Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Gut

• Publication date

  2004-03-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1136/gut.2003.030841PMID 15016754PMCID PMC1774017
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas.

  2003cited by this paper
• Genetics supersedes epigenetics in colon cancer phenotype.

  2003cited by this paper
• Frequent CpG island methylation in serrated adenomas of the colorectum.

  2003cited by this paper
• Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas.

  2003influential reference
• Morphologic Reappraisal of Serrated Colorectal Polyps

  2003cited by this paper
• Characterization of sporadic colon cancer by patterns of genomic instability.

  2003cited by this paper
• BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair.

  2003cited by this paper
• Concordant CpG island methylation in hyperplastic polyposis.

  2002cited by this paper
• Molecular characteristics of serrated adenomas of the colorectum

  2002cited by this paper
• Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer.

  2002cited by this paper
• CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability.

  2002cited by this paper
• CpG island methylation in aberrant crypt foci of the colorectum.

  2002cited by this paper
• Hyperplastic Polyposis: Association With Colorectal Cancer

  2001cited by this paper
• Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer.

  2001cited by this paper
• Sporadic colorectal cancers with microsatellite instability and their possible origin in hyperplastic polyps and serrated adenomas.

  2001cited by this paper
• Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability.

  2001cited by this paper
• HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers.

  2001cited by this paper
• Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.

  2000cited by this paper
• Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

  2000cited by this paper
• HPP1: A novel transmembrane protein commonly methylated in colorectal polyps and cancers

  2000cited by this paper
• Pathology and genetics: Tumours of the digestive system

  2000cited by this paper
• Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum

  2000influential reference
• Phenotypic and molecular characteristics of hyperplastic polyposis.

  2000influential reference
• Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.

  2000influential reference
• Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum

  2000cited by this paper
• Distinct methylation pattern and microsatellite instability in sporadic gastric cancer

  1999cited by this paper
• Optimisation of DNA and RNA extraction from archival formalin-fixed tissue.

  1999cited by this paper
• DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?

  1999cited by this paper
• Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways.

  1999cited by this paper
• CpG island methylator phenotype in colorectal cancer.

  1999cited by this paper
• The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

  1998cited by this paper
• Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum

  1998influential reference
• Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

  1997influential reference
• High frequency of K-ras mutations in human colorectal hyperplastic polyps.

  1997influential reference
• Alternative genetic pathways in colorectal carcinogenesis.

  1997cited by this paper
• Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

  1996cited by this paper
• FAMILIAL GIANT HYPERPLASTIC POLYPOSIS PREDISPOSING TO COLORECTAL CANCER: A NEW HEREDITARY BOWEL CANCER SYNDROME

  1996cited by this paper
• Serrated adenomatous polyposis in humans.

  1996cited by this paper
• Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

  1994cited by this paper
• Molecular determinants of dysplasia in colorectal lesions.

  1994cited by this paper
• Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

  1993cited by this paper
• Identification and quantification of aberrant crypt foci and microadenomas in the human colon.

  1991cited by this paper
• Mixed Hyperplastic Adenomatous Polyps/Serrated Adenomas: A Distinct Form of Colorectal Neoplasia

  1990influential reference
• Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer.

  1989cited by this paper
• Structure and significance of metaplastic nodules in the rectal mucosa

  1968cited by this paper

• A Case of Serrated Polyposis Syndrome Resulting in Metachronous Medullary Carcinoma of the Transverse Colon

  2025cites this paper
• Novel Methylation Biomarkers for Colorectal Cancer Prognosis

  2021cites this paper
• Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review)

  2021cites this paper
• Integrative Analysis of DNA Methylation and Gene Expression Profiles Identifies Colorectal Cancer-Related Diagnostic Biomarkers

  2021cites this paper
• Current Microsatellite Instability Testing in Management of Colorectal Cancer.

  2020cites this paper
• 대장내시경 후 대장암: 중간 대장암의 원인과 예방

  2020cites this paper
• Serrated neoplasia in the colorectum: gut microbiota and molecular pathways

  2020cites this paper
• TMEFF2: A Transmembrane Proteoglycan with Multifaceted Actions in Cancer and Disease

  2020cites this paper
• Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia.

  2019cites this paper
• Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update.

  2018cites this paper
• Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis

  2018cites this paper
• Endothelial PAS domain protein 1 gene hypomethylation is associated with colorectal cancer in Han Chinese

  2018cites this paper
• Significant association of PRMT6 hypomethylation with colorectal cancer

  2018cites this paper
• Comprehensive DNA Methylation and Mutation Analyses Reveal a Methylation Signature in Colorectal Sessile Serrated Adenomas

  2017cites this paper
• Análisis del riesgo de cáncer colorrectal en pacientes con múltiples pólipos serrados y estudio de marcadores moleculares con implicaciones en su diagnóstico y prevención

  2017cites this paper
• Findings in young adults at colonoscopy from a hospital service database audit

  2017cites this paper
• Molecular characteristics of colorectal serrated polyps and hyperplastic polyps

  2016cites this paper
• Зубчатые образования толстой кишки

  2016cites this paper
• The molecular characteristics of colonic neoplasms in serrated polyposis: a systematic review and meta‐analysis

  2016influential citation
• Serrated polyposis associated with a family history of colorectal cancer and/or polyps: The preferential location of polyps in the colon and rectum defines two molecular entities

  2016influential citation
• Serrated Polyposis Syndrome

  2016cites this paper
• Mutation profile of KRAS and BRAF genes in patients with colorectal cancer: association with morphological and prognostic criteria.

  2015cites this paper
• Epigenetics Territory and Cancer

  2015cites this paper
• Methylation in Colorectal Cancer

  2015cites this paper
• Comethylation of p 16 and MGMT genes in colorectal carcinoma: Correlation with clinicopathological features and prognostic value

  2014cites this paper
• Risco de pólipos e cancro colorretal em doentes com acromegalia: experiência de 20 anos

  2014cites this paper
• Caracterización fenotípica y genotípica de las poliposis colónicas atenuadas. Biomarcadores diagnósticos y pronósticos

  2014cites this paper
• Cronkhite-Canada Syndrome: A Case Report and Literature Review of Gastrointestinal Polyposis Syndrome

  2014cites this paper
• The Association between Mutations Detected in Tissue and Plasma from Patients with Colorectal Adenoma and Adenocarcinoma

  2014cites this paper
• Epigenetic alterations in colorectal cancer: the CpG island methylator phenotype.

  2013cites this paper
• STATINS AUGMENT THE CHEMOSENSITIVITY OF COLORECTAL CANCER CELLS INDUCING EPIGENETIC REPROGRAMMING AND REDUCING COLORECTAL ‘STEMNESS’ VIA THE BONE MORPHOGENETIC PROTEIN PATHWAY

  2013cites this paper
• Overview of Colorectal Cancer

  2013cites this paper
• The stem cell marker CD133 is highly expressed in sessile serrated adenoma and its borderline variant compared with hyperplastic polyp

  2013cites this paper
• Molecular Mechanisms of Colorectal Carcinogenesis

  2013cites this paper
• Polyps and tumour-like lesions of the large intestine

  2012cites this paper
• Epithelial neoplasms of the colorectum

  2012cites this paper
• Cancer Stem Cells in Colorectal Cancer: Genetic and Epigenetic Changes.

  2012cites this paper
• Generation and characterization of Tmeff2 mutant mice.

  2012cites this paper
• Gallstone disease is associated with rectal cancer: a meta-analysis

  2012cites this paper
• Serrated polyposis syndrome: molecular, pathological and clinical aspects.

  2012cites this paper
• Epigenetic regulation and colorectal cancer.

  2012cites this paper
• Gallstones Are Associated with Colonic Adenoma: A Meta-analysis

  2012cites this paper
• Cutaneous papillomas as indicators of the presence of colon polyps in patients with acromegaly

  2012cites this paper
• Serrated Polyposis: An Enigmatic Model of Colorectal Cancer Predisposition

  2011cites this paper
• Serrated Pathway to Colorectal Carcinogenesis: A Molecular Perspective

  2011cites this paper
• Hyperplastic Polyps: Are They Completely Innocent?

  2011cites this paper
• Sporadic colorectal polyps and mismatch repair proteins.

  2011cites this paper
• Prevalencia de expresión de genes MLH1 y MSH2 en pólipos serrados colorrectales y su correlación morfológica y citoarquitectural

  2011cites this paper
• TMEFF2 Is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma

  2011influential citation
• Molecular Features of Colorectal Hyperplastic Polyps and Sessile Serrated Adenoma/Polyps From Korea

  2011cites this paper
• The presence of large serrated polyps increases the risk of colorectal cancer

  2011cites this paper
• Sessile serrated adenomas and classical adenomas: An epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract

  2011influential citation
• Defining Phenotypes and Cancer Risk in Hyperplastic Polyposis Syndrome

  2011cites this paper
• Inappropriate colonoscopic surveillance of hyperplastic polyps.

  2011cites this paper
• 9 – Stool and Blood Sampling for Early Detection of Colorectal Cancer

  2011cites this paper
• Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell ‘stemness’ via the bone morphogenetic protein pathway

  2011cites this paper
• Proximal and large hyperplastic and nondysplastic serrated polyps detected by colonoscopy are associated with neoplasia.

  2010cites this paper
• DNA methylation markers in colorectal cancer

  2010influential citation
• The Pathologist and the Phenotype of Hereditary Colorectal Cancer

  2010cites this paper
• The presence of large serrated polyps increases risk for colorectal cancer.

  2010cites this paper
• Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas.

  2010cites this paper
• Repeated colonoscopic screening of patients with acromegaly: 15-year experience identifies those at risk of new colonic neoplasia and allows for effective screening guidelines.

  2010cites this paper
• Hyperplastic Polyposis Syndrome: Colorectal Cancer Predisposition

  2010cites this paper
• Clinicopathological Features of Colon Polyps from African-Americans

  2010cites this paper
• KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers.

  2010cites this paper
• Genetic basis for susceptibility to lung cancer: Recent progress and future directions.

  2010cites this paper
• Lessons from Lynch syndrome: a tumor biology-based approach to familial colorectal cancer.

  2010cites this paper
• Mechanisms of prostate cancer initiation and progression.

  2010cites this paper
• Tgf-beta signaling alterations and colon cancer.

  2010cites this paper
• Development of sporadic microsatellite instability in colorectal tumors involves hypermethylation at methylated-in-tumor loci in adenoma.

  2010cites this paper
• Role of the serrated pathway in colorectal cancer pathogenesis.

  2010cites this paper
• Hereditary Colorectal Cancer

  2010cites this paper
• Analysis of families with Lynch syndrome complicated by advanced serrated neoplasia: the importance of pathology review and pedigree analysis

  2009cites this paper
• Pathologic Features and Biologic Importance of Colorectal Serrated Polyps

  2009cites this paper
• Serrated polyps and colorectal cancer: new pathway to malignancy.

  2009cites this paper
• A perspective on bi-allelic MUTYH mutations in patients with hyperplastic polyposis syndrome.

  2009cites this paper
• Sonic hedgehog relates to colorectal carcinogenesis

  2009cites this paper
• Serrated polyps of the large intestine: a molecular study comparing sessile serrated adenomas and hyperplastic polyps

  2009cites this paper
• Large Intestine (Colon)

  2009cites this paper
• CHAPTER 19 – Polyps of the Large Intestine

  2009cites this paper
• Serrated Neoplasia Pathway

  2009cites this paper
• DNA Methylation in Colorectal Cancer: Multiple Facets of Tumorigenesis

  2009cites this paper
• Sessile Serrated Adenoma (SSA) vs. Traditional Serrated Adenoma (TSA)

  2008cites this paper
• COX‐2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics

  2008cites this paper
• Nomenclature, molecular genetics and clinical significance of the precursor lesions in the serrated polyp pathway of colorectal carcinoma.

  2008cites this paper
• CHFR as a Potential Anticancer Target

  2008cites this paper
• Surveillance of patients at increased risk of colon cancer: inflammatory bowel disease and other conditions.

  2008cites this paper
• Genetic and epigenetic changes in aberrant crypt foci and serrated polyps

  2008cites this paper
• Selective expression of gastric mucin MUC6 in colonic sessile serrated adenoma but not in hyperplastic polyp aids in morphological diagnosis of serrated polyps

  2008cites this paper
• BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?

  2008cites this paper
• RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A.

  2008cites this paper
• RAS Signaling in Colorectal Carcinomas through Alterations of RAS, RAF,

  2008cites this paper
• [Sessile serrated polyps of the colorectum: how to distinguish a sessile serrated adenoma from a hyperplastic polyp in a daily practice?].

  2008cites this paper
• The mechanism of cancer involves short interfering RNA (siRNA)

  2008cites this paper
• Methylation of estrogen receptor alpha and mutL homolog 1 in normal colonic mucosa: association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia.

  2007cites this paper
• Molecular classification and genetic pathways in hyperplastic polyposis syndrome

  2007cites this paper
• Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions.

  2007influential citation
• Comethylation of p16 and MGMT genes in colorectal carcinoma: correlation with clinicopathological features and prognostic value.

  2007cites this paper
• The role of the bone morphogenetic protein pathway in colorectal cancer

  2007cites this paper
• Serrated colorectal polyps and the serrated neoplastic pathway: Emerging concepts in colorectal carcinogenesis

  2007cites this paper