jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Cell

• Publication date

  1989-12-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0092-8674(89)90755-1PMID 2513129
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• jun: oncogene and transcription factor.

  1990cited by this paper
• The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes.

  1989cited by this paper
• Preferential heterodimer formation by isolated leucine zippers from fos and jun.

  1989cited by this paper
• Characterization of junD: a new member of the jun proto‐oncogene family.

  1989cited by this paper
• jun-D: a third member of the jun gene family.

  1989cited by this paper
• The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation.

  1989cited by this paper
• Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction.

  1989cited by this paper
• The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity.

  1989cited by this paper
• Deregulated expression of human c-jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-1a cells as a single gene.

  1989cited by this paper
• Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains.

  1989cited by this paper
• Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.

  1989cited by this paper
• Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation

  1989cited by this paper
• Removal of an mRNA destabilizing element correlates with the increased oncogenicity of proto-oncogene fos.

  1989cited by this paper
• Structure and chromosomal localization of the functional intronless human JUN protooncogene.

  1988cited by this paper
• Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein

  1988cited by this paper
• The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1.

  1988cited by this paper
• c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities.

  1988cited by this paper
• Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.

  1988cited by this paper
• A gene activated by growth factors is related to the oncogene v-jun.

  1988cited by this paper
• Common DNA binding site for Fos protein complexes and transcription factor AP-1.

  1988cited by this paper
• The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites.

  1988cited by this paper
• Transforming but not immortalizing oncogenes activate the transcription factor PEA1.

  1988cited by this paper
• The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.

  1988cited by this paper
• fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen

  1988cited by this paper
• L-myc cooperates with ras to transform primary rat embryo fibroblasts

  1988cited by this paper
• Fos-associated protein p39 is the product of the jun proto-oncogene.

  1988cited by this paper
• fos-associated cellular p39 is related to nuclear transcription factor AP-1.

  1988cited by this paper
• Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters.

  1988cited by this paper
• Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

  1988cited by this paper
• Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

  1988cited by this paper
• Transcriptional autoregulation of the proto-oncogene fos

  1988cited by this paper
• A Harvey-ras responsive transcription element is also responsive to a tumour-promoter and to serum

  1988cited by this paper
• Fos and Jun: the AP-1 connection.

  1988cited by this paper
• Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing

  1988cited by this paper
• DNA binding activities of three murine Jun proteins: stimulation by Fos.

  1988cited by this paper
• The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes.

  1988cited by this paper
• The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous.

  1987cited by this paper
• Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.

  1987cited by this paper
• Avian sarcoma virus 17 carries the jun oncogene.

  1987cited by this paper
• Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.

  1987cited by this paper
• Neoplastic transformation by the human gene N-myc

  1987cited by this paper
• Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements.

  1987cited by this paper
• Two different factors bind to the alpha‐domain of the polyoma virus enhancer, one of which also interacts with the SV40 and c‐fos enhancers.

  1987cited by this paper
• Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.

  1987cited by this paper
• Expression of a transfected human c-myconcogene inhibits differentiation of a mouse erythroleukaemia cell line

  1986cited by this paper
• Basic methods in molecular biology

  1986cited by this paper
• Establishment and identification of small cell lung cancer cell lines having classic and variant features.

  1985cited by this paper
• Specific growth response of ras-transformed embryo fibroblasts to tumour promoters

  1985cited by this paper
• Reverse transcription of retroviral genomes: mutations in the terminal repeat sequences

  1985cited by this paper
• c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene.

  1984cited by this paper
• Oncogene-induced transformation of C3H 10T1/2 cells is enhanced by tumor promoters.

  1984cited by this paper
• Isolation of a transforming sequence from a human bladder carcinoma cell line.

  1982cited by this paper
• FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA

  1982cited by this paper
• Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

  1981cited by this paper
• Normal rat cell lines deficient in nuclear thymidine kinase.

  1981cited by this paper
• Differentiation as a requirement for simian virus 40 gene expression in F-9 embryonal carcinoma cells.

  1979cited by this paper
• Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

  1979cited by this paper
• The induction of differentiation in teratocarcinoma stem cells by retinoic acid.

  1978cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper

• Comprehensive Analysis Based on Genes Associated With Cuproptosis, Ferroptosis, and Pyroptosis for the Prediction of Diagnosis and Therapies in Coronary Artery Disease

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• Genome-wide CRISPR/Cas9 screen reveals JunB downmodulation of HIV co-receptor CXCR4

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• Generation of functionally distinct T-cell populations by altering the viscoelasticity of their extracellular matrix

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• Comparative Study of DNA Ploidy and BRAF Immunohistochemistry between Colonic Adenocarcinoma and Inflammatory Colonic Lesions

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• JUNB suppresses distant metastasis by influencing the initial metastatic stage

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• Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia

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• Effects of Insulin and Insulin-Mimetics on mRNA Levels of c-fos and c-jun in Primary Rat Hepatocytes in Culture

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  2015cites this paper
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• Expressão imuno-histoquímica das proteínas Jab1, p27, c-jun e c-fos no adenoma pleomórfico, adenocarcinoma polimorfo de baixo grau e carcinoma adenoide cístico das glândulas salivares

  2014cites this paper
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  2014cites this paper
• Understanding the function of the JunB transcription factor in anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma

  2013cites this paper
• Cleavage of the JunB Transcription Factor by Caspases Generates a Carboxyl-terminal Fragment That Inhibits Activator Protein-1 Transcriptional Activity*

  2013cites this paper
• The role of the AP-1 proteins c-Jun and JunB in the development and function of plasmacytoid dendritic cells

  2013influential citation
• Identification and characterization of glima 38 , a glycosylated islet cell membrane antigen , which together with GAD 65 and IA 2 marks the early phases of autoimmune response in type 1 diabetes

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• The FOS Transcription Factor Family Differentially Controls Trophoblast Migration and Invasion*

  2013cites this paper
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• Role of translocated promoter region protein in transcriptional regulation of c jun

  2009cites this paper
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