boundary function at the human growth hormone locus

  2014cites this paper
• Uncovering Enhancer Functions Using the α-Globin Locus

  2014cites this paper
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  2014cites this paper
• The Dwarf Phenotype in GH240B Mice, Haploinsufficient for the Autism Candidate Gene Neurobeachin, Is Caused by Ectopic Expression of Recombinant Human Growth Hormone

  2014cites this paper
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  2013cites this paper
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  2013influential citation
• Chromatin looping and organization at developmentally regulated gene loci

  2013cites this paper
• Constitutive somatostatin receptor subtype 2 activity attenuates GH synthesis.

  2013cites this paper
• POU1F1-mediated activation of hGH-N by deoxyribonuclease I hypersensitive site II of the human growth hormone locus control region.

  2012cites this paper
• Negative Regulation of Human Growth Hormone Gene Expression by Insulin Is Dependent on Hypoxia-inducible Factor Binding in Primary Non-tumor Pituitary Cells*

  2012cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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• Differential placental hormone gene expression during pregnancy in a transgenic mouse containing the human growth hormone/chorionic somatomammotropin locus.

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• Epigenetic Gene Regulation—Lessons from Globin

  2009cites this paper
• The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression

  2008cites this paper
• Enhancer requirement for histone methylation linked with gene activation

  2008cites this paper
• Transcription and Chromatin Organization of a Housekeeping Gene Cluster Containing an Integrated β-Globin Locus Control Region

  2008cites this paper
• Growth hormone (GH1) gene variation and the growth hormone receptor (GHR) exon 3 deletion polymorphism in a West-African population.

  2008cites this paper
• Molecular physiology of pituitary development: signaling and transcriptional networks.

  2007cites this paper
• Sequencing and genomic annotation of the chicken (Gallus gallus) Hox clusters, and mapping of evolutionarily conserved regions

  2007cites this paper
• Distal control of the pig whey acidic protein (WAP) locus in transgenic mice.

  2007cites this paper
• Nucleosome and transcription activator antagonism at human β-globin locus control region DNase I hypersensitive sites

  2007cites this paper
• Epigenetic Activation of the Human Growth Hormone Gene Cluster during Placental Cytotrophoblast Differentiation

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• Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease

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• The Cloning and Characterization of the Histone Acetyltransferase Human Homolog Dmel\TIP60 in Drosophila melanogaster: Dmel\TIP60 Is Essential for Multicellular Development

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  2007cites this paper
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• SHARED LONG-RANGE REGULATORY ELEMENTS COORDINATE EXPRESSION OF THE NACHR BETA4/ALPHA3/ALPHA5 CLUSTER

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• Hepatocyte nuclear factor-3alpha binding at P sequences of the human growth hormone locus is associated with pituitary repressor function.

  2006cites this paper
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  2006cites this paper
• Tissue-Specific Chromatin Modifications at a Multigene Locus Generate Asymmetric Transcriptional Interactions

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• Locus control region transcription plays an active role in long-range gene activation.

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• On a chromosome far, far away: LCRs and gene expression.

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• A Single Base Difference between Pit-1 Binding Sites at the hGH Promoter and Locus Control Region Specifies Distinct Pit-1 Conformations and Functions

  2006cites this paper
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  2006cites this paper
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• Hyperacetylated Chromatin Domains: Lessons from Heterochromatin*

  2005cites this paper
• Organizing the genome: enhancers and insulators.

  2005cites this paper
• A conserved, extended chromatin opening within alpha-globin locus during development.

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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
• Promoters and control elements: designing expression cassettes for gene therapy.

  2004cites this paper
• A conserved sequence upstream of the B29 (Igβ, CD79b) gene interacts with YY1

  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper