An exact mathematical expression for describing competitive binding of two different ligands to a protein molecule

No abstract is available for this paper.

• Publication year

  1995

• Venue

  FEBS Letters

• Publication date

  1995-02-27

• Fields of study

  Mathematics, Chemistry, Medicine

• Identifiers
  DOI 10.1016/0014-5793(95)00062-EPMID 7875313
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MSR--a program for kinetic analysis of enzyme modification data on PC.

  1993cited by this paper
• A novel spectroscopic titration method for determining the dissociation constant and stoichiometry of protein-ligand complex.

  1992cited by this paper
• Fluorescence displacement method for the determination of receptor-ligand binding constants.

  1992cited by this paper
• Analysis of receptor binding displacement curves by a nonhomologous ligand, on the basis of an equivalent competition principle.

  1992cited by this paper
• Why, when, and how biochemists should use least squares.

  1992cited by this paper
• A simple method for calculating the dissociation constant of a receptor (or enzyme).unlabeled ligand complex from radioligand displacement measurements.

  1991cited by this paper
• Effects of surface amino acid replacements in cytochrome c peroxidase on complex formation with cytochrome c.

  1991cited by this paper
• A multisubstrate adduct inhibitor of a purine biosynthetic enzyme with a picomolar dissociation constant.

  1989cited by this paper
• Measurement of ligand binding to proteins by fluorescence spectroscopy.

  1985cited by this paper
• Measurement of ligand-protein interaction by electrophoretic and spectroscopic techniques.

  1985cited by this paper
• Enzyme Structure and Mechanism

  1979cited by this paper
• Encyclopaedic dictionary of mathematics for engineers and applied scientists

  1977cited by this paper
• Encyclopaedic Dictionary of Mathematics

  1977cited by this paper
• Data Reduction and Error Analysis for the Physical Sciences

  1969cited by this paper
• A SPECTROPHOTOMETRIC ASSAY FOR AVIDIN AND BIOTIN BASED ON BINDING OF DYES BY AVIDIN.

  1965cited by this paper
• A nomogram for ammonium sulphate solutions.

  1953cited by this paper
• Pancreatic trypsin inhibitor. II. Reaction with trypsin.

  1953cited by this paper

• Fine‐tuned interactions between globular and disordered regions of single‐stranded DNA binding (SSB) protein are required for dynamic condensation under physiological conditions

  2025influential citation
• Linker Modification Enables Control of Key Functional Group Orientation in Macrocycles.

  2025cites this paper
• Hierarchy in regulator interactions with distant transcriptional activation domains empowers rheostatic regulation

  2025cites this paper
• Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics.

  2025cites this paper
• Formulation insights into competitive binding of N6-cyclohexyladenosine and 8-(p-sulfophenyl)theophylline with hydroxypropyl-β-cyclodextrin.

  2025cites this paper
• Characterization of Bacillus velezensis EV17 and K-3618 and Their Polyketide Antibiotic Oxydifficidin, an Inhibitor of Prokaryotic Translation with Low Cytotoxicity

  2025cites this paper
• Mathematical models for the EP2 and EP4 signaling pathways and their crosstalk.

  2025cites this paper
• N‑Aryl‑N‑Lactosylamides as Potent and Highly Selective Inhibitors of Galectin‑3 with Antifibrotic Activity

  2025cites this paper
• Selective engineering of condensation properties of single-stranded DNA binding (SSB) protein via its intrinsically disordered linker region

  2025cites this paper
• Molecular basis for the recognition of low-frequency polyadenylation signals by mPSF

  2025cites this paper
• Hub Occupancy by Competitively Interacting Proteins Obeys a Simple Queuing Law

  2025cites this paper
• To be, or not to be cleaved: Directed evolution of a canonical serine protease inhibitor against active and inactive protease pair identifies binding loop residue critical for prevention of proteolytic cleavage

  2025cites this paper
• Substrate Preorganization Within Photoactive Pt12L24 Nanospheres for Accelerated Decarboxylation Catalysis at Low Concentrations

  2025cites this paper
• Exploring the Potential of Homologous Recombination Protein PALB2 in Synthetic Lethal Combinations

  2025cites this paper
• Structure–Reactivity Relationships in a Small Library of Imine-Type Dynamic Covalent Materials: Determination of Rate and Equilibrium Constants Enables Model Prediction and Validation of a Unique Mechanical Softening in Dynamic Hydrogels

  2024cites this paper
• Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a precision-guided warhead scaffold

  2024cites this paper
• Computational Model-Assisted Development of a Nonenzymatic Fluorescent Glucose-Sensing Assay

  2024cites this paper
• General quasi-equilibrium multivalent binding model to study diverse and complex drug-receptor interactions of biologics

  2024cites this paper
• Single-Molecule Observation of Competitive Protein–Protein Interactions Utilizing a Nanopore

  2024cites this paper
• Quantitative analysis of MBW complex formation in the context of trichome patterning

  2024cites this paper
• Binding Curve Viewer: Visualizing the Equilibrium and Kinetics of Protein–Ligand Binding and Competitive Binding

  2024cites this paper
• Does size matter? - Comparing pyranoses with septanoses as ligands of the bacterial lectin FimH.

  2024cites this paper
• From X-ray crystallographic structure to intrinsic thermodynamics of protein–ligand binding using carbonic anhydrase isozymes as a model system

  2024cites this paper
• Rapid Protein–Ligand Affinity Determination by Photoinduced Hyperpolarized NMR

  2024cites this paper
• An artificial nickel chlorinase based on the biotin–streptavidin technology

  2024cites this paper
• Triphenylphosphonium Analogs of Short Peptide Related to Bactenecin 7 and Oncocin 112 as Antimicrobial Agents

  2024cites this paper
• Probing the Origin of Affinity in the GM1-Cholera Toxin Complex through Site-Selective Editing with Fluorine

  2024cites this paper
• The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

  2024cites this paper
• Evaluation of High-Affinity Monoclonal Antibodies and Antibody-Drug Conjugates by Homogenous Time-Resolved FRET.

  2024cites this paper
• LuBiA (Luciferase-Based Binding Assay): Glowing Peptides as Sensitive Probes to Study Ligand-Receptor Interactions.

  2024cites this paper
• Simultaneous Dopamine and Serotonin Monitoring in Freely Moving Crayfish Using a Wireless Electrochemical Sensing System.

  2024cites this paper
• BiSim Tool: a binding simulation tool to aid and simplify ligand-binding assay design and development

  2024cites this paper
• BCL-XL–targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors

  2024cites this paper
• Evaluation of High-Affinity Monoclonal Antibodies and Antibody-Drug Conjugates by Homogenous Time-Resolved FRET

  2024cites this paper
• Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity.

  2024cites this paper
• Hybrid Molecules of Azithromycin with Chloramphenicol and Metronidazole: Synthesis and Study of Antibacterial Properties

  2024cites this paper
• High Affinity Inhibitors of the Macrophage Infectivity Potentiator Protein from Trypanosoma cruzi, Burkholderia pseudomallei, and Legionella pneumophila—A Comparison

  2024cites this paper
• Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines.

  2023cites this paper
• Fluorescence Anisotropy and Polarization in the Characterization of Biomolecular Association Processes and Their Application to Study SH2 Domain Binding Affinity.

  2023cites this paper
• Direct observation of cortactin protecting Arp2/3-actin filament branch junctions from GMF-mediated destabilization.

  2023cites this paper
• Affinity measurement of strong ligands with NMR spectroscopy: Limitations and ways to overcome them.

  2023cites this paper
• Transient states during the annealing of mismatched and bulged oligonucleotides

  2023cites this paper
• Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei.

  2023cites this paper
• Interaction of DWORF with SERCA and PLB as determined by EPR spectroscopy.

  2023cites this paper
• Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients

  2023cites this paper
• Analysis of Structure-Activity Relationships of Novel Inhibitors of the Macrophage Infectivity Potentiator (Mip) Proteins of Neisseria meningitidis, Neisseria gonorrhoeae, and Burkholderia pseudomallei.

  2023cites this paper
• Deactivatable Bisubstrate Inhibitors of Protein Kinases

  2022cites this paper
• Bayesian regression and model selection for isothermal titration calorimetry with enantiomeric mixtures

  2022cites this paper
• Fluorescence Anisotropy Assay with Guanine Nucleotides Provides Access to Functional Analysis of Gαi1 Proteins.

  2022cites this paper
• Picomolar fluorescent probes for compound affinity determination to carbonic anhydrase IX expressed in live cancer cells

  2022cites this paper
• Conjugates of Desmycosin with Fragments of Antimicrobial Peptide Oncocin: Synthesis, Antibacterial Activity, Interaction with Ribosome

  2022cites this paper
• Fine-tuning of the Hsc70-based human protein disaggregase machinery by the distinctive C-terminal extension of Apg2.

  2022cites this paper
• Mechanism of endosomal escape by pH-responsive nucleic-acid vectors.

  2022cites this paper
• Conjugates of Chloramphenicol Amine and Berberine as Antimicrobial Agents

  2022cites this paper
• An Artificial Metalloenzyme Based on a Copper Heteroscorpionate Enables sp3 C–H Functionalization via Intramolecular Carbene Insertion

  2022cites this paper
• Stabilization of a protein by a single halogen‐based aromatic amplifier

  2022cites this paper
• Highway to Cell: Selection of the Best Cell-Penetrating Peptide to Internalize the CFTR-Stabilizing iCAL36 Peptide

  2022influential citation
• QSAR models reveal new EPAC-selective allosteric modulators

  2022cites this paper
• Studying the interaction between PEX5 and its full-length cargo proteins in living cells by a novel Försteŕs resonance energy transfer-based competition assay

  2022influential citation
• Binding pocket stabilization by high-throughput screening of yeast display libraries

  2022cites this paper
• The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loops

  2022cites this paper
• Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins

  2022cites this paper
• Mechanistic modeling as an explanatory tool for clinical treatment of chronic catatonia

  2022cites this paper
• In vivo nanoscopic landscape of neurexin ligands underlying anterograde synapse specification.

  2022cites this paper
• Structure of VanS from vancomycin-resistant enterococci: A sensor kinase with weak ATP binding

  2022cites this paper
• Crystal structures and functional analysis of the ZnF5-WWE1-WWE2 region of PARP13/ZAP define a distinctive mode of engaging poly(ADP-ribose)

  2022cites this paper
• Mechanistic analysis by NMR spectroscopy: A users guide.

  2022cites this paper
• Cationic helicenes as selective G4 DNA binders and optical probes for cellular imaging

  2021cites this paper
• Development of an AchillesTAG degradation system and its application to control CAR-T activity

  2021cites this paper
• Targeting protein–protein interactions in the DNA damage response pathways for cancer chemotherapy

  2021cites this paper
• CST does not evict elongating telomerase but prevents initiation by ssDNA binding

  2021influential citation
• Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells

  2021cites this paper
• Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin

  2021cites this paper
• Intracellular Protein–Drug Interactions Probed by Direct Mass Spectrometry of Cell Lysates

  2021cites this paper
• Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome

  2021cites this paper
• Changing Cross-Reactivity for Different Immunoassays Using the Same Antibodies: Theoretical Description and Experimental Confirmation

  2021cites this paper
• NMR Reporter Assays for the Quantification of Weak-Affinity Receptor–Ligand Interactions

  2021cites this paper
• Triphenilphosphonium Analogs of Chloramphenicol as Dual-Acting Antimicrobial and Antiproliferating Agents

  2021cites this paper
• Staphylococcus aureus resistance to albocycline can be achieved by mutations that alter cellular NAD/PH pools.

  2021cites this paper
• SERSbot: Revealing the Details of SERS Multianalyte Sensing Using Full Automation

  2021cites this paper
• Exploring the binding of rationally engineered tandem-repeat proteins to E3 ubiquitin ligase Keap1

  2021cites this paper
• Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative

  2021cites this paper
• Divalent ligand-monovalent molecule binding

  2021cites this paper
• Ligand Discovery: High-Throughput Binding: Fluorescence Polarization (Anisotropy).

  2021cites this paper
• Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen-Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design.

  2021cites this paper
• The DNA Damage-Sensing NER Repair Factor XPC-RAD23B Does Not Recognize Bulky DNA Lesions with a Missing Nucleotide Opposite the Lesion

  2020cites this paper
• Conformational ordering of intrinsically disordered peptides for targeting translation initiation.

  2020cites this paper
• Allosteric Mechanisms of Nonadditive Substituent Contributions to Protein-Ligand Binding.

  2020cites this paper
• Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax.

  2020cites this paper
• Evolution of insulin at the edge of foldability and its medical implications

  2020cites this paper
• “Register-shift” insulin analogs uncover constraints of proteotoxicity in protein evolution

  2020cites this paper
• Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction

  2020cites this paper
• Solving the Competitive Binding Equilibria Between Many Ligands: Application to High-Throughput Screening and Affinity Optimization.

  2020cites this paper
• Structure Determination of the Transactivation Domain of p53 in Complex with S100A4 Using Annexin A2 as a Crystallization Chaperone.

  2020cites this paper
• Binding constants determination of cyclodextrin inclusion complexes by affinity capillary electrophoresis. How to overcome the limitations induced by the UV-detector?

  2020cites this paper
• Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist.

  2020cites this paper
• A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

  2020cites this paper
• KLR-70: A novel cationic inhibitor of the bacterial Hsp70 chaperone.

  2020cites this paper
• Unexpected CK2β-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2.

  2020cites this paper
• Exploring long-range cooperativity in the 20S proteasome core particle from Thermoplasma acidophilum using methyl-TROSY–based NMR

  2020cites this paper