Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Circulation

• Publication date

  2012-07-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCULATIONAHA.112.104380PMID 22705887PMCID PMC3430727
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Common Genetic Variation in the 3′-BCL11B Gene Desert Is Associated With Carotid-Femoral Pulse Wave Velocity and Excess Cardiovascular Disease Risk: The AortaGen Consortium

  2012cited by this paper
• The renin-angiotensin system, bone marrow and progenitor cells.

  2012cited by this paper
• Mechanisms of Premature Vascular Aging in Children With Hutchinson-Gilford Progeria Syndrome

  2012cited by this paper
• The Rotterdam Study: 2012 objectives and design update

  2011cited by this paper
• ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS

  2011cited by this paper
• Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging

  2011cited by this paper
• Broad segmental progeroid changes in short-lived Ercc1−/Δ7 mice

  2011cited by this paper
• Glucagon-Like Peptide 1 Prevents Reactive Oxygen Species–Induced Endothelial Cell Senescence Through the Activation of Protein Kinase A

  2010cited by this paper
• Targeted Deletion of the 9p21 Noncoding Coronary Artery Disease Risk Interval in Mice

  2010cited by this paper
• Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging

  2010cited by this paper
• DNA damage, aging, and cancer.

  2009cited by this paper
• eNOS uncoupling and endothelial dysfunction in aged vessels.

  2009cited by this paper
• Alterations in mechanical properties of mesenteric resistance arteries in experimental portal hypertension.

  2009cited by this paper
• Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

  2009cited by this paper
• Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects.

  2009cited by this paper
• Statins Use a Novel Nijmegen Breakage Syndrome-1–Dependent Pathway to Accelerate DNA Repair in Vascular Smooth Muscle Cells

  2008cited by this paper
• Chromosome 9p21 and cardiovascular disease: the story unfolds.

  2008cited by this paper
• Characterization of inhibitors of phosphodiesterase 1C on a human cellular system

  2007cited by this paper
• qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data

  2007cited by this paper
• Vascular Cell Senescence Contribution to Atherosclerosis

  2006cited by this paper
• Endothelial Function Is Associated With Pulse Pressure, Pulse Wave Velocity, and Augmentation Index in Healthy Humans

  2006cited by this paper
• A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

  2006cited by this paper
• Vascular smooth muscle cell senescence in atherosclerosis.

  2006cited by this paper
• Gab 1 , SHP 2 , and Protein Kinase A Are Crucial for the Activation of the Endothelial NO Synthase by Fluid Shear Stress

  2005cited by this paper
• Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells

  2005cited by this paper
• Endothelial aging.

  2005cited by this paper
• Transcription-coupled repair and premature ageing.

  2005cited by this paper
• Gab1, SHP2, and Protein Kinase A Are Crucial for the Activation of the Endothelial NO Synthase by Fluid Shear Stress

  2005cited by this paper
• DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.

  2003cited by this paper
• Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease.

  2003cited by this paper
• Functional characterization of global genomic DNA repair and its implications for cancer.

  2003cited by this paper
• Polymorphisms in DNA repair genes and associations with cancer risk.

  2002cited by this paper
• Elevated Levels of Oxidative DNA Damage and DNA Repair Enzymes in Human Atherosclerotic Plaques

  2002cited by this paper
• Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction

  2002cited by this paper
• Premature Aging in Mice Deficient in DNA Repair and Transcription

  2002cited by this paper
• Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

  2002cited by this paper
• The relation of oxidative DNA damage to hypertension and other cardiovascular risk factors in Tanzania

  2001cited by this paper
• eNOS Activity Is Reduced in Senescent Human Endothelial Cells: Preservation by hTERT Immortalization

  2001cited by this paper
• Increased nitrovasodilator sensitivity in endothelial nitric oxide synthase knockout mice: role of soluble guanylyl cyclase.

  2000cited by this paper
• Hypertension causes premature aging of endothelial function in humans.

  1997cited by this paper
• Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery.

  1996cited by this paper
• Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells.

  1995cited by this paper
• A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

  1995cited by this paper
• Aging and endothelial function in normotensive subjects and patients with essential hypertension.

  1995cited by this paper
• Antioxidative activity of 5,6,7,8-tetrahydrobiopterin and its inhibitory effect on paraquat-induced cell toxicity in cultured rat hepatocytes.

  1995cited by this paper
• Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women.

  1994cited by this paper
• Reduction of nitric oxide producing activity associated with in vitro aging in cultured human umbilical vein endothelial cell.

  1993cited by this paper
• Antiproliferative action of cyclic GMP-elevating vasodilators in cultured rabbit aortic smooth muscle cells.

  1989cited by this paper

• Colchicine Alleviates Non-Atherosclerotic Vascular Aging by Targeting Endothelial Dysfunction and Inflammatory Status

  2026cites this paper
• Exercise and the hallmarks of cardiovascular aging.

  2026cites this paper
• An endothelial RNA splicing atlas catalogs effects of IL-1β and identifies an alternative PROCR isoform with genetic links to pleiotropic vascular disease.

  2026cites this paper
• Transcriptomic signatures of gray matter volume loss in cerebral small vessel disease.

  2026cites this paper
• SUL-138 mitigates accelerated endothelial aging and protects the kidney

  2025cites this paper
• Interrelations of aortic spring function, cardiovascular disease risk factors, and left ventricular diastolic function: The Framingham Heart Study

  2025cites this paper
• Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS‐STING Pathway and Reverses Macrophage‐Like VSMC Phenotypes in Progeroid DNA‐Repair‐Deficient Ercc1Δ /− Mice

  2025influential citation
• Declining activity of serum response factor in aging aorta in relation to aneurysm progression

  2025cites this paper
• Interconnected Pathways and Therapeutic Implications for Cardiovascular Aging and Diseases

  2025cites this paper
• Microvascular Health as a Key Determinant of Organismal Aging

  2025cites this paper
• Geroscience and pathology: a new frontier in understanding age-related diseases

  2024cites this paper
• OGG1 prevents atherosclerosis-induced vascular endothelial cell injury through mediating DNA damage repair

  2024cites this paper
• Adiponectin secretion by perivascular adipose tissue supports impaired vasodilation in a mouse model of accelerated vascular smooth muscle cell and adipose tissue aging.

  2024cites this paper
• Endothelial Senescence: From Macro- to Micro-Vasculature and Its Implications on Cardiovascular Health

  2024cites this paper
• A pooled analysis of host factors that affect nucleotide excision repair in humans

  2024cites this paper
• The modified 6-chromanol SUL-238 protects against accelerated vascular aging in vascular smooth muscle Ercc1-deficient mice

  2024cites this paper
• Genomic instability and genetic heterogeneity in aging: insights from clonal hematopoiesis (CHIP), monoclonal gammopathy (MGUS), and monoclonal B-cell lymphocytosis (MBL)

  2024cites this paper
• A Brief Overview of Cholinergic and Phosphodiesterase-5 Inhibitors in Diabetic Bladder Dysfunction

  2024cites this paper
• Vascular senescence and atherosclerotic plaque vulnerability: investigating the telomere-mitochondria crosstalk—rationale and design of the VICTORIA Study

  2024cites this paper
• Exploration and bioinformatic prediction for profile of mRNA bound to circular RNA BTBD7_hsa_circ_0000563 in coronary artery disease

  2024cites this paper
• Inhibition of vascular calcification by Compound Danshen Dripping Pill through multiple mechanisms.

  2024cites this paper
• Vascular Aging and Atherosclerosis: A Perspective on Aging

  2024cites this paper
• Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response

  2024influential citation
• Model Systems to Study the Mechanism of Vascular Aging

  2023influential citation
• DNA damage response, a double-edged sword for vascular aging.

  2023cites this paper
• Pharmacological modulation of vascular ageing: a review from VascAgeNet.

  2023cites this paper
• New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death

  2023cites this paper
• Reduction of double-strand DNA break repair exacerbates vascular aging

  2023cites this paper
• N6-Methyladenosine in Vascular Aging and Related Diseases: Clinical Perspectives

  2023cites this paper
• Iron overload induces cerebral endothelial senescence in aged mice and in primary culture in a sex‐dependent manner

  2023cites this paper
• Clinical Impact And Mechanisms Of Non-Atherosclerotic Vascular Aging: The New Kid to be Blocked.

  2023cites this paper
• Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease: JACC Scientific Statement.

  2023cites this paper
• Hallmarks of cardiovascular ageing

  2023cites this paper
• The Role of BTBD7 in Normal Development and Tumor Progression

  2023cites this paper
• Targeting Vascular Smooth Muscle Cell Senescence: A Novel Strategy for Vascular Diseases

  2023cites this paper
• Cardiac System during the Aging Process

  2023cites this paper
• DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice

  2023cites this paper
• DNA repair mechanisms: Exploring potentials of nutraceutical

  2023cites this paper
• ERCC1 polymorphism and its expression associated with ischemic stroke in Chinese population

  2023cites this paper
• Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease

  2022cites this paper
• Vascular Aging and Damage in Patients with Iron Metabolism Disorders

  2022cites this paper
• The Effects of Acute and Chronic Selective Phosphodiesterase 1 Inhibition on Smooth Muscle Cell-Associated Aging Features

  2022cites this paper
• Phosphodiesterase-1 in the cardiovascular system.

  2022cites this paper
• A potential role of autophagy-mediated vascular senescence in the pathophysiology of HFpEF

  2022cites this paper
• Identification of circular RNA BTBD7_hsa_circ_0000563 as a novel biomarker for coronary artery disease and the functional discovery of BTBD7_hsa_circ_0000563 based on peripheral blood mononuclear cells: a case control study

  2022cites this paper
• A protein with broad functions: damage-specific DNA-binding protein 2

  2022cites this paper
• DNA damage response signaling: A common link between cancer and cardiovascular diseases

  2022cites this paper
• Stromal Vascular Fraction Reverses the Age-Related Impairment in Revascularization following Injury

  2022cites this paper
• The landscape of aging

  2022cites this paper
• Cellular senescence and cardiovascular diseases: moving to the "heart" of the problem.

  2022cites this paper
• Soluble guanylate cyclase activator BAY 54–6544 improves vasomotor function and survival in an accelerated ageing mouse model

  2022cites this paper
• Alteration of E2F2 Expression in Governing Endothelial Cell Senescence

  2022cites this paper
• Transcriptomics of angiotensin II-induced long noncoding and coding RNAs in endothelial cells

  2022cites this paper
• Modification Effect of PARP4 and ERCC1 Gene Polymorphisms on the Relationship between Particulate Matter Exposure and Fasting Glucose Level

  2022cites this paper
• Potential Actions of Baicalein for Preventing Vascular Calcification of Smooth Muscle Cells In Vitro and In Vivo

  2022cites this paper
• Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications.

  2022cites this paper
• Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling

  2022cites this paper
• Circulatory metabolites trigger ex vivo arterial endothelial cell dysfunction in population chronically exposed to diesel exhaust

  2022cites this paper
• Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis

  2022cites this paper
• Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years

  2021cites this paper
• Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice

  2021cites this paper
• Role of Oxidative DNA Damage and Repair in Atrial Fibrillation and Ischemic Heart Disease

  2021cites this paper
• Cardiovascular System

  2021cites this paper
• Selective Phosphodiesterase 1 Inhibition Ameliorates Vascular Function, Reduces Inflammatory Response, and Lowers Blood Pressure in Aging Animals

  2021cites this paper
• Endothelial SIRT1 as a target for the prevention of arterial ageing: promises and challenges.

  2021cites this paper
• Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats.

  2021cites this paper
• Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation

  2021cites this paper
• Neurovascular dysfunction and neuroinflammation in a Cockayne syndrome mouse model

  2021cites this paper
• Vascular Ageing Features Caused by Selective DNA Damage in Smooth Muscle Cell

  2021cites this paper
• Inflammatory Molecular Mediators and Pathways Involved in Vascular Aging and Stroke: A Comprehensive Review.

  2021cites this paper
• Transcriptome-wide analysis of intracranial artery in patients with moyamoya disease showing upregulation of immune response, and downregulation of oxidative phosphorylation and DNA repair.

  2021cites this paper
• Targeting senescent cells for vascular aging and related diseases.

  2021cites this paper
• Estimation of total mediation effect for high-dimensional omics mediators

  2021cites this paper
• Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities

  2021cites this paper
• Carotid Disease and Ageing: A Literature Review on the Pathogenesis of Vascular Senescence in Older Subjects

  2020cites this paper
• The importance of the NO-cGMP pathway in age-related cardiovascular disease: focus on phosphodiesterase-1 and soluble guanylate cyclise.

  2020cites this paper
• Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications and other age-related diseases.

  2020cites this paper
• Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population

  2020cites this paper
• Mechanisms of Vascular Aging, A Geroscience Perspective: JACC Focus Seminar.

  2020cites this paper
• Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

  2020cites this paper
• Vascular Smooth Muscle Cell-Specific Progerin Expression Provokes Contractile Impairment in a Mouse Model of Hutchinson-Gilford Progeria Syndrome that Is Ameliorated by Nitrite Treatment

  2020cites this paper
• Local endothelial dna repair defect causes aging-resembling endothelial-specific dysfunction.

  2020cites this paper
• Targeting senescent cells to attenuate cardiovascular disease progression.

  2020cites this paper
• Cockayne Syndrome: The many challenges and approaches to understand a multifaceted disease

  2020cites this paper
• Vascular ageing in hypertension: focus on mitochondria.

  2020cites this paper
• Cellular senescence in vivo: from cells to tissues to pathologies.

  2020cites this paper
• Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease

  2020cites this paper
• Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging

  2020cites this paper
• Nitric Oxide-cGMP Signaling in Hypertension: Current and Future Options for Pharmacotherapy.

  2020cites this paper
• Time-dependent replicative senescence vs. disturbed flow-induced pre-mature aging in atherosclerosis

  2020cites this paper
• Therapeutic Potential of Senolytics in Cardiovascular Disease

  2020cites this paper
• ROS-Induced DNA Damage as an Underlying Cause of Aging

  2020cites this paper
• Transcription blockage by DNA damage in nucleotide excision repair-related neurological dysfunctions.

  2020cites this paper
• Targeting CGRP and 5‐HT1F Receptors for the Acute Therapy of Migraine: A Literature Review

  2019cites this paper
• DNA Damage and Senescence-Associated Inflammation in Cardiovascular Disease.

  2019cites this paper
• Cardiovascular System

  2019cites this paper
• New Trends in Vascular Inflammation Research: From Biology to Therapy

  2019cites this paper
• Longitudinal linear combination test for gene set analysis

  2019cites this paper
• Placental effects and transfer of sildenafil in healthy and preeclamptic conditions

  2019cites this paper
• Aging and Cardiovascular Diseases: The Role of Cellular Senescence

  2019cites this paper